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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences MNJ (Malang Neurology Journal) Majalah Kesehatan FKUB

Machlusil Husna, Machlusil

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Author-ID : 592590

Agriculture, Biological Sciences & Forestry Environmental Science Medicine & Pharmacology Neuroscience Public Health

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DIAGNOSIS AND MANAGEMENT OF NONCONVULSIVE STATUS EPILEPTICUS (NCSE) Pramesti, Fathia Annis; Husna, Machlusil; Kurniawan, Shahdevi Nandar; Rahayu, Masruroh
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Status epilepticus is an emergency condition in the field of neurology are often undiagnosed and are associated with high mortality and long-term disability. One type of status epilepticus is nonconvulsive status epilepticus (NCSE) in which the diagnosis of NCSE is very difficult because the clinical manifestations appear is agitation or confusion, nystagmus or bizarre behavior such as lip smacking or take goods in the air.The diagnosis was based on clinical features, especially the mental status or the disrupted of consciousness and the changes in the EEG. Diagnosis of NCSE is an important first step, which can avoid the delay in therapy in order to prevent irreversible brain damage. Treatment is by administering benzodiazepines and antiepileptic drugs, while the prognosis is determined by the etiology and associated with brain damage there.

BIOMOLECULAR MECHANISM OF ANTI EPILEPTIC DRUGS Husna, Machlusil; Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 4, No 1 (2018): January
Publisher : Malang Neurology Journal

Epilepsy therapy is almost always chronic and often used more than one drug. Currently, antiepileptic drugs are still the mainstay of therapy for epilepsy. An understanding of the pharmacodynamics and pharmacokinetics of these drugs would be very helpful in choosing the right medication and develop a study to determine the drugs mechanism further. Mechanism of action of AED (anti epileptic drug) can be categorized into four main groups: (1) modulation of voltage-gated ion channels, including sodium, calcium, and potassium; (2) increase in GABA inhibition through an effect on GABA-A receptors, the GAT-1 GABA transporter, or GABA transaminase; (3) direct modulation of the synaptic release of such SV2A and Î±2Î´; and (4) inhibition of excitatory synapses through ionotropik glutamate receptors including AMPA receptors. AED work to balance the process of inhibition and excitation in the brain, so it can be used both for epilepsy and other diseases with similarities with the pathophysiology of epilepsy.

THE RELATIONSHIP OF CARPAL TUNNEL SYNDROME CLINICAL SYMPTOMPS AND ELECTRONEUROMYOGRAPHY RESULTS IN RSSA MALANG Kurniawan, Shahdevi Nandar; Husna, Machlusil; Rasyid, Harun Al; Bilqis, Nadiya Elfira
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Background. Carpal tunnel syndrome (CTS) is caused by entrapment neuropathy of the median nerve in the carpal tunnel that can be detected with electroneuromyography (ENMG).Objective. To determine whether there are significant differences in parameters of ENMG examination between CTS groups with mild-to-moderate and severe clinical symptoms.Methods. The study design was observational analytic using cross sectional design approach of the patient's medical record data as many as 61 samples.Results. From 61 samples, there were dominancy of age â‰¥ 40 years old as many as 80.32% and gender female as many as 88.52%. There was no significant differences in age and gender between the two groups (p=0.073 and p=1.000 respectively). Sensory amplitude, MSDL, and Ring Diff are significantly different between the two groups (p=0.005, p=0.020, and p=0.031 respectively). There are no significant difference of motor amplitude and MMDL between the two groups (p=0.384 and p=0.196 respectively).Conclusion. Sensory amplitude value having a relationship with the severity of clinical symptoms. ENMG examination and clinical symptoms of CTS were independent parameters, that should not be used alone to make a diagnosi both of them could enhance the accuracy of diagnosis.

AMPLITUDO SENSORY NEURON ACTION POTENTIAL USING AS INSTALLATION OF POLYNEUROPATHY DIAGNOSIS Kinesya, Billi; Husna, Machlusil; Kurniawan, Shahdevi Nandar; Ridwan, Mochammad
Malang Neurology Journal Vol 4, No 1 (2018): January
Publisher : Malang Neurology Journal

Background. Polyneuropathy is the pathologic changes and functional disturbances in the peripheral nervous system. These changes manifest as sign and symptoms such as numbness, burning, allodynia, atrophy, and lose of stimulation responses. Diagnosing polyneuropathy can use electrodiagnostic method like electroneuromyography (ENMG). One of the most sensitive ENMG parameters for polyneuropathy is SNAP amplitude which can be measured at Sural Nerve.Objective. The goal of this study is to know whether SNAP amplitude can be used to diagnose polyneuropathy.Methods. The study design is diagnostic test in cross-sectional method.Results. Samples were taken from 108 ENMG medical records of Neurology Department Saiful Anwar General Hospital during the whole 2014. Two variables which are compared are polyneuropathy diagnosis and SNAP amplitude. Fisher test shows significant differences between the two with p = 0.04. Diagnostic test shows sensitivity 68.3%, spesifisity 80%, positive predictive value 97.1%, and negative predictive value 20.5%.Conclusion. There is a significant relationship between SNAP amplitude reduction with the diagnosis of polyneuropathy.

CORRELATION BETWEEN LEUKOCYTE COUNT WHEN ADMITTED IN EMERGENCY ROOM (ER) WITH CLINICALLY ACUTE ISCHEMIC STROKE PATIENTS Husna, Machlusil; Kusworini, Kusworini; Wulansari, Dian Ayu
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Background. Stroke is a local or extensive disorder of brain function that occurs suddenly and rapidly, can cause death without another cause except vascular. Based on pathophysiology of acute ischemic stroke, leukocytes play an important role against deterioration and clinical manifestations in patients by releasing three inflammatory mediators, plugging mechanism in microcirculation, and vasoconstriction. Objective. To investigate the relationship between the clinical manifestations of acute ischemic stroke (incoming, outgoing, and improvement) as measured by the NIHSS score with the number of leukocytes . Methods. The study design was a retrospective cohort sampling. Samples were taken from 62 patients with acute ischemic stroke (31 patients who have normal leukocytes and 31 patients who showed leukocytosis) in Dr. Saiful Anwar (RSSA) Malang hospital that met the inclusion criteria of the study.Results. The results of the statistical test used is Kolmogorov-Smirnov test for incoming NIHSS (p = 0.999), and Chi-Square Test for outcoming NIHSS (p = 0.000) and improved patient (p = 0.001).Conclusion. Patients who have normal leukocyte count at the beginning of treatment is likely to have clinical manifestations by category of incoming NIHSS similar to patients who showed leukocytosis, and tend to have clinical manifestations by category of outcoming NIHSS and improvement or significantly better than patients which showed leukocytosis.

THE EFFECT OF BETA GLUCAN OF SACCHAROMYCES CEREVISAE ON THE DECREASE OF ALPHA SYNUCLEIN EXPRESSION IN THE BRAIN SUBSTANTIA NIGRA OF PARKINSONâ€™S WISTAR STRAIN RATS (Rattus novergicus) MODEL INDUCED WITH ROTENONE Rahayu, Masruroh; Kurniawan, Shahdevi Nandar; Husna, Machlusil; Hermawan, Hanestya Oky
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Background. One of the regenerative therapy modalities in Parkinson is using the beta glucan effect contained in Saccharomyces cerevisae.Objective. To identify the effect of reduction in alpha synuclein expression on the brain substantia nigra in Parkinson's rat model after given Saccharomyces cerevisae. Methods. This research applied true experimental design by in vivo with draft randomized post test only controlled group design. The sample was divided into five groups, each of them consisted of 5 rats. Variables measured were the decreasing level of alpha synuclein. Results. There was a significant difference between positive control and negative control group.Conclusion. The addition of Saccharomyces cerevisae is able to lower the alpha synuclein expression in Parkinsonâ€™s Wistar strain rat models significantly with maximum at the dose of 72 mg/kgBB.

BIOMOLECULAR ASPECTS AND UPDATE ON TREATMENT OF CEREBRAL MALARIA Husna, Machlusil; Prasetyo, Bowo Hery
Malang Neurology Journal Vol 2, No 2 (2016): July
Publisher : Malang Neurology Journal

Malaria is still becoming a health problem in the world and in Indonesia. Cerebral malaria is one of many features of severe and life threatening malaria. Many hypotheses underlying the pathophysiology of cerebral malaria have been disclosed, but the one that evolved nowdays is the hyphotesis of mechanical, permeability, humoral, and MMPs. These hypotheses proposed about biomolecular aspects of cerebral malaria and the mechanism is still not well understood. The understanding of this pathophysiology will aid the treatment of cerebral malaria. Current basic treatment of cerebral malaria is the ACT (artemisinin base combination treatment) drugs, supportive treatment and the management of its complications which is indispensable. Many research has been conducted and still in progress for finding the best optimal treatment.

DIAGNOSTIC TEST OF TORONTO AND MODIFIED TORONTO SCORING, MONOFILAMENT TEST, AND VIBRATE SENSATION TEST USING 128 HZ TUNING FORK FOR DIABETIC POLYNEUROPATHY Purbasari, Bethasiwi; Anggraini, Vivi Laras; Pratiwi, Made Dinda; Husna, Machlusil; Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 4, No 1 (2018): January
Publisher : Malang Neurology Journal

Background. The prevalence of diabetes mellitus has been epidemically increasing throughout all the world population, and diabetic polyneuropathy (PNP-DM) is one of the most common neurologic manifestation of this disease. Clinical research has proved that effective bedside screening of PNP-DM can significantly reduce the incidence of foot ulcer and limb amputation. Objective. To measure the diagnostic test of polyneuropathy scoring, monofilament 10-g SemmesWeinsteinÂ test, and 128 Hz tuning fork test as an early detection measure for PNP-DM.Methods. This research was conducted using a cross sectional approach from Januari 2016 to Juli 2017.Results. Among the total study population of 43 (23 men and 20 woman), Modified Toronto Score has the highest sensitivity (100%), PPV (93%) and accuracy (93%). Toronto score has the highest NPV (9%).Conclusion. Modified Toronto Score has good diagnostic value as screening tool in PNP-DM.

DIAGNOSTIC TEST OF POLYNEUROPATHY SCORE, 10-G SEMMES WENSTEIN MONOFILAMENT (SWM) AND VIBRATION PERCEPTION TRESHOLD (VPT)-QUANTITATIVE SENSORY TESTING (QST) IN DISTAL SENSORY POLYNEUROPATHY (DSP)-HUMAN IMMUNODEFICIENCY VIRUS (HIV) Purbasari, Bethasiwi; Kurniawan, Shahdevi Nandar; Husna, Machlusil; Candradikusuma, Didi; Al-Rasyid, Harun
Malang Neurology Journal Vol 5, No 1 (2019): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.01.4

Background: HIV/AIDS is a worldwide pandemic. Peripheral neuropathy is the most common neurologic complication with distal sensory polyneuropathy (HIV-DSP) as the most frequent form of manifestation. HIV-DSP is one of the major causes of global pain morbidity and often undiagnosed earlier, resulting in treatment given when HIV-DSP grade is already severe. Early detection is imperative to prevent the progression of HIV-DSP and improve patientâ€™s quality of life. Polyneuropathy score, 10-g Semmes-Weinstein Monofilament (SWM) and vibration perception threshold (VPT)-quantitative sensory testing (QST) are considered to be potential candidates for HIVDSPÂ screening tool.Objective:Â To measure the reability of Polyneuropathy Score, SWM and VPT- QST in diagnosingÂ HIV-DSP.Methods:Â This research is a descriptive study with cross-sectional design. Research was conducted onÂ 77 patients of HIV/AIDS outpatient clinic in RS Saiful Anwar (RSSA) during November 2016 - AprilÂ 2017 (n = 77). Patients were screened for HIV-DSP by using polyneuropathy score, such as: MichiganÂ Neuropathy Screening Instrument (MNSI), Toronto Clinical Scoring Sysytem (TCSS), BriefÂ Peripheral Neuropathy Score (BPNS), SWM, and VPT-QST. Sensitivity, specificity, positiveÂ predictive value and negative predictive value of BPNS, TCSS, MNSI, SWM and VPT-QST areÂ analyzed using cross tabulation. Area under receiver operating characteristic (ROC) curve analysisÂ was used to measure diagnostic accuracy of each tools. SPSS 19.0 was used for statistical analysis.Results:Â TCSS had a sensitivity, specificity, positive predictive value, negative predictive valueÂ positive likelihood ratio, negative likelihood ratio, and accuracy as much as: 70%, 97%, 97%, 74%,Â 23,33, 0,28 and 83%. The result of TCSS analysis using ROC showed that TCSS had excellentÂ diagnostic value with AUC (Area Under Curve) of 0.89 (95%CI 82%-96,5%). The AUC of BPNSÂ score, monofilamen and VPT-QST respectively: 0,469, 0,194, and 0,189.Conclusion:Â The result of the HIV-DSP diagnostic test using TCSS score has the best value comparedÂ to other tools.

ELECTRONEUROMYOGRAPHY EXAMINATION OF DIABETIC POLYNEUROPATHY PATIENTS Nurlaela, Siti; Kurniawan, Shahdevi Nandar; Husna, Machlusil
Malang Neurology Journal Vol 5, No 1 (2019): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.01.1

Background: Diabetic polyneuropathy (DPN) is one of the chronic complications that occur in approximately 80% of diabetes mellitus (DM) patients. This condition is a results of metabolic, vascular, and immunological disorders.Objective: To determine the profile of electroneuromyography (ENMG) examination of DPN patients at neurology clinic of Saiful Anwar General Hospital.Methods: This cross-sectional observational descriptive study was carried out at Saiful Anwar General Hospital Malang from June 1, 2015 to December 31, 2015, with purposive sampling method. A total of 43 DM patients with symptoms of polyneuropathy fulfilling inclusion criteria and no exclusion criteria were examined for ENMG. ENMG examirnation were including distal latency, amplitude and nerve conduction velocity of 4 motoric nerves (median, ulnar, tibial, peroneal) & 3 sensory nerves (median, ulnar, sural), and F waves of ulnar, median and peroneal nerves of the left and right extremities.Results: Of the 43 patients evaluated in this study, the mean sensory sural nerve conduction velocity was 13.01 m/s. The majority type of nerve damage in diabetic polyneuropathy patients in this studywere mixed type (52.33% in the median nerve, 60.47% in the ulnar nerve, 72.10% in the tibial nerve, and 54.65% in the peroneal nerve in motor nerve studies and 80.23% in the median nerve and 88.37% in the peroneal nerve in the sensory nerve studies).Conclusion: The nerve damage that occurs in DPN patients at Saiful Anwar general Hospital is severe, with the majority being the axonal demyelinating type, especially in the sensory nerve fibers in the inferior extremities.

Co-Authors Al-Rasyid, Harun Anggraini, Vivi Laras Aulanni'am, Aulanni'am Bowo Hery Prasetyo, Bowo Hery Damayanti, Ria Dian Ayu Wulansari, Dian Ayu Didi Candradikusuma Hanestya Oky Hermawan, Hanestya Oky Harun Al Rasyid Hidayat Sujuti I Ketut Suada Kinesya, Billi Kusworini Handono Masruroh Rahayu, Masruroh Mondiani, Yeni Quinta Nadiya Elfira Bilqis, Nadiya Elfira Pramesti, Fathia Annis Pratiwi, Made Dinda Purbasari, Bethasiwi Rahma, Annisa Shahdevi Nandar Kurniawan, Shahdevi Nandar Siti Nurlaela

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