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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat Indonesian Journal of Cancer Pharmaceutical Sciences and Research (PSR) Jurnal Kefarmasian Indonesia

Binar Asrining Dhiani

Fakultas Farmasi Universitas Muhammadiyah Purwokerto,

Author-ID : 253374

Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

Published : 16 Documents Claim Missing Document

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Antiproliferative Effect of Chloroform Extract of Cangkring Leaves (Erythrina fusca Lour.) and Its Isolates against Hela Cells Puspitasari, Endah; Setyowati, Endah Dwi; Dhiani, Binar Asrining; Riyanto, Sugeng
Indonesian Journal of Cancer Chemoprevention Vol 3, No 1 (2012)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4.399 KB)

Cervical cancer is a type of cancer possessing the 3rd highest incidence among women worldwide. Todays therapies against cancer are still ineffective, thus people are seeking for alternative method. Erythrina fusca Lour. has been used traditionally as anticancer. This experiment is conducted to study the ability of chloroform extract of E.fusca Lour. leaves and its isolates on HeLa cervical cancer cells. The cytotoxicity assay and doubling time assay were done using direct counting method, while the DNA staining assay was done using acrydine orange. The chloroform extract and isolate #30 showed cytotoxic activity with IC50 of 16 and 5 Î¼g/ml, respectively, while isolate #2 and isolate #8 didnt. The effluent #30 could not affect HeLa cells growth at the given concentration, but it might promote DNA fragmentation indicating apoptosis induction. The molecular mechanisme underlying these effects still need to be further explored.Keywords : Â Erythrina fusca Lour., isolate and effluent of chloroform extract, antiproliferative, cervical cancer

FORMULASI DAN AKTIVITAS ANTIBAKTERI LOTION MINYAK ATSIRI BUAH ADAS (Foeniculum vulgare Mill) Caesar, Rahma Yuanita; Hapsari, Indri; Dhiani, Binar Asrining
Media Farmasi: Jurnal Ilmu Farmasi Vol 11, No 1: Maret 2014
Publisher : Universitas Ahmad Dahlan

Buah adas mengandung minyak atsiri antara lain anethole, fenchone dan metil chavicol. Senyawa anethole dilaporkan memiliki aktivitas antibakteri pada bakteri Gram Positif dan Gram Negatif. Penelitian ini bertujuan untuk membuat lotion minyak atsiri dari buah adas dan menentukan aktivitas antibakterinya terhadap Staphylococcus aureus dan Pseudomonas aeruginosa. Penelitian ini dilakukan untuk membuat lotion menggunakan minyak atsiri buah adas yang diperoleh dari destilasi uap air dengan konsentrasi 1, 5, dan 10% (Formula I, II dan III). Kemudian lotion tersebut diuji parameter fisik dan ditentukan aktivitas antibakterinya. Hasil penelitian menunjukkan bahwa semakin tinggi konsentrasi minyak atsiri, sediaan lotion yang dibuat memiliki daya lekat dan viskositas semakin rendah. Variasi konsentrasi minyak atsiri tidak memberikan pengaruh pada sifat organoleptis, pH dan kestabilan lotion. Diketahui pula bahwa semakin tinggi konsentrasi minyak atsiri pada sediaan lotion maka semakin tinggi daya sebar dan diameter zona hambatnya terhadap pertumbuhan Staphylococcus aureusdan Pseudomonas aeruginosa.Minyak atsiri buah adas memiliki aktifitas antibakteri setelah dibuat dalam sediaan lotion meskipun lemah. Formula yang menunjukkan aktivitas antibakteri yang paling tinggi adalah formula III dengan konsentrasi 10% minyak atsiri. Kata kunci: Foeniculum vulgare Mill, lotion, antibakteri

Anti-inflammation and anti-platelet aggregation activities of the ethanolic extract of Graptophyllum pictum leaves in Wistar rats Yulia Ratnasari; Susanti Susanti; Binar Asrining Dhiani
Pharmaciana Vol 10, No 2 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Graptophyllum pictum is a well-known folk medicine in Indonesia. The red leaves are widely used for their anti-inflammatory properties to relieve hemorrhoids. However, little is known about to what extent these properties can affect platelet aggregation. This study was aimed to determine the anti-inflammation and anti-platelet aggregation activities of the ethanolic extract of Graptophyllum pictum (EEGP). Apart from the ear and hind-paw edema assay, anti-platelet aggregation and bleeding time assay were also performed on male Wistar rats. The test animals were grouped into six groups: three treatment groups termed EEGP100, EEGP600, and EEGP3000 (received 100, 600, and 3000 mg/kg BW of EEGP, respectively), one control-solvent group (1% CMC-Na), and two positive control groups (aspirin and Na-diclofenac). Based on the percentage of edema inhibition, absorbance change, and bleeding time, EEGP600 and EEGP3000 produced a comparable percentage of edema inhibition to that of Na-diclofenac, which was not found in EEGP100. Also, EEGP600 and EEGP3000, but not EEGP100, inhibited platelet aggregation as effective as aspirin (positive control). In conclusion, if administered at 600 and 3000 mg/kg BW, the ethanolic extract of Graptophyllum pictum can function as an anti-inflammatory agent that inhibits platelet aggregation.Â

FORMULASI DAN AKTIVITAS ANTIBAKTERI LOTION MINYAK ATSIRI BUAH ADAS (Foeniculum vulgare Mill) Rahma Yuanita Caesar; Indri Hapsari; Binar Asrining Dhiani
Media Farmasi: Jurnal Ilmu Farmasi Vol 11, No 1: Maret 2014
Publisher : Universitas Ahmad Dahlan

Buah adas mengandung minyak atsiri antara lain anethole, fenchone dan metil chavicol. Senyawa anethole dilaporkan memiliki aktivitas antibakteriÂ pada bakteri Gram Positif dan Gram Negatif. Penelitian ini bertujuan untuk membuat lotion minyak atsiri dari buah adas dan menentukan aktivitas antibakterinya terhadap Staphylococcus aureus dan Pseudomonas aeruginosa. Penelitian ini dilakukan untuk membuat lotion menggunakan minyak atsiri buah adas yang diperoleh dari destilasi uap air dengan konsentrasi 1, 5, dan 10% (Formula I, II dan III). Kemudian lotion tersebut diuji parameter fisik dan ditentukan aktivitas antibakterinya. Hasil penelitian menunjukkan bahwa semakin tinggi konsentrasi minyak atsiri, sediaan lotion yang dibuat memiliki daya lekat dan viskositas semakin rendah. Variasi konsentrasi minyak atsiri tidak memberikan pengaruh pada sifat organoleptis, pH dan kestabilan lotion. Diketahui pula bahwa semakin tinggi konsentrasi minyak atsiri pada sediaan lotion maka semakin tinggi daya sebar dan diameter zona hambatnya terhadap pertumbuhan Staphylococcus aureusdan Pseudomonas aeruginosa. Minyak atsiri buah adas memiliki aktifitas antibakteri setelah dibuat dalam sediaan lotion meskipun lemah. Formula yang menunjukkan aktivitas antibakteri yang paling tinggi adalah formula III dengan konsentrasi 10% minyak atsiri.

Antiproliferative Effect of Chloroform Extract of Cangkring Leaves (Erythrina fusca Lour.) and Its Isolates against HeLa Cells Endah Puspitasari; Endah Dwi Setyowati; Binar Asrining Dhiani; Sugeng Riyanto
Indonesian Journal of Cancer Chemoprevention Vol 3, No 1 (2012)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev3iss1pp358-363

Cervical cancer is a type of cancer possessing the 3rd highest incidence among women worldwide. Today’s therapies against cancer are still ineffective, thus people are seeking for alternative method. Erythrina fusca Lour. has been used traditionally as anticancer. This experiment is conducted to study the ability of chloroform extract of E. fusca Lour. leaves and its isolates on HeLa cervical cancer cells. The cytotoxicity assay and doubling time assay were done using direct counting method, while the DNA staining assay was done using acrydine orange. The chloroform extract and isolate # 30 showed cytotoxic activity with IC50 of 16 and 5 µg/ml, respectively, while isolate # 2 and isolate # 8 didn’t. The effluent # 30 could not affect HeLa cells growth at the given concentration, but it might promote DNA fragmentation indicating apoptosis induction. The molecular mechanisms underlying these effects still need to be further explored.Keywords: Erythrina fusca Lour., isolate and effluent of chloroform extract, antiproliferative, cervical cancer

Peningkatan pengetahuan guru dan orang tua siswa taman kanak-kanak tentang penggunaan suplemen vitamin yang tepat Binar Asrining Dhiani; Siti Nurjanah; Narendra Istia Putri; Ihza Ihtimamul Umam
Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Vol 4, No 2 (2021): Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS)
Publisher : University of Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jipemas.v4i2.9138

COVID-19 global pandemic increases the usage of vitamin supplement products. However, easy access to purchase and consume the product increases the risk for its misuse. Lack of information and or misinformation available for vitamin supplement product usage leads to its abuse. Teachers' and parents' role in deciding the choice and use of vitamin supplement products for the pupil and children is crucial. Thus, a program was held to provide information about the correct usage of vitamin supplement products for teachers and parents. The program was performed for the teachers and pupil parents of TK Aisyiyah Ledug via online. The attractive audio-visual program materials were delivered via animation video, artistic leaflet, and presentation. The teachers and parents responded positively toward the program. All attendants actively participated, and 100% of attendants agreed that the program was interesting and increased their knowledge on the appropriate usage of vitamin supplement products.

FORMULASI GRANUL INSTAN JUS KELOPAK BUNGA ROSELA (Hibiscus sabdariffa L) DENGAN VARIASI KONSENTRASI POVIDON SEBAGAI BAHAN PENGIKAT SERTA KONTROL KUALITASNYA M. Dafit Mulyadi; Ika Yuni Astuti; Binar Asrining Dhiani
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 08 No. 03 Desember 2011
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v8i03.1128

ABSTRAK Rosela (Hibiscus sabdariffa L) merupakan tanaman yang serba guna. Sebagai obat tradisional, kelopak rosela berkhasiat sebagai antioksidan, antiseptik, diuretik, antikolesterol. Penelitian ini bertujuan untuk mengetahui konsentrasi povidon terhadap persyaratan mutu granul yang baik, tanggapan rasa dan deteksi kandungan flavonoid dalam granul instan ekstrak rosela. Kelopak segar rosela dihaluskan dengan bantuan berupa blender kemudian sari yang diperoleh diuapkan untuk menghilangkan kandungan air sampai terbentuk ekstrak kental. Granul instan jus rosela dibuat dengan metode granulasi basah dalam 3 formula yang berdasarkan konsentrasi povidon yang berbeda yaitu F I 1%, F II 3%, FIII 5%. Uji yang dilakukan terhadap granul instant ekstrak rosela adalah uji fisik granul dan uji tanggapan rasa. Hasil uji fisik granul instan menunjukaan bahwa formula I memenuhi persyaratan sifat fisik granul yang baik. Untuk uji waktu alir granul (8,29 0,38 detik), uji sudut diam (39,11 0,790), uji susut pengeringan %MC (2,99 0,046), uji distribusi ukuran partikel (692,1797 µm). Hasil uji tanggapan rasa menunjukan bahwa granul instan ekstrak rosela dapat diterima oleh responden. Kata kunci: kelopak bunga rosela, povidon, granul instan. ABSTRACT Roselle is a very useful plant. Widely used as traditional medicine, its calyx functions as antioxidant, antiseptic, diuretic, and anticholesterol. This research is aimed at knowing the concentrate of povidone toward the condition of a good quality of granule, taste reaction, and the detection of content of flavonoid in the instant granule of the roselle extract. The fresh calyx roselle was pounded with mixer and then the obtained essence was steamed to lose the water content, until thick extract was derived. The instant granule of rosella juice was formulated with wet granulation method in 3 formulas which is based on differrent concentrate of povidone, they are F I (1%), F II (3%), F III (5%). The test were done to the instant granule from the extract Hibiscus sabdariffa for its granule physical test and taste reaction test. The result of the test of physical instant granule showed that F I meet the requirement of good granule. For flow rate test (8,29 0,38 second), point of quit test (39,11 0,790), moisture content test with %MC (2,99 0,046), and for test distribution of the size of particle with microscopis method (692,1797 µm). The result of the test of taste reaction showed that the extract of instant granule can be accept by the respodent. Keyword ׃ fresh calyx roselle, Povidone, granule instant

The Potential Roles of Jamu for COVID-19: A Learn from the Traditional Chinese Medicine Hartanti, Dwi; Dhiani, Binar Asrining; Charisma, Shintia Lintang; Wahyuningrum, Retno
Pharmaceutical Sciences and Research Vol. 7, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

As the pandemic of the coronavirus disease 2019 (COVID-19) continues while there is no drug and vaccine available, every effort to discover one should be considered. This review aimed to discuss the potential use of jamu, the Indonesian traditional herbal medicine, to deal with COVID-19 by following those of more-established traditional Chinese medicine (TCM). The online literature search using the PubMed database, as well as the circulars from the Indonesian Ministry of Health, were carried out to collect data up to June 07, 2020. The use of TCM for the treatment and prevention of COVID-19 has been officiated in the Chinese National Clinical Guideline on COVID-19 Associated Pneumonia, with shen-fu-tang + su-he-xiang pill and xiang-sha-liu-junzi- tang as the most frequently suggested formulae to treat severe and recovery stages of COVID-19, respectively. In Indonesia, the highly promoted product for the prevention of this disease is likely the adaptation of a TCM formula, while the use of some other formulae, which mainly containing Zingiberaceae, is suggested by the Government for the said purpose. The rationalization of the use of medicinal plants and suggested polyherbal formulae, based on their available pharmacological activity and the bioactive compounds, is also discussed in this review. The use of jamu for COVID-19, however, needs to be carefully considered for the limited scientific data available to support it.

Molecular Docking Analysis of Acanthus ilicifolius Compounds Toward CUL4B-DDB1-AhR-ERα Complex Protein for Antiosteoporosis Discovery Dhiani, Binar Asrining; Sarmoko, Sarmoko; Wahyuningrum, Retno; Yulianto, Akbar
Pharmaceutical Sciences and Research Vol. 10, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Osteoporosis represents a significant global public health issue, particularly among the aging population. Its incidence reaches 18.3% of the total population, with the highest prevalence observed in elderly postmenopausal women. A key factor in osteoporosis is the decreased expression level of estrogen receptor alpha (ERα), attributed to its degradation by the ubiquitin ligase protein complex Cullin4B (CUL4B), DNA damage binding 1 (DDB1), and aryl hydrocarbon receptor (AhR), collectively known as CUL4BAhR. Acanthus ilicifolius L contains compounds exhibiting antiosteoporosis activity, primarily by inhibiting osteoclastogenesis via RANKL. However, no reports exist of antiosteoporosis agents that act by inhibiting ERα degradation via CUL4BAhR. This study employed an in silico approach to predict active compounds from A. ilicifolius that could inhibit ERα degradation via CUL4BAhR, potentially developing them into antiosteoporosis agents. We utilized the 3D structures of proteins CUL4B-DDB1 (PDB ID:4A0L), AhR (5NJ8), and ERα (1A52) in various molecular docking tools, including ClusPro2.0, PyRx0.8, PyMol, PLIP, and SWISS-MODEL for QMEAN and structure assessment analysis. The ligands tested were acancifoliuside, acanthaminoside, acteoside, isoacteoside, (-)-lyoniresinol, (-)-lyioniresinol-3a-O-β-glucopyranoside, and estradiol. Acteoside displayed lower binding affinity energy (-9.7 kcal/mol) compared to estradiol (-8.9 kcal/mol) and was the lowest among all compounds. Acteoside was found to weaken the interaction between CUL4B-Rbx1 and CUL4B-DDB1 but not between AhR and ERα. Consequently, acteoside could be a viable candidate as an antiosteoporosis agent by inhibiting ERα degradation via the CUL4B-DDB1-AhR pathway. Further biochemical, in vitro, and in vivo studies are required to strengthen this evidence.

Penggunaan Deksametason pada Pasien COVID-19: Systematic Review dan Meta-analisis Mardhiyyah, Cut Ainul; Setiawan, Didik; Dhiani, Binar Asrining
Jurnal Kefarmasian Indonesia VOLUME 13, NOMOR 1, FEBRUARI 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i1.5455

COVID-19 is associated with disseminated lung damage in patients, Dexamethasone can reduce lung injury caused by inflammation and there reduce the progression to respiratory failure and prevent death. This systematic review aimed to determine the benefits and safety of Dexamethasone in COVID-19 treatment. The study was performed by a comprehensive literature search which were published in several databases i.e., PubMed, Science Direct, VHL Regional Portal, and ClinicalTrials.gov within the search time of 28 November 2020. Inclusion criteria were articles on the study on COVID-19 patients who received Dexamethasone, observational and experimental studies on the outcomes use evaluation of Dexamethasone. Exclusion criteria are the articles that do not provide control in controlled studies and do not show clear research results on the use of Dexamethasone. An initial search from four databases by entering keywords resulted in 1,046 articles. After screening articles duplication we obtained 835 studies. Finally, 6 articles were obtained after we screened for the article that it can be obtained its full text and 5 articles joined in articles included in the meta-analysis. The analysis showed that Dexamethasone in Covid-19 patients could reduce the incidence of death within 28 days with RR of 0.78 (95% CI 0.57–0.97 P=0.13) compared with Methylprednisolone, Dexamethasone was compared without corticosteroids with RR 0.89 (95% CI 0.82-0.97 P=0.01). Dexamethasone also reduced mechanical ventilator use during treatment with RR 0.95 (95% CI = 0.86-1.05 P = 0.28) compared without corticosteroids. The conclusion from these results: the use of Dexamethasone can reduce the number of deaths in COVID-19 patients, especially severe and critically ill category patients.

Co-Authors Adi Garnadi Rahman, Adi Garnadi Anisah Arif Dwi Utomo Astri Puspitasari Caesar, Rahma Yuanita Charisma, Shintia Lintang Dewi Andriyani Didik Setiawan Dwi Hartanti Elis Yuliya Sandi, Elis Yuliya Endah Dwi Setyowati Endah Dwi Setyowati Endah Puspitasari Faisal Akhmal Muslikh Fitriyani Fitriyani Galih Satrio Putra Ihza Ihtimamul Umam Ika Yuni Astuti Indri Hapsari Indri Hapsari M. Dafit Mulyadi Mardhiyyah, Cut Ainul Nabilla, Ishma Yasmin Narendra Istia Putri Nimas Mahataranti Nunuk Aries Nurulita Pri Iswati Utami Putri, Irsalina Nurul Putri, Narendra Istia Rahma Yuanita Caesar Rahma Yuanita Caesar Retno Wahyuningrum Salmasfattah, Novyananda Sarmoko Sarmoko Siti Nurjanah Siti Nurjanah Sudarso Sudarso Sugeng Riyanto Sugeng Riyanto Sundhani, Elza Susanti Susanti Tri Setyo Bayuaji, Tri Setyo Umam, Ihza Ihtimamul Wahyuningrum4, Retno Wiranti Sri Rahayu Yulia Ratnasari Yulianto, Akbar

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