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All Journal The Indonesian Biomedical Journal JURNAL ABDI MASYARAKAT INDONESIA (JAMIN) Jurnal Abdimas Kesehatan Terpadu
Melanie Sadono Djamil, Melanie Sadono
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Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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Pelatihan Pemeliharaan Kesehatan Gigi dan Mulut dalam Mencegah Kepikunan pada Komunitas Pra-Lansia Rizal, Muhammad Ihsan; Djamil, Melanie Sadono; Wulansari, Selviana; Hayunintyas, Ria Aryani; Tadjoedin, Fatimah Maria
JURNAL ABDIMAS KESEHATAN TERPADU Vol. 3 No. 2 (2024): Jurnal Abdimas Kesehatan Terpadu
Publisher : Fakultas Kedokteran Gigi, Universitas Trisakti bekerjasama dengan Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/jakt.v3i2.18140

Abstract

Dementia is described as a loss in cognitive abilities that leads daily tasks to become dysfunctional. Because this disease is a global health issue with no therapy, prevention and early detection are important priorities in its care. Periodontitis is one of the risk factors considered to be linked to dementia. Periodontitis is a complex chronic disease that causes destruction to the teeth's supporting tissues, specifically the alveolar bone, periodontal ligament, gingiva, and cementum. The buildup of dental biofilm because of poor oral hygiene is a risk factor for periodontal disease, which can proceed to periodontitis. Periodontitis is becoming more common as people become older, and it is one of the leading causes of tooth loss. By maintaining better oral hygiene, periodontal disease, a risk factor for dementia, can be reduced or prevented. It is anticipated that dental and oral maintenance education in the pre-elderly population will lower the risk of senility when people reach old age. Pre-elderly citizens (aged 45–59) in the Menteng Sukabumi region of Central Jakarta are the focus of promotion, education, and training in maintaining dental and oral hygiene. The pre-elderly residents will benefit from this training and counseling if they have a basic understanding of the connection between periodontal disease and senility and what can be done to avoid it. In conclusion, community service activities that focus on education and dental care are important steps to reduce the risk of dementia. Service activities must begin with raising awareness. Organizing free dental check-ups for the community, especially for those who cannot afford it, also needs to be encouraged.
Cara Menjaga Kesehatan Gigi dan Mulut untuk Mengatasi Kegoyangan Gigi pada Lansia Kusnoto, Joko; Octarina; Djamil, Melanie Sadono; Nofrizal, Riko; Maitimu, Fergie Christin; Kusnadi, Stephanie Justine
Jurnal Abdi Masyarakat Indonesia (JAMIN) Vol 6 No 2 (2024): JURNAL ABDI MASYARAKAT INDONESIA (JAMIN)
Publisher : Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/jamin.v6i2.19695

Abstract

As people age, their overall health status, including oral health, tends to decline. Among the elderly, oral health issues often receive less attention, making proper education essential regarding common problems such as tooth mobility and ways to maintain oral health. This community service activity was conducted for the elderly in RT 014 / RW 008, Jatipulo Village, Palmerah District, West Jakarta. The method used in the counseling session included presentations and demonstrations with educational aids. Participants' knowledge was evaluated before and after the session to assess the program's effectiveness using multiple-choice questionnaires. The evaluation results showed an increase in the average post-test scores compared to the pre-test scores. Thus, it can be concluded that this counseling activity successfully improved the knowledge of the elderly in RT 014 / RW 008, Jatipulo Village, Palmerah District, West Jakarta, regarding oral health. 
Curcuma xanthorrhiza Rhizome Extract Induces Apoptosis in HONE-1 Nasopharyngeal Cancer Cells Through Bid Ranggaini, Dewi; Sandra, Ferry; Halim, Johni; Ichwan, Solachuddin Jauhari Arief; Djamil, Melanie Sadono
The Indonesian Biomedical Journal Vol 15, No 1 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i1.2217

Abstract

BACKGROUND: Curcuma xanthorrhiza rhizomes have been demonstrated to have anticancer properties toward various types of cancer cells. The effect of C. xanthorrhiza rhizome extract (CXRE) on nasopharyngeal cancer (NPC) cells, including HONE-1 cell line has not been elucidated yet. Therefore, the effect of CXRE on the apoptosis of HONE-1 cells and its possible underlying mechanism are necessary to be explored.METHODS: C. xanthorrhiza rhizomes were minced, dried, extracted with distilled ethanol, filtered, and evaporated to produce CXRE. HONE-1 cells were seeded, starved, and treated with dimethyl sulfoxide (DMSO), Doxorubicin, or various concentrations of CXRE. Treated HONE-1 cells were stained with 4',6'-diamidino-2-phenylindole (DAPI) and the number of viable cells was counted. HONE-1 cells were also collected, lysed, and further processed for immunoblotting analysis to measure Bid activity.RESULTS: The number of viable HONE-1 cells decreased in concentration- and time-dependent manner. The number of viable cells in 50 and 250 μg/mL CXRE-treated groups were significantly lower compared with that in the DMSO-treated group after 24 h. At 48 h incubation period, the number of viable cells in 10, 50 and 250 μg/mL CXRE-treated groups were significantly lower compared with that in the DMSO-treated group. The number of viable cells in 250 μg/mL CXRE-treatment group was not significantly different compared with that in the Doxorubicin-treated group after 48 h. Bid expression levels in CXRE-treated groups were lower compared with that in the DMSO-treated group.CONCLUSION: CXRE could induce apoptosis via Bid activation, hence reducing the viability of HONE-1 cells.KEYWORDS: Curcuma xanthorrhiza, nasopharyngeal cancer, HONE-1 cells, apoptosis, Bid
Alnustone and Curcumin from Curcuma xanthorrhiza Roxb. as Potential Multi-Target Anti-Inflammatory Adjuvants in Pulpitis: An in silico Molecular Docking Study Sandra, Ferry; Djamil, Melanie Sadono; Natassya, Priska; Endriyana, Jessica; Pratitis, Visi Endah
The Indonesian Biomedical Journal Vol 18, No 2 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i2.4083

Abstract

BACKGROUND: Pulpitis is an inflammatory disorder of the dental pulp driven by activation of the toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88)/interleukin-1 receptor-associated kinase 1 (IRAK-1)/tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6)/nuclear factor kappa B (NF-κB) signaling cascade and excessive production of pro-inflammatory cytokines. Bioactive compounds from Curcuma xanthorrhiza have demonstrated anti-inflammatory potential, but their molecular interactions with key proteins involved in pulpal inflammation remain unclear. This study aimed to evaluate the binding affinity and interaction profiles of major C. xanthorrhiza derived compounds with inflammation-related protein targets using an in silico molecular docking approach.METHODS: The active molecule (arcurcumae, germacrone, curcumin, xanthorrhizol, alnustone, and α-cedrene) were obtained from PubChem, while target proteins (TLR4, MyD88, IRAK-1, TRAF6, inhibitor of kappa B kinase (IKK), NF-κB, interleukin (IL)-1β, TNF-α, and IL-6) were retrieved from the protein data bank. Toxicity and physicochemical properties were predicted using ProTox-3.0 and SwissADME. Active molecule and protein preparation was performed using PyRx and BIOVIA Discovery Studio, respectively. The molecular docking was conducted with CB-Dock 2.0 employing AutoDock Vina.RESULTS: Alnustone and curcumin exhibited the strongest multi-target binding affinities toward several key proteins involved in the TLR4/MyD88/IRAK-1/TRAF6/IKK/NF-κB inflammatory signaling pathway. Alnustone demonstrated particularly strong interactions with TLR4 (-9.0 kcal/mol), IRAK-1 (-8.7 kcal/mol), NF-κB (-7.3 kcal/mol), TNF-α (-8.3 kcal/mol), and IL-6 (-6.1 kcal/mol), while curcumin showed high binding affinity to TRAF6 (-8.3 kcal/mol) and IL-1β (-8.6 kcal/mol). Interaction analyses indicated stable ligand–protein complexes supported by hydrogen bonding, hydrophobic interactions, and π-alkyl contacts within the active binding sites.CONCLUSION: Alnustone and curcumin displayed relatively strong multi-target binding to key proteins in the TLR4/MyD88/NF-κB pathway, supporting their possible potential as adjunctive anti-inflammatory agents for pulpitis and warranting further experimental validation.KEYWORDS: Curcuma xanthorrhiza, molecular docking, pulpitis, NF-κB, anti-inflammatory
Co-Authors Endriyana, Jessica Ferry Sandra Halim, Johni Hayunintyas, Ria Aryani Ichwan, Solachuddin Jauhari Arief Joko Kusnoto Kusnadi, Stephanie Justine Maitimu, Fergie Christin Muhammad Ihsan Rizal, Muhammad Ihsan Natassya, Priska Octarina Pratitis, Visi Endah Ranggaini, Dewi Riko Nofrizal Tadjoedin, Fatimah Maria Wulansari, Selviana