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KEJADIAN REAKSI OBAT YANG TIDAK DIKEHENDAKI YANG MENYEBABKAN PASIEN USIA LANJUT DIRAWAT DI RSCM Christianie, Merry; Setiati, Siti; Trisna, Yulia; Andrajati, Retnosari
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 3, No 4 (2007)
Publisher : Indonesian Research Gateway

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Study had been conducted on adverse drug reaction (ADR) that cause older patient enter the internist ward Rumah Sakit Dr. Cipto Mangunkusumo in Mei-Juli 2005, to study the incidence proportion, frequent clinical manifestation, and the medication cause the event. Study had been done using cross-sectional design, and the causal evaluation was done using Naranjo algorithm. Total patient included in this study was 102. Incidence proportion of ADR that cause older patient enter the internist ward Rumah Sakit Dr. Cipto Mangunkusumo was 14.7%. One of 15 ADR was catagorized as ”definite”, while the other 14 were categorized as “probable”. The most clinical manifestations were gastrointestinal bleeding and hypoglicaemic shock. Medications responsible for these event were mostly NSAID (non-steroidal anti inflammation drug) dan oral hypoglycaemic drug. ABSTRAK Telah dilakukan penelitian tentang kejadian reaksi obat yang tidak dikehendaki (ROTD) yang menyebabkan pasien usia lanjut dirawat di ruang perawatan penyakit dalam Instalasi Rawat Inap B Rumah Sakit Dr. Cipto Mangunkusumo, periode Mei-Juli 2005 untuk mengetahui proporsi kejadian, manifestasi klinik yang sering terjadi dan obat yang sering menyebabkannya. Penelitian dilakukan dengan menggunakan desain studi potong lintang (cross-sectional) dan untuk penilaian kausalitas ROTD digunakan algoritma Naranjo. Total pasien yang ikut serta dalam penelitian ini berjumlah 102 orang. Diperoleh proporsi kejadian ROTD yang menyebabkan pasien usia lanjut dirawat di ruang perawatan penyakit dalam Instalasi Rawat Inap B Rumah Sakit Dr. Cipto Mangunkusumo sebesar 14,7% (interval kepercayaan 95%: 11,2-18,2%). Satu dari 15 ROTD yang terjadi dikategorikan pasti (definite) dan 14 kejadian dikategorikan besar kemungkinan (probable). Manifestasi klinik terbesar adalah perdarahan saluran cerna dan penurunan kesadaran karena hipoglikemi. Obat yang sering menyebabkan pasien dirawat karena ROTD tersebut adalah obat anti-inflamasi non-steroid (NSAID) dan obat hipoglikemi oral.

PERBANDINGAN PENGGUNAAN OBAT ANTARA PASIEN PNEUMONIA RAWAT INAP DI RUMAH SAKIT Rais, Yulia; Trisna, Yulia; Andrajati, Retnosari
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 1 (2012)
Publisher : Indonesian Research Gateway

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Pneumonia is the third major disease suffered by inpatient class III in RSUPN Dr. CiptoMangunkusumo Jakarta, among other are patient of Jamkesmas, Askessos and Gakin.Treatment expense for patient Jamkesmas based on the tariff packet of INA-DRG.Thepurposes of this study were to compare of drug use by ATC/DDD methode and comparedthe portion of the cost for drugs and health supplies to INA-DRG Tariff, among the thirdpatient group. Design of this study was cross sectional. Data were collected retrospectivelyfrom medical record and prescriptions for inpatient of pneumonia with Jamkesmas,Askessos, and Gakin Program at Cipto Mangunkusumo Hospital Jakarta, over period ofMarch 2008 – March 2009. The result of this study showed that quantity of drug use atJamkesmas, Askessos and Gakin successively were differed, successively 391,500;380,211; and 741,895 DDD/hbd. Generic name in DU90% at Jamkesmas, Askessos andGakin were also significantly differed, i.e. 22 (31%), 19 (24%), 37 items (40%). There wasalso a significant difference among the three health insurances in regards with the portion ofthe cost for drugs and health supplies to INA-DRG Tariff.ABSTRAKPneumonia adalah penyakit ketiga terbanyak yang diderita oleh pasien di ruang rawat inapkelas III di RSUPN Dr. Cipto Mangunkusumo Jakarta, diantaranya adalah pasienJamkesmas, Askessos dan Gakin. Biaya perawatan bagi pasien Jamkesmas dilakukanberdasarkan Tarif paket INA-DRG. Penelitian bertujuan untuk membandingkan penggunaanobat dengan Metode ATC/DDD dan membandingkan persentase biaya obat dan alatkesehatan terhadap Tarif INA-DRG antara ketiga kelompok pasien. Penelitian dilakukandengan rancangan studi potong lintang. Data diambil secara retrospektif dari rekam medikdan resep dokter untuk pasien pneumonia program Jamkesmas, Askessos dan Gakin,periode Maret 2008 – Maret 2009. Hasil penelitian menunjukkan kuantitas penggunaan obatpada pasien Jamkesmas, Askessos dan Gakin berbeda bermakna, berturut-turut adalah391,500; 380,211; 741,895 DDD/shr. Obat dengan nama generik dalam segmen DU90%pada pasien Jamkesmas, Askessos dan Gakin berturut-turut juga brbeda bermakna,berturut-turut 22 item (31%), 19 item (24%), 37 item (40%). Juga terdapat terdapatperbedaan yang bermakna dalam persentase biaya obat dan alat kesehatan terhadap TarifINA-DRG antara ketiga kelompok yang dibandingkan.

KEJADIAN REAKSI OBAT YANG TIDAK DIKEHENDAKI YANG MENYEBABKAN PASIEN USIA LANJUT DIRAWAT DI RSCM Christianie, Merry; Setiati, Siti; Trisna, Yulia; Andrajati, Retnosari
Jurnal Farmasi Indonesia Vol 3, No 4 (2007)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v3i4.89

Study had been conducted on adverse drug reaction (ADR) that cause older patient enter the internist ward Rumah Sakit Dr. Cipto Mangunkusumo in Mei-Juli 2005, to study the incidence proportion, frequent clinical manifestation, and the medication cause the event. Study had been done using cross-sectional design, and the causal evaluation was done using Naranjo algorithm. Total patient included in this study was 102. Incidence proportion of ADR that cause older patient enter the internist ward Rumah Sakit Dr. Cipto Mangunkusumo was 14.7%. One of 15 ADR was catagorized as â?definiteâ?, while the other 14 were categorized as â??probableâ?. The most clinical manifestations were gastrointestinal bleeding and hypoglicaemic shock. Medications responsible for these event were mostly NSAID (non-steroidal anti inflammation drug) dan oral hypoglycaemic drug. Â ABSTRAK Telah dilakukan penelitian tentang kejadian reaksi obat yang tidak dikehendaki (ROTD) yang menyebabkan pasien usia lanjut dirawat di ruang perawatan penyakit dalam Instalasi Rawat Inap B Rumah Sakit Dr. Cipto Mangunkusumo, periode Mei-Juli 2005 untuk mengetahui proporsi kejadian, manifestasi klinik yang sering terjadi dan obat yang sering menyebabkannya. Penelitian dilakukan dengan menggunakan desain studi potong lintang (cross-sectional) dan untuk penilaian kausalitas ROTD digunakan algoritma Naranjo. Total pasien yang ikut serta dalam penelitian ini berjumlah 102 orang. Diperoleh proporsi kejadian ROTD yang menyebabkan pasien usia lanjut dirawat di ruang perawatan penyakit dalam Instalasi Rawat Inap B Rumah Sakit Dr. Cipto Mangunkusumo sebesar 14,7% (interval kepercayaan 95%: 11,2-18,2%). Satu dari 15 ROTD yang terjadi dikategorikan pasti (definite) dan 14 kejadian dikategorikan besar kemungkinan (probable). Manifestasi klinik terbesar adalah perdarahan saluran cerna dan penurunan kesadaran karena hipoglikemi. Obat yang sering menyebabkan pasien dirawat karena ROTD tersebut adalah obat anti-inflamasi non-steroid (NSAID) dan obat hipoglikemi oral.

PERBANDINGAN PENGGUNAAN OBAT ANTARA PASIEN PNEUMONIA RAWAT INAP DI RUMAH SAKIT Rais, Yulia; Trisna, Yulia; Andrajati, Retnosari
Jurnal Farmasi Indonesia Vol 6, No 1 (2012)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v6i1.96

Pneumonia is the third major disease suffered by inpatient class III in RSUPN Dr. CiptoMangunkusumo Jakarta, among other are patient of Jamkesmas, Askessos and Gakin.Treatment expense for patient Jamkesmas based on the tariff packet of INA-DRG.Thepurposes of this study were to compare of drug use by ATC/DDD methode and comparedthe portion of the cost for drugs and health supplies to INA-DRG Tariff, among the thirdpatient group. Design of this study was cross sectional. Data were collected retrospectivelyfrom medical record and prescriptions for inpatient of pneumonia with Jamkesmas,Askessos, and Gakin Program at Cipto Mangunkusumo Hospital Jakarta, over period ofMarch 2008 â?? March 2009. The result of this study showed that quantity of drug use atJamkesmas, Askessos and Gakin successively were differed, successively 391,500;380,211; and 741,895 DDD/hbd. Generic name in DU90% at Jamkesmas, Askessos andGakin were also significantly differed, i.e. 22 (31%), 19 (24%), 37 items (40%). There wasalso a significant difference among the three health insurances in regards with the portion ofthe cost for drugs and health supplies to INA-DRG Tariff.ABSTRAKPneumonia adalah penyakit ketiga terbanyak yang diderita oleh pasien di ruang rawat inapkelas III di RSUPN Dr. Cipto Mangunkusumo Jakarta, diantaranya adalah pasienJamkesmas, Askessos dan Gakin. Biaya perawatan bagi pasien Jamkesmas dilakukanberdasarkan Tarif paket INA-DRG. Penelitian bertujuan untuk membandingkan penggunaanobat dengan Metode ATC/DDD dan membandingkan persentase biaya obat dan alatkesehatan terhadap Tarif INA-DRG antara ketiga kelompok pasien. Penelitian dilakukandengan rancangan studi potong lintang. Data diambil secara retrospektif dari rekam medikdan resep dokter untuk pasien pneumonia program Jamkesmas, Askessos dan Gakin,periode Maret 2008 â?? Maret 2009. Hasil penelitian menunjukkan kuantitas penggunaan obatpada pasien Jamkesmas, Askessos dan Gakin berbeda bermakna, berturut-turut adalah391,500; 380,211; 741,895 DDD/shr. Obat dengan nama generik dalam segmen DU90%pada pasien Jamkesmas, Askessos dan Gakin berturut-turut juga brbeda bermakna,berturut-turut 22 item (31%), 19 item (24%), 37 item (40%). Juga terdapat terdapatperbedaan yang bermakna dalam persentase biaya obat dan alat kesehatan terhadap TarifINA-DRG antara ketiga kelompok yang dibandingkan.

Blood Pressure and Heat Shock Protein 70 Levels Related to Acute Ischemic Stroke Severity Indra, Syarif; Khair, Umul; Trisna, Yulia
Green Medical Journal Vol 2 No 2 August (2020): Green Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/gmj.v2i2.55

Introduction: Hypertension is a risk factor of ischemic stroke, the prevalence of ischemic stroke in Indonesia is 34.1%. Heat Shock Protein (HSP) 70 increases in hypertension and acute phase of ischemic stroke. To determine differences of blood pressure (BP) and HSP 70 levels, related to the acute ischemic stroke severity. Methods: This was a cross-sectional study that was carried out in the Neurological Ward of Dr.M.Djamil Hospital and National Stroke Hospital, from May to September 2019. Inclusion criteria were obtained consecutively. BP was measured with a sphygmomanometer, stroke severity was measured by NIHSS, and HSP 70 levels was analyzed by the ELISA. Computerized statistical analyzes were performed using SPSS software version 23.0 for windows. The result was statistically significant if the p-value < 0.05. Results: There were 40 samples consisted of 26 (65%) male, mean age 59.78 years. The systolic BP ranging from 130 to 190 mmHg (median 160), the diastolic BP ranging from 70 to 100 mmHg (median 90), the HSP 70 levels ranging from 2.50 to 19.56 ng/mL (median 2.72). There were 18 patients with mild stroke and 22 patients with moderate stroke. There was no significant difference between systolic blood pressure (SBP), diastolic blood pressure (DBP), and severity of stroke (p=0,369; p=0,221, respectively). There was no significant difference between HSP 70 levels and the severity of stroke (p=0,312). There was no relation between the degree of BP and HSP 70 levels. Conclusion: There were no significant differences of SBP, DBP, and HSP 70 with the acute ischemic stroke severity.

Pola Pengobatan Fluor Albus Di Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo Serta Faktor-Faktor Yang Mempengaruhinya (Analisis Data Rekam Medik Tahun 2006-2007) Rusdi, Numlil Khaira; Trisna, Yulia; Soemiati, Atiek
Majalah Ilmu Kefarmasian Vol. 5, No. 2
Publisher : UI Scholars Hub

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The objectives of this study were to know (1) Patients’ characteristics (2) The most etiology of leucorrhoea (3) Association between clinical manifestations or genital symp-toms with etiology of leucorrhoea (4) Therapy management of leucorrhoea by obstet-ric-gynecologist and venereologist (5) Factors influenced the treatment of leucorrhoea (6) Compliance with hospital therapeutic guidelines. The study was cross sectional and retrospective. A total of 437 patients hospitalized from January 2006-December 2007 were included. The results showed that leucorrhoea was found in 17,6% of patients at sexually transmitted disease clinic and 82,4% of patients at obstetric-gynecology clinic. The majority of patients were in productive age, married, and housewife, with most of genital symptoms were pruritus and curd-like vaginal dis-charge. The most of etiology leucorrhoea in this study was candidiasis. Statistically, there were association between genital symptoms with candidiasis and bacterial vaginosis (p<0,05). The specific genital symptoms of candidiasis were pruritus and curd-like vaginal discharge, whereas for bacterial vaginosis were homogeneous and increased vaginal discharge. There were different treatments of vaginal discharge be-tween obstetric-gynecologist and venereologist. For candidiasis, the obstetric-gyne-cologist preferred to use fluconazole, and metronidazole+nystatin (Flagistatin®); whereas the venereologist used clotrimazole and itraconazole. For bacterial vaginosis, obstet-ric-gynecologist used clindamycin and metronidazole+nystatin (Flagistatin®), while venereologist preferred to use metronidazole. For trichomoniasis there was no different treatment between obstetric-gynecologist and venereologist. In pregnancy, antibiot-ics used to treat leucorrhoea were clindamycin, fluconazole, metronidazole+nystatin (Flagistatin®), metronidazole, and nystatin. Prescribing compliance with the hospi-tal therapeutics guidelines were 37,8%. The type of antibiotics used were azitromycin, clindamycin, clotrimazole, doxycycline, fluconazole, itraconazole, ketoconazole, and metronidazole. Statistics analysis by Logistic regression (Cl 95%) showed that factors influenced the treatment of leucorrhoea included genital symptoms (OR = 0,975), risk factors (OR = 0,917), etiology (OR = 1,103), and comorbid diseases (OR = 1,387).

Kejadian Reaksi Obat yang Tidak Dikehendaki yang Menyebabkan Pasien Usia Lanjut Dirawat Di Ruang Perawatan Penyakit Dalam Instalasi Rawat Inap B Rumah Sakit Dr. Cipto Mangunkusumo Christianie, Merry; Setiati, Siti; Trisna, Yulia; Andrajati, Retnosari
Majalah Ilmu Kefarmasian Vol. 5, No. 3
Publisher : UI Scholars Hub

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Objectives. To determine the prevalence of adverse drug reaction related hospital ad-missions in geriatric patients, to describe the most frequent clinical manifestations and the drugs responsible to adverse drug reaction related hospital admissions. Design. Observational cross-sectional study. Methods. Naranjo algorithm used to assess the adverse drug reaction causality. Subjects and setting. Geriatric patients admitted to geriatric inpatient installation of Cipto Mangunkusumo general hospital over one month period and assessed for cause of admissions. Results. 14,7% of 102 admissions were identified to be adverse drug reaction related hospital admissions. One adverse drug reaction was categorized as definite and 14 were probable causality. Gastrointestinal bleeding and hypoglicemia were the most common clinical manifestation found. The drugs most frequent responsible for these adverse drug reactions were nonsteroidal antiinflamatory drugs and oral antidiabetic drugs. Conclusion. Adverse drug reactions are an important cause of hospital admission in geriatric patients.

Perbandingan Penggunaan Efavirenz dan Nevirapine Terhadap Kolesterol LDL Pasien HIV/AIDS Anggriani, Yusi; Yunihastuti, Evy; Trisna, Yulia; Rosanti, Ade; Manninda, Reise; Annisa, Rifka
Pharmaceutical Sciences and Research Vol. 6, No. 2
Publisher : UI Scholars Hub

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Lipid metabolism disorder is one of common condition among HIV (Human Immunodeficiency Virus)/AIDS (Acquired Immune Deficiency Syndrome) patients who used first line antiretroviral efavirenz and nevirapine. This study was conducted to compare LDL (Low Density Lipoprotein) cholesterol between two group HIV/AIDS patients with efavirenz and nevirapine. The prospective study was performed in 2 months. HIV/AIDS patients who used first line antiretroviral at least for 6 months, aged ≥18 years old, not pregnant, without Mycobacterium ovium complex opportunistic infection and antihyperlipidemic, corticosteroid, retinoid in last 3 months were included. The 70 patients who enrolled in this study were divided into two groups. The independent T test was carried out to analyze the different of LDL cholesterol between two group. The group of patients using efavirenz showed 142.31 ±41,461 mg/dL and the group of nevirapine 126.83 ±40,55 mg/dL LDL cholesterol. This study showed that patient with efavirenze had higher LDL than nevirapine, but not statistically different.

PENGARUH PROMOSI, HARGA, KUALITAS PELAYANAN TERHADAP KEPUTUSAN PEMBELIAN PRODUK PT. NATURAL NUSANTARA Trisna, Yulia; Suryatama, Fajar; Handriani, Eka
BISECER (Business Economic Entrepreneurship) Vol 7, No 2 (2024): Juli 2024
Publisher : Universitas Darul Ulum Islamic Centre Sudirman GUPPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61689/bisecer.v7i2.592

Promosi merupakan salah satu faktor penting penentu keberhasilan perusahaan dalam pemasaran. Kurangnya promosi yang dilakukan oleh mitra-mitra PT. Natural Nusantara sehingga menyebabkan turunnya volume penjualan. Dengan harga produk PT. Natural Nusantara memang terkesan mahal dibanding dengan perusahaan lainnya. Customer sebelum melakukan pembelian, kebanyakan terlebih dahulu memperhatikan harga yang ditawarkan. Harga sering dijadikan parameter dalam melakukan pembelian. Namun dalam kualitas pelayanan Stockist PT.Natural Nusantara masih kurang. Karena di Stockist PT.Natural Nusantara tidak ada customer service, jadi untuk pelayanannya sangat kurang. Kualitas pelayanan merupakan isu krusial bagi setiap perusahaan, apapun bentuk produk yang dihasilkan. Faktor – faktor yang mempengaruhi keputusan pembelian : 1) Pengenalan masalah, 2) Pencarian informasi, 3) Evaluasi. Jenis penelitian ini menggunakan metode kuantitatif dengan pendekatan asosiatif . Populasi dalam penelitian ini seluruh konsumen stockist PT.Natural Nusantara dengan jumlah populasi sebanyak 100 orang. Teknik sampling yang digunakan adalah purposive sampling. Berdasarkan hasil analisa sperhitungan yang telah dilakukan, variabel Promosi (X1) dengan nilai koefisien korelasi sebesar 0,631 yang berada dalam kategori “kuat’’. Promosi (X1) berpengaruh terhadap keputusan pembelian (Y) yang ditunjukkan dengan nilai regresi sebesar 0,430 dan mempunyai nilai t hitung sebesar 8.501 > t tabel (1.984) dengan nilai signifikansi 0,00 < 0,05 dan bernilai positif. Artinya promosi berpengaruh positif dan signifikan terhadap keputusan pembelian. Variabel harga(X2) dengan nilai koefisien korelasi sebesar 0,708 yang berada dalam kategori “kuat’’. Harga (X2) berpengaruh terhadap keputusan pembelian (Y) yang ditunjukkan dengan nilai regresi sebesar 1.013 mempunyai nilai t hitung sebesar 9.931 > t tabel (1.984) dengan nilai signifikansi 0,00 < 0,05 dan bernilai positif. Artinya harga berpengaruh positif dan signifikan terhadap keputusan pembelian. Variabel kualitas pelayanan pelayanan (X3) dengan nilai koefisien korelasi sebesar 0,562 yang berada dalam kategori “sedang’’. Kualitas pelayanan (X3) berpengaruh terhadap keputusan pembelian (Y) yang ditunjukkan dengan nilai regresi sebesar 0,694. Mempunyainilai t hitung sebesar 6.729 > t tabel (1.984) dengan nilai signifikansi 0,00 < 0,05 dan bernilai positif. Artinya kualitas pelayanan berpengaruh positif dan signifikan terhadap keputusan pembelian. Hasil statistic uji F diperoleh nilai Fhitung 53.778 > nilai F tabel2.70. Dengan tingkat signifikansi sebesar 0,00 < 0,05 secara simultan atau bersama – sama mempunyai pengaruh yang signifikan terhadap keputusan pembelian. Kata kunci : Promosi, Harga, Kualitas Pelayanan, Keputusan Pembelian

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