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All Journal Jurnal MIPA PHARMACON Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Pharmacology and Clinical Pharmacy Research Jurnal Lentera Farma
ERLADYS MELINDAH RUMONDOR, ERLADYS MELINDAH
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health

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Anti-proliferative Activity of Crotalaria pallida Aiton on MCF-7 Breast Cancer Cells Rumondor, Erladys M.; Moektiwardoyo, Moelyono; Barliana, Melisa I.
Pharmacology and Clinical Pharmacy Research Vol 2, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (326.492 KB) | DOI: 10.15416/pcpr.v2i3.16218

Abstract

 Crotalaria pallida Aiton (C. pallida Aiton) is empirically used as dietary supplement to treat cancer by the people of North Sulawesi. However, its scientific pharmacology activity has not been explored yet. Therefore, this study was conducted to evaluate anti-proliferative activity of C. pallida Aiton on MCF-7 breast cancer cells. The extraction of leaves and seeds were performed using ethanol, ethyl acetate, n-hexane, and water. Phytochemical screening was then performed to identify secondary metabolites in this extract. Anti-proliferative activity was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results indicated that ethyl acetate fraction of C. pallida Aiton has the lowest IC50 (29,67). In conclusion, ethyl acetate fraction of C. pallida Aiton is potential to be developed as anti cancer agent.Keywords: Crotalaria pallida Aiton, WST assay, MCF-7 cell line
REVIEW - PENGEMBANGAN KURKUMIN DAN ANDROGRAFOLIDA UNTUK SEDIAAN PARENTERAL Mansauda, Karlah; Rumondor, Erladys Melindah
PHARMACON Vol 9, No 1 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.27419

Abstract

ABSTRACTCurcuma longa Linn (Kunyit) and Andrographis paniculata (Burm.f.) Nees (Sambiloto) are some examples of plants that grown in Indonesia that provides many health benefits with their isolated coumpound Curcumin and Andrographolide, respectively. However, due to their low water-solubility, low stability, rapid metabolism, poor absorption, and degradation during processing or within the gastrointestinal tract and alkaline conditions therefor reduces its oral bioavailability and consequently decreasing its development as a therapeutic drugs via oral. The advantage of parenteral route of administration including reduced toxicity, improved drug solubility and stability, prolonged circulation time, and enhanced tissue penetration. This review summarizes and discusses published journals on the key development on parenteral delivery system of curcumin and andrographolide as active ingredients. Keywords : Curcumin, Andrographolide, Parenteral ABSTRAKCurcuma longa Linn (Kunyit) dan Andrographis paniculata (Burm.f.) Nees (Sambiloto) adalah beberapa contoh tanaman yang tumbuh di Indonesia yang memberikan banyak manfaat kesehatan dengan senyawa yang terkandung didalamnya seperti Kurkumin dan Andrografolida. Namun karena sifatnya sukar larut dalam air, stabilitas rendah, metabolisme yang cepat, susah diabsorbsi, dan terdegradasi dalam asam lambung dan kondisi alkali, akibatnya menurunkan bioavailabilitas oralnya dan mengurangi manfaatnya. Pemberian secara parenteral adalah rute yang memiliki keuntungan termasuk mengurangi toksisitas, meningkatkan kelarutan obat dan stabilitas, memperpanjang waktu sirskulasi, dan peningkatan penetrasi jaringan. Ulasan ini merangkum dan membahas jurnal pada mengenai pengembangan sistem penghantaran secara parenteral dengan kurkumin dan andrografolida sebagai senyawa aktifnya. Kata Kunci : Kurkumin, Andrografolida, Parenteral
ANALISIS KEPUASAN PASIEN RAWAT JALAN TERHADAP MUTU PELAYANAN KEFARMASIAN DI PUSKESMAS TANAWANGKO Bunet, Greey C.E.; Lolo, Widya A.; Rumondor, Erladys M.
PHARMACON Vol 9, No 3 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.30024

Abstract

ABSTRACTPatient satisfaction is an important indicator for pharmaceutical services and has a close relationship with service quality. A good quality of services will provide satisfaction to patient so that it affects to return the Health Center. The purpose of this study was to determine the satisfaction of outpatients with the quality of pharmaceutical services at the Tanawangko Health Center. This research is a descriptive study and the data collection tool used is the questionnaire given to 277 respondents. Based on the research results obtained, it is known that each question on the 5 dimensions has a negative value with an average value (-0.38) this value is obtained from the average value of the total service quality index between expectations and reality, meaning the patient is not satisfied. The reality received is lower yhan expectations.Keywords :  Level of satisfaction, expectations, reality. ABSTRAK Kepuasan pasien merupakan indikator penting bagi pelayanan kefarmasian dan memiliki hubungan erat dengan kualitas pelayanan. Kualitas pelayanan yang baik akan memberikan kepuasan kepada pasien sehingga mempengaruhi pasien untuk kembali lagi ke Puskesmas. Tujuan dari penelitian ini untuk mengetahui kepuasan pasien rawat jalan terhadap mutu pelayanan kefarmasian di Puskesmas Tanawangko. Penelitian ini merupakan penelitian deskriptif dan alat pengumpulan data yang digunakan yaitu kuesioner diberikan kepada 277 responden. Berdasarkan hasil penelitian yang diperoleh, diketahui bahwa setiap pertanyaan pada 5 dimensi memiliki nilai negatif dengan nilai rata-rata (-0,38) nilai ini diperoleh dari rata-rata nilai indeks total kualitas pelayanan antara harapan dan kenyataan, artinya pasien tidak puas. Kenyataan yang diterima lebih rendah dibandingkan dengan harapan.Kata Kunci  : Tingkat kepuasan, harapan, kenyataan.
PENGUKURAN KINERJA INSTALASI FARMASI RSUD DATOE BINANGKANG DENGAN METODE BALANCED SCORECARD BERDASARKAN PERSPEKTIF PELANGGAN SERTA PERSPEKTIF PERTUMBUHAN DAN PEMBELAJARAN Tawalujan, Wulan P.; Citraningtyas, Gayatri; Rumondor, Erladys M.
PHARMACON Vol 9, No 3 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.30022

Abstract

ABSTRACTPerformance measurement by balanced scorecard method needed to be done at the pharmacy installation of RSUD Datoe Binangkang to see the performance achievements that have been done and the basis for further performance improvement. This research aims to know performance of pharmacy installation of RSUD Datoe Binangkang with the balanced scorecard method based on customer perspective with learning and growth perspective. This research was a non experimental with evaluative descriptive design. The data was collected with retrospective and prospective methods. This research used both qualitative and quantitative data. Qualitative data was obtained by interview and direct observation. Quantitative data was obtained by questionnaires. The result research of performance at customer perspective with patient satisfaction indicator showed that patients have not been satisfied with the services provided with the value of gap for each dimension are: tangibles -0,22, reliability -0,17, responsiveness -0,19, assurance -0,02, emphaty -0,05. Performance at learning and growth perspective with indicators of employee job satisfaction high 3,23, work spirit very high 3,37 and percentage of employee training low 0%. The conclusion obtained from both perspective were indicators with good performance was job satisfaction and work spirit. Indicators with not good performance that require attention to be improved was employee training and patient satisfaction.Keywords: Performance, Pharmacy Installation, Balanced Scorecard, Customer Perspective,  Learning and Growth Perspective.ABSTRAK Pengukuran kinerja dengan metode balanced scorecard perlu dilakukan di Instalasi Farmasi RSUD Datoe Binangkang untuk melihat pencapaian kinerja yang telah dilakukan serta dasar bagi perbaikan kinerja selanjutnya. Penelitian ini bertujuan untuk mengetahui kinerja Instalaasi Farmasi RSUD Datoe Binangkang dengan metode balanced scorecard berdasarkan perspektif pelanggan serta perspektif pertumbuhan dan pembelajaran. Penelitian ini merupakan jenis penelitian non eksperimental dengan rancangan deskriptif evaluatif. Data diperoleh secara retrospektif dan prospektif. Kriteria data berupa data kualitatif dan kuantitatif. Data kualitatif melalui wawancara dan observasi langsung. Data kuantitatif melalui kuesioner. Hasil penelitian kinerja pada perspektif pelanggan dengan indikator kepuasan pasien menunjukkan pasien belum puas terhadap pelayanan yang diberikan, dengan perolehan nilai gap pada setiap dimensi yaitu: berwujud -0,22, kehandalan -0,17, ketanggapan -0,19, jaminan -0,02, empati -0,05. Kinerja pada perspektif pertumbuhan dan pembelajaran dengan indikator kepuasan kerja karyawan tinggi 3,23, semangat kerja karyawan sangat tinggi 3,37, dan persentase pelatihan karyawan rendah 0%. Kesimpulan yang didapat pada kedua perspektif bahwa indikator dengan kinerja yang baik yaitu kepuasan kerja dan semangat kerja. Indikator dengan kinerja yang kurang baik yang memerlukan perhatian untuk diperbaiki yaitu pelatihan karyawan dan kepuasan pasien.Kata Kunci: Kinerja, Instalasi Farmasi, Balanced Scorecard, Perspektif Pelanggan, Perspektif Pertumbuhan dan Pembelajaran.
Formulasi dan Uji Stabilitas Fisik Sediaan Krim Ekstrak Etanol Kulit Buah Pisang Goroho (Musa acuminafe L.) Konsentrasi 12.5% Sebagai Tabir Surya Lumentut, Natalia; Edi, Hosea Jaya; Rumondor, Erladys Melindah
Jurnal MIPA Vol 9, No 2 (2020)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jmuo.9.2.2020.28248

Abstract

Penelitian ini bertujuan untuk melihat stabilitas fisik dari formulasi sediaan krim ekstrak etanol kulit buah pisang Goroho pada konsentrasi 12.5%. Evaluasi sifat fisik meliputi uji organoleptik, homogenitas, pH, daya sebar dan daya lekat. Uji stabilitas dilakukan menggunakan metode cycling test selama 6 siklus dengan menguji kembali sifat fisiknya. Hasil pengujiann sifat fisik (siklus 0) sediaaan krim yaitu uji organoleptik (bau: khas etanol buah pisang; warna: hijau; tekstur: semi solid), homogenitas (susunan homogen), pH 5.04±0.25, daya sebar 3.43±0.12 cm, daya lekat 30.55±2.09 detik, dan uji stabilitas selama cycling test (siklus 1-siklus 6) tidak ada perbedaan yang bermakna.The aim of this research was to determine the physical stability of the cream ethanol extract of Goroho banana peels at a concentration of 12.5%. Evaluation of physical properties includes organoleptic test, homogeneity, pH, dispersibility and adhesion. The stability test was carried out using the cycling test method for 6 cycles by re-testing its physical properties. Test result of physical properties (cycle 0) cream preparation, namely organoleptic test (odor: typical of banana ethanol, color: green, texture: semi-solid), homogeneity (homogeneous arrangement), pH 5.04 ± 0.25, spread capacity 3.43 ± 0.12 cm and power sticky 30.55 ± 0.12 seconds, and the stability test during the cycle test there was no significant difference.
UJI INVIVO EKSTRAK UMBI BAWANG HUTAN (Eleutherine americana Merr.) TERHADAP GAMBARAN MAKROSKOPIS ORGAN JANTUNG TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) Rondonuwu, Greifen Triky; Simbala, Herny; Rumondor, Erladys
PHARMACON Vol 10, No 2 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.34043

Abstract

ABSTRACTForest onion bulbs (Eleutherine americana Merr.), Including the Iridaceae family, have been used for generations by the Dayak people as medicinal plants for various types of diseases such as breast and colon cancer, hypertension, diabetes mellitus, hypercholesterolemia and stroke. This study was conducted to evaluate the effect and side effects of extracts of forest onion bulbs to the macroscopic description of cardiac organ in rats. Thirty male white rats Wistar strain was used as research object, which is divided into three groups of dose that applied with the ethanol extract of Forest onion bulbs orally (5mg/ml, 10mg/ml, 15mg/ml)  and one group as controls for comparison. The tests were carried out for 15 days, with observations made against the body weight of rats, macroscopic observation of cardiac organ and observation of cardiac organ weights. The results showed that the provision of forest onion bulbs extract did not cause significant changes based on the graph of observations made on the macroscopic image of the heart organ and the weight of the rats. Keywords : Forest onion bulbs (Eleutherine Americana Merr.), cardiac macroscopic, white rat (Rattus norvegicus)  ABSTRAKUmbi bawang hutan (Eleutherine americana Merr.) termasuk familia Iridaceae, secara turun temurun telah dipergunakan oleh masyarakat dayak sebagai tumbuhan obat untuk berbagai jenis penyakit seperti kanker payudara dan kolon, hipertensi, diabetes mellitus, hiperkolesterol dan strok. Penelitian ini bertujuan untuk  melihat pengaruh yang ditimbulkan dari konsumsi ekstrak  Umbi bawang hutan terhadap gambaran makroskopis organ jantung pada tikus putih. Penelitian dilakukan menggunakan hewan percobaan  tikus putih jantan galur wistar berjumlah 30 ekor, yang dibagi dalam empat kelompok dosis yang diberi ekstrak etanol umbi bawang hutan secara oral yaitu (5mg/ml, 10mg/ml, 15mg/ml) dan satu kelompok kontrol sebagai pembanding. Masa pengujian dilakukan selama 15 hari, dengan pengamatan yang dilakukan berupa pengamatan berat badan tikus, pengamatan makroskopis organ jantung dan pengamatan berat organ. Hasil penelitian menunjukkan bahwa pemberian ektrak umbi bawang hutan tidak menimbulkan perubahan yang signifikan berdasarkan grafik pengamatan yang dilakukan pada gambaran makroskopis organ jantung serta penimbangan berat badan tikus. Kata kunci : Umbi bawang hutan (Eleutherine americana Merr.), makroskopis jantung, tikus putih (Rattus norvegicus)
PERSPEKTIF PELANGGAN DAN PERSPEKTIF PEMBELAJARAN DAN PERTUMBUHAN DALAM MENGUKUR KINERJA INSTALASI FARMASI RUMAH SAKIT ADVENT MANADO DENGAN METODE BALANCED SCORECARD Agow, Mikhael C.; Citraningtyas, Gayatri; Rumondor, Erladys M.
PHARMACON Vol 10, No 1 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.32756

Abstract

ABSTRACTPerformanced measurement used Balanced Scorecard with customer perspective and learn and growth perspective offers comprehensive solution to found how customers value products or services and how companies improved the resources of human quality become competent workers and  able to produce excellent performance for the organization. This studied aims to determine the performance of Pharmacy Installation at Manado Advent Hospital based on the customer perspective and learning and growth perspective. The typed of research was non-experimental research with descriptive evaluative design. Data were obtained prospectively and retrospectively. The criteria of data were qualitative and quantitative. Qualitative data form an observation data and interviews. Quantitative data form questionnaire. The results customer perspective has 83.45% of patient satisfied to performanced of Pharmacy Installation at Manado Advent Hospital. Learning and growth perspective got results the employees has high satisfaction of job and spirit worked with value 3.05 and 3.06. The employee training of Pharmacy Installation at Manado Advent Hospital was never been implemented. The conclusions good performanced on patient satisfaction based on costumer perspective. Learn and growth perspective has good performance from work spirit and employee job satisfaction but poor performance that must be improved was employee trained.Keywords : Performance, Pharmacy Installation, Balanced Scorecard, Customer Perspective, Learning and Growth Perspective.ABSTRAKPengukuran kinerja menggunakan Balanced Scorecard dengan perspektif pelanggan dan perspektif pembelajaran dan pertumbuhan menawarkan solusi menyeluruh untuk mengetahui bagaimana pelanggan menilai produk atau jasa serta cara perusahaan meningkatkan kualitas sumber daya manusia untuk menjadi pekerja yang kompeten dan mampu menghasilkan kinerja yang prima bagi organisasi. Penelitian ini bertujuan untuk mengetahui kinerja Instalasi Farmasi Rumah Sakit Advent Manado berdasarkan perspektif pelanggan dan perspektif pertumbuhan dan pembelajaran. Penelitian ini merupakan jenis penelitian non eksperimental dengan rancangan deskriptif evaluatif. Data diperoleh secara prospektif dan retrospektif. Kriteria data berupa data kualitatif dan data kuantitatif. Data kualitatif berupa data observasi dan wawancara langsung. Data kuantitatif berupa kuesioner.  Hasil penelitian yang diperoleh yaitu kinerja perspektif pelanggan yaitu 83,45 % pasien menyatakan puas terhadap kinerja Instalasi Farmasi Rumah Sakit Advent Manado. Perspektif pembelajaran dan pertumbuhan memperoleh hasil karyawan memiliki semangat kerja dan kepuasan kerja yang tinggi yaitu 3,05 dan 3,06. Pelatihan karyawan Instalasi Rumah Sakit Advent Manado belum pernah dilakukan. Kesimpulan yang diperoleh yaitu kinerja yang baik pada kepuasan pasien, semangat kerja dan kepuasan kerja karyawan. Kinerja kurang baik yang harus diperbaiki yaitu pelatihan karyawan.Kata kunci : Kinerja, Instalasi Farmasi, Balanced Scorecard, Perspektif Pelanggan, Perspektif Pertumbuhan dan Pembelajaran
PENGUKURAN KINERJA INSTALASI FARMASI RSUD DATOE BINANGKANG KABUPATEN BOLAANG MONGONDOW DENGAN METODE BALANCED SCORECARD Laleno, Ellysa N.; Citraningtyas, Gayatri; Rumondor, Erladys M.
PHARMACON Vol 9, No 4 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.31369

Abstract

ABSTRACTPerformance measurement used the Balanced Scorecard method needs to be done at Datoe Binangkang Hospital General Pharmacy Installation to measure the performance achievements that have been carried out by Datoe Binangkang Hospital General Pharmacy Installation and as a basis for further performance improvement. This research aims to determine the performance of IFRS Datoe Binangkang with the Balanced Scorecard method in terms of the financial perspective and the perspective of internal business processes. This research is descriptive used a retrospective approach to financial perspective and prospective for internal business processes. Primary data were obtained from direct observation and secondary data were obtained from IFRS financial administration reports and Datoe Binangkang District Hospital. The results showed that in the financial perspective of 2019: the contribution of IFRS to RSUD 73.01%, ITOR 3.65 times and the average age of inventor 100 days. Internal business perspective: The level of availability of drugs is 95%, the average dispensing time for non-concoction prescriptions is 22.17 minutes and prescription concoctions at IFRS that are usually given to children, replaced with drugs that are already available according to the patient's illness, the component of drug information given to patients still does not meet the standards set by the Indonesian Minister of Health  No. 73 of 2016. The conclusion is the performance of Datoe Binangkang Hospital Pharmacy Installation is quite good, but needs to be improved in terms of drug inventory control, dispensing time and drug information services. Key words: Performance, Pharmacy Installation Datoe Binangkang District Hospital, Balanced ScorecardABSTRAK Pengukuran kinerja dengan metode Balanced Scorecard perlu dilakukan di Instalasi Farmasi RSUD Datoe Binangkang untuk mengukur pencapaian kinerja yang telah dilakukan Instalasi Farmasi RSUD Datoe Binangkang serta sebagai dasar untuk perbaikan kinerja selanjutnya. Penelitian ini bertujuan untuk mengetahui kinerja IFRS Datoe Binangkang dengan metode Balanced Scorecard ditinjau dari perspektif keuangan dan perspektif proses bisnis internal. Penelitian ini bersifat deskriptif dengan menggunakan pendekatan retrospektif untuk perspektif keuangan dan prospektif untuk proses bisnis internal. Data primer diperoleh dari observasi langsung, wawancara dan data sekunder diperoleh dari laporan administrasi keuangan IFRS dan RSUD Datoe Binangkang. Hasil penelitian menunjukan bahwa pada perspektif keuangan tahun 2019: kontribusi IFRS ke RSUD 73,01%, ITOR 3,65 kali dan average age of inventory 100 hari. Perspektif bisnis internal: Tingkat ketersediaan obat 95%, average dispensing time untuk resep non-racikan 22,17 menit dan resep racikan di IFRS yang biasanya diberikan pada anak, diganti dengan obat-obatan yang sudah tersedia sesuai dengan penyakit yang diderita pasien, komponen informasi obat yang diberikan kepada pasien masih belum memenuhi standar yang telah ditetapkan oleh Permenkes RI No. 73 Tahun 2016. Kesimpulannya yaitu kinerja Instalasi Farmasi RSUD Datoe Binangkang sudah cukup baik, akan tetapi perlu dilakukan perbaikan dalam hal pengendalian persediaan obat, dispensing time dan pelayanan informasi obat. Kata kunci : Kinerja, Instalasi Farmasi RSUD Datoe Binangkang, Balanced  Scorecard
UJI EFEKTIVITAS FORMULASI SEDIAAN KRIM EKSTRAK KULIT BUAH PISANG GOROHO (Musa acuminafe L.) TERHADAP BAKTERI Staphylococcus aureus Pangemanan, Stephany P.; Edy, Hosea J.; Rumondor, Erladys M.
PHARMACON Vol 9, No 3 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.30030

Abstract

ABSTRACT Goroho Banana Skin (Musa acuminafe L.) is a plant that contains flavonoid compounds, saponins and tannins that can inhibit bacterial growth. This study aims to test the antibacterial effectiveness of ethanol extract cream of goroho banana peel and evaluate the preparations using parameters of physical properties and physical stability. This research uses laboratory experimental methods. Cream formula is made with a variety of ethanol extract concentrations of Goroho Banana peel 2.5%, 5%, 7.5%, 10%, 12.5%. Goroho Banana peel extract was obtained by maceration using 96% ethanol solvent. The study of antibacterial test of ethanol extract of Goroho Banana peel using wells method on Staphylococcus aureus bacteria resulted in inhibition of 7.03 ± 3.29 mm at a concentration of 12.5%. All tests are carried out before and during the cycling test. The results obtained before and during the cycling testshowed that the cream preparations met organoleptic requirements, homogeneity, cream pH 6.807 (4.5-6.5), cream adhesion 9.63 seconds (<4 seconds), cream spread 4, 53 cm (5-7 cm). It can be concluded that the ethanol extract of Goroho Banana peel cream meets stable physical test parameters and has moderate antibacterial activity. Keywords: Goroho Banana Peel (Musa acuminafe L.), Antibacterial, Cream. ABSTRAK Kulit Buah Pisang Goroho (Musa acuminafe L.) merupakan tanaman yang mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat pertumbuhan bakteri. Penelitian ini bertujuan untuk menguji efektivitas antibakteri sediaan krim ekstrak etanol kulit buah pisang goroho dan mengevaluasi sediaan dengan menggunakan parameter uji sifat fisik dan stabilitas fisik. Penelitian ini menggunakan metode eksperimental laboratorium, Formula sediaan krim dibuat dengan variasi konsentrasi ekstrak etanol kulit buah Pisang Goroho 2,5%, 5%, 7,5%, 10%, 12,5%. Ekstrak kulit buah Pisang Goroho diperoleh dengan cara maserasi menggunakan pelarut etanol 96%. Penelitian uji antibakteri sediaan krim esktrak etanol kulit buah Pisang Goroho menggunakan metode sumuran pada bakteri Staphylococcus aureus menghasilkan daya hambat 7,03±3,29 mm pada konsentrasi 12,5%. Semua pengujian dilakukan sebelum dan selama cycling test. Hasil penelitian yang didapat sebelum dan selama cycling test menunjukkan bahwa sediaan krim memenuhi persyaratan organoleptis, homogenitas, pH krim 6,807 (4,5-6,5), daya lekat krim 9,63 detik (<4 detik), daya sebar krim 4,53 cm (5-7 cm). Dapat disimpulkan bahwa sediaan krim ekstrak etanol kulit buah Pisang Goroho memenuhi parameter uji fisik stabil dan memiliki aktivitas  antibakteri yang sedang. Kata kunci : Kulit Buah Pisang Goroho (Musa acuminafe L.), Antibakteri, Krim.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAN FRAKSI SPONS Mycale Vansoesti DARI PERAIRAN PULAU MANTEHAGE MINAHASA UTARA TERHADAP PERTUMBUHAN BAKTERI Escherichia coli DAN Staphylococcus aureus Luntungan, Brigita Michelle; Wewengkang, Defny S.; Rumondor, Erladys
PHARMACON Vol 10, No 2 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.34040

Abstract

ABSTRACTSponges are multi-cell marine biota whose tissue and organ functions are very simple. In the development of medicine, sponges have been shown to contain active compounds as guiding compounds in the synthesis of the latest drugs. The purpose of this study was to determine the antibacterial activity of the extracts and fractions of the sponge Mycale vansoesti collected from the waters of Mantehage Island against Escherichia coli and Staphylococcus aureus bacteria. The sponge samples were extracted using the maceration method with 95% ethanol. The antibacterial activity test used the disc diffusion agar method of Kirby and Bauer. The results showed that Mycale vansoesti sponge produced antibacterial activity in all extracts and fractions used namely ethanol extract, chloroform fraction, n-hexane fraction, and methanol fraction against Escherichia coli and Staphylococcus aureus bacteria with a value of about 6.63-8.82 mm and included in the moderate category of inhibition, this is proven by the formation of a clear zone around the disc. Keywords: Mycale vansoesti, Antibacterial, Staphylococcus aureus, Escherichia coli ABSTRAKSpons merupakan biota laut multi sel yang fungsi jaringan dan organnya sangat sederhana. Dalam perkembangan pengobatan, spons terbukti mengandung senyawa aktif sebagai senyawa pemandu dalam sintesis obat-obatan terbaru. Tujuan dari penelitian ini untuk mengetahui adanya aktivitas antibakteri dari ekstrak dan fraksi spons Mycale vansoesti yang diperoleh dari perairan Pulau Mantehage terhadap bakteri Escherichia coli dan Staphylococcus aureus. Metode ekstraksi yang digunakan adalah maserasi dengan pelarut etanol 95%. Pengujian Aktivitas Antibakteri menggunakan metode difusi agar Kirby and Bauer. Hasil penelitian menunjukkan bahwa spons Mycale vansoesti menghasilkan aktivitas antibakteri pada semua ekstrak dan fraksi yang digunakan yaitu ekstrak etanol, fraksi kloroform, fraksi n-heksan, dan fraksi metanol terhadap bakteri Escherichia coli dan Staphylococcus aureus dengan nilai sekitar 6,63-8,82 mm dan termasuk dalam daya hambat kategori sedang. Hal ini dibuktikan dengan terbentuknya zona bening disekitar cakram. Kata Kunci : Mycale vansoesti, Antibakteri, Staphylococcus aureus, Escherichia coli
Co-Authors Adithya Yudistira Agow, Mikhael C. Alfiani Idie Barliana, Melisa I. Berlian Tasya Tumundo Billy Arthur Porajow Brian G. A. Adilan Bryan Andrew Tikonuwu Bunet, Greey C.E. Christo Togelang Datu, Olvie S. Datu, Olvie Syenni Defny Silvia Wewengkang Edi, Hosea Jaya Elly Suoth Fatimawali . Gayatri Citraningtyas Grafland Langkay Henki Rotinsulu, Henki Hermelina Yosephina Burdam Herni I. E. Simbala Herny E.I. Simbala Hosea J. Edy, Hosea J. Idie, Alfiani Ira Handayani Puspita Prins Jabes Wolter Kanter Julianri Sari Lebang, Julianri Sari Karlah L. R. Mansauda Kevin R. Mengko Kinanti, Agata Mega Kindangen, Eunike Elizabeth Kiwol, Hilda Komang Ayu May Widyani Laleno, Ellysa N. Lampongajo, Stela Mahdalena Lontaan, Gloria J. Lumbu, Alisa W. R. Lumentut, Natalia Luntungan, Brigita Michelle Luy Parala Marampung, Wahyuni Melisa I. Barliana Melisa Oktafiani Makalunsenge Miracle Cristia Meyfi Bambulu Moelyono Moektiwardoyo Moelyono Moektiwardoyo, Moelyono Mohtar, Khumairah Nadine Natari Pangemanan, Stephany P. Rolos, Tesalonika N. Rondonuwu, Greifen Triky Sambou, Christel N. SELLYANA MAHARANI BAWEKES Shalomyta Monangin Tawalujan, Wulan P. Trina E. Tallei, Trina E. Tumundo, Berlian Tasya Viocindy Riska Nusaly Viska Fadila Tompunu Widya Astuty Lolo, Widya Astuty Wiranatika Jhonatan Sangkoy Yulien C. Sambode