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Profile of Anti-Diphtheria Toxoid Immunoglobulin G among Pre-School Children in the Senen District, Jakarta, Indonesia Santi, Theresia; Jo, Juandy; Prayitno, Ari; Munasir, Zakiudin; Hegar, Badriul
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 7 No. - (2023): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v7i-.189

Abstract

Background: Diphtheria is a re-emerging disease in Indonesia that can be prevented by vaccination. This study evaluates the anti-diphtheria toxoid immunoglobulin G levels among healthy children aged 6 – 7 years old who had not received the second booster immunization for Diphtheria, Tetanus, and Pertussis (DTP) commonly administered at 5 – 7 years old. Methods: This cross-sectional study was conducted in the Senen district of Jakarta, Indonesia. All subjects had been vaccinated with three doses of immunization for DTP during the first year of life, and subsequently classified into a group of children who received the first booster immunization of DTP at 18 – 24 months old and who had not received it yet. Antibody against Diphtheria toxoids within the sera samples was assessed by commercial Anti-Diphtheria toxoid IgG Enzyme-Linked Immunosorbent Assay and classified in four groups: no protection (< 0.01 IU/ml), uncertain (0.01 – 0.09 IU/ml), full protection (0.10 – 1 IU/ml) and long-term protection (>1 IU/ml). Results: Eighty-nine children were included in this study; only 71 subjects (79.7%) had received the first DTP booster at 18–24 months old. The specific humoral immunity against diphtheria was observed among 57 children (64%). Notably, among the 89 subjects, only two subjects not receiving the first DTP booster still had antibody protection for diphtheria (p=0.001, OR 27.5, 95% CI: 5.71 – 132.42). Conclusion: The first diphtheria booster vaccination at 18 – 24 months old is crucial to protect pre-school children against diphtheria.
Validity and Reliability Test of the Office Syndrome Screening Questionnaire Nusasenjaya, Radite; Raksanagara, Ardini Saptaningsih; Santi, Theresia; Melati, Rima; Purwoko, Reza Yuridian; Ridwansyah, Ridwansyah
Journal La Medihealtico Vol. 6 No. 1 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i1.1812

Abstract

Office Syndrome is increasingly common due to sedentary work environments and inadequate ergonomic practices. This condition is characterized by a variety of symptoms, such as musculoskeletal pain, visual fatigue, sensory disturbances, sleep disturbances, and mental stress, which impact workers’ health and reduce productivity. However, the assessment of this condition is often hampered by the lack of comprehensive and standardized measurement tools. This study aims to develop and test the validity and reliability of an office syndrome screening questionnaire that covers seven dimensions: physical pain, muscle fatigue, visual fatigue, sensory disturbances, decreased productivity, sleep disturbances, and mental stress. The study was conducted cross-sectionally involving 47 office workers in the Jababeka area, Cikarang, who met the inclusion criteria. Data were collected using a questionnaire that was filled out independently via Google Form. Validity testing was carried out using Pearson correlation analysis (items are valid if r > 0.3 and p < 0.05), while reliability testing used Cronbach’s Alpha (reliable if α > 0.7). The results showed that all items had a significant correlation to the total score (p < 0.05), with correlation values ranging from 0.416 to 0.697. The highest correlation was found in the items "Decreased work efficiency" (r = 0.697) and "Difficulty concentrating" (r = 0.673), while the item "Muscle tension" had the lowest correlation (r = 0.416) but was still valid. The overall Cronbach's Alpha was 0.745, indicating good reliability. This screening questionnaire was proven to be valid and reliable to measure symptoms of office syndrome comprehensively.
Resilience of Health Workers in Disaster Crisis Situations in Indonesia: An Economic Based Literature Study Santi, Theresia
FIRM Journal of Management Studies Vol 8, No 2 (2023): FIRM JOURNAL OF MANAGEMENT STUDIES
Publisher : President University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33021/firm.v8i2.5803

Abstract

Resilience among health workers refers to their ability to withstand and adapt to pressure. Such pressure can arise in crisis and disaster situations, including pandemics, natural disasters, or conflicts. As the frontline providers of healthcare services, health workers frequently encounter both physical and mental challenges that can affect their performance. Previous research has identified several factors influencing resilience, including mental health, institutional support, and resource availability. However, efforts to enhance resilience still face various research gaps, particularly regarding the implementation of effective strategies, especially in developing countries. This review aims to analyse the factors influencing health worker resilience, evaluate evidence-based strategies for strengthening resilience, and identify challenges and solutions in the Indonesian context. The findings suggest that a holistic approach - encompassing individual, institutional, and policy interventions - is essential to address key challenges, such as burnout, resource disparities, and limitations in training. This study seeks to contribute academically by expanding the literature on health worker resilience, providing a foundation for future research, and offering practical recommendations to improve educational policies and health workforce management. Specifically, the findings of this narrative review can support universities in integrating resilience concepts into health curricula and disaster preparedness training programs.
Perbandingan Efikasi dan Keamanan Parasetamol serta Ibuprofen dengan Dosis Berdasarkan Berat Badan dalam Penanganan Demam Anak: Uji Klinis Acak Terbuka Prawira, Yogi; Agustina, Agustina; Hamik, Welli; Santi, Theresia; Garniasih, Dina; Tandra, Irene Mutiara; Lukman, Leni; Sugiharto, Jessica; Ardini, Ni Putu
Sari Pediatri Vol 27, No 5 (2026)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp27.5.2026.299-308

Abstract

Latar belakang. Demam adalah keluhan tersering di praktik pediatri Indonesia. Parasetamol dan ibuprofen menjadi antipiretik utama, baik dengan pengawasan medis maupun swamedikasi. Namun, sebagian besar produk di Indonesia masih menggunakan panduan dosis berbasis usia, padahal variasi berat badan anak yang lebar berisiko menyebabkan dosis kurang atau berlebih.Tujuan. Menilai efikasi dan keamanan pemberian tunggal parasetamol dan ibuprofen berbasis berat badan dalam menurunkan demam pada anak usia 2-15 tahun di Indonesia.Metode. Penelitian ini merupakan uji klinis fase III, acak terbuka, dua lengan paralel, non-inferioritas, dan multisenter. Subjek diacak menerima parasetamol sirup 250 mg/5 mL (10-15 mg/kg) atau ibuprofen suspensi 100 mg/5 mL (5-10 mg/kg). Suhu timpani diukur pada menit ke-15, 30, 60, 120, 180, dan 240 setelah pemberian pertama. Keamanan dievaluasi melalui efek samping serta pemeriksaan hematologi, fungsi hati dan ginjal, dan CRP dalam 48-72 jam setelah dosis terakhir.Hasil. Sebanyak 93 anak dibagi menjadi dua kelompok: parasetamol (45 anak) dan ibuprofen (48 anak). Penurunan suhu mulai terlihat pada 15 menit pertama (rata-rata 0,55°C). Pada menit ke-60, penurunan suhu kedua obat sebanding (parasetamol 1,13°C; ibuprofen 1,06°C). Pada menit ke-240, ibuprofen unggul 0,20°C, tetapi masih dalam batas non-inferioritas (0,65°C). Efek samping ringan dan sementara, tanpa kejadian serius. Laboratorium menunjukkan peningkatan ringan enzim hati (?7 U/L) dan penurunan CRP ±17 mg/L, sesuai proses penyembuhan alami.Kesimpulan. Dosis parasetamol dan ibuprofen berbasis berat badan terbukti cepat, aman, dan setara dalam menurunkan demam anak Indonesia. Keduanya dapat menjadi terapi lini pertama yang fleksibel. Temuan ini mendukung penerapan panduan dosis berbasis berat badan (mg/kg) menggantikan panduan berbasis usia.
Microbial profiles and antimicrobial resistance patterns in neonatal intensive care units: an analysis of the impact of the COVID-19 pandemic in Indonesia Santi, Theresia; Robertus, Thomas; Dewanto, Naomi Esthernita Fauzia; Hidayat, Feronica Kusuma; Hidayat, Ferry; Sungono, Veli; Jo, Juandy
Paediatrica Indonesiana Vol. 66 No. 2 (2026): March 2026
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background Neonatal sepsis requires prompt antimicrobial treatment. A lack of information on patterns of antibiotic resistance among the bacteria across hospitals hinders the treatment. The COVID-19 pandemic contributed to changes in neonatal infection patterns and antimicrobial resistance.  Data describing these changes remain scarce in Indonesia. Objective To determine the spectrum of pathogens and their antibiotic resistance patterns among Indonesian neonates with sepsis, prior and during the COVID-19 pandemic. Methods This retrospective study  was done to examine patterns of pathogens and antibiotic resistance in neonates admitted to the neonatal intensive care units (NICUs) at Siloam Hospital Kebon Jeruk and Lippo Cikarang for 6 years, i.e., January 2018 to December 2020 (“Prior/Early COVID-19 Pandemic” or first phase) and January 2021 to December 2023 (“Mid/Late COVID-19 Pandemic” or second phase). The inclusion criteria were newborns with suspected or proven sepsis who underwent microbiological specimen collection for the assessment of antimicrobial resistance. We compared patterns of isolated pathogens and their antibiotic resistance of neonates with sepsis in two private hospitals, prior and during the COVID-19 pandemic. Results There were more participants in the first phase than in the second phase (44 vs. 33, respectively), resulting in more pathogenic isolates in the former than the latter phase (43 vs. 23, respectively). There were more Gram-negative bacteria detected than Gram-positive bacteria, although a reduction of several Gram-negative bacterial species from the order of Enterobacterales (including Klebsiella pneumoniae and Escherichia coli) was detected in the second phase. The resistance of Enterobacterales to gentamicin and third-generation cephalosporins was substantially increased in the second phase. Conclusion Despite an overall decline in isolate numbers, the observed increase in antibiotic resistance among Enterobacterales in the second phase may reflect suboptimal stewardship and indiscriminate use of broad-spectrum antibiotics during the COVID-19 pandemic. This highlights the growing challenge of antimicrobial resistance in neonatal sepsis management in Indonesia.