Garuda - Garba Rujukan Digital

UJI AKTIVITAS ANTIJAMUR SEDIAAN KRIM EKSTRAK ETANOL DAUN CIPLUKAN (Physalis angulata L.) TERHADAP Candida albicans Muhamad Khudzaifi; Muhammad Nurul Fadel; Fahrudin Arif; Akhyasin Akhyasin; Eko Retnowati
IJF (Indonesia Jurnal Farmasi) Vol 7, No 2 (2022): Indonesia Jurnal Farmasi
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijf.v7i2.1762

Latar belakang : Penyakit infeksi merupakan salah satu permasalahan yang banyak terjadi di Indonesia. Salah satu infeksi yang banyak ditemukan adalah infeksi yang disebabkan oleh jamur Candida albicans. Kejadian resistensi antijamur telah menjadi permasalahan sehingga diperlukan adanya inovasi baru. Salah satunya dengan pengembangan tanaman obat yang telah diteliti memiliki khasiat sebagai antijamur. Salah satunya adalah tanaman Ciplukan (Physalis angulata L.). Daun ciplukan memiliki kandungan senyawa aktif berupa alkaloid, saponin, tanin, dan flavonoid yang merupakan senyawa aktif biologis sebagai antimikroba. Tujuan : Mengetahui aktivitas antijamur krim ekstrak etanol daun Ciplukan (Physalis angulata L.) terhadap jamur Candida albicans. Metode : Penelitian ini menggunakan difusi cakram dengan konsentrasi yang digunakan yaitu 5%, 10%, dan 15% diletakkan pada media SDA yang telah ditumbuhi oleh jamur Candida albicans yang kemudian akan diinkubasi serta diukur diameter zona hambatnya. Hasil : Pada konsentrasi 5% pada hari ke 1 dan ke 21 didapatkan diameter zona hambat sebesar 15 mm dan 14 mm, konsentrasi 10% mendapatkan hasil pada hari ke 1 18 mm dan hari ke 21 sebesar 15 mm, kemudian konsentrasi 15% pada hari ke 1 dan ke 21 mendapat hasil 20 mm, dan pada kontrol positif didapati hasil 34 mm pada hari ke 1 dan pada hari ke 21 mendapat 33 mm. Kesimpulan : Berdasarkan data diatas dapat disimpulkan bahwa krim ekstrak etanol daun Ciplukan (Physalis angulata L.) dapat menghambat jamur Candida albicans.

FORMULASI DAN UJI EFEKTIVITAS SEDIAAN ROLL ON AROMATERAPI BERBAHAN AKTIF MINYAK ATSIRI DAUN JERUK NIPIS (Citrus aurantifolia) SEBAGAI RELAKSASI PADA KELINCI ANGGORA (Oryctolagus cuniculus domesticus) Ferliano Miko Fachriansyah; Riana Putri Rahmawati; Fahrudin Arif
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1550

Anxiety disorder is a mental condition characterized by excessive feelings of fear and worry. Individuals experiencing this disorder may feel anxious almost constantly, which can interfere with their daily lives. Aromatherapy is a therapeutic practice that utilizes essential oils extracted from plant parts—typically through distillation—to enhance physical and emotional well-being. The development of aromatherapy as a treatment can be applied to roll-on formulations due to their convenient and practical use, aligning with public preference. This study aims to evaluate the physical quality and effectiveness of an aromatherapy roll-on preparation containing lime leaf (Citrus aurantifolia) essential oil for relaxation in Angora rabbits (Oryctolagus cuniculus domesticus). Physical quality assessments included homogeneity test, organoleptic evaluation, pH measurement, user preference test, and skin irritation test. Effectiveness testing was conducted based on varying concentrations (3%, 4%, 5%) and a control group. The collected data were processed using SPSS software, applying a one-way ANOVA. The findings revealed that all preparations were yellow liquids with the distinctive citrus aroma of lime essential oil. Homogeneity and pH tests confirmed that all formulations met the criteria for topical application. In terms of effectiveness, the 5% concentration yielded the most optimal results. Normality and homogeneity tests indicated that all data sets had normal and homogeneous distributions (p>0,05), fulfilling requirements for ANOVA. The ANOVA results showed a significant difference among the five treatment groups (p<0,05). Post Hoc analysis identified a significant difference between the negative control group and all other treatment groups (p<0,05).

FORMULASI SEDIAAN LIP BALM KULIT MANGGIS (Garcinia mangostana L.) SEBAGAI ANTIOKSIDAN Sakna Binta Munaya; Endang Setyowati; Fahrudin Arif
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1624

Lip balm is a cosmetic preparation designed to help protect, nourish, and moisturize the lips. This study utilizes mangosteen peel extract (Garcinia mangostana L.), which is rich in antioxidants, as the active ingredient in lip balm formulations. The aim of the study is to evaluate the physical quality and antioxidant activity of five lip balm formulas containing varying concentrations of mangosteen peel extract (10%, 15%, 20%, 25%) and one comparison formula containing 10% vitamin C. Physical quality tests included organoleptic evaluation, homogeneity test, and pH measurement. In addition, antioxidant activity was assessed using the DPPH method, along with skin irritation and user preference tests. The results showed that all lip balm formulas exhibited good organoleptic characteristics and homogeneity, with pH values ranging from (4.5 to 6.5). Irritation tests revealed no negative skin reactions. User preference tests indicated that Formulas F3 and F4 were the most favored in terms of texture, aroma, and comfort of use. The highest antioxidant activity was observed in Formula F5 (IC₅₀ = 46.6 µg/mL), followed by F4 (64.3 µg/mL), F3 (101 µg/mL), F2 (112 µg/mL), and F1 (113 µg/mL). These findings demonstrate that mangosteen peel extract can be successfully formulated into lip balm products that meet physical quality standards and exhibit significant antioxidant activity. The formula containing 25% extract (F4) showed the most optimal overall performance among the tested formulations.

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK BIJI KAPUK RANDU (Ceiba pentandra (L) Gaertn) DENGAN METODE DPPH Ariyanis Salma; Endang Setyowati; Fahrudin Arif
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1626

Kapuk randu (Ceiba pentandra (L). Gaertn) is a plant that is widely found in Indonesia and has long been used in traditional medicine. The seeds of this plant are known to contain various secondary metabolite compounds such as alkaloids, flavonoids, saponins, tannins and phenolics that have the potential to be antioxidants. This study aims to identify the compounds contained in randu kapok seeds and evaluate their potential antioxidant activity. The research method involves the extraction of kapuk seeds using maceration with 70% ethanol solvent. Furthermore, qualitative phytochemical screening is carried out to identify groups of compounds such as alkaloids, saponins, flavonoids, tannins, and phenolics. The antioxidant activity test was carried out using the DPPH method with concentration variations of 40, 80, 120, 160, and 200 ppm. The results of phytochemical screening showed that randu kapok seed extract was positive for alkaloid and flavonoid compounds. Antioxidant activity testing yielded an average IC50 value of 276.5 μg/mL. Based on categorization, the IC50 value indicates that randu kapuk seed extract has very weak antioxidant activity.

TINGKAT KEPATUHAN PENGGUNAAN ALLOPURINOL 100 MG TERHADAP KUALITAS HIDUP PASIEN GOUT DI DESA DONOREJO, KARANG TENGAH, DEMAK, JAWA TENGAH Ayu Aprilia Atika Sari; Eko Retnowati; Fahrudin Arif
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1639

Gout is a metabolic disorder that results in chronic accumulation of excess uric acid in the blood/hyperuricemia, resulting in the accumulation and formation of uric acid crystals abnormally in the intra-articular space. One of the risk factors that can cause an increase in the incidence of morbidity and mortality of gout sufferers is patient non-compliance in taking anti-gout medication. Anti-gout treatment must be carried out routinely to improve the patient's quality of life. This research to analyze the level of compliance with the use of allopurinol 100 mg on the quality of life of gout patients in Donorejo Village, Karang Tengah, Demak, Central Java. This study is a non-experimental observational study with a cross-sectional research approach. The sample in this study were gout sufferers in the last 3 months, namely June - August 2025 in Donorejo Village, Karang Tengah, Demak, Central Java, namely 105 respondent samples. The sampling technique in this study used a total sampling approach. The data used in the study were primary data in the form of MMAS-8 and WHOQOL-BREF questionnaires, as well as secondary data in the form of medical records of gout patients. Bivariate analysis was performed using the Chi-square (x2) test. Post-test medication adherence showed that the majority of respondents had a high level of medication adherence, with 77 respondents (73.3%). The post-test Chi-square test obtained a P-value of 0.000, indicating that Ho was rejected and Ha was accepted. This indicates a relationship between adherence to 100 mg allopurinol and the quality of life of gout patients in Donorejo Village, Karang Tengah, Demak, Central Java. The Odd Ratio value obtained was 57.061, indicating that adherence to 100 mg allopurinol in compliant gout patients had a 57.061 times better quality of life than non-compliant gout patients.

FORMULASI DAN UJI STABILITAS FISIK DEODORAN SPRAY KOMBINASI EKSTRAK DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav.) DAN DAUN BELIMBING WULUH (Averrhoa bilimbi L) SEBAGAI ANTIBAKTERI TERHADAP Staphylococcus aureus Anisa Nurjanah; Zaenal Fanani; Fahrudin Arif
Nusantara Hasana Journal Vol. 5 No. 4 (2025): Nusantara Hasana Journal, September 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i4.1688

Body odor problems triggered by the activity of bacteria such as Staphylococcus aureus are a concern in tropical regions such as Indonesia, which have high temperatures and humidity. Long-term use of synthetic chemical deodorants carries the risk of side effects, so safe and effective natural alternatives are needed. This study aims to formulate and evaluate the physical stability and antibacterial effectiveness of a spray deodorant preparation made from a combination of red betel leaf extract (Piper crocatum Ruiz and Pav.) and starfruit leaf extract (Averrhoa bilimbi L.). The extract was obtained through a maceration method with 70% ethanol as a solvent. This study used a laboratory experimental design with a quantitative approach. The study population was a spray deodorant preparation formulated in four variations: F0 (Negative control), F1 (7.5% red betel leaf + 2.5% starfruit leaf), F2 (5% + 5%), and F3 (2.5% + 7.5%). Physical stability tests included organoleptic tests, pH, displaced volume, and homogeneity. Antibacterial activity test was carried out using the well diffusion method against Staphylococcus aureus ATCC 25923. Data analysis was performed using normality test, homogeneity test, and one-way ANOVA test, and Tukey HSD post-hoc test. The results showed significant differences between treatment groups, but no significant differences between test formulas. All formulas met physical stability standards and showed strong antibacterial activity (inhibition zone 12.1 -14.37 mm). Formula F2 showed the highest inhibition, indicating a synergistic effect of a balanced extract ratio. This study contributes to the development of natural spray deodorant products that are safe, effective, and have the potential to replace synthetic ingredients in pharmaceutical formulations.

Analisis Kemometrika Kandungan Fitokimia dan Uji Anti Acne Ekstrak Etanol 70% dan Etil Asetat Daun Alpukat : (Persea Americana Mill) Pramesti Anggun Asyifa; Endang Setyowati; Fahrudin Arif
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 1 (2025): Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i1.7566

Human skin requires care to prevent and treat acne caused by Propinobacterium acnes bacteria. Researchers are exploring the use of avocado leaves as a natural therapy to treat acne. Avocado leaves contain antibacterial and anti-inflammatory compounds such as flavonoids, saponins, and alkaloids. This study aims to measure the total flavonoid and phenolic content in extracts obtained with 70% ethanol and avocado ethyl acetate and analyze their anti-acne activity. Total flavonoids were determined using a reagent consisting of 10% AlCl3 and 5% acetic acid. Total phenolic determination was carried out using the Folin-Ciocalteu reagent with gallic acid as a reference standard. Measurement of phytochemical levels used the UV-Vis spectrophotometry method. Antibacterial testing was carried out using Staphylococcus aureus bacteria with concentrations of 12%, 14%, and 16%. The positive control used clindamycin. The negative control used 10% DMSO. The disc diffusion method was used to observe the inhibition zone in this study. The results of this study will be processed using chemometrics to analyze complex chemical data. The data results showed that 70% ethanol extract produced total flavonoid levels of 8.6954% mgEK/mL and total phenolics of 15.4385% mgEAG/mL, higher than ethyl acetate extract with total flavonoid results of 3.418% mgEK/mL and total phenolics of 4.6052% mgEAG/mL. The results of antibacterial activity at concentrations of 12%, 14%, 16%, 70% ethanol extract were 10.5±0.70 mm; 12.1±0.28 mm; 14.3±0.57 mm, respectively, which had higher activity than ethyl acetate extract with results of 9.1±0.28 mm; 10.5±0.5 mm; 12.3±0.57 mm, the highest antibacterial activity at a concentration of 16%. Chemometric analysis using Principal Component Analysis (PCA) showed a strong positive correlation between phytochemical content and antibacterial activity. The highest antibacterial activity was found in the 70% ethanol extract at a concentration of 16%.

Title

Found 7 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 7 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 7 Documents
Search