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All Journal Universa Medicina Jurnal Biomedika dan Kesehatan AMMA : Jurnal Pengabdian Masyarakat
Atut Cicih Mayasari
Universitas Trisakti
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Hubungan antara ekspresi vascular endothelial growth factor (VEGF) jaringan dengan respon kemoradiasi pada pasien kanker serviks Mayasari, Atut Cicih; Wratsangka, Raditya
Jurnal Biomedika dan Kesehatan Vol 3 No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

LATAR BELAKANGKanker serviks masih merupakan masalah keganasan utama yang dihadapi wanita seluruh dunia. Tidak adanya gejala pada penderita kanker serviks stadium awal, sering menyebabkan keterlambatan dalam diagnosis. Vascular endothelial growth factor (VEGF) merupakan salah satu faktor yang berperan penting dalam proses angiogenesis dan merupakan sinyal yang digunakan oleh sel kekurangan oksigen untuk memicu pertumbuhan pembuluh darah. Penelitian ini bertujuan membandingkan respon klinik kemoradiasi pada pasien kanker serviks yang mempunyai ekspresi VEGF tinggi, sedang dan rendah. METODEPenelitian ini menggunakan rancangan studi kasus kontrol untuk mencari hubungan antara ekspresi VEGF dengan respon kemoradiasi pada penderita kanker serviks. Sebagai kelompok kasus adalah pasien dengan respon terapi parsial dan kelompok kontrol adalah pasien dengan respon terapi komplit. Empat puluh lima pasien, masing-masing terdiri dari 15 pasien kelompok kasus dan 30 pasien kelompok kontrol. Data sekunder diambil dari rekam medis RS Cipto Mangunkusumo Jakarta. Dilakukan penelusuran blok parafin ke bagian Patologi Anatomi RS Cipto Mangunkusumo Jakarta. Pemeriksaan ekspresi VEGF dilakukan terhadap jaringan biopsi kanker serviks sebelum kemoterapi. HASILPada faktor risiko umur, didapatkan nilai p=0.18 dan OR 0.37. Maka tidak ada hubungan yang bermakna secara statistik, namun secara klinik mempunyai nilai protektif lemah. Pada analisa lebih lanjut hanya didapatkan 2 pasien usia ≥ 50 tahun yang mempunyai ekspresi VEGF kuat. Pada faktor risiko stadium, diferensiasi sel, dan body mass index (BMI) berturut-turut mempunyai nilai p 1; 0.46 dan 1, sedangkan nilai OR 1; 2 dan 1, maka tidak bermakana secara statistik dan klinik. Jenis histologi nilai p 0.19 dan OR 3.27 secara statistik tidak bermakna namun secara klinik bermakna. Ekspresi VEGF mempunyai nilai p 0.03 dan OR 0.45 jadi secara statistik dan klinik bermakna. Setelah dilakukan analisis multi variat maka yang mempunyai hubungan paling bermakna secara statistik dan klinik dengan respon terapi adalah ekspresi VEGF. KESIMPULANEkspresi VEGF yang kuat akan memberikan respon terapi/outcome yang buruk.
Soy-isoflavone supplementation tends to reduce menopausal symptoms in postmenopausal women Raditya Wratsangka; Atut Cicih Mayasari
Universa Medicina Vol. 32 No. 2 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.118-127

Abstract

BACKGROUNDMenopausal symptoms in postmenopausal women tend to decrease healthrelated quality of life (HRQoL). The present study’s objective was to determine the effect of daily supplementation of 100 mg soy isoflavones on menopausalsymptoms of healthy postmenopausal women. Isoflavones are phytoestrogens abundantly found in soy beans, and several studies have demonstrated that isoflavones are the best among the phytoestrogens.METHODSThe study was a community-based double blind randomized controlled trial involving 60 healthy postmenopausal women, aged between 48–60 years, in the Mampang Prapatan District, South Jakarta. Participants were block-randomized to receive either 100 mg soy-isoflavone + 500 mg calcium carbonate (intervention group) or 500 mg calcium carbonate only (control group). Both supplements were taken daily for 12 weeks, from January to April 2010. Menopausal symptoms(measured by Menopause Rating Scale questionnaire) were assessed at baseline and after supplementation. Chi-square test was used to examine the effect of soy isoflavone supplementation on menopausal symptoms.RESULTSFifty-six (93.3%) of participants completed the study. There were no statistically significant differences (p>0.05) in the prevalence of menopausal symptoms between the isoflavone group and the control group. However, supplementationof soy isoflavones for 12 weeks tended to decrease the prevalence of menopausal symptoms in women with normal body mass index and adequate daily dietary isoflavone intake.CONCLUSIONDaily supplementation of 100 mg soy isoflavones for 12 weeks tend to decrease the incidence of menopausal symptoms in postmenopausal women.
Deteksi Anemia, Penyuluhan, Suplementasi Zat Besi Pada Ibu Hamil Di Desa Nagrak Dan Ciangsana, Bogor Atut Cicih Mayasari; Rully Ayu Nirmalasari HP; Tiara Melati
AMMA : Jurnal Pengabdian Masyarakat Vol. 2 No. 7 : Agustus (2023): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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Abstract

Indonesian anemic proportions in pregnant women were 48,9% in 2018 report from Statistic Registration of Republic of Indonesia. About 50% of anemia is caused by iron deficiency. This poses a severe public health problem in Indonesia since anemia in pregnancy contributes to 16 – 40% maternal deaths. It also causes morbidity during gestation, delivery, post and perinatal not only to the mother but also the baby. A cross-sectional study was conducted by investigating the level of hemoglobin in pregnant women at the Center of Science Technology and Community Development Nagrak. Other parameters measured include middle upper arm circumference (MUAC), body mass index (BMI, using categories from WHO Asia Pacific). Descriptive analysis and t-test was conducted using Microsoft Excel 2022. At the time of the study, 24 pregnant women participated. Twelve women were found anemic (50%, CI 95% 9,7 – 11,2). The mean level of hemoglobin amongst the anemic population were 9,14 (CI 95% 8,3 – 10). The study also found 13% of the population were underweight, and 17% had MUAC of less than 23,5 cm. This study finds 17% of anemic women were underweight (p value 0,000). Total of 25% of anemic women had MUAC of less than 23,5 cm (p value 0,000). Anemia in pregnancy is prevalent in women at the Center of Science Technology and Community Development Nagrak. Other associating parameters include BMI and MUAC. Thus, iterating the importance of routine education and close support for iron supplementation within the community.
Dilema Managemen Tatalaksana Persalinan pada Anencephali sebagai Janin Letal Yunitra, Imelda; Wiranti, Hervi; Nirmalasari, Rully Ayu; Mayasari, Atut Cicih; Dhanardono, RM Denny; Maharani, Laksmi
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Anencephaly is a congenital anomaly of the central nervous system, caused by a disruption in brain and skull development of a fetus, which includes the disruption of the cerebral hemispheres, cerebellum, spinal cord, and pyramidal tract. This is a lethal condition that most fetuses born with this condition cannot survive after being delivered. The prevalence of this condition is 1 in 1000 deliveries. Early detection through prenatal ultrasound testing is essential to make a correct and precise plan for managing the pregnancy and delivery process, thus avoiding potential maternal complications. We reported a 33-year-old pregnant woman who was diagnosed with having anencephalic fetus at 24 weeks of pregnancy. The patient has been informed about this condition and offered a termination, but she refused to do so and is willing to continue the pregnancy. Induction of labor was planned at 40 weeks of pregnancy, but the process was impaired, so a cesarean section was performed to save the mother. The baby was delivered with anencephaly, as shown by the ultrasound result, and died 2 days after being delivered. The mother recovered well and was given education about the importance of folic acid intake for the next pregnancy. Conclusion of this case was labor management of anencephalic fetus was planned according to medical indication, with a special individual approach due to the obstetric condition. Yet, the delivery method should be based more on the mother's condition rather than the baby's, including the maternal emotional factor.
Kejadian Solusio Plasenta tanpa Rasa Nyeri dengan Perdarahan Retroplasenta 80%: Laporan Kasus Mayasari, Atut Cicih; Abikusno, Nugroho; Maharani, Laksmi; Wratsangka, Raditya
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.91-97

Abstract

The maternal mortality rate in Indonesia is still high. According to the Indonesian Household Health Survey (SKRT) in 2001 found that bleeding  in pregnancy contributes as the main cause of maternal mortality. Antepartum hemorrhage can be caused by placental abruption (PA) and placenta previa. This bleeding condition is an emergency case because it threatens the lives of both mother and  fetus (mother-fetal dyad). Placental abruption is usually accompanied by pain due to continuous uterine contractions. In this case, although concealed hematoma exists in almost 80% of PA cases, the mother shows no sign or symptom even though the fetus is severely at risk. This condition can cause delayed management that leads to mother and fetal mortality, known as asymptomatic placental abruption.
Co-Authors Denny Dhanardono Laksmi Maharani Nugroho Abikusno Raditya Wratsangka Raditya Wratsangka, Raditya Rully Ayu Nirmalasari HP Rully Ayu Nirmalasari, Rully Ayu Tiara Melati Wiranti, Hervi Yunitra, Imelda