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All Journal Jurnal Ilmiah Farmasi Jurnal Mandala Pharmacon Indonesia ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal farmasi UIN Alauddin Makassar Eureka Herba Indonesia Molekul: Jurnal Ilmiah Kimia
Doloking, Haeria
Universitas Islam Negeri Alauddin Makassar
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Studi potensi ubi kelapa (Dioscorea alata. L) sebagai bahan penghancur tablet Haeria Doloking; Nur Syamsi Dhuha; Pratiwi Ningsi
Jurnal Ilmiah Farmasi Vol. 15 No. 1 (2019): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol15.iss1.art1

Abstract

IntisariLatar Belakang: Salah satu upaya untuk mewujudkan kemandirian produksi bahan baku farmasi Indonesia adalah dengan memanfaatkan pabrik sebagai sumber. Dioscorea alata L sebagai salah satu sumber pati perlu dipelajari untuk pengembangan potensial sebagai tablet disintegran.Tujuan: Tujuan penelitian ini adalah untuk mengetahui karakteristik pati Dioscorea alata L. dan mengetahui potensi sebagai bahan disintegran tablet.Metode: Analisis karakteristik meliputi proksimat, kandungan amilosa, morfologi granular, kristalinitas, kekuatan pengembangan, dan pengikatan kapasitas air. Studi potensial sebagai disintegran dilakukan dengan merumuskan tablet piroksikam menggunakan pati Dioscorea alata dibandingkan dengan pati jagung. Evaluasi sifat-sifat disintegran dilakukan dengan uji disintegrasi, uji kerapuhan, uji kekerasan, dan uji disolusi tablet.Hasil: Berdasarkan studi karakteristik pati Dioscorea alata L., kadar air, abu, protein, dan lemak masing-masing adalah 13,08%, 0,23%, 1,43%, dan 0,81%. Kemudian, Amilosa adalah 18,08%. Daya bengkak dan pengikatan kapasitas air menunjukkan 1,21 dan 3,31. Analisis morfologi granular menunjukkan bentuk ellipsoid dan bola. Kristal pati menunjukkan bentuk semikristal dengan pola kristal ortorombik. Uji disintegrasi tablet menunjukkan bahwa formula I dan II, memiliki waktu hancur 3,50 dan 4,25. Uji kelayakan formula I dan formula II adalah 0,011% dan 0,008%. Uji kekerasan Formula I dan Formula II menunjukkan 5kg dan 6kg. Uji disolusi Formula I dan Formula II menunjukkan 88,85% dan 85,58%.Kesimpulan: Dari hasil tersebut, pati Dioscorea alata L. berpotensi sebagai bahan penghancur tabletKata kunci: Dioscorea alata L., tablet, disintegrant, pati, bahan baku Potential Study of Ubi Kelapa (Dioscorea Alata. L) Starch as Tablet Desintegrant MaterialAbstract Background: One of the efforts to realize the sovereignty of Indonesia's pharmaceutical raw material production is to utilize the plant as a source. Dioscorea alata L as one of the starch sources needs to be studied for potential development as a tablet disintegrant.Objective: The aims of the research are to determine  the characteristic of Dioscorea alata L. starch and to find out the potential as tablet disintegrant material.Method: Characteristic analysis include are proximate, amylose content, granular morphology, crystallinity, swelling power, and water capacity binding. The potential study as disintegrant  was performed by formulating a piroxicam tablet using  Dioscorea alata starch compared to corn starch. Evaluation of the disintegrant properties was performed by disintegration test, friability test, hardness test, and dissolution test of the tablets.Results: Based on the characteristic study of Dioscorea alata L. starch, water, ash, protein, and fat contents are 13.08%, 0.23%, 1.43%, and 0.81%, respectively. Then, Amylose is 18.08%. Swelling power and water capacity binding  shows 1.21 and 3.31. Glanular morphology analysis shows ellipsoid and spherical form. The crystallinity of the starch shows as semicrystal form with orthorhombic crystal pattern. Tablet disintegration test shows that formula I and II, has disintegration time 3.50 and 4.25. Friability test of formula I and formula II is 0.011% and 0.008%. Hardness test of Formula I and Formula II shows 5kg and 6kg.  Dissolution test of Formula I and formula II shows 88.85% and 85.58%.Conclusion: Over the results, the Dioscorea alata L. starch has the potential as the tablet disintegrant materialKeywords: Dioscorea alata L., tablet, disintegrant, starch, raw material
Acute Toxicity Ethanol Extract of Bidara Leaves (Ziziphus spina-christi L.) Against Liver and Kidney Function of White Rats Nur Syamsi Dhuha; Haeria; Hardyanti Eka Putri
Eureka Herba Indonesia Vol. 1 No. 1 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i1.3

Abstract

Bidara plants have the efficacy as antioxidants, anti-inflammatory, antimicrobial, anti- fungal and prevents tumours. Bidara is efficacious to protect human DNA cells caused by damage from actinic radiation. This study aims to explore the acute toxicity test of the ethanol extract of Bidara leaves using white mice as experimental animals. A total of 30 white rats (Rattus norvegicus) Wistar strain obtained from the Eureka Research Laboratory (Palembang, Indonesia) weighing between 200 - 250 grams. After one week of adaptation, the mice were randomly divided into the following six groups, each containing five animals: Normal control group and Bidara extract group (50mg/kg BW; 150 mg/kg BW; 450 mg/kg BW; 1350 mg/kg BW; and 4050 mg/kg BW). This study shows that the extract of Bidara leaves has a relatively high toxic dose, namely at a dose of 4050 mg/kg BW. Bidara leaf extract at doses below 1500 mg/kg BW, shows no toxic effect on the liver. In conclusion, bidara leaf extract has a toxic dose above 4000 mg/kg BW in Wistar white rats.
Physicochemical Properties of Palm Oil Fraction (Elaeis guineensis Jacq) Haeria Doloking; Mukhriani Mukhriani; Muh Rusdi; Silmi Rafi’ah; Fadhilah Fitriana
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.14036

Abstract

Study about physicochemical properties of olein and stearin fraction of palm oil has been conducted. Research aim was to determine the chemical physical properties of the olein and stearin fractions of palm oil (Elaeis guineensi Jacq) that was originated from North Mamuju, West Sulawesi. Palm oil was fractionated by dry fractionation method to collect the olein and stearin fractions. The physical chemical characteristics of fractions were determined by acid value, saponification value, peroxide value, and iodine value parameters that measured by titrimetry method. The result of analysis showed that the acid values for the olein and stearin fractions acid were 7.04 and 5.83 mg NaOH/g, saponification values were 198.53 and 194.71 mg KOH/g, peroxide values were 0.77 mek O2/kg and 0.79 mek O2/kg, and iodine values were 34.12 and 32.87 g iod/100 g.
Formation of Hydrochlorothiazide – Para-aminobenzoic Acid Cocrystals by Solvent Evaporation Method Haeria Doloking; Ayu Tri Sartika; Nurshalati Tahar
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 1 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v4i1.21301

Abstract

Hydrochlorothiazide is a diuretic drug used for mild to moderate hypertension were classified in Class II BSC. The purpose of this study was to explore the formation of hydrochlorothiazide-para-aminobenzoic acid cocrystal by solvent evaporation method. Cocrystals are prepared with a molar ratio of 1:0; 1:1; 1:2; and 2:1 between hydrochlorothiazide and para-aminobenzoic acid. The cocrystals were characterized by Scanning Electron Microscopy (SEM), X-ray Diffractometry (XRD), Differential Scanning Calorimetry (DSC), and Fourier Transform Infrared (FT-IR) spectrophotometer. The hydrochlorothiazide-para-aminobenzoic acid cocrystal has new crystalline peaks at 2θ of 14.904o; 15.41o; 25.553o; 26.5o; 29.844o; 31.083o indicating the formation of a new crystalline phase. The cocrystal showed the melting point at 188.57oC which is different from the initial components. The FTIR spectra of cocrystal showed the shifting of absorption peaks of groups of initial components indicating of formation of hydrochlorothiazide-para-aminobenzoic acid cocrystal through intermolecular hydrogen bond interactions between amine/sulfonamide group and carboxyl group.
Antioxidant Activity Study of Zingiber Zerumbet Rhizome Extract and Fraction Haeria Doloking; Mukhriani; Rima Amalia; Andri Anugrah Pratama
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.37351

Abstract

Zingiber zerumbet is a member of the Zingiberaceae family with known pharmacological potentials. This study aims to characterize the phytochemical elements and evaluate the antioxidant potential of the methanol extract, soluble ethyl acetate, and n-hexane-soluble fractions of Zingiber zerumbet rhizome. Identify secondary metabolites for the alkaloids, saponins, flavonoids, polyphenols, tannins, and steroids/triterpenoids using the chemical reaction method in test tubes. Antioxidant activity was determined based on DPPH absorbance measurements using UV-Vis Spectrophotometry. The methanolic extract contained alkaloids, flavonoids, polyphenols/tannins, steroids, and triterpenoids. The ethyl acetate soluble fraction contained flavonoids and polyphenols/tannins, and the n-hexane soluble fraction contained alkaloids and flavonoids. The free radical scavenging activities of ascorbic acid, methanol extract, ethyl acetate, and the n-hexane soluble fraction were 7.79; 100,956; 69,476, and 77,780 ppm, respectively. The findings indicated that the methanolic extract, ethyl acetate, and n-hexane soluble fraction were suitable sources of natural antioxidants.
Flavonoids: A Review On Extraction, Identification, Quantification, and Antioxidant Activity Doloking, Haeria; Tahar, Nurshalati; Mukhriani; Surya Ningsi
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 1 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i1.29329

Abstract

Flavonoids are polyphenolic compounds with a fifteen carbon basic skeleton (C6-C3-C6) composed of two benzene rings, A and B, connected by a pyran-C heterocyclic ring. The high interest in flavonoid research appears due to the numerous benefits of this compound based on its antioxidant activity. Various authors reported multiple studies in this regard. The research on methods of extraction, identification, quantification, and testing of antioxidant activity is compiled in this review. The most important part of this study is a review of the antioxidant activity assay method, which is equipped with the reaction mechanism.
Antioxidant Activity of Zerumbone and Its Pharmacological Prospects in Oxidative Stress Conditions: A Narrative Review Doloking, Haeria; Lallo, Subehan; Manggau, Marianti A; Rifai, Yusnita
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.39968

Abstract

Introdiction: Oxidative stress is a condition caused by an imbalance between the level of oxidants in cells and tissues and the ability of the biological system to detoxify these reactive products. To compensate for the excess oxidant molecules, the human body requires the intake of antioxidant compounds through diet or medicinal plants to overcome the deficiency of these endogenous antioxidants. Zerumbone is the main bioactive compound of the Zingiber zerumbet L. Smith rhizome that was reported to have antioxidant activity and different pharmacological effects, like anti-inflammatory, anti-cancer, antidiabetic, immunomodulatory, anti-neurodegenerative disease, hepatoprotective, and gastroprotective. Aims: This review aims to gather available scientific research data regarding the antioxidant activity of zerumbone and its pharmacological prospects under conditions of oxidative stress. This paper is an overview of previous research on the various pharmacological activities of zerumbone and studies of its mechanism of action related to oxidative stress at the molecular level. The selected articles are related research reports for the 2010–2022 period, which can be accessed online through NCBI, Science Direct, MDPI, and Google Scholar. Result: The research results mentioned in this review paper can summarize knowledge to explain the pharmacological potential of zerumbone so that it can be used as a starting point or comparison in designing further research. Conclusion: The results of the reviews show that the various pharmacological prospects of zerumbone are related to oxidative stress conditions through various modes of action.
Integrating The Network Pharmacology and Molecular Docking to Uncover The Potential Mechanism Of Rutin In Fighting Diabetes Mellitus Putri, Stella Anatasya Putri; Maharani, Andi Rani Gustia; Luthfiana, Dewi; Nweze, Leonard Chinecherem; Setiawansyah, Arif; Susanti, Gita; Doloking, Haeria
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 7 No. 1 (2024)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i1.49701

Abstract

Introduction: Rutin is a flavonol glycoside that is known to have blood sugar reducing activity. However, its molecular mechanism in reducing blood sugar level remains unclear. This study was employed to elucidate the pharmacological mechanism of rutin as antidiabetic agent. Methods: Potential target of rutin was screened in relevant databases to construct a compound-target network. Network pharmacology was utilized to identify targets associated with disease, gene ontology and KEGG pathways and confirmed its potential binding affinity using Autodock 4.2 assisted by ADT interface. Result: The result highlighted mTor, PIK3R1, and NFKB1R as a potential target of Rutin through network pharmacology. This target involved in the insulin signaling pathways, insulin resistance, type 2 diabetes mellitus, B receptor signaling pathways, AGE-RAGE signaling pathway in diabetic complications and pancreatic cancer. All docking protocols were valid with RMSD value for TNF-a, NF-KB, PI3K were 0.72 Å, 0.67 Å, ​​and 0.54 Å, respectively. The molecular docking has confirmed the potential mechanism of rutin as antidiabetic agent by stably bound with these proteins with estimated free binding energy values of -8.54 kcal/mol (NF-KB), -8.01 kcal/mol (PI3K), and -6.22 kcal/mol (TNF-a). Conclusion: The study has given insight into the molecular mechanism of rutin in the management of DM by stably bound with NF-KB, TNF-a, and PI3K. However, further laboratory experimental research is needed, particularly in vitro and in vivo assay
Metode dan Jenis Pelarut untuk Ekstraksi Zerumbone dari Rimpang Zingiber zerumbet L. Smith: Kajian Pustaka: bahasa indonesia Doloking, Haeria
Jurnal Farmasi UIN Alauddin Makassar Vol 11 No 1 (2023): Jurnal Farmasi Edisi Juni
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jfuinam.v11i1.37390

Abstract

The choice of extraction method and the solvent is a determining factor in the efficiency of extracting phytochemicals with unique and diverse physicochemical characteristics. This literature review aims to collect and examine information regarding the methods and solvents for extracting the zerumbone compound from the rhizome of Zingiber zerumbet (L) Smith. used and has been reported by various researchers. Data and information were collected using databases such as MDPI and Google Scholar. This study found various zerumbone extraction techniques, namely Microwave-Assisted Extraction, Supercritical-CO2, Subcritical Water Extraction, hydro distillation, soxhletation, reflux, and maceration. The solvents used were ethanol, methanol, ethyl acetate, n-hexane, chloroform, and water. The literature review shows that extraction efficiency with certain techniques depends on selecting the right solvent. Keywords: Microwave-Assisted Extraction, Supercritical-CO2, Subcritical Water Extraction, hydro distillation, Reflux
Aktivitas Antimitosis dan Identifikasi Golongan Senyawa Aktif Ekstrak Daun Katuk (Sauropus androgynus L. Merr) terhadap Sel Telur Bulu Babi (Tripneustes gratilla Linn.) Doloking, Haeria; Ningsi, Surya; Nasrawati Basir
Jurnal Farmasi UIN Alauddin Makassar Vol 11 No 2 (2023): Jurnal Farmasi Edisi November
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jfuinam.v11i2.45721

Abstract

Abstract Introduction: Katuk leaves (Sauropus androgynus L.Merr) are a plant that contains a variety of phytochemicals that have the potential to be developed as cancer drugs derived from natural ingredients. Objective: to determine the antimitotic activity of soluble and insoluble ethanol extracts of n-hexane of katuk leaves towards inhibiting cell division. sea urchin (Tripneustus gratilla Linn) eggs and determined the IC50 value of the n-hexane soluble and insoluble fractions, as well as identifying bioactive compounds in the most active Sauropus androgynus fraction. Methods: extraction using 96% ethanol solvent then partitioning using n-hexane solvent using liquid-solid technique. The extract obtained was then tested for its antimitotic effect using sea urchin egg cells. Results: The hexane insoluble extract had antimitotic activity with an IC50 of 0.79 μg/ml and the n-hexane soluble ethanol extract 16.46 μg/ml. Fractionation of the n-hexane insoluble ethanol extract using vacuum liquid chromatography produced 15 fractions which were further divided into subfractions A, B and C. Each subfraction had an IC50 of 2.63 μg/ml, 0.06 μg/ml and 3.98 μg/ml respectively. Conclusion: Fraction B showed the best activity with an inhibition value of 0.06 μg/ml. The results of the identification of bioactive compounds in fraction B showed the presence of phenol, flavonoid, triterpenoid, and steroid compounds. Keywords: cytotoxic, flavonoids, terpenoids, anti-cancer, subfraction
Co-Authors Andri Anugrah Pratama Arif Setiawansyah Ayu Tri Sartika Dhuha, Nur Syamsi Dwi Wahyuni Leboe Fadhilah Fitriana Gita Susanti, Gita Hardyanti Eka Putri Hariratul Jannah Isriany Ismail Kairani, Utari Estina Khaerani Lallo, Subehan Lalo, Ahmad Leboe, Dwi Wayuni Ludgensia Indradewi Kurniati Luthfiana, Dewi M. Rusdi Maddeppungeng, Nurul Muhlisah Maharani, Andi Rani Gustia Mantur Yudokus Marianti A Manggau Muhlisuddin, Muhlisuddin Mukhriani Mukhriani, Mukhriani Nasrawati Basir Ningsi, Surya Nur Aeti Nur Syamsi Dhuha Nur Syamsi Dhuha Nurshalati Tahar Nurwana Nweze, Leonard Chinecherem Pratiwi Ningsi Putri, Stella Anatasya Putri Rima Amalia Silmi Rafi’ah Suprapto Prayitno Surya Ningsi Tahar, Nurshalati Tahir, Karlina Amir Wahyuddin, Munifah Yusnita Rifai, Yusnita