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All Journal JURNAL DINAMIKA EKONOMI PEMBANGUNAN MNJ (Malang Neurology Journal) International Journal of Business, Economics, and Social Development Narra J JUKEJ: Jurnal Kesehatan Jompa Jurnal Sains, Teknologi dan Kesehatan
Yeni Purnamasari, Yeni
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Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : Narra J

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Perindopril decreases angiotensin-converting enzyme 2 (ACE2) expression in human adipocytes exposed to SARS-CoV-2 S1 spike protein Harsoyo, Primasitha M.; Ardiana, Meity; Hermawan, Hanestya O.; Purnamasari, Yeni; Anandita, Faizal A.
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.746

Abstract

The expression of angiotensin-converting enzyme 2 (ACE2) in the adipose tissues of obese patients needs further study, as it may aid infection and serve as a viral reservoir. There has been controversy over whether to use ACE inhibitors to prevent coronavirus disease 2019 (COVID-19) severity. Perindopril, an ACE2 inhibitor, has been proposed; however, its relationship with COVID-19 has not yet been clear. The aim of this study was to investigate the effect of perindopril to reduce the expression of ACE2 and pro-inflammatory cytokine in adipocytes exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Enzymatic isolation of adipose tissues was performed from obese male donor patients aged 30–50 years, then exposed it with SARS-CoV-2 S1 spike protein. This study also included human recombinant ACE2 (hrsACE2) as a comparison to perindopril. The expression of ACE2 was evaluated using ELISA. Our data indicated that SARS-CoV-2 Spike protein exposure increased ACE2 expression significantly. Administration of perindopril decreased ACE2 expression (43.37 µg/mL) significantly compared to the positive group (80.31 µg/mL) (p<0.001). Perindopril administration also decreased IL-6 levels significantly compared to positive group(p<0.001).  This study highlights that perindopril could reduce the ACE2 expression and pro-inflammatory cytokine levels in adipocytes exposed to SARS-CoV-2 S1 spike protein.
Co-Authors Adhayanti, Ida Anandita, Faizal A. Arief Alamsyah Nasution, Arief Alamsyah Badrul Munir, Badrul Carolina, Hilda Harsoyo, Primasitha M. Hermawan, Hanestya O. Hidayati, Nisaulfathona Irma Rahmawati Lintangsari, Nastiti Ninda Lubis, Mohammad Riza Meity Ardiana Nindia Sugih Arto, Nindia Sugih Nursanti, Irna Ramadhan, Wiangga Febranto Tarigan, Radar Radius Youvella, Sylvia