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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kesehatan Andalas Global Medical and Health Communication Green Medical Journal Scientific Journal Journal of Pharmaceutical and Sciences.
Indra, Syarif
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Blood Pressure and Heat Shock Protein 70 Levels Related to Acute Ischemic Stroke Severity Indra, Syarif; Khair, Umul; Trisna, Yulia
Green Medical Journal Vol 2 No 2 August (2020): Green Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/gmj.v2i2.55

Abstract

Introduction: Hypertension is a risk factor of ischemic stroke, the prevalence of ischemic stroke in Indonesia is 34.1%. Heat Shock Protein (HSP) 70 increases in hypertension and acute phase of ischemic stroke. To determine differences of blood pressure (BP) and HSP 70 levels, related to the acute ischemic stroke severity. Methods: This was a cross-sectional study that was carried out in the Neurological Ward of Dr.M.Djamil Hospital and National Stroke Hospital, from May to September 2019. Inclusion criteria were obtained consecutively. BP was measured with a sphygmomanometer, stroke severity was measured by NIHSS, and HSP 70 levels was analyzed by the ELISA. Computerized statistical analyzes were performed using SPSS software version 23.0 for windows. The result was statistically significant if the p-value < 0.05. Results: There were 40 samples consisted of 26 (65%) male, mean age 59.78 years. The systolic BP ranging from 130 to 190 mmHg (median 160), the diastolic BP ranging from 70 to 100 mmHg (median 90), the HSP 70 levels ranging from 2.50 to 19.56 ng/mL (median 2.72). There were 18 patients with mild stroke and 22 patients with moderate stroke. There was no significant difference between systolic blood pressure (SBP), diastolic blood pressure (DBP), and severity of stroke (p=0,369; p=0,221, respectively). There was no significant difference between HSP 70 levels and the severity of stroke (p=0,312). There was no relation between the degree of BP and HSP 70 levels. Conclusion: There were no significant differences of SBP, DBP, and HSP 70 with the acute ischemic stroke severity.
CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY Attiya Istarini; Indra, Syarif
JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 9 No. 3 (2021): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (195.958 KB)

Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) merupakan penyakit neuropati autoimun kronik. CIDP klasik ditandai dengan hilangnya persepsi sensorik dan kelemahan anggota gerak secara progresif dan disertai hilangnya refleks selama lebih dari 8 minggu. Penyakit ini cukup jarang terjadi, namun apabila tidak di tatalaksana dengan tepat dapat menyebabkan kecacatan. Diagnosis CIDP ditegakkan berdasarkan gejala klinis, pemeriksaan analisa LCS, dan pemeriksaan elektrodiagnostik. Pilihan terapi CIDP yang cukup efektif dan terjangkau adalah kortikosteroid, dimana obat ini berfungsi menekan inflamasi dengan menghambat aktivitas sel T. Prognosis CIDP relatif baik pada pasien usia muda, gejala kelemahan otot proksimal, respon terhadap terapi steroid, dan dari studi elektrofisiologi terdapat perlambatan conduction velocities yang ringan
Spasmofilia dengan Hipoparatiroidisme Pasca Tiroidektomi Susanti, Lydia; Indra, Syarif; Noza, Aulia
Scientific Journal Vol. 1 No. 4 (2022): SCIENA Volume I No 4, July 2022
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (577.766 KB) | DOI: 10.56260/sciena.v1i4.57

Abstract

Spasmofilia merupakan keadaan patologis dimana terjadi hiperiritabilitas saraf dan otot (neuromuskular) akibat adanya gangguan keseimbangan elektrolit,  terutama ion kalsium (Ca2+) dan ion magnesium (Mg2+) yang ditandai dengan munculnya kedutan otot, kesemutan dan spasme karpopedal. Hipoparatiroidisme merupakan keadaan dimana produksi hormon paratiroid yang tidak adekuat. Keadaan ini jarang ditemukan dan umumnya disebabkan oleh kerusakan atau pengangkatan kelenjar paratiroid pada saat operasi tiroid. Laporan kasus ini  membahas mengenai pasien perempuan berusia 25 tahun dengan spasmofilia  dan hipoparatiroidisme sekunder  ec tiroidektomi.
Indoxyl Sulfate Levels and Its Relation with Executive Function in Routine Hemodialysis Patients Syafrita, Yuliarni; Susanti, Restu; Indra, Syarif; Harun, Harnavi
Global Medical & Health Communication (GMHC) Vol 11, No 2 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i2.10964

Abstract

Executive function is a crucial cognitive domain that can be adversely affected by various toxic substances, including the uremic toxin indoxyl sulfate. Although it's known that indoxyl sulfate has harmful effects on intra or extra-kidney organs, its impact on executive function remains unclear. This study aimed to evaluate indoxyl sulfate levels in patients with chronic kidney disease (CKD) undergoing hemodialysis and to understand its correlation with executive function impairments. This observational cross-sectional study was conducted at the Dr. M. Djamil General Hospital Padang Hemodialysis Unit from March to July 2022; 60 patients undergoing hemodialysis and 20 healthy controls participated. Executive function was assessed using the Trail Making Test B (TMT-B). Indoxyl sulfate levels were quantified using an ELISA assay with the Assay Genie kit. The Mann-Whitney test set statistical significance at a p<0.05. The average age of the subjects was 51.4±11.4 years, with 53% being male. The mean indoxyl sulfate levels were considerably higher in the CKD group (118.79 ng/ml, range: 11–1,709 ng/ml) compared to the control group (6.028±1.829 ng/ml), with a significant difference (p<0.001). Impaired executive function was observed in 75% of the CKD patients. The average indoxyl sulfate level was 165.12 ng/ml (range: 29–1,709 ng/mL) in the impaired executive function group and 71.22 ng/ml (range: 11–333 ng/mL) in the group with normal executive function, indicating a significant difference (p=0.013). Patients with CKD undergoing hemodialysis exhibit elevated serum indoxyl sulfate levels compared to healthy individuals. Moreover, CKD patients with impaired executive function have notably higher indoxyl sulfate levels than those with normal executive function. Further research is needed to elucidate the mechanistic links between indoxyl sulfate and cognitive impairments.
Hubungan Morfologi Plak pada Stenosis Arteri Karotis Ekstrakranial dengan Kejadian Stroke Iskemik Sutia, Dedi; Indra, Syarif; Permana, Hendra; Arinda, Lenny; Rahmi, Afriyeni Sri
Jurnal Kesehatan Andalas Vol. 9 No. 2 (2020): Online June 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i2.1274

Abstract

Stenosis arteri ekstrakranial bermanifestasi dalam berbagai kondisi, mulai dari asimptomatik hingga stroke iskemik. Salah satu modalitas diagnostik untuk mengevaluasi gambaran stenosis tersebut adalah carotid duplex. Terdapatnya plak pada stenosis arteri ekstrakranial mempengaruhi kejadian stroke iskemik. Namun masih belum jelas hubungan antara morfologi plak pada stenosis arteri ekstrakranial dengan kejadian stroke iskemik. Tujuan: Menentukan hubungan morfologi plak pada stenosis arteri karotis ekstrakranial dengan kejadian stroke iskemik. Metode: Penelitian ini merupakan studi analitik dengan desain cross sectional yang dilakukan pada 20 orang sampel pada bulan Januari hingga September 2018 di RSUP Dr M Djamil, Padang. Kriteria inklusi adalah pasien yang telah didiagnosis stenosis arteri ekstrakranial dengan plak dari pemeriksaan carotid duplex dan kriteria eksklusi adalah pasien yang tidak datang kontrol atau tidak bisa dihubungi. Hubungan antar variable diuji dengan uji Chi-square. Hasil dianggap bermakna secara statistik jika nilai p<0,05. Hasil: Sebanyak 12 orang (60%) sampel adalah perempuan dan 8 orang (40%) adalah laki-laki. Median umur sampel adalah 56 tahun (37-71 tahun). Morfologi plak berupa plak nonulcerated sebanyak 11 orang (55%) dan plak ulcerated sebanyak 9 orang (45%). Kejadian stroke iskemik ditemukan sebanyak 9 orang (45%) dan tidak stroke sebanyak 11 orang (55%). Terdapat hubungan antara morfologi plak pada stenosis arteri ekstrakranial dengan kejadian stroke iskemik (p = 0,02); RR = 5. Simpulan: Terdapat hubungan bermakna antara morfologi plak pada stenosis arteri ekstrakranial dengan kejadian stroke iskemik.Kata Kunci: morfologi plak, stenosis arteri ekstrakranial, stroke iskemik
Plasma pTau181 dan Gejala Neuropsikiatri pada Demensia Alzheimer: Sebuah Studi Cross-Sectional Fadhilah, Nailatul; Syafrita, Yuliarni; Susanti, Restu; Indra, Syarif; Susanti, Lydia; Putri, Fanny Adhy
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1143

Abstract

Alzheimer’s disease is the leading cause of dementia, marked by progressive cognitive decline and neuropsychiatric disturbances collectively known as behavioral and psychological symptoms of dementia (BPSD). Plasma phosphorylated tau at threonine-181 (pTau181) has emerged as a minimally invasive biomarker of tau-related neurodegeneration, but its association with BPSD remains uncertain. This study investigated the relationship between plasma pTau181 levels and BPSD in Alzheimer’s dementia. An analytical observational study with a cross-sectional design was conducted in patients clinically diagnosed with predefined eligibility criteria. Plasma pTau181 concentrations were measured using enzyme-linked immunosorbent assay (ELISA), while BPSD was assessed using the Neuropsychiatric Inventory Questionnaire (NPI-Q). Statistical analyses were performed to examine associations between plasma pTau181 and BPSD status. Plasma pTau181 levels ranged from 4.32 to 97.23 pg/mL, with a median plasma pTau181 level of 19.29 pg/mL (IQR: 11.81-25.05) in patients without BPSD and 20.67 pg/mL (IQR: 11.81-43.41) in those with BPSD. No significant differences in pTau181 levels were observed between patients with and without BPSD (p = 0.310). These findings suggest that plasma pTau181 may not be directly related to the presence of BPSD in Alzheimer’s dementia. While plasma pTau181 remains a promising biomarker of tau pathology, its predictive value for neuropsychiatric symptoms appears limited. Longitudinal studies are needed to explore its role in BPSD pathophysiology further.
Co-Authors Afriyeni Sri Rahmi Andi Fadilah Yusran Putri, Andi Fadilah Yusran Arinda, Lenny ATTIYA ISTARINI Harun Harnavi Hendra Permana K, Firstisa Nuzulia Khair, Umul Lydia Susanti, Lydia Nailatul Fadhilah Noza, Aulia Putri, Fanny Adhy Restu Susanti Sutia, Dedi Yulia Trisna, Yulia Yuliarni Syafrita