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All Journal Medical Journal of Indonesia Folia Medica Indonesiana Jurnal Media Gizi Indonesia (MGI) The Indonesian Journal of Public Health The Indonesian Biomedical Journal Jurnal Health Sains Narra J Yuridika Asian Journal of Social and Humanities
Meity Ardiana
Departemen Kardiologi Dan Kedokteran Vaskuler Fakultas Kedokteran Universitas Airlangga/RSUD Dr. Soetomo, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Veterinary Other

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ENERGI, MAKRONUTRIEN, DAN CAROTID INTIMA-MEDIA THICKNESS (CIMT) PADA REMAJA OBESITAS [Energy, Macronutrients, and Carotid Intima-Media Thickness (CIMT) in Obese Adolescents] Nur Aisiyah Widjaja; Roedi Irawan; Meity Ardiana; Meta Herdiana Hanindita; Rendi Aji Prihaningtyas
Media Gizi Indonesia Vol. 15 No. 1 (2020): JURNAL MEDIA GIZI INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v15i1.22-26

Abstract

Obesity prevalence is increasing in adolescents. Subclinical chronic infl ammation in obesity causes complication, such as atherosclerosis. Cardiovascular disease is one of the complications of obesity that causes premature death. Carotid intima-media thickness (CIMT) is a subclinical marker of atherosclerosis which easily performed and noninvasive. Early detection of atherosclerosis can improved outcome. Healthy diet have a negative correlation with CIMT meanwhile high calori diet increase CIMT. This study aimed to examine the eff ect of energy and macronutrients intake on CIMT in obese adolescents. A cross sectional study was conducted on 59 adolescents aged 13-16 years old with obesity in pediatric clinic of Dr. Soetomo General Hospital using consecutive sampling method. Dietary intake was obtained through 1 x 24 hours food recall. Anthropometric measurements include body height and weight. Body Mass Index (BMI) was calculated. Obesity is defi ned as BMI higher than 95th percentile based on age and gender (CDC 2000 curve). CIMT examination was performed using B mode ultrasonography on the neck. Statistical analysis was perfomed using mutiple linear regression to analyze the eff ect of total energy, fat, and carbohydrate on CIMT. There were 59 obese adolescents included in this study, consist of 27 (45.8%) female adolescents and 32 (54.2%) male adolescents. No eff ects of total energy, carbohydrate, and fat on CIMT was found in obese adolescents (p>0.05). Further research with more subjects and at least 2x24 hours food recall are needed to assess the eff ect of calories and macronutrients on CIMT in obese adolescents.
Mortality among Heart Failure Patients in the Presence of Cachexia Andrianto; Ula Nur Pramesti Karman; Sony Wibisono Mudjanarko; Meity Ardiana; Hanestya Oky Hermawan
Folia Medica Indonesiana Vol. 59 No. 1 (2023): March
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (564.741 KB) | DOI: 10.20473/fmi.v59i1.39512

Abstract

Highlights: Around 38.8% of heart failure patients with cachexia died during the 180-1,876-day follow-up period. Cachexia increases the risk of mortality in heart failure patients. Abstract: Despite the fact that obesity has long been recognized as a risk factor for cardiovascular disease, the mortality rate of heart failure (HF) patients with cachexia is still high. Several studies have been conducted to investigate the association between cachexia and mortality in HF patients. However, the research results vary, as do the diagnostic criteria employed to assess cachexia. This meta-analysis aimed to conclusively summarize the association between cachexia and mortality in HF patients. The data were obtained from prospective or retrospective cohort studies with full texts in English or Indonesian and keywords related to "cachexia," "heart failure," and/ or "mortality". Studies that did not assess mortality in HF patients with cachexia and had no full text accessible were omitted. A literature search was conducted through four databases (PubMed, Web of Science, Scopus, and SAGE Journals) using keywords, reference searches, and/ or other methods on April 2022 in accordance with the Preferred Reported Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data from the selected studies were presented and analyzed using qualitative and quantitative synthesis methods. The Newcastle-Ottawa Scale (NOS) was used to assess the risk of bias in the selected cohort studies. The qualitative synthesis contained nine studies, whereas the quantitative synthesis (meta-analysis) included six studies. Cachexia was found in 16.0% of the 4,697 patients studied. During the 180-1,876-day follow-up period, 33.0% of the patients died, with a mortality rate of 38.8% among the patients with cachexia. The pooled analysis revealed cachexia to be a significant predictor of mortality in HF patients (hazard ratio (HR)=3.84; 95% CI=2.28-6.45; p<0.00001), but with significant heterogeneity (p<0.00001; I2=88%). In conclusion, cachexia worsens HF prognosis.
EFFECTS OF CONSUMING BISCUITS MADE FROM MORINGA OLEIFERA LEAF ON BODY WEIGHT AND HEIGHT OF CHILDREN UNDER FIVE IN BANGKALAN, MADURA ISLAND Anna Surgean Veterini; Enny Susanti; Meity Ardiana; Annis Catur Adi; Heni Rachmawati
Media Gizi Indonesia Vol. 18 No. 2 (2023): MEDIA GIZI INDONESIA (NATIONAL NUTRITION JOURNAL)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v18i2.150-156

Abstract

One of the efforts to maintain children’s nutritional status is to prevent weight faltering, which was formerly known as failure to thrive. Unresolved weight faltering will cause several problems, such as growth failure, stunting, decreased IQ, morbidity, and mortality in children. Stunting is one of the big problems that occur in Indonesia. One of the continuous strategies to prevent weight faltering is through food supplementation, such as consuming moringa leaf which is high in protein in the form of biscuits. This study aims to determine the effects of consuming biscuits made from Moringa oleifera leaf on children's growth in Bangkalan, Indonesia. This study used experimental research method for two months. The sample was drawn using consecutive sampling technique. The subjects in this study were 31 children under five whose weight and height were not according to age. Before moringa biscuits were distributed, children’s body weight and height were measured. The nutritional status was evaluated every month for two months. The parameters measured were weight gain and height increase. The results were analyzed using univariate and multivariate tests on SPSS. After giving moringa oleifera biscuits for two months at the Village Health Post (Pos Kesehatan Desa/Poskesdes) of Bangkalan, children’s body weight increased by 0.35 kg per month and their height increased by 0.65 cm per month. The distribution of biscuits can be continued to preventing stunting.
Corporate Criminal Liability in Procurement of Goods and Services in Hospital Meity Ardiana; Adriano Adriano; Kurniadi Doni; Yulianto Yulianto
Yuridika Vol. 38 No. 2 (2023): Volume 38 No 2 May 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ydk.v38i2.43674

Abstract

Procurement of goods and services for the benefit of the government is one of the tools to drive the wheels of economy in order to improve the national economy in order to create people's welfare and improve the quality of human resources. However, there are many problems in the implementation of the goods and services procurement program, such as mark-ups that exceeded the limit and law enforcement which was considered problematic, this resulted in the difficulty of determining which administrators were responsible for violations in the procurement of goods and services, given the complex form of management in a corporation that raises doubts about the possibility of the corporation to be held criminally liable and sentenced. Especially in hospitals which, at every level, every subject who carries out their duties and functions, can represent the hospital as a corporation. This article discusses corporate criminal responsibility for violations committed by Directors, Budget User Authorities, procurement committees and/or project executors in the procurement of goods and services in hospitals. This study will answer how is the criminal responsibility for violations committed by the Director and Committee in the procurement of goods and services at the Hospital and how is corporate criminal responsibility towards third parties for violations committed in the procurement of goods and services at the Hospital. The method used is qualitative and the approaches used are statute, conceptual, and case.
Losartan Has a Comparable Effect to Human Recombinant ACE2 in Reducing Interleukin-6 (IL-6) Levels on Human Adipocytes Exposed to SARS-CoV-2 Spike Protein Hanestya Oky Hermawan; Meity Ardiana; I Gde Rurus Suryawan; Primasitha Maharany Harsoyo; Muhammad Rafli
The Indonesian Biomedical Journal Vol 15, No 5 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i5.2552

Abstract

BACKGROUND: High angiotensin-converting enzyme 2 (ACE2) expression in adipocyte cells facilitates the initiation of SARS-CoV-2 infection and triggers a cytokine storm. This finding suggests that obesity is an independent risk factor for the severity of the symptoms caused by COVID-19. The use of cardiovascular medications that focus on ACE2, such as angiotensin II receptor blockers, remains controversial, and their effects on inflammatory cytokine production and ACE2 expression in cells, especially adipocytes, remain inconsistent.METHODS: The human adipocytes were isolated from obese donor subcutaneous adipose tissue and infected with the subunit S1 spike protein from SARS-Cov-2. The adipocytes were later treated with either hrsACE2 or losartan. The levels of ACE2 and inflammatory cytokines interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α were measured using enzyme linked immunosorbent assay (ELISA). ACE2 and S1 spike protein binding assays were also performed. RESULTS: ACE2, IL-6, and TNF-α levels were significantly increased in human adipocyte cells infected with SARS-Cov-2 but not IL-1β. There was a statistically significant positive correlation between ACE2 and IL-6 (r=0.878, p<0.001). Administration of losartan and hrsACE2 was shown to reduce ACE2 levels and its binding to the SARS-CoV-2 S1 spike protein, and IL-6 levels were statistically significant, but had no significant effect on IL-1β or TNF-α levels.CONCLUSION: This study shows that the administration of losartan in COVID-19 may not be harmful, but instead has a protective effect similar to that of hrsACE2 in preventing a cytokine storm, especially IL-6.KEYWORDS: obesity, SARS-CoV-2, losartan, IL-6, ACE2
Relationship Between Central Obesity and The Risk of Hypertension in Obesity Adolescents Putri Ardina Maharani; Nur Aisiyah Widjaja; Meity Ardiana; Meta Herdiana Hanindita
Asian Journal of Social and Humanities Vol. 2 No. 03 (2023): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v2i03.199

Abstract

The increasing prevalence of central obesity in adolescents is accompanied by an increase in risk factors for cardiovascular disease. The study aims to analyze the relationship between central obesity and the risk of hypertension in obese adolescents, including both male and female subjects. This study was undertaken to provide opportunities for further exploration of the relationship between central obesity and hypertension in adolescents. The study was a retrospective observational study that utilized medical record data from a previous research project entitled "Polimorfisme Gen Adiponectin ADIPOQ +45 T>G, ADIPOQ – 11377 C>G dengan Kadar Adiponektin Pada Remaja Obesitas dan Resiko Sindrom Metabolik." This data was obtained from research conducted on obese adolescents aged 13-18 years in junior and senior high schools in Surabaya and Sidoarjo who met the criteria. The sample comprised 140 obese adolescents, who were then categorized into two groups: those without central obesity and those with central obesity. Statistical data were analyzed using SPSS with the Chi Square test. There is a very strong and significant relationship between central obesity and the risk of hypertension in obese adolescents (p = 0.000; r = 0.373); central obesity and the risk of hypertension in obese male adolescents (p = 0.001; r = 0.587); and central obesity and the risk of hypertension in obese female adolescents (p = 0.003; r = 0.300). The study found a significant relationship between central obesity and hypertension risk in obese adolescents. Adolescents with central obesity were 3.6 times more likely to develop hypertension than those without. Male adolescents with central obesity were 6.5 times more likely to develop hypertension than those without. Female adolescents with central obesity were 2.9 times more likely to develop hypertension
Effect of SARS-CoV-2 spike protein exposure on ACE2 and interleukin 6 productions in human adipocytes: An in-vitro study Ardiana, Meity; Suryawan, I GR.; Hermawan, Hanestya O.; Harsono, Primasitha M.; Shafira, Aisya A.; Anandita, Faizal A.
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.284

Abstract

Since adipocytes play a crucial role in pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection due to their interaction with angiotensin-converting enzyme 2 (ACE2) and interleukin 6 (IL-6), obesity is associated with an increased risk of coronavirus disease 2019 (COVID-19) mortality. Discovery of ACE2 as a SARS-CoV-2 receptor raises a controversy about whether to use ACE inhibitors (ACEIs) could be an optional therapy to prevent cytokine storms. Studies assessing the expressions of ACE2 and IL-6 upon exposure to SARS‑CoV‑2 is therefore important as a basis for therapeutical trials in the future. The aim of this study was to determine the effect of SARS-CoV-2 spike protein exposure on the production of ACE2 and IL-6 in adipocyte cells. Adipocytes were collected from abdominal adipose tissues of healthy and obese 45-year-old male donor having neither a history of SARS‑CoV‑2 infection nor COVID-19 vaccination. After being stained using the oil red O protocol, the viable adipocytes were then exposed to S1 subunit of SARS-CoV-2 spike protein. The levels of ACE2 and IL-6 were then examined using the enzyme-linked immunosorbent assay (ELISA). The results showed significant increase of ACE2 (90.22 µg/mL) and IL-6 level (60.01 µg/mL) in human adipocytes upon exposure compared to unexposed control cells (ACE2 13.33 µg/mL; IL-6 21.33 µg/mL), both comparisons had p<0.001). This study provides insight into the basic mechanism of severe COVID-19 symptoms in obese patients and provides a basic information of the potential of ACE inhibitors as an optional therapy for COVID-19 patients with obesity.
Perindopril decreases angiotensin-converting enzyme 2 (ACE2) expression in human adipocytes exposed to SARS-CoV-2 S1 spike protein Harsoyo, Primasitha M.; Ardiana, Meity; Hermawan, Hanestya O.; Purnamasari, Yeni; Anandita, Faizal A.
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.746

Abstract

The expression of angiotensin-converting enzyme 2 (ACE2) in the adipose tissues of obese patients needs further study, as it may aid infection and serve as a viral reservoir. There has been controversy over whether to use ACE inhibitors to prevent coronavirus disease 2019 (COVID-19) severity. Perindopril, an ACE2 inhibitor, has been proposed; however, its relationship with COVID-19 has not yet been clear. The aim of this study was to investigate the effect of perindopril to reduce the expression of ACE2 and pro-inflammatory cytokine in adipocytes exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Enzymatic isolation of adipose tissues was performed from obese male donor patients aged 30–50 years, then exposed it with SARS-CoV-2 S1 spike protein. This study also included human recombinant ACE2 (hrsACE2) as a comparison to perindopril. The expression of ACE2 was evaluated using ELISA. Our data indicated that SARS-CoV-2 Spike protein exposure increased ACE2 expression significantly. Administration of perindopril decreased ACE2 expression (43.37 µg/mL) significantly compared to the positive group (80.31 µg/mL) (p<0.001). Perindopril administration also decreased IL-6 levels significantly compared to positive group(p<0.001).  This study highlights that perindopril could reduce the ACE2 expression and pro-inflammatory cytokine levels in adipocytes exposed to SARS-CoV-2 S1 spike protein.
PROFILE OF METABOLIC SYNDROME COMPONENTS IN OBESE ADOLESCENTS: STUNTING VS. NON-STUNTING Harits, Muhammad; Widjaja, Nur Aisiyah; Ardiana, Meity
The Indonesian Journal of Public Health Vol. 19 No. 2 (2024): THE INDONESIAN JOURNAL OF PUBLIC HEALTH
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijph.v19i2.2024.302-315

Abstract

Introduction: Stunted children are more likely to become obese, with a prevalence of 1.33% in children under the age of five. Aims: To evaluate the metabolic syndrome (MetS) profile in overweight/obese adolescents who are either stunted or not, and to determine the associations between stunting characteristics (height-for-age z-score, or HAZ) and anthropometric measurements (waist circumference, hip circumference, and waist-to-hip ratio), as well as MetS indicators. Methods: A retrospective observational study was conducted focusing on adolescents who were overweight or obese. Subjects were divided into 2 groups based on height-for-age z-score (HAZ): stunting group and non-stunting group. Subject numbers were determined by total sampling due to the number of stunted being small. Results: The prevalence of MetS in stunting overweight/ obese adolescents was 18.75%, dominated by female. There was a significant difference on BMI (34.60 (26.80-45.09) vs. 31.11 (27.34-40.13, p=0.040), waist-to-height ratio (0.63 (0.54-0.73) vs. 0.58 (0.52-0.64), p=0.005), hip circumference (111.27 (95-135) vs. 102.50 (87-114) cm, p=0.012) and systole blood pressure (124.37 (110-140) vs. 116.25 (100-130) mmHg, p=0.032), greater in stunting subjects than non-stunting. Waist-to-hip ratio was lower in stunting than non-stunting (0.85 (0.69-0.97) vs. 0.92 (0.81-0.99), p=0.012). HAZ was correlated negatively with BMI (r=-0.358, p=0.044), but correlated positively with hip circumference (r=0.215, p=0.023). Conclusion: Adolescents who were stunted and overweight/obese exhibited higher values for BMI, waist-to-height ratio, hip circumference, and systolic blood pressure compared to non-stunted individuals who were overweight/obese. There was a correlation between the height-for-age z-score and both BMI and waist-to-hip ratio.
Dyslipidemia And Hypertension Among Indonesian Hajj Pilgrims: A Cross-Sectional Study Ardiana, Meity; Nirwana, Wira
Jurnal Health Sains Vol. 5 No. 8 (2024): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i8.1344

Abstract

There has been an increase in the preval_ence of cardiovascular disease in Indonesia due to an increased preval_ence of hypertension. Cardiovascular disease is the primary cause of morbidity and mortality among Indonesian Hajj pilgrims. Dyslipidemia and hypertension are positively correlated, with dyslipidemia potentially contributing to hypertension through the mechanism of atherosclerosis. The primary objective of this study is to identify the association between hypertension and dyslipidemia among Indonesian hajj pilgrims. A cross-sectional study involving 114,069 participants in total. The Indonesian Hajj pilgrims in 2023 were the research population. Pre-embarkation medical exams were performed by qualified healthcare professionals, and data were taken from Hajj medical service records. Using bivariate analysis and the Chi-Square (χ2) test, the proportions of age and gender were compared between the hypertension and non-hypertension groups. The relationship between triglyceride, HDL, and LDL levels and hypertension was determined through logistic regression analysis. Logistic regression analysis was used to provide a multivariate analysis of the relationship between dyslipidemia and hypertension. The hypertension group has an average age of 60.2 + 11.6 years old (p<0.0001). There was no difference in the effect of gender on hypertension (p=0.105). HDL, LDL, and Triglyceride serum levels significantly affected the preval_ence of hypertension (p<0.0001). Dyslipidemia was a risk factor for hypertension with an OR of 1.084 (1.057-1.112) (95% CI). Dyslipidemia is a risk factor for hypertension. Serum levels of HDL, LDL, and triglycerides affect blood pressure.
Co-Authors Adriano Anandita, Faizal A. Andrianto Anna Surgean Veterini Annis Catur Adi Enny Susanti Hanestya Oky Hermawan Hanestya Oky Hermawan Hanestya Oky Hermawan, Hanestya Oky Hanindita, Meta Herdiana Harits, Muhammad Harsono, Primasitha M. Harsoyo, Primasitha M. Heni Rachmawati Hermawan, Hanestya O. I. Gde Rurus Suryawan Kurniadi Doni Muhammad Rafli Nirwana, Wira Nur Aisiyah Widjaja, Nur Aisiyah Primasitha Maharany Harsoyo Putri Ardina Maharani Putri, Primasitha Maharani Harsoyo Rahma, Safira Rendi Aji Prihaningtyas Roedi Irawan Shafira, Aisya A. Sony Wibisono Suryawan, I GR. Ula Nur Pramesti Karman Wira Nirwana Yeni Purnamasari, Yeni Yulianto Yulianto