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All Journal Pharmaceutical Sciences and Research (PSR) Eduvest - Journal of Universal Studies
Sutriyo Sutriyo, Sutriyo
Departemen Farmasi FMIPA-UI Depok
Aerospace Engineering Computer Science & IT Health Professions Neuroscience Social Sciences

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Utilization of Near-Infrared Spectroscopy Combined with PLS-2 Regression Learner to Predict Metformin HCL Tablet Dissolution Profile Zakaria, Mohamad Rahmatullah; Sutriyo, Sutriyo; Hayun, Hayun; Rukmana, Taufiq Indra
Eduvest - Journal of Universal Studies Vol. 5 No. 1 (2025): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i1.1566

Abstract

One of the assurances of pharmaceutical tablet's quality, effectivity, and safety is the dissolution test, which is commonly known by pharmaceutical manufacturers. Conventionally, this test is performed by simulating the release rate of a drug using a Dissolution Tester, which mimics the human gastrointestinal condition. As stated by the current compendial for tablet dosage form, the dissolution rate is mandatory, with no exception for Metformin HCl tablets. This laboratory method is often time-consuming, unsafe for organic reagent exposure, and produces waste. This problem requires rapid, simple, and nondestructive technologies, hence having powerful analytical performance. One of the technologies that is widely used is Near Infrared (NIR) spectroscopy. This study utilized the NIR spectrum as a predictor to generate a mathematical model using Partial Least Square Regression (PLS-2) to build a dissolution rate model for the Metformin HCl tablet, which uses the Farmakope Indonesia IV <1231> (FI-IV) dissolution method as the compendial reference method. The PLS-2 model was built, which shows the low difference between SEC and SECV in each sampling point and a good correlation in the coefficient of determination (R2) of each point's time of dissolution within 0.900 to 0.953. The challenge test was performed to prove the predictability of the PLS-2 model with NIR against the actual reference FI-IV method using differential and similarity Factors (f2 & f1), enabling real-time release testing (RTRT).
Co-Authors . Iskandarsyah Adilla Novitasari, Adilla Arry Yanuar Bustamam, Alhadi Dian Hayati Febrian Hevike Filosane, Febrian Hevike Hasan Rachmat, Hasan Hayun Hayun, Hayun Indah, Rosari Joshita Djajadisastra, Joshita Khairunnisya, Khairunnisya Maulana, Irvan Mega Suryani, Mega Mita Rosalina, Mita Mun’im, Abdul Rosmala Dewi Rukmana, Taufiq Indra Siti Nur Aeni, Siti Nur Sundarsih, Sundarsih Zakaria, Mohamad Rahmatullah Zuraida Syafara Dzuhro, Zuraida Syafara