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All Journal Jurnal NERS Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Journal of Holistics and Health Sciences (JHHS) CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Surabaya Biomedical Journal
Peppy Nawangsasi
Faculty Of Medicine, University Of Hang Tuah, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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The Hygiene Hypothesis And Covid-19: A Look At The Evidence And New Perspectives Peppy Nawangsasi; Ronald Pratama Adiwinoto; Verna Biutifasari; Tamam Jauhar; Wahyu Prasasti Mutiadesi
ANATOMICA MEDICAL JOURNAL | AMJ Vol 6, No 3 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/amj.v6i3.15787

Abstract

The hygiene hypothesis postulates that early-life exposure to infectious agents and microbes has a significant impact on the maturation of the immune system, providing protection against allergies and autoimmune diseases.Recent studies have challenged the hypothesis's universality, suggesting that it might only be relevant in developed countries. New perspectives on the hygiene hypothesis propose a multifaceted theory that considers not only microbial exposure but also factors such as diet, stress, and the environment. The role of specific immune cells in the development of allergies and autoimmune diseases has been emphasized, and innovative therapies based on manipulation of immune cells have been proposed. The importance of reconciling the hygiene hypothesis with recent insights into the human microbiome and the importance of maintaining a balance between hygiene and microbial exposure is also emphasized. Lastly, the article delves into the hygiene hypothesis, investigates the connection between gut microbiota dysbiosis and the development of allergies and autoimmune diseases, and examines the influence of COVID-19 on both gut microbiota and immune function.Keywords: allergies and autoimmune diseases, gut microbiome dysbiosis
Stres dan Gangguan Siklus Menstruasi Mahasiswi Fakultas Kedokteran dan Psikologi Distyvanya, Shakira Azzahra; Nawangsasi, Peppy; Herdiyantini, Mita; Adiwinoto, Ronald Pratama; Setyawan, Febri Endra Budi
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 4 No. 3 (2024): Februari
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v4i3.203

Abstract

ABSTRAK Stres merujuk pada kondisi karena adanya ketidaksesuaian antara harapan dan keinginan, di mana tuntutan dan kapabilitas seseorang untuk memenuhinya tidak sejalan. Diketahui bahwa prevalensi stres pada mahasiswi kedokteran cenderung tinggi karena tekanan yang mereka hadapi, sehingga menimbulkan disparitas dalam tingkat stres antara mahasiswi fakultas kedokteran dan psikologi. Penelitian ini bertujuan untuk mengetahui hubungan antara stres dengan gangguan siklus menstruasi pada mahasiswi Fakultas Kedokteran dan Fakultas Psikologi Universitas Hang Tuah. Metode penelitian menggunakan pendekatan cross-sectional dengan teknik simple random sampling. Penelitian melibatkan 92 mahasiswi Fakultas Kedokteran dan 59 mahasiswi Fakultas Psikologi Universitas Hang Tuah.. Hasil analisis statistik menggunakan uji Spearman, uji Tabulasi Silang, dan uji Kendall's tau-b menunjukkan adanya hubungan yang signifikan antara stres dengan gangguan siklus menstruasi (uji Spearman dan uji Tabulasi Silang: p = 0 dan tingkat signifikansi α = 0,05) dengan nilai koefisien korelasi sebesar 0,412. Temuan ini tidak mengindikasikan adanya hubungan signifikan antara stres dengan fakultas (uji Kendall's tau-b: p = 0,342 dan α = 0,05). Selain itu, tidak terdapat hubungan yang signifikan antara gangguan siklus menstruasi dan fakultas (uji Kendall's tau-b: p = 0,440 dan α = 0,05). Kata kunci: Stres; Gangguan Siklus Menstruasi;, Mahasiswi Kedokteran; Mahasiswi Psikologi
Pengaruh Myers Briggs Type Indicator (MBTI) Dengan Tingkat Stres Mahasiswa Kedokteran Sari, Arine Talitha; Nawangsasi, Peppy; Irawati, Ade; Biutifasari, Verna
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 5 No. 1 (2024): Juni
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

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Abstract

Myers-Briggs Type Indicator (MBTI) is a tool to measure personality types whose results are presented through 4 dichotomies namely Extraversion/Introversion, Sensing/Intuition, Thinking/Feeling, and Judging/Perceiving. A person's personality type will affect the level of stress they feel. Stress is a condition when our body reacts due to a change in our environment, either physical or mental changes that cause us to feel disturbed. This study aims to determine the relationship between personality type based on Myers-Briggs Type Indicator (MBTI) with stress levels in medical students. This type of research is observational analytic. Respondents used were 62 people who were filled in by 2020 students at the Faculty of Medicine, Hang Tuah University and then analyzed using the Kendall Tau-b method. It was found that 15 respondents experienced mild stress, 39 respondents experienced moderate stress, and as many as 7 respondents experienced severe stress. 30 respondents of extroverted personality, 31 respondents of introverted personality, 43 respondents of sensing personality, 18 respondents of intuition personality, 28 respondents of thinking personality, 33 respondents of feeling personality, 52 respondents of judging personality and there are 9 respondents with perceiving personality type. The significance value between personality type and stress level exceeds the α value (α = 0.05) which means that there is no relationship between personality type and stress level
PENGARUH OBESITAS TERHADAP KARAKTERISTIK POLA BERJALAN : LITERATURE REVIEW Mintardjono, Wahyu Prasasti Mutiadesi; Wardiansah; Hartanto; Peppy Nawangsasi
Surabaya Biomedical Journal Vol 3 No 1 (2023): September 2023
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v3i1.115

Abstract

Obesity is a global health problem with increasing prevalence worldwide. One aspect of concern is how obesity can affect an individual's gait characteristics, leading to musculoskeletal disorders. Numerous studies have explored the gait characteristics experienced by individuals with obesity. The objective of this literature review is to provide further information on the gait characteristics of individuals with obesity, which can be utilized for the prevention of obesity-related musculoskeletal disorders. The methodology employed in this study is a literature review, creating conclusions from selected data sources from various national and international journals published between 2011 and 2021. The findings reveal that obesity can lead to decreased balance, reduced walking speed, and influence several gait characteristic parameters, such as changes in step length and width, stride length, as well as various angles formed by the knee and ankle joints during walking, resulting in a distinct gait pattern compared to normal gait. Therefore, it can be concluded that individuals with obesity are prone to exhibit an altered gait pattern, which can potentially contribute to musculoskeletal problems such as osteoarthritis.
GABRA6 and SLC6A4 genotypes are correlated with the fasting blood glucose and physical fitness in the seemingly healthy young adults Viskasari P Kalanjati; Mariana Wahjudi; Kusuma E. Purwantari; Visuddho; Peppy Nawangsasi; Rury T. Oktariza; Krisnawan A. Pradana; Dzanuar Rahmawan; Bambang E. Suwito
Jurnal Ners Vol. 18 No. 1 (2023): MARCH 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jn.v18i1.43770

Abstract

Introduction: We examined environmental and genetic factors potentially correlated with the blood glucose and physical fitness in Kediri, East Java, Indonesia to elucidate the predominant cardiovascular disease risk. Methods: This was a cross-sectional study on 68 adults aged 18-22 years. Direct interview was conducted to get socio-economy,  daily diets (rice/ R, snacks and sweets/ SS, veggies and fruits/ VF), daily activity (locomotors and non-locomotors) data. Peripheral blood-GABRA6 and SLC6A4 polymorphisms, fasting blood glucose (FBG), blood pressure, 3 fitness parameters (1 min push-up, 3 minutes step up, pulse rate after 3 minutes step-up) were measured by 2 independent and pre-trained medical doctors. Kruskal-Wallis, Chi-Square, and eta-coefficient tests were used to seek differences between genotypes and correlation strength between variables, respectively (significant if p<0.05). Results: Both gene's genotypes showed significant correlations with the FBG (p=0.042, p=0.013, respectively); GABRA6 polymorphism significantly correlated with SU (p=0.033). There was a significant difference in the FBG between 2 VF subgroups (p=0.02). Strongest association was found between FBG and SLC6A4 (η=0.3); PR and GABRA6 (η=0.168), PU and SLC6A4 (η=0.38); SU and Locomotors (η=0.237). Conclusions: In these seemingly healthy young adults, daily diets and the genotypes of both genes have a good association with the FBG and physical fitness levels.
Stres Akademik sebagai Faktor Risiko Dispepsia Fungsional pada Mahasiswa Preklinik Fakultas Kedokteran Universitas Hang Tuah : Academic Stress as a Risk Factor for Functional Dyspepsia among Preclinical Medical Students at Hang Tuah University Naufal Waly Anas; M. Fathi Ilmawan; Peppy Nawangsasi; I Ketut Tirka Nandaka
Journal of Holistics and Health Sciences Vol. 8 No. 1 (2026): Journal of Holistics and Health Sciences (JHHS), Maret
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/jhhs.v8i1.696

Abstract

Medical education is widely recognized for its high academic demands, intensive schedules, and frequent examinations, all of which may contribute to academic stress among students. Unmanaged stress can affect the autonomic nervous system and increase gastric acid secretion through interactions within the brain–gut axis, manifesting as gastrointestinal disturbances, particularly functional dyspepsia. This study aimed to examine the relationship between academic stress and the occurrence of functional dyspepsia among preclinical medical students of the Faculty of Medicine, Hang Tuah University, class of 2022. This study employed an descriptive correlational design with a cross-sectional approach. The sampling technique used was purposive sampling, involving 72 students selected from the 2022 cohort population. Data were collected using PSS-10 to assess stress levels and R4-FDDQ to diagnose functional dyspepsia. Data analysis was conducted using the Chi-square statistical test. The results demonstrated a statistically significant association between academic stress and functional dyspepsia, as indicated by the Chi-square test with a p-value of 0,014. This study concludes that there is a significant relationship between academic stress and the occurrence of functional dyspepsia among preclinical medical students of the Faculty of Medicine, Hang Tuah University, class of 2022. Higher levels of academic stress are associated with an increased likelihood of developing functional dyspepsia.   ABSTRAK Pendidikan kedokteran dikenal memiliki tuntutan akademik yang tinggi, padatnya jadwal, dan ujian yang sering, yang berpotensi memicu stres akademik pada mahasiswa. Stres yang tidak tertangani dapat memengaruhi sistem saraf otonom dan meningkatkan sekresi asam lambung melalui interaksi brain-gut axis, yang bermanifestasi sebagai gangguan pencernaan, khususnya dispepsia fungsional. Tujuan dari penelitian ini untuk mengetahui hubungan antara stres akademik dan kejadian dispepsia fungsional pada mahasiswa preklinik Fakultas Kedokteran Universitas Hang Tuah angkatan 2022. Penelitian ini menggunakan desain deskriptif korelasi dengan pendekatan cross-sectional. Teknik pengambilan sampel menggunakan purposive sampling dengan jumlah responden sebanyak 72 mahasiswa dari populasi angkatan 2022. Pengumpulan data dilakukan menggunakan PSS-10 untuk mengukur tingkat stres dan R4-FDDQ untuk diagnosis dispepsia fungsional. Analisis data dilakukan menggunakan uji statistik Chi-Square. Hasil penelitian menunjukkan bahwa terdapat hubungan yang bermakna antara stres akademik dengan dispepsia fungsional dari hasil uji Chi-Square dengan nilai p-value sebesar 0,014. Kesimpulan dari penelitian ini adalah terdapat hubungan yang signifikan antara stres akademik dan kejadian dispepsia fungsional pada mahasiswa preklinik Fakultas Kedokteran Universitas Hang Tuah angkatan 2022. Semakin tinggi tingkat stres akademik, semakin besar peluang terjadinya dispepsia fungsional.
Co-Authors Bambang E. Suwito Biutifasari, Verna Distyvanya, Shakira Azzahra Dzanuar Rahmawan Febri Endra Budi Setyawan Hartanto Herdiyantini, Mita I KETUT TIRKA NANDAKA Irawati, Ade Krisnawan A. Pradana Kusuma E. Purwantari M. Fathi Ilmawan Mariana Wahjudi Mintardjono, Wahyu Prasasti Mutiadesi Naufal Waly Anas Ronald Pratama Adiwinoto Rury T. Oktariza Sari, Arine Talitha Tamam Jauhar Viskasari P. Kalanjati Visuddho Wahyu Prasasti Mutiadesi Wardiansah