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All Journal ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Pengabdian kepada Masyarakat
Andri Anugrah Pratama
UIN Alauddin Makassar
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EDUKASI PEMANFAATAN OBAT TRADISIONAL SEBAGAI ASI BOOSTER Andi Ulfah Magefirah Rasyid; Sri Widyastuti; Fityatun Usman; Zulkifli Zulkifli; Syafruddin Syafruddin; Muhammad Taufiq Duppa; Muhammad Guntur; Nurfadilah Nurfadilah; Rahmadani Rahmadani; Sulaiman Sulaiman; Anshari Masri; Ainun Jariah; Andri Anugrah Pratama; Haryanto Haryanto
J-ABDI: Jurnal Pengabdian kepada Masyarakat Vol. 2 No. 7: Desember 2022
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53625/jabdi.v2i7.3956

Abstract

Various types of plants in the surrounding environment that have medicinal properties are many that can be obtained and utilized, and can even be planted themselves, which are known as family medicinal plants. This medicinal plant has begun to be widely studied, especially Indonesian Native Medicinal Plants, because it has relatively small side effects when compared to modern medical drugs. Communities in Pattallassang District generally have various types of medicinal plants that are planted in their yards and are often used as alternative treatments for certain types of diseases or as supplements, one example being breastfeeding boosters, which are very much needed by mothers in carrying out their activities. exclusive breastfeeding program. To support the exclusive breastfeeding program, various efforts must be made, one of which is the use of breastfeeding boosters, which is expected to help increase the production of breast milk. The purpose of the community service activity is to increase understanding of the importance of exclusive breastfeeding and to provide education about the use of several plants that have the potential as breastfeeding boosters in terms of processing techniques and more rational ways of using them. This service is carried out at Merpati Posyandu, Pattallassang Village, Pattallassang District, Takalar Regency. The method of providing community service activities is by providing counseling and demonstrations on how to process and manufacture good traditional medicines. The results of the activity assessment showed that participants gained knowledge about the types of traditional medicines, especially breastfeeding boosters, along with good processing and manufacturing methods of traditional medicines.
Antioxidant Activity Study of Zingiber Zerumbet Rhizome Extract and Fraction Haeria Doloking; Mukhriani; Rima Amalia; Andri Anugrah Pratama
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.37351

Abstract

Zingiber zerumbet is a member of the Zingiberaceae family with known pharmacological potentials. This study aims to characterize the phytochemical elements and evaluate the antioxidant potential of the methanol extract, soluble ethyl acetate, and n-hexane-soluble fractions of Zingiber zerumbet rhizome. Identify secondary metabolites for the alkaloids, saponins, flavonoids, polyphenols, tannins, and steroids/triterpenoids using the chemical reaction method in test tubes. Antioxidant activity was determined based on DPPH absorbance measurements using UV-Vis Spectrophotometry. The methanolic extract contained alkaloids, flavonoids, polyphenols/tannins, steroids, and triterpenoids. The ethyl acetate soluble fraction contained flavonoids and polyphenols/tannins, and the n-hexane soluble fraction contained alkaloids and flavonoids. The free radical scavenging activities of ascorbic acid, methanol extract, ethyl acetate, and the n-hexane soluble fraction were 7.79; 100,956; 69,476, and 77,780 ppm, respectively. The findings indicated that the methanolic extract, ethyl acetate, and n-hexane soluble fraction were suitable sources of natural antioxidants.
English English Fitril Imani; Yusnita Rifai; Herlina Rante; Ansari Masri; Andri Anugrah Pratama; Musabbiha
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.37548

Abstract

This study aims to predict the compounds from Ocimum basillicum that have potential as glioma inhibitors by inhibiting the enzyme isocitrate dehydrogenase (IDH). Forty-two compounds from Ocimum basillicum were carried out by molecular docking to the IDH receptor using the AutodockTools 1.5.7 program and continued prediction of pharmacokinetic profile and toxicity using ADMETab 2.0 and Toxtree. The validation of the molecular docking method showed an RMSD value of 1.8509 A. As a result of the research, we discovered several compounds had the best interactions in our investigation. Those compounds were Apigenin, Catechin, Chloronergic Acid, Ellagic Acid, Quercetin, Rutin, Eriodictyol, and Chicoric Acid, with binding affinity values of -7.1, -6.7, -7.1, -7.1, -7.1, -8.5, -7.2, and -6.5, respectively. Several compounds are predicted to have the potential to be developed as glioma inhibitors. Furthermore, the ADMET's predictions show that these potential compounds still require improvement in pharmacokinetics and toxicity. However, further laboratory investigations like in vitro and in vivo assays need to be conducted.
Co-Authors Ainun Jariah Andi Ulfah Magefirah Rasyid Ansari Masri Anshari Masri Fitril Imani Fityatun Usman Haeria Doloking Haryanto Haryanto Herlina Rante Muhammad Guntur Muhammad Taufiq Duppa Mukhriani, Mukhriani Musabbiha Nurfadilah Rahmadani Rahmadani Rima Amalia Sri Widyastuti Sulaiman Sulaiman Syafruddin Syafruddin Yusnita Rifai Zulkifli Halid