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All Journal INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Al-Kimia Akta Kimia Indonesia Journal of Pharmaceutical Care Anwar Medika Indonesian Journal of Cancer Pharmaceutical Sciences and Research (PSR)
Galih Satrio Putra
University Of Surabaya
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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Tren Penyalahgunaan Narkoba di wilayah Jawa Timur tahun 2016-2017 Putra, Galih Satrio
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 4 No 1 (2021): Journal of Pharmaceutical Care Anwar Medika
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36932/jpcam.v4i1.61

Abstract

Penelitian ini bertujuan untuk mengidentifikasi, membandingkan, memganalisis, dan mengevaluasi tren penggunaan narkoba di wilayah Jawa Timur pada tahun 2016-2017. Metode pengambilan data penyalahgunaan pada narkoba di wilayah Jawa Timur pada tahun 2016 dilakukan secara retrospective dan pengambilan data pata tahun 2017 dilakukan secara cross sectional. Proses identifikasi dan analisis barang bukti menggunakan metode kromatografi gas dengan instrument GC-MS type Agilent 7890 A; MS type Agilent 5975 C with Triple Axis Detector, type coloum HP-5 dan fase gerak berupa gas helium. Hasil pengambilan data diperoleh kasus penyalahgunaan narkoba pada tahun 2017 mengalami peningkatan sebesar 22% (5791) dibandingkan pada tahun 2016 (4726). Penggunaan narkotika golongan I Metamfetamin mengalami peningkatan sebesar 17 % (3763) dibandingkan pada tahun 2016 (3218). Pada tahun 2017 penyalahgunaan OOT (Obat-Obat Tertentu) seperti Triheksifenidil mengalami peningkatan sebesar 44% (1487) dibandingkan pada tahun 2016 (1035). Pada tahun 2017 telah ditemukan narkotika golongan I yaitu AB Fubinaka yang terdapat ada sampel berupa tembakau yang tidak pernah ditemukan pada tahun sebelumnya. Berdasarkan hasil analisis dan evaluasi data yang didapat ditahun 2016 dan 2017 terdapat peningkatan yang signifikan dan diidentifikasi narkotika jenis baru yaitu AB Fubinaka yang mulai menjadi tren di tahun 2017. Data ini dapat digunakan oleh Pemerintah, BNN, Kepolisian, BPOM dan masyarakat untuk mengatasi ancaman penggunaan narkoba di tahun yang akan datang.
Synthesis and Molecular Docking Studies of N’-benzoylsalicylhydrazide derivatives as antituberculosis through InHA enzym inhibition Harry Santosa; Galih Satrio Putra; Tegar Achsendo Yuniarta; Tutuk Budiati
Indonesian Journal of Pharmacy Vol 29 No 4, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1120.908 KB) | DOI: 10.14499/indonesianjpharm29iss4pp198

Abstract

The specific aims of this study is to synthesize and to study the possible mechanism of N’-benzoylsalicylhydrazide derivatives as an antituberculosis agent through InhA (Enoyl acyl carrier protein reductase) inhibition using in silico method. Five analogues of N’-benzoylsalicylhydrazide were synthesized using microwave irradiation from methyl salicylate as starting material, which yielded 80-90% product on average. This indicates a considerable improvement in terms of effectivity and efficiency, compared to the more conventional method using reflux condition. Character-ization of the compounds were subsequently carried out by UV, FTIR, 1H-NMR, 13C-NMR spectroscopy, which confirmed that the compounds had been successfully synthesized. Ultimately, molecular docking was performed using Molegro Virtual Docker (MVD) on the active site of InhA enzyme to predict the activity of the compounds. The results showed that all compounds performed comparatively well against N-(4-Methylbenzoyl)-4-benzylpiperidine as the native ligand and also yielded lower docking score than isoniazide (INH). From this study it can be concluded that N’-benzoylsalicylhydrazide derivatives could be synthesized using microwave irradiation with good product yield and all of the synthesized analogues are suggested to possess antituberculosis activity via InhA enzyme inhibition. In vitro activity will have to be determined in the future to validate whether N’-benzoylsalicylhydrazide derivatives perform well as a potential antituberculosis agent.
Design and Molecular Docking Studies of Quinazoline Derivatives as Antiproliferation Anita Puspa Widiyana; Galih Satrio Putra; Luthfi Ahmad Muchlashi; Mellany Ika Sulistyowaty; Tutuk Budiati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 2 (2016): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (284.943 KB) | DOI: 10.20473/jfiki.v3i22016.44-48

Abstract

Background: Nowadays, a lot of new active substances as anticancer agents have been developed. One of the protein targets of anticancer is selective cyclooxygenase-2 (COX-2). Selective COX-2 is the regulator of cell proliferation. Objective: In this research, quinazoline derivatives were used to design the anticancer agent through a selective COX-2 inhibition. The potential activity of quinazoline derivatives could be increased by substitution in position 2 and 3 of quinazolinone. Molecular docking of selective COX-2 inhibition was required to predict their antiproliferation activity. Methods: The molecular docking of quinazoline derivatives was carried out using Molegro Virtual Docker (MVD) Ver.5.5. Twenty-one of quinazoline derivatives were docked into selective COX-2 with PDB code 3LN1. The interaction was evaluated based on the re-ranked score comparison between quinazoline derivatives with co-crystallized ligand CEL_682. Celecoxib was used as the reference to this research. Results: The result indicated that 18 of 21 quinazoline derivatives showed the approximately re-ranked score -131.508 to -108.418 kcal/mol. Eight of these 18 new quinazoline derivatives have re-ranked score better than Celecoxib. Conclusions: In conclusion, 8 of the new quinazoline derivatives are feasible to be synthesize and performed their in vitro evaluation.
Perbandingan Metode Sintesis Senyawa 1-benzil-3-(4-etil-benzoil)urea dan 1-benzil-3-(4-klorometil-benzoil)urea sebagai Calon Obat Antikanker Farida Suhud; Daryono Hadi Tjahjono; Tegar Achsendo Yuniarta; Galih Satrio Putra; Melanny Ika Sulistyowaty
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 8 No. 3 (2021): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v8i32021.277-283

Abstract

Pendahuluan: Pengembangkan obat antikanker yang selektif dari turunan hidroksiurea masih diteliti sampai saat ini. Tujuan: Penelitian ini bertujuan untuk membandingkan metode sintesis senyawa turunan hidroksiurea yaitu 1-benzil-3-(4-etil-benzoil)urea dan 1-benzil-3-(4-klorometil-benzoil)urea. Metode: Optimasi metode sintesis yang dilakukan dengan membandingkan produk hasil sintesis dengan pemanasan refluks dan tanpa pemasanan refluk. Produk yang didapat dilakukan analisis elusidatif meliputi FTIR, 1H-NMR dan 13C-NMR. Hasil: berdasarkan hasil perbandingan metode sintesis menggunakan refluks menyebabkan terbentuknya dua produk samping sehingga perlu dilakukan pemisahan dengan kromatograsi kolom antara produk utama dengan dua produk sampingnya. Metode tanpa pemasanan lebih dipilih karena tidak menghasilkan dua produk hasil samping walaupun rendemen masih dalam rentang 20-30%. Kesimpulan: Metode sintesis senyawa turunan 1-benzil-3-benzoilurea lebih direkomendasikan tanpa pemasanan daripada menggunakan pemanasan refluks, tetapi penelitian kedepannya harus didapatkan metode yang lebih baik untuk mendapatkan rendemen yang lebih besar.
Studi In-silico menghambat enzim α-glukosidase pada fitokimia yang terkandung pada Momordica charantia Linn. (Pare) sebagai terapi diabetes Marisca Evalina Gendokesumo; Galih Satrio Putra; Farida Anwari; Widianat Widianat; Mauren Elysia
Akta Kimia Indonesia Vol 7, No 1 (2022)
Publisher : LPPM, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j25493736.v7i1.12588

Abstract

Momordica charantia Linn. (Pare) adalah salah satu tanaman yang sering digunakan oleh masyarakat untuk menurunkan kadar gula darah pada pasien diabetes militus. Secara empiris Fitokimia yang terkandung pada  Momordica charantia Linn. yang berasa pahit dipercaya dapat melawan efek manis dari gula. Oleh karena itu Penelitian ini bertujuan untuk mengidentifikasi mekanisme penghambatan enzim alfa glukosidase pada senyawa yang terkandung dari Momordica charantia Linn. (Pare) yaitu cucurbitene, lanostene,  momordicin derivatives, momordicoside derivatives, goyaglycoside derivatives dalam menghambat enzim α-glukosidase secara in-silico menggunakan Molegro Virtual Docker (MVD) Ver.5.5 yang dibandingkan dengan native ligandnya dan acarbose. Hasil in-silico menunjukan bahwa glikosida yang terdapat pada Momordica charantia Linn memiliki potensi menghambat enzim α-glukosidase. Salah satunya adalahnya Momordicoside B (-192.74 Kcal/mol) yang memiliki moldock score yang lebih rendah dibandingkan native ligannya (-75.00 Kcal/mol) dan acarbose (-151.73 Kcal/mol).
Pemodelan Molekul Turunan p-Metoksi sinnamoil Hidrazida Sebagai Inhibitor Checkpoint Kinase 1 dan Inhibitor Aromatase secara In silico Putra, Galih Satrio; Sulistyowatya, Melanny Ika; Ekowati, Juni; Budiati, Tutuk
Pharmaceutical Sciences and Research Vol. 4, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The development of anticancer drugs from ethyl p-methoxycinnamate (EPMC) derivatives has been done to compounds high activity in inducing cancer cells apoptosis and minimal side effects. p-Methoxycinnamoyl hydrazide derivates, modified from EPMC structure, were docked into the ligand-binding pocket of Check point kinase 1 enzymes (2YWP) and the aromatase enzyme (3S7S) using software Molegro Virtual Docker (MVD) Ver.5.5. We compared the Rerank score of native ligand with p-Methoxycinnamoyl hydrazide derivates. Rerank scores of compounds 4b and 4c (-99.98 Kcal/mol and -99.80 Kcal/mol) were lower than the native ligand A42 in inhibiting the enzyme checkpoint kinase 1. Rerank values of p-Methoxycinnamoyl hydrazide derivate compounds were greater than the native ligand EXM in inhibiting the enzyme aromatase. p-Methoxycinnamoyl hydrazide derivate compounds, especially compounds 4b and 4c, had anticancer mechanism by inhibiting the checkpoint kinase 1 enzyme pathway and showed no activity in inhibiting the aromatase enzyme.
Polimer Kitosan-Natrium Tripolifosfat Tercetak Molekul: Sintesis dan Aplikasinya untuk Ekstraksi Residu Antibiotik pada Hasil Peternakan Amanda, Eviomitta Rizki; Sabilillah Lukito Pradana, Alif; Yusril Fitroni, Muhammad; Reza Adzania, Imelda; Nisfi Laili, Wida; Nurfadlilah, Lilik; Satrio Putra, Galih
Al-Kimia Vol 12 No 2 (2024): DECEMBER
Publisher : Study Program of Chemistry - Alauddin State Islamic University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-kimia.v12i2.48765

Abstract

Analysis of antibiotic residues in livestock products is challenging due to the low concentration of antibiotic residues and the complexity of the sample matrix. This study successfully used selective adsorbents from molecular imprinted polymer (MIP) materials for sample preparation. An adsorbent made of chitosan-based molecular imprinted polymer (Chi-MIP) was used to extract tetracycline residues from egg and milk samples. The adsorbent was made by preparing 0.1 grams of Chi-MIP in a 2x2 cm cellulose filter paper bag. Next, an adsorbent containing tetracycline was added to the sample. The extraction process was carried out using a hotplate stirrer. At the end of the extraction process, the extracted antibiotics are removed from the adsorbent through a desorption process in an organic solvent via an ultrasonicator. After that, the desorbed analytes were analyzed via a UV‒Vis spectrophotometer at a wavelength of 267 nm. To obtain optimum results, the extraction conditions were optimized to obtain the following results: extraction time of 12 minutes, desorption time of 3 minutes, and ethyl acetate as the desorbing organic solvent. Using the standard addition method, method validation results were obtained for each milk and egg sample matrix, which indicated a linearity range of 1–5mg/L, a correlation coefficient (R2) of 0.99, accuracy values ​​of 98.22% and 88.10%, precisions of 2.74% and 1.06%, LoDs of 0.4 mg/L and 0.51mg/L, LoQs of 1.52mg/L and 1.70mg/L, and enrichment factors of 3.27.
Virtual Screening and Comparison of the Binding Effectiveness of Doxorubicin, Paclitaxel, and Ergoloid to ERβ-MDM2 Complex Protein as New Breast Cancer Drug Candidates Salmasfattah, Novyananda; Dhiani, Binar Asrining; Muslikh, Faisal Akhmal; Putra, Galih Satrio
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1325

Abstract

Background: The prevalence of breast cancer continues to increase, it is the second leading cause of death after lung cancer. Estrogen receptor beta (ERβ) has an important role in breast cancer pathology, activation of Akt pathway will trigger E3 ubiquitin ligase murine double minute 2 (MDM2) to ERβ, which will increase the risk of breast cancer. Thus, both proteins have potential as therapeutic agents in breast cancer drug development. This study aims to find breast cancer drug candidates from natural products and compare the effectiveness of these compounds with Doxorubicin and Paclitaxel.Method: ERβ (PDB ID: 3OLS) and MDM2 (PDB ID: 1T4E) proteins were combined using ClusPro 2.0. Doxorubicin and Paclitaxel ligands were obtained from PubChem, there are 842 natural products obtained from the ZINC database, when the energy minimization is reduced to 839 natural products. Virtual screening between proteins and ligands was performed using PyRx 8.0, followed by analysis of amino acid residues resulting from interactions between proteins and ligands using protein interaction calculator (PIC) and protein ligand interaction profiler (PLIP). Results: Ergoloid compounds have the lowest binding affinity compared to doxorubicin and paclitaxel compounds, and are able to interact strongly with the ERβ-MDM2 Protein as determined from the results of interactions between proteins and ligands using PIC and PLIP.Conclusion: Ergoloid compounds can interact well with ERβ-MDM2 Protein. Thus, it can be used as a breast cancer drug candidate in the future. In vitro, in vivo, and biochemical testing needs to be done to confirm this discovery
Co-Authors Amanda, Eviomitta Rizki Anita Puspa Widiyana Binar Asrining Dhiani Daryono Hadi Tjahjono Faisal Akhmal Muslikh Farida Anwari Farida Suhud Harry Santosa Juni Ekowati Luthfi Ahmad Muchlashi Marisca Evalina Gendokesumo Mauren Elysia Melanny Ika Sulistyowaty Mellany Ika Sulistyowaty Nisfi Laili, Wida Nurfadlilah, Lilik Reza Adzania, Imelda Sabilillah Lukito Pradana, Alif Salmasfattah, Novyananda Tegar Achsendo Yuniarta Tutuk Budiati Widianat Widianat Yusril Fitroni, Muhammad