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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Folia Medica Indonesiana Care : Jurnal Ilmiah Ilmu Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Paulus Liben, Paulus
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Efek Pemberian Fraksi Ekstral Etanol Daun Sirih (Piper betle L) pada Penurunan Nafsu Makan dan Berat Badan Tikus Wistar Jantan Mude, Serafin Anastasia; Tamayanti, Wahyu Dewi; Liben, Paulus
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2547.38 KB) | DOI: 10.33508/jfst.v1i1.701

Abstract

Telah dilakukan penelitian mengenai elek pemberian Iraksi air ekstrak etanol pada daun sirih (Piper betle L.) pada penurunan nalsu makan dan berat badan pad a tikus Wistar. Pa~a penelitian ini tikus Wistar (Rattus norvegicus) jantan sebanyak 25 ekor dibagi dalam 5 kelompok, kelompok kontrol negatil K(-); 3 kelompok uji (Fl, F2, F3); dan kelompok kontrol positil (P). K(-) menerima perlakuan PGA 3% tanpa bahan aktil; Fl, F2, F3 masing-masing menerima Iraksi air ekstrak etanol daun sirih dengan dosis 300, 450, dan 600 mglkgBB; dan P menerima orlistat dengan dosis 10,B mglkgBB. Setiap perlakuan diberikan seeara oral selama 7 hari berturut-turut sekali sehari sebelum pengamatan. Jumlah sisa makanan dan berat badan (BB) ditimbang dan dieatat setiap hari. Hasil penelitian menunjukkan bahwa Fl, F2, dan F3 mampu menurunkan nalsu makan dan berat badan t ikus putih dibandingkan terhadap K(-). Selisih rerata penurunan jumlah makanan adalah 3,4 g (Fl); 3,8 g (F2); dan 4,2 g (F3). Penurunan tersebut setara dengan penurunan jumlah makanan kelompok P yaitu 4,2 g. Pada sisi BB, Fl; F2; dan F3 menunjukkan selisih rerata penurunan BB sebesar 14,6 g; 20,8 g dan 26,6 g. Selisih penurunan yang dihasilkan oleh F3 menunjukkan nilai mendekati penurunan berat badan oleh kelompok P yaitu 28,6 g. Penelitian ini mengindikasikan bahwa pemberian Iraksi air ekstrak etanol daun sirih (Piper betie L.) dalam dosis 300; 450; dan 600 mglkgBB seeara ora l mampu menurunkan jumlah makanan dan berat badan pada tikus Wistar jantan . Perhitungan koelisien korelasi menunjukkan tidak ada hubungan linear antara peningkatan dosis dengan peningkatan penurunan jumlah makanan dan berat badan tikus.
CORRELATION OF HEARING IMPAIRMENT AND COMMUNICATION DISORDER AMONG GERIATRIC IN GERIATRIC CLINIC, DR. SOETOMO HOSPITAL SURABAYA Kartika M, A Ratna; Purnami, Nyilo; Liben, Paulus
Folia Medica Indonesiana Vol. 51 No. 4 (2015): Oktober - December 2015
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (46.439 KB) | DOI: 10.20473/fmi.v51i4.2859

Abstract

The objective of this study was to analyze correlation between hearing impairment and communication disorder among geriatrics in Geriatric Clinic, Dr. Soetomo Hospital. A randomized cross-sectional study design has been used in this study. Analysis was done by filling in some questionnaire and interview to some patients who were randomly selected according to predetermined condition. The data were collected and reviewed for the factors, which were assumed as risk factors of hearing disorder and life's quality deterioration. Statistical analysis was performed using Fisher's Exact Test using SPSS program version 17. Results showed correlation between hearing impairment and the quality of life and social communication (p=0.033, OR=6.11). However, there was no correlation between hearing impairment with diabetes mellitus (p=0.255), with hypertension (p=0.565), and noisy environment (p=0.689). In conclusion, the study showed that there is correlation between hearing impairment and communication disorder.
Efek Pemberian Fraksi Ekstral Etanol Daun Sirih (Piper betle L) pada Penurunan Nafsu Makan dan Berat Badan Tikus Wistar Jantan Mude, Serafin Anastasia; Tamayanti, Wahyu Dewi; Liben, Paulus
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 1 No. 1 (2013)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v1i1.701

Abstract

Telah dilakukan penelitian mengenai elek pemberian Iraksi air ekstrak etanol pada daun sirih (Piper betle L.) pada penurunan nalsu makan dan berat badan pad a tikus Wistar. Pa~a penelitian ini tikus Wistar (Rattus norvegicus) jantan sebanyak 25 ekor dibagi dalam 5 kelompok, kelompok kontrol negatil K(-); 3 kelompok uji (Fl, F2, F3); dan kelompok kontrol positil (P). K(-) menerima perlakuan PGA 3% tanpa bahan aktil; Fl, F2, F3 masing-masing menerima Iraksi air ekstrak etanol daun sirih dengan dosis 300, 450, dan 600 mglkgBB; dan P menerima orlistat dengan dosis 10,B mglkgBB. Setiap perlakuan diberikan seeara oral selama 7 hari berturut-turut sekali sehari sebelum pengamatan. Jumlah sisa makanan dan berat badan (BB) ditimbang dan dieatat setiap hari. Hasil penelitian menunjukkan bahwa Fl, F2, dan F3 mampu menurunkan nalsu makan dan berat badan t ikus putih dibandingkan terhadap K(-). Selisih rerata penurunan jumlah makanan adalah 3,4 g (Fl); 3,8 g (F2); dan 4,2 g (F3). Penurunan tersebut setara dengan penurunan jumlah makanan kelompok P yaitu 4,2 g. Pada sisi BB, Fl; F2; dan F3 menunjukkan selisih rerata penurunan BB sebesar 14,6 g; 20,8 g dan 26,6 g. Selisih penurunan yang dihasilkan oleh F3 menunjukkan nilai mendekati penurunan berat badan oleh kelompok P yaitu 28,6 g. Penelitian ini mengindikasikan bahwa pemberian Iraksi air ekstrak etanol daun sirih (Piper betie L.) dalam dosis 300; 450; dan 600 mglkgBB seeara ora l mampu menurunkan jumlah makanan dan berat badan pada tikus Wistar jantan . Perhitungan koelisien korelasi menunjukkan tidak ada hubungan linear antara peningkatan dosis dengan peningkatan penurunan jumlah makanan dan berat badan tikus.
TERDAPAT PERBEDAAN PENGARUH CIRCUIT BODY WEIGHT TRAINING (CBWT) SUBMAKSIMAL TERHADAP PENURUNAN PERSENTASE LEMAK TUBUH, LEMAK SUBKUTAN DAN MENINGKATKAN OTOT SKELETAL Pambudi, A. Agam Haris; Liben, Paulus; Rejeki, Purwo Sri
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 8, No 3 (2020): EDITION NOVEMBER 2020
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v8i3.1294

Abstract

Physical activity with moderate intensity can be implemented with various types of exercise, including multiple movements done in turns which take a bodyweight as a training load known as the circuit body weight training (CBWT). The purpose of this research to prove influence CBWT moderate intensity to the percentage of the body fat, subcutaneous fat and muscles skeletal a person trained and untrained. This is research experimental with the methods pretest-posttest design. 20 people women aged 18 to 23 years was obtained using proportionate stratified random sampling. Consisting of K1 10 people trained and K2 10 people untrained. Done the measurement of the percentage of the body fat, subcutaneous fat and muscles skeletal use weight body composition monitor model HBF-375 Karada scan. The subject is given the treatment CBWT moderate intensity (64-76% heart rate maximum) for 30 menit, after which the measurement was done again 5 minutes after treatment. The data were analyzed using the SPSS statistical tests with paired t-test and the continued independent t-test. Body fat pre K1 mean ∆ (0,53%±0,28), and K2 mean ∆ (0,92%±0,69), the value of p = 0,119 (p
AKTIVITAS FISIK AKUT INTERVAL DAN KONTINYU INTENSITAS MODERAT TIDAK DAPAT MENURUNKAN KADAR BIOMARKER RESORPSI TULANG CTx Triardhana, Yanuar Alfan; Sari, Gadis Meinar; Liben, Paulus
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 9, No 2 (2021): EDITION JULY 2021
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v9i2.1510

Abstract

Physical activity will affect the bone remodeling process and have an impact on bone health. Physical activity would activate osteoblasts and precursor through lane HPA Axis to start the process of bone remodeling. When the process of remodeling of bone occurs there are molecules of collagen which is released into the circulation, i.e. CTx (osteoclast marker). The aim of this study to showing effect of acute continuous and interval physical activity with moderate intensity on CTx. This research was using the type of research field experimental by using the pretest-posttest design. Sixteen adult male was selected on this study and devided into 2 with 8 people every group. Blood sample was taken before and 1 hour after the physical activity. The results obtained showed the acute effect of continuous physical activity with moderate intensity to CTx with a mean pretest 0,93 ± 0,566 posttest 0,559 ± 0,398 ng/mL (p = 0.173 0.05), acute effect of moderate intensity interval physical activity on CTx with the mean pretest 0,451 ± 0,302 posttest 0,524 ± 0,284 ng/mL (p = 0.693 0.05). From this study can be concluded that there was no effect of acute continuous and interval physical activity with moderate intensity on CTx. 
AKTIVITAS FISIK AKUT INTENSITAS TINGGI MEMPERBAIKI KADAR IL-6 OTOT MODEL MENCIT DIABETES MELITUS Purwoto, Septyaningrum Putri; Purwanto, Bambang; Liben, Paulus
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 8, No 3 (2020): EDITION NOVEMBER 2020
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v8i3.1299

Abstract

Diabetes mellitus is a metabolic disease whose prevalence continues to increase. Diabetes mellitus sufferers are advised to do lifestyle interventions in the form of physical activity. Physical activity provides benefits for diabetics, through the autocrine response of muscles to release IL-6 for muscle repair. The purpose of this study was to determine the appropriate intensity of physical activity against muscle IL-6 in diabetic mice. The subjects in this study were male mice (balb / c) weighing 20-30 grams. This study was divided into 4 groups. The treatment in the form of treadmill activity is carried out once with heating for 5 minutes and core for 30 minutes. This study used a True Experimental research design using a Random Control Group Posttest-Only Design research design. The variable measured in this study was muscle IL-6, namely the calf muscle (gastrocnemious and soleus muscles) of the left and right legs of each subject 24 hours after acute physical activity. Acute physical activity causes the release of interleukin-6 by myofibers. Based on the analysis results showed that there was a significant effect of low, medium, and high intensity acute physical activity on muscle IL-6 levels (p = 0.05). In addition, it also showed that the highest average muscle IL-6 level was the high intensity treatment group with a value of 325.17267 mg / dL. These results prove that high-intensity acute physical activity improves IL-6 levels in the muscle muscle model of diabetes mellitus mice.
Co-Authors A Ratna Kartika M, A Ratna Bambang Purwanto Mude, Serafin Anastasia Nyilo Purnami Pambudi, A. Agam Haris Purwoto, Septyaningrum Putri Rejeki, Purwo Sri Sari, Gadis Meinar Triardhana, Yanuar Alfan Wahyu Dewi Tamayanti, Wahyu Dewi