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All Journal KOVALEN: Jurnal Riset Kimia Jurnal Analis Kesehatan Kendari
Nohong
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology

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Identifikasi dan Uji Aktivitas Antioksidan Senyawa Metabolit Sekunder Ekstrak Tanaman Cleome viscosa L: Identification and Antioxidants Activity Tests of Secondary Metabolite Compounds of Clome viscosa L. Plant Extracts Imran; Nurliana, Laily; Natsir, Muh.; Nohong; Kadir, La Ode Abd; Rudi, La; Ruslan; Azis, Thamrin
KOVALEN: Jurnal Riset Kimia Vol. 9 No. 1 (2023): April Edition
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2023.v9.i1.16340

Abstract

Cleome viscosa L. has been used empirically by people on the island to treat diseases that have clinical symptoms such as malaria (fever, sweating, chills, and muscle aches). The purpose of this study was to determine the class of secondary metabolites and antioxidant activity. The extraction was carried out using the maceration method, while the fractionation was carried out using the separating funnel. The secondary metabolites found in the Cleome viscosa L. plant extract are alkaloids, flavonoids, steroids, terpenoids, tannins, and saponins. Antioxidant test conducted by DPPH method showed that the positive control of ascorbic acid and methanol extract obtained IC50 values of 3.86 ppm and 37.4 ppm, respectively.
UJI AKTIVITAS ANTIOKSIDAN SENYAWA METABOLIT SEKUNDER DARI EKSTRAK KULIT BATANG PALIASA (Kleinhovia hospita Linn) Imran; Angga Febrian; Zainal Syam Arifin; Thamrin Azis; I Wayan Sutapa; Nohong; La Agusu; Syahrir; Alwahab
Jurnal Analis Kesehatan Kendari Vol. 7 No. 2 (2025): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 7 (2) Juni 2025)
Publisher : Program Study of Medical Laboratory Technology , Politeknik Bina Husada Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46356/jakk.v7i2.351

Abstract

This study aims to test the antioxidant activity of secondary metabolite compounds contained in paliasa (Kleinhovia hospita Linn) stem bark extract. This plant is traditionally known to have health benefits, but research on the antioxidant activity of its stem bark is still limited. Extraction was done using a maceration method using a methanol solvent, followed by liquid-liquid fractionation using n-hexane and ethyl acetate to separate compounds based on their polarity. Phytochemical screening showed that the n-hexane fraction contained alkaloids and terpenoids, while the ethyl acetate fraction contained alkaloids, flavonoids, tannins, and saponins. The antioxidant activity of both fractions was tested using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method with absorbance measurements at a wavelength of 517 nm. The test results showed that the ethyl acetate fraction had an IC50 value of 51.7687 ppm, while the n-hexane fraction had an IC50 value of 60.5442 ppm. Based on the classification of antioxidant activity, both fractions are categorized as strong antioxidants (IC50 between 50-100 ppm). For comparison, vitamin C has an IC50 value of 14.3421 ppm, indicating strong antioxidant activity. The results of this study indicate that paliasa bark extract, especially the ethyl acetate fraction, has the potential as a source of natural antioxidants that can be further developed in the pharmaceutical, cosmetic, and food industries as an alternative to synthetic antioxidants with toxicity risks.
Co-Authors Alwahab Alwahab Angga Febrian I Wayan Sutapa Imran Kadir, La Ode Abd La Agusu La Rudi Laily Nurliana Muh. Natsir, Muh. Ruslan Syahrir THAMRIN AZIS Zainal Syam Arifin