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All Journal Indonesian Journal of Pharmaceutical Science and Technology UNEJ e-Proceeding Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Kefarmasian AKFARINDO Jurnal Vokasi Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Riset Farmasi Applied Science and Technology Research Journal Kunir: Jurnal Farmasi Indonesia (KJFI) Pharmacon: Jurnal Farmasi Indonesia
Fitri Andriani Fatimah
Universitas Nahdlatul Ulama Yogyakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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DESCRIPTION OF THE SYMPTOMS OF HYPERTENSION CHARACTERISTICS CONFIRMED BY COVID-19 AT THE INPATIENT INSTALLATION OF PANEMBAHAN HOSPITAL, YOGYAKARTA IN 2020 Fitri Andriani Fatimah; Anis Febri Nilansari; Rahmad A Hi Wahid
UNEJ e-Proceeding 2022: The 2nd International Student Conference 2022
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: The trend of hypertension is increasing every year. It is estimated that 1.13 billion people worldwide have hypertension 2/3 of low-middle income countries. Hypertension is the highest comorbid group in COVID-19 patients, which is 50.5%. This causes an increased risk of dangerous infections that can lead to death. The fact that the SARS-Cov-2 virus uses the Angiotensin Converting Enzym-2 receptor as an entry point to colonize in the body can cause vasoconstriction and inflammation that can worsen the incidence of hypertension and cardiovascular disease. Purpose: This study aims to determine the characteristics of hypertensive patients with confirmed COVID-19 in the inpatient installation of Panembahan Hospital, Senopati, Bantul in 2020. Methods: This study is a descriptive observational study using secondary data in the form of medical records conducted at Panembahan Hospital, Senopati, Bantul. A total of 21 medical record samples were taken that met the inclusion criteria. Samples were taken from December to October 2020 using the total sampling technique. Results: The results of data analysis using the SPSS program obtained a total of 21 samples that met the criteria. There were 10 male patients (47.6%), female 11 patients (52.4%), age >54 years totaling 15 patients (71.4%). The dominant symptoms felt were cough, fever, headache, shortness of breath, malaise, abdominal pain and sore throat totaling 19 patients (90.4%). Conclusion: COVID-19 disease with the most comorbidities is Hypertension, Hypertension with Diabetes Mellitus, followed by Hypertension with Chronic Kidney Failure. The therapy patterns that are often used in Panembahan Hospital, Senopati, Bantul for hypertension patients with Covid-19 are Calcium Channel Blocker (Amlodipine), Angiotensin Receptor Blocker (Valsartan and Candesartan), and Loop Diuretics (Furosemide and Spironolactone).
Profil Penggunaan Antikoagulan pada Pasien COVID-19 dengan Komorbid Hipertensi di Rawat Inap RSUD Panembahan, Bantul, Yogyakarta Rahmat A Hi Wahid; Anis Febri Nilansari; Fitri Andriani Fatimah
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 4, No 1 (2023): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v4i1.11554

Abstract

Hypertension is the highest comorbid group in COVID-19 patients, followed by diabetes mellitus and heart disease. The increase in coagulopathy and thromboembolism secondary to COVID-19 has received global attention, with several surveys and reports of increased mortality. The use of anticoagulants in the treatment of COVID-19 patients needs to be done. This study aims to determine the profile of the use of anticoagulants in COVID-19 patients with hypertension who are hospitalized in Panembahan Hospital, Senopati, Bantul, Yogyakarta. The research method is descriptive observational research using secondary data in the form of medical records. Data were taken retrospectively from the medical records of COVID-19 patients with hypertension who were hospitalized at Panembahan Hospital, Bantul, Yogyakarta for the period 2020-2021. A total of 67 medical records met the inclusion criteria, 46 patients (68.7%) were given anticoagulants and 21 patients (31.3%) were not given anticoagulants. The highest use of anticoagulants was in the age group of 55-65 years (n=28) and 30-54 years (n=21). Heparin (11.9%) and Rivaroxaban (9%) were the single anticoagulants most frequently used for hospitalized COVID-19 patients at Panembahan Hospital, Bantul, Yogyakarta. While the most used combinations were Heparin with Rivaroxaban (20.9%), and Enoxaparin with Rivaroxaban (9%).
Analisis Efektivitas Biaya Terapi Antihipertensi pada Pasien Rawat Inap Covid-19 dengan Hipertensi di RSUD Panembahan Senopati Bantul Yogyakarta Fitri Andriani Fatimah; Anis Febri Nilansari; Rahmat A Hi Wahid
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 11 No. 2 (2022): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v11i2.19224

Abstract

Abstract. Hypertension is the highest comorbid group of Covid-19patients, which is 50.5%, followed by diabetes mellitus 34.5% and heart disease 19.6%. Most hypertensive patients have blood pressure that is not controlled with single therapy, while the cost of treatment is increasing every year. The presence of comorbid hypertension in Covid19 patients has an impact on increasing costs, with the highest average cost being in pharmaceutical costs. This needs to be analyzed to find out which antihypertensive drugs are the most cost-effective and provide the best therapeutic outcomes, especially during the Covid-19pandemic. The purpose of this study was to determine the most costeffective antihypertensive therapy in hypertensive patients with Covid19 in 2020-2022 at Panembahan Senopati Hospital, Bantul, Yogyakarta. This study uses a non-experimental research method that is descriptive analytic. Data was collected retrospectively based on medical records, laboratory results and drug price ceilings in the hospital administration. Cost-effectiveness analysis was carried out by comparing the average direct medical cost to the percentage of patients whose blood pressure reached the target based on ACER parameters and was declared cured (the results of the swab-test or PCR examination were declared negative). The results of the study on 63 Covid-19 patients with hypertension showed that the most costeffective antihypertensive drug class for hypertension monotherapy was the CCB group, the most cost-effective combination of 2 antihypertensive therapies was the ARB and Diuretics and the 3 most costeffective combination of antihypertensive drug classes. effective is a combination of BB, ACEI and diuretics.
Description Of Antihypertensive Drugs Use In Hypertensive Outpatients With Diabetes Mellitus At Panembahan Senopati Bantul Hospital A Hi Wahid, Rahmat; Febri Nilansari, Anis; Andriani Fatimah, Fitri
APPLIED SCIENCE AND TECHNOLOGY REASERCH JOURNAL Vol. 3 No. 1 (2024): Applied Science and Technology Research Journal
Publisher : Lembaga Penelitian dan Pengabdian Mayarakat (LPPM) Universitas PGRI Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31316/astro.v3i1.6143

Abstract

Hypertension (HT) is still a health problem in the world, including in Indonesia. Hypertension in patients with type 2 diabetes mellitus (T2DM) will have an impact on worsening conditions and multi-complications, including macrovascular, microvascular, and insulin resistance complications. This can be prevented by providing appropriate and rational therapy so that the effectiveness of therapy is achieved and avoid worsening conditions and complications. This study aims to determine the pattern of antihypertensive drug use in HT patients with comorbid T2DM in the outpatient installation of Panembahan Senopati Hospital, Bantul for the period of August 2023. The study was designed with a descriptive non-experimental method, cross-sectional with a retrospective approach. The source of research data is secondary data derived from medical records of HT patients with T2DM for the period of August 2023 with data collection by purposive sampling. A total of 157 HT patients met the inclusion criteria in this study with the prevalence of women (n = 106; 67.50%) and men (n = 51; 32.50%), most ages in the 55-65 year range (n = 57; 36.30%). A total of 66 patients (42.10%) received monotherapy, while 91 (57.90) patients received polytherapy. Candesartan (n=80; 27.68%) and Amlodipine (n=78; 26.99%) monotherapy with oral administration were the most common treatment options in this study. Overall, the most widely used drug classes were Angiotensin Receptor Blockers (ARB) (41.18%), Calcium Channel Blockers (CCB) (32.5%), and Diuretics (14.1%). While the most common combination of drug groups is ARB + CCB (24.8%). This study concluded that the use of drugs mainly was polytherapy and in general the use of antihypertensive drugs consisted of 7 classes of drugs namely Angiotensin Receptor Blockers, Calcium Channel Blockers, Diuretics, ẞ- blockers, Centrally-acting Agents, ACE-Inhibitors, Vasodilators
UJI AKTIVITAS ANTIOKSIDAN MINUMAN SERBUK INSTAN TEMULAWAK (Curcuma xanthorriza Roxb) PRODUKSI MITRA SEHAT KIRINGAN BANTUL Naila Imroatus Sholikhah; Muhammad Alfian; Fitri Andriani Fatimah
Jurnal Kefarmasian Akfarindo Vol 8 No 1 (2023)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.v8i1.179

Abstract

Temulawak (Curcuma xanthorhiza Roxb) merupakan tanaman yang sering dimanfaatkan sebagai obat tradisional dan diketahui tanaman ini mengandung senyawa kurkumin yang dapat berperan sebagai antioksidan. Pada penelitian Meiliyana (2021) menunjukkan hasil kadar rata-rata kurkumin dalam minuman serbuk instan temulawak UMKM Mitra Sehat di Desa Wisata Jamu Kiringan dari 3 kemasan yang berbeda berturut-turut adalah sampel A sebesar 42,28%, sampel B sebesar 40,4% dan sampel C sebesar 46,54% yang membuktikan bahwa sampel mengandung kurkumin. Namun belum ada pembuktian uji antioksidan pada serbuk instan temulawak tersebut. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan pada serbuk instan temulawak yang di produksi UMKM Mitra Sehat di Desa Wisata Jamu kiringan. Pada penelitian ini dilakukan uji antioksidan pada tiga sampel yang berbeda menggunakan metode DPPH (2,2-Diphenyl-1-picrylhydrazyl). Masing-masing sampel diuji menggunakan spektrofotometri UV-Vis pada panjang gelombang 516 nm. Penetapan aktivitas antioksidan dengan metode DPPH dinyatakan dengan nilai IC50 (Inhibiton Concentration 50). Hasil penelitian menunjukkan bahwa aktivitas antioksidan pada minuman serbuk instan temulawak (Curcuma xanthorriza Roxb) yang di produksi UMKM Mitra Sehat di Desa Wisata Jamu Kiringan Bantul termasuk dalam kategori sedang dengan nilai IC50 masing-masing sampel secara berturut-turut adalah sampel A sebesar (144,126 ppm), sampel B sebesar (141,839 ppm), dan sampel C sebesar (141,765 ppm).
Willingness to Pay and Factors that Influence Curcuma xanthorrhiza Use during The COVID-19 in Kiringan Village, Bantul Hidayati, Listiana; Fatimah, Fitri Andriani
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, no. 3 (The 3rd Mandala Waluya International Conference on Pharmaceutical Science and
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i3.54080

Abstract

The Indonesian government officially announced a positive case of a patient exposed to COVID-19 in 2020. The purpose of the study was to determine the characteristics of the community in Kiringan Hamlet, calculate the willingness to pay (WTP) value for temulawak and determine the factors that influence the WTP value during COVID-19. The method used descriptive-analytical non-experimental, which involved distributing questionnaires to consumers and herbal medicine producers in Kiringan Village, Bantul, Yogyakarta. The number that met the inclusion criteria was 276 respondents. The primary data obtained were then analyzed descriptively, followed by a WTP analysis using the contingent valuation modeling (CVM) approach and a factor analysis using regression analysis. The results showed that the age distribution obtained from 69 respondents was 36-45 years old (25%), the majority of female gender with 156 respondents (57%), education level was high school with 137 respondents (50%), 172 people (62%) with income level below 1,000,000.00 IDR, the average WTP value of temulawak was 10,956.52 IDR. In contrast, the total WTP value of temulawak reached 3,024,000.00 IDR. Occupation factors (p=0.004), number of family members (p=0.040), and duration of consumption (p=0.005) also affected the WTP of temulawak.
Formulasi Sabun Cair Antibakteri dengan Bahan Aktif Ekstrak Biji Kakao (Theobroma cacao L.) Muhammad Alfian; Lita Siswanti; Fitri Andriani Fatimah
Jurnal Riset Farmasi Volume 4, No. 2, Desember 2024, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrf.v4i2.4866

Abstract

Abstrak. Mikroorganisme patogen, seperti Staphylococcus aureus, dapat menyebabkan penyakit kulit. Biji kakao mengandung metabolit sekunder, seperti flavonoid, tanin, dan alkaloid, dengan aktivitas antibakteri. Penelitian ini bertujuan mengidentifikasi kandungan metabolit sekunder pada ekstrak biji kakao, serta menguji sifat fisik dan aktivitas antibakteri sabun cair ekstrak biji kakao terhadap S. aureus. Ekstraksi dilakukan dengan metode maserasi, diikuti skrining fitokimia, dan formulasi sabun cair F0 (ekstrak 0%), F1 (20%), F2 (40%), dan F3 (60%). Uji aktivitas antibakteri menggunakan metode difusi sumuran dengan diameter zona hambat diukur pada semua formula dan kontrol positif (sabun cair Dettol). Hasil fitokimia menunjukkan ekstrak mengandung flavonoid, alkaloid, dan tanin. Uji organoleptik, tinggi busa, dan homogenitas semua formula memenuhi syarat, namun viskositas hanya F0 dan F1 yang memenuhi. Uji pH semua formula tidak memenuhi standar. Uji antibakteri menunjukkan daya hambat kuat pada F0 (12,698 mm), F1 (13,251 mm), F2 (10,12 mm), dan F3 (14,383 mm), sedangkan kontrol positif memiliki daya hambat kategori sedang (6,195 mm). Abstract. Skin diseases are conditions affecting the body's surface, often caused by microorganisms like Staphylococcus aureus. Cocoa beans (Theobroma cacao) contain secondary metabolites such as alkaloids, flavonoids, and tannins, which exhibit antibacterial properties. This study aimed to identify the phytochemical compounds in cocoa bean extract, develop a liquid soap formulation, assess its physical properties, and evaluate its antibacterial activity against S. aureus. The cocoa bean extract was obtained through the maceration method and underwent phytochemical screening. Four liquid soap formulations were created: F0 (0% extract), F1 (20% extract), F2 (40% extract), and F3 (60% extract). Antibacterial activity was tested using the well diffusion method by measuring the inhibition zone diameters of the formulations and the positive control (liquid Dettol soap). Phytochemical analysis confirmed the presence of flavonoids, alkaloids, and tannins. Organoleptic tests, including foam height and homogeneity, met the standards for all formulations, while viscosity standards were met only by F0 and F1. However, none of the formulations met pH standards. Antibacterial tests showed strong inhibition in all formulations: F0 (12.698 mm), F1 (13.251 mm), F2 (10.12 mm), and F3 (14.383 mm). The positive control showed medium inhibition (6.195 mm).
Skrining Kadar Gula Darah Sewaktu (GDS) pada Guru dan Karyawan di SMK-SMF “Indonesia” Yogyakarta Sebagai Upaya Deteksi Dini Risiko Diabetes Melitus Yogananda, Amrina Amalia; Hidayati, Listiana; Hasanudin, Muhammad Nurul; Faizah, Nurul; Alfian, Muhammad; Fatimah, Fitri Andriani
Jurnal Vokasi Vol 9, No 2 (2025): Juli
Publisher : Politeknik Negeri Lhokseumawe

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30811/vokasi.v9i2.7299

Abstract

Salah satu penyakit tidak menular dengan kasus yang meningkat setiap tahun adalah diabetes melitus. Kejadian DM di Kota Yogyakarta menjadi yang tertinggi dibandingkan dengan Kabupaten lain di daerah Istimewa Yogyakarta. Pemeriksaan kadar gula darah dilakukan sebagai bentuk pencegahan, mendeteksi kemungkinan diabetes atau prediabetes, dan mengontrol komplikasi terutama bagi pasien diabetes melitus. Kegiatan pengabdian kepada masyarakat bertujuan untuk memberikan gambaran kadar gula darah kepada guru dan karyawan di SMK-SMF “Indonesia” Yogyakarta dan risiko terjadinya penyakit diabetes melitus. Tahapan yang dilakukan pada kegiatan pengabdian adalah koordinasi dan persiapan, pemeriksaan kadar gula darah, serta edukasi kepada responden. Jumlah guru dan karyawan yang berpartisipasi dalam kegiatan pemeriksaan kadar gula darah berjumlah 36 orang dengan jumlah responden laki-laki sebanyak 10 orang (27,78%) dan responden perempuan berjumlah 26 orang (72,22%). Pemeriksaan kadar gula darah dilakukan menggunakan kadar gula darah sewaktu dan diperoleh hasil responden dengan kadar gula darah 200 mg/dL sebanyak 35 orang (97,22%) dan 1 responden (2,78%) yang memiliki GDS ≥200 mg/dL. Responden perempuan 100% memiliki kadar gula darah 200 mg/dL, sedangkan pada responden laki-laki terdapat 1 responden yang memiliki kadar gula darah sewaktu ≥200 mg/dL. Responden dengan kadar gula darah sewaktu ≥200 mg/dL disarankan untuk melakukan pemeriksaan rutin ke fasilitas kesehatan terdekat dan diminta mengurangi asupan gula berupa makanan atau minuman manis karena berisiko menderita penyakit diabetes melitus. Responden dengan kadar gula darah sewaktu yang baik diberikan edukasi mengenai batasan gula yang dikonsumsi dalam satu hari, aktivitas fisik yang perlu dilakukan, makanan-minuman yang disarankan dan dihindari.
Pelatihan Kreatif Sabun Aromaterapi sebagai Alternatif Usaha Tambahan bagi Pengrajin Jamu Dusun Kiringan, Canden, Bantul Fatimah, Fitri Andriani; Hidayati, Listiana
Jurnal Vokasi Vol 9, No 2 (2025): Juli
Publisher : Politeknik Negeri Lhokseumawe

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30811/vokasi.v9i2.7369

Abstract

Pengabdian kepada masyarakat (PKM) ini dilaksanakan melalui pelatihan kewirausahaan kreatif dengan tema pembuatan sabun aromaterapi, bertujuan untuk membuka peluang usaha baru bagi masyarakat, khususnya ibu-ibu pengrajin jamu di Dusun Kiringan, Canden, Bantul, Yogyakarta. Kegiatan ini diselenggarakan pada tanggal 13 Desember 2024 dan diimplementasikan melalui tiga tahap proses, yaitu: (1) pemaparan materi, (2) praktik langsung pembuatan sabun, serta (3) sesi diskusi dan tanya jawab. Dusun Kiringan memiliki potensi tanaman apotek hidup yang kaya senyawa aktif antibakteri, sehingga mendukung para pengrajin jamu untuk mengembangkan produk berbasis kosmetik, seperti sabun cair, sebagai bentuk diversifikasi usaha berbahan alami. Tujuan utama dari kegiatan ini adalah memberikan pelatihan kewirausahaan berbasis kreativitas melalui pembuatan sabun aromaterapi yang diharapkan dapat menjadi cikal bakal usaha mandiri pengrajin jamu. Hasil dari kegiatan ini berupa produk sabun mandi ukuran 100 ml per botol, dengan keunikan aroma yang berasal dari ekstrak sereh dan cengkeh. Pelatihan kewirausahaan berbasis kreativitas melalui pembuatan sabun aromaterapi telah memberikan pengetahuan dan keterampilan praktis kepada peserta, sehingga diharapkan mampu mendorong lahirnya usaha mandiri baru yang berpotensi meningkatkan perekonomian masyarakat secara berkelanjutan.
Hubungan Pengetahuan terhadap Perilaku Penggunaan Kosmetik Mengandung Merkuri pada Mahasiswa di DIY Khasanah, Indayati; Faizah, Nurul; Fatimah, Fitri Andriani
KUNIR: JURNAL FARMASI INDONESIA Vol 3 No 1 (2025): JULI
Publisher : Program Studi Farmasi (S-1), Fakultas Ilmu Kesehatan, Universitas Bhamada Slawi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36308/kjfi.v3i1.723

Abstract

Penggunaan kosmetika merupakan bagian yang tak terpisahkan dari kehidupan sehari-hari, terutama di kalangan mahasiswa. Namun, perlu diperhatikan bahwa beberapa produk kosmetika mengandung bahan berbahaya seperti merkuri. Tujuan penelitian ini adalah untuk mengetahui hubungan tingkat pengetahuan terhadap perilaku penggunaan kosmetik mengandung merkuri pada mahasiswa di DIY. Desain penelitian yang digunakan pada penelitian ini adalah kuantitatif dengan menggunakan desain analitik dan pendekatan cross sectional menggunakan alat ukur kuisioner dengan sampel 400 orang responden yang memenuhi kriteria inklusi. Analisis data dilakukan beberapa uji yaitu uji validitas, uji reabilitas dan analisis nivariat. Hasil pada uji validitas yang dilakukan pada 30 responden didapatkan data bahwa variabel pengetahuan dan perilaku penggunaan dinyatakan valid dan realibel karena r Hitung lebih besar dari r Tabel. Pada variabel pengetahuan didapatkan hasil 76% (304) responden dengan tingkat pengetahuan yang tinggi, 23,5% (94) responden dengan tingkat pengetahuan sedang, dan 0,5% (2) responden dengan tingkat kategori rendah. Pada variabel Perilaku penggunaan didapatkan hasil 86,25% (345) responden dengan tingkat perilaku yang tinggi, 13,25% (53) responden dengan tingkat perilaku sedang, dan 0,5% (2) responden dengan tingkat perilaku rendah. Digunakan metode Spearman Rank untuk mengetahui korelasi antar variabel. Setelah dilakukan uji didapatkan hasil bahwa pengetahuan memiliki hubungan dengan perilaku penggunaan kosmetik karena nilai p-value yang didapat 0.001 (<0,05) yang berarti memiliki hubungan, dan pada nilai correlation coefficient sebesar 0,641 yang termasuk dalam kategori hubungan yang kuat.
Co-Authors A Hi Wahid, Rahmat Anis Febri Nilansari Anis Febri Nilansari Anis Febri Nilansari Hasanudin, Muhammad Nurul Khasanah, Indayati Listiana Hidayati Lita Siswanti Muhammad Alfian Muhammad Alfian Muhammad Alfian, Muhammad Nilansari, Anis Febri NURUL FAIZAH Rahmad A Hi Wahid Rahmat A Hi Wahid Rahmat A Hi Wahid ST. Mualifah Yogananda, Amrina Amalia