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All Journal Sari Pediatri Paediatrica Indonesiana FIRM: Journal of Management Studies PREPOTIF : Jurnal Kesehatan Masyarakat JOURNAL LA MEDIHEALTICO Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Theresia Santi, Theresia
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Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Evaluation of anti-diphtheria toxoid antibody persistence in school-age children in Jakarta, Indonesia Santi, Theresia; Prayitno, Ari; Munasir, Zakiudin; Hadinegoro, Sri Rezeki S.; Harahap, Alida Roswita; Werdhani, Retno Asti; Sah Bandar, Ivo Novita; Jo, Juandy; Hegar, Badriul
Paediatrica Indonesiana Vol. 64 No. 5 (2024): September 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.5.2024.447-53

Abstract

Background Diphtheria can be effectively prevented by adequate immunization. A combined vaccine against diphtheria toxoid, pertussis, and tetanus toxoid (DPT) is currently used in routine pediatric immunizations. Outbreaks of diphtheria could emerge in Indonesia as a consequence of declining routine vaccination during the COVID-19 pandemic. Objective To analyze the impact of the first (administered at 18-24 months of age ) and second diphtheria boosters (administered at 5-7 years of age ) in retaining protective levels of anti-diphtheria toxoid antibodies. We also investigated for relevant factors associated with anti-diphtheria toxoid antibody titers. Methods This cross-sectional study was conducted in the Senen District of Jakarta, Indonesia. The inclusion criteria were healthy children aged 6 to 7 years with documented history of DPT vaccination. Primary vaccination defined as 3 doses of DPT at age less than 1 year , first booster was DPT vaccination at 18-24 years of age, and second booster was diphtheria-tetanus (DT) vaccination received at 5 to 7 years of age. Peripheral blood specimens were obtained from participating children, after informed consent was provided by their parents. Antibodies against diphtheria in sera specimens were assessed by commercial anti-diphtheria toxoid immunoglobulin G (IgG) enzyme-linked immunosorbent assay. Results There were 154 children included in the study, with a female majority (61%). Overall, specific humoral immunity against diphtheria was observed in 113 children (73.4%). There was no statistical difference in immunity level between genders. Importantly, children who received the first and second diphtheria booster had significantly higher anti-diphtheria antibody level than those who did not receive both diphtheria booster (P<0.001). Conclusion Booster vaccinations are crucial among school-age children in Indonesia to improve their anti-diphtheria immunity and to minimize a risk of diphtheria outbreaks.
Profile of Anti-Diphtheria Toxoid Immunoglobulin G among Pre-School Children in the Senen District, Jakarta, Indonesia Santi, Theresia; Jo, Juandy; Prayitno, Ari; Munasir, Zakiudin; Hegar, Badriul
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 7 No. - (2023): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v7i-.189

Abstract

Background: Diphtheria is a re-emerging disease in Indonesia that can be prevented by vaccination. This study evaluates the anti-diphtheria toxoid immunoglobulin G levels among healthy children aged 6 – 7 years old who had not received the second booster immunization for Diphtheria, Tetanus, and Pertussis (DTP) commonly administered at 5 – 7 years old. Methods: This cross-sectional study was conducted in the Senen district of Jakarta, Indonesia. All subjects had been vaccinated with three doses of immunization for DTP during the first year of life, and subsequently classified into a group of children who received the first booster immunization of DTP at 18 – 24 months old and who had not received it yet. Antibody against Diphtheria toxoids within the sera samples was assessed by commercial Anti-Diphtheria toxoid IgG Enzyme-Linked Immunosorbent Assay and classified in four groups: no protection (< 0.01 IU/ml), uncertain (0.01 – 0.09 IU/ml), full protection (0.10 – 1 IU/ml) and long-term protection (>1 IU/ml). Results: Eighty-nine children were included in this study; only 71 subjects (79.7%) had received the first DTP booster at 18–24 months old. The specific humoral immunity against diphtheria was observed among 57 children (64%). Notably, among the 89 subjects, only two subjects not receiving the first DTP booster still had antibody protection for diphtheria (p=0.001, OR 27.5, 95% CI: 5.71 – 132.42). Conclusion: The first diphtheria booster vaccination at 18 – 24 months old is crucial to protect pre-school children against diphtheria.
Validity and Reliability Test of the Office Syndrome Screening Questionnaire Nusasenjaya, Radite; Raksanagara, Ardini Saptaningsih; Santi, Theresia; Melati, Rima; Purwoko, Reza Yuridian; Ridwansyah, Ridwansyah
Journal La Medihealtico Vol. 6 No. 1 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i1.1812

Abstract

Office Syndrome is increasingly common due to sedentary work environments and inadequate ergonomic practices. This condition is characterized by a variety of symptoms, such as musculoskeletal pain, visual fatigue, sensory disturbances, sleep disturbances, and mental stress, which impact workers’ health and reduce productivity. However, the assessment of this condition is often hampered by the lack of comprehensive and standardized measurement tools. This study aims to develop and test the validity and reliability of an office syndrome screening questionnaire that covers seven dimensions: physical pain, muscle fatigue, visual fatigue, sensory disturbances, decreased productivity, sleep disturbances, and mental stress. The study was conducted cross-sectionally involving 47 office workers in the Jababeka area, Cikarang, who met the inclusion criteria. Data were collected using a questionnaire that was filled out independently via Google Form. Validity testing was carried out using Pearson correlation analysis (items are valid if r > 0.3 and p < 0.05), while reliability testing used Cronbach’s Alpha (reliable if α > 0.7). The results showed that all items had a significant correlation to the total score (p < 0.05), with correlation values ranging from 0.416 to 0.697. The highest correlation was found in the items "Decreased work efficiency" (r = 0.697) and "Difficulty concentrating" (r = 0.673), while the item "Muscle tension" had the lowest correlation (r = 0.416) but was still valid. The overall Cronbach's Alpha was 0.745, indicating good reliability. This screening questionnaire was proven to be valid and reliable to measure symptoms of office syndrome comprehensively.
Resilience of Health Workers in Disaster Crisis Situations in Indonesia: An Economic Based Literature Study Santi, Theresia
FIRM Journal of Management Studies Vol 8, No 2 (2023): FIRM JOURNAL OF MANAGEMENT STUDIES
Publisher : President University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33021/firm.v8i2.5803

Abstract

Resilience among health workers refers to their ability to withstand and adapt to pressure. Such pressure can arise in crisis and disaster situations, including pandemics, natural disasters, or conflicts. As the frontline providers of healthcare services, health workers frequently encounter both physical and mental challenges that can affect their performance. Previous research has identified several factors influencing resilience, including mental health, institutional support, and resource availability. However, efforts to enhance resilience still face various research gaps, particularly regarding the implementation of effective strategies, especially in developing countries. This review aims to analyse the factors influencing health worker resilience, evaluate evidence-based strategies for strengthening resilience, and identify challenges and solutions in the Indonesian context. The findings suggest that a holistic approach - encompassing individual, institutional, and policy interventions - is essential to address key challenges, such as burnout, resource disparities, and limitations in training. This study seeks to contribute academically by expanding the literature on health worker resilience, providing a foundation for future research, and offering practical recommendations to improve educational policies and health workforce management. Specifically, the findings of this narrative review can support universities in integrating resilience concepts into health curricula and disaster preparedness training programs.
OFFICE SYNDROME LITERATURE REVIEW : LATEST RESEARCH INSIGHTS AND FUTURE DIRECTIONS Nusasenjaya, Radite; Santi, Theresia; Purwoko, Reza Yuridian; Melati, Rima; Anugrah, Andreas Surya
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 1 (2025): APRIL 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i1.38142

Abstract

Sindroma Perkantoran atau Office syndrome merupakan kumpulan gejala yang terutama terjadi akibat kebiasaan bekerja dengan posisi statis dalam jangka waktu lama, yang sering timbul pada pekerja kantor. Sindrom ini mencakup berbagai gangguan muskuloskeletal dan masalah kesehatan lainnya yang disebabkan oleh duduk yang berkepanjangan, postur tubuh yang buruk, gerakan berulang, dan pengaturan ergonomis yang tidak memadai. Tinjauan literatur ini bertujuan untuk mengisi kesenjangan pengetahuan, menyediakan gambaran holistik tentang Sindroma Perkantoran, dan memberikan dasar untuk penelitian lebih lanjut serta pengembangan rekomendasi berbasis bukti. Metodologi penelitian menggunakan narrative literature review dengan pencarian sistematis melalui database PubMed, Scopus, Web of Science, CINAHL, dan PsycINFO menggunakan kata kunci spesifik. Temuan penelitian menunjukkan prevalensi Sindroma Perkantoran mencakup gangguan muskuloskeletal berkisar 33,8-95,3%, dengan tingkat keparahan lebih tinggi di negara berkembang dibanding negara maju. Sindroma Perkantoran mencakup dua masalah utama: gangguan muskuloskeletal (work related musculoskeletal disorder/WMSD) dan Sindrom Penglihatan Komputer (Computer Vision Syndrome/CVS). Faktor risiko meliputi penggunaan komputer dalam waktu lama, usia lanjut, gerakan berulang, stres, posisi yang sama dalam waktu lama, beban kerja berat, merokok, pengalaman kerja berkepanjangan, kurang latihan fisik, dan status pendidikan. Responden perempuan dilaporkan lebih mungkin mengalami gangguan muskuloskeletal dibandingkan laki-laki. Penanganan mencakup pendekatan non-farmakologis seperti edukasi ergonomi dan perbaikan postur kerja, serta pendekatan farmakologis menggunakan analgesik, relaksan otot, dan obat adjuvan. Inovasi terkini termasuk terapi seluler seperti Mesenchymal Stem Cells (MSC), Platelet-Rich Plasma (PRP), eksosom, dan potensi modulasi vitamin D.
Perbandingan Efikasi dan Keamanan Parasetamol serta Ibuprofen dengan Dosis Berdasarkan Berat Badan dalam Penanganan Demam Anak: Uji Klinis Acak Terbuka Prawira, Yogi; Agustina, Agustina; Hamik, Welli; Santi, Theresia; Garniasih, Dina; Tandra, Irene Mutiara; Lukman, Leni; Sugiharto, Jessica; Ardini, Ni Putu
Sari Pediatri Vol 27, No 5 (2026)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp27.5.2026.299-308

Abstract

Latar belakang. Demam adalah keluhan tersering di praktik pediatri Indonesia. Parasetamol dan ibuprofen menjadi antipiretik utama, baik dengan pengawasan medis maupun swamedikasi. Namun, sebagian besar produk di Indonesia masih menggunakan panduan dosis berbasis usia, padahal variasi berat badan anak yang lebar berisiko menyebabkan dosis kurang atau berlebih.Tujuan. Menilai efikasi dan keamanan pemberian tunggal parasetamol dan ibuprofen berbasis berat badan dalam menurunkan demam pada anak usia 2-15 tahun di Indonesia.Metode. Penelitian ini merupakan uji klinis fase III, acak terbuka, dua lengan paralel, non-inferioritas, dan multisenter. Subjek diacak menerima parasetamol sirup 250 mg/5 mL (10-15 mg/kg) atau ibuprofen suspensi 100 mg/5 mL (5-10 mg/kg). Suhu timpani diukur pada menit ke-15, 30, 60, 120, 180, dan 240 setelah pemberian pertama. Keamanan dievaluasi melalui efek samping serta pemeriksaan hematologi, fungsi hati dan ginjal, dan CRP dalam 48-72 jam setelah dosis terakhir.Hasil. Sebanyak 93 anak dibagi menjadi dua kelompok: parasetamol (45 anak) dan ibuprofen (48 anak). Penurunan suhu mulai terlihat pada 15 menit pertama (rata-rata 0,55°C). Pada menit ke-60, penurunan suhu kedua obat sebanding (parasetamol 1,13°C; ibuprofen 1,06°C). Pada menit ke-240, ibuprofen unggul 0,20°C, tetapi masih dalam batas non-inferioritas (0,65°C). Efek samping ringan dan sementara, tanpa kejadian serius. Laboratorium menunjukkan peningkatan ringan enzim hati (?7 U/L) dan penurunan CRP ±17 mg/L, sesuai proses penyembuhan alami.Kesimpulan. Dosis parasetamol dan ibuprofen berbasis berat badan terbukti cepat, aman, dan setara dalam menurunkan demam anak Indonesia. Keduanya dapat menjadi terapi lini pertama yang fleksibel. Temuan ini mendukung penerapan panduan dosis berbasis berat badan (mg/kg) menggantikan panduan berbasis usia.
Vitamin D deficiency in newborns: a tropical paradox Dewanto, Naomi Esthernita F.; Santi, Theresia; Sugiri, Zaneth; Napitupulu, Nancy; Jo, Juandy
Paediatrica Indonesiana Vol. 66 No. 1 (2026): January 2026
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background  Previous studies have shown a 'tropical paradox' in Indonesia, where despite being a tropical country with abundant sunlight, a widespread vitamin D inadequacy is observed in various populations. This paradox extends to Indonesian children, who predominantly exhibit low vitamin D levels, yet research specifically investigating vitamin D status in the newborn remains notably limited. Objective To determine the prevalence of low level of vitamin D and elucidate its correlation with the conditions of newborns in Jakarta, Indonesia. Methods This retrospective study analyzed data from newborns undergoing assessment at Siloam Hospital Kebon Jeruk, Jakarta, from June 2022 to May 2024. We collected the following data: newborn’s vitamin D level, demographic and clinical characteristics, as well as available maternal data. Serum 25-hydroxyvitamin D [25(OH)D] levels between < 20, 20–29.9 and ≥ 30 ng/mL were classified as deficient, insufficient, and sufficient, respectively. Statistical analyses were used to compare baseline characteristics and outcomes based on vitamin D status. Results Of the 243 newborns studied, 70.4% were classified as vitamin D deficient, 22.2% as insufficient, and 7.4% as sufficient. Subjects’ median vitamin D level was 15.7 (range 1.2 – 57.1)  ng/mL. No significant difference in vitamin D levels was observed between male and female newborns (p=0.190) and between newborns with birthweight < 2,500 and the ones with birth weight ≥2,500 grams (p=0.794). Vitamin D levels were not significantly different between healthy and sick newborns (p=0.537). Maternal vitamin D status was available for only a small proportion (15.6%) of mothers, highlighting the need for further investigation into maternal-newborn vitamin D status. Conclusion Although a high prevalence of newborn with vitamin D deficiency was observed in our study participants, no significant difference in vitamin D levels was observed between healthy and sick newborns. No correlation was observed between sex or birth weight, and vitamin D levels as well. Future inquiries should explore maternal vitamin D status in greater detail and assess the prolonged health consequences of hypovitaminosis D in newborns.  
Co-Authors Agustina Anugrah, Andreas Surya Ardini Saptaningsih Raksanagara, Ardini Saptaningsih Ardini, Ni Putu Ari Prayitno, Ari Badriul Hegar Dewanto, Naomi Esthernita F. Dina Garniasih, Dina Hamik, Welli Harahap, Alida Roswita Ivo Novita Sah Bandar Juandy Jo Lukman, Leni Napitupulu, Nancy Nusasenjaya, Radite Purwoko, Reza Yuridian Retno Asti Werdhani Ridwansyah Ridwansyah Rima Melati Sri Rezeki S. Hadinegoro, Sri Rezeki S. Sugiharto, Jessica Sugiri, Zaneth Tandra, Irene Mutiara Yogi Prawira, Yogi Zakiudin Munasir