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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat Indonesian Journal of Cancer Pharmaceutical Sciences and Research (PSR) Jurnal Kefarmasian Indonesia

Binar Asrining Dhiani

Fakultas Farmasi Universitas Muhammadiyah Purwokerto,

Author-ID : 253374

Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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Antiproliferative Effect of Chloroform Extract of Cangkring Leaves (Erythrina fusca Lour.) and Its Isolates against Hela Cells Puspitasari, Endah; Setyowati, Endah Dwi; Dhiani, Binar Asrining; Riyanto, Sugeng
Indonesian Journal of Cancer Chemoprevention Vol 3, No 1 (2012)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4.399 KB)

Cervical cancer is a type of cancer possessing the 3rd highest incidence among women worldwide. Todays therapies against cancer are still ineffective, thus people are seeking for alternative method. Erythrina fusca Lour. has been used traditionally as anticancer. This experiment is conducted to study the ability of chloroform extract of E.fusca Lour. leaves and its isolates on HeLa cervical cancer cells. The cytotoxicity assay and doubling time assay were done using direct counting method, while the DNA staining assay was done using acrydine orange. The chloroform extract and isolate #30 showed cytotoxic activity with IC50 of 16 and 5 Î¼g/ml, respectively, while isolate #2 and isolate #8 didnt. The effluent #30 could not affect HeLa cells growth at the given concentration, but it might promote DNA fragmentation indicating apoptosis induction. The molecular mechanisme underlying these effects still need to be further explored.Keywords : Â Erythrina fusca Lour., isolate and effluent of chloroform extract, antiproliferative, cervical cancer

FORMULASI DAN AKTIVITAS ANTIBAKTERI LOTION MINYAK ATSIRI BUAH ADAS (Foeniculum vulgare Mill) Caesar, Rahma Yuanita; Hapsari, Indri; Dhiani, Binar Asrining
Media Farmasi: Jurnal Ilmu Farmasi Vol 11, No 1: Maret 2014
Publisher : Universitas Ahmad Dahlan

Buah adas mengandung minyak atsiri antara lain anethole, fenchone dan metil chavicol. Senyawa anethole dilaporkan memiliki aktivitas antibakteri pada bakteri Gram Positif dan Gram Negatif. Penelitian ini bertujuan untuk membuat lotion minyak atsiri dari buah adas dan menentukan aktivitas antibakterinya terhadap Staphylococcus aureus dan Pseudomonas aeruginosa. Penelitian ini dilakukan untuk membuat lotion menggunakan minyak atsiri buah adas yang diperoleh dari destilasi uap air dengan konsentrasi 1, 5, dan 10% (Formula I, II dan III). Kemudian lotion tersebut diuji parameter fisik dan ditentukan aktivitas antibakterinya. Hasil penelitian menunjukkan bahwa semakin tinggi konsentrasi minyak atsiri, sediaan lotion yang dibuat memiliki daya lekat dan viskositas semakin rendah. Variasi konsentrasi minyak atsiri tidak memberikan pengaruh pada sifat organoleptis, pH dan kestabilan lotion. Diketahui pula bahwa semakin tinggi konsentrasi minyak atsiri pada sediaan lotion maka semakin tinggi daya sebar dan diameter zona hambatnya terhadap pertumbuhan Staphylococcus aureusdan Pseudomonas aeruginosa.Minyak atsiri buah adas memiliki aktifitas antibakteri setelah dibuat dalam sediaan lotion meskipun lemah. Formula yang menunjukkan aktivitas antibakteri yang paling tinggi adalah formula III dengan konsentrasi 10% minyak atsiri. Kata kunci: Foeniculum vulgare Mill, lotion, antibakteri

Anti-inflammation and anti-platelet aggregation activities of the ethanolic extract of Graptophyllum pictum leaves in Wistar rats Yulia Ratnasari; Susanti Susanti; Binar Asrining Dhiani
Pharmaciana Vol 10, No 2 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Graptophyllum pictum is a well-known folk medicine in Indonesia. The red leaves are widely used for their anti-inflammatory properties to relieve hemorrhoids. However, little is known about to what extent these properties can affect platelet aggregation. This study was aimed to determine the anti-inflammation and anti-platelet aggregation activities of the ethanolic extract of Graptophyllum pictum (EEGP). Apart from the ear and hind-paw edema assay, anti-platelet aggregation and bleeding time assay were also performed on male Wistar rats. The test animals were grouped into six groups: three treatment groups termed EEGP100, EEGP600, and EEGP3000 (received 100, 600, and 3000 mg/kg BW of EEGP, respectively), one control-solvent group (1% CMC-Na), and two positive control groups (aspirin and Na-diclofenac). Based on the percentage of edema inhibition, absorbance change, and bleeding time, EEGP600 and EEGP3000 produced a comparable percentage of edema inhibition to that of Na-diclofenac, which was not found in EEGP100. Also, EEGP600 and EEGP3000, but not EEGP100, inhibited platelet aggregation as effective as aspirin (positive control). In conclusion, if administered at 600 and 3000 mg/kg BW, the ethanolic extract of Graptophyllum pictum can function as an anti-inflammatory agent that inhibits platelet aggregation.Â

FORMULASI DAN AKTIVITAS ANTIBAKTERI LOTION MINYAK ATSIRI BUAH ADAS (Foeniculum vulgare Mill) Rahma Yuanita Caesar; Indri Hapsari; Binar Asrining Dhiani
Media Farmasi: Jurnal Ilmu Farmasi Vol 11, No 1: Maret 2014
Publisher : Universitas Ahmad Dahlan

Buah adas mengandung minyak atsiri antara lain anethole, fenchone dan metil chavicol. Senyawa anethole dilaporkan memiliki aktivitas antibakteriÂ pada bakteri Gram Positif dan Gram Negatif. Penelitian ini bertujuan untuk membuat lotion minyak atsiri dari buah adas dan menentukan aktivitas antibakterinya terhadap Staphylococcus aureus dan Pseudomonas aeruginosa. Penelitian ini dilakukan untuk membuat lotion menggunakan minyak atsiri buah adas yang diperoleh dari destilasi uap air dengan konsentrasi 1, 5, dan 10% (Formula I, II dan III). Kemudian lotion tersebut diuji parameter fisik dan ditentukan aktivitas antibakterinya. Hasil penelitian menunjukkan bahwa semakin tinggi konsentrasi minyak atsiri, sediaan lotion yang dibuat memiliki daya lekat dan viskositas semakin rendah. Variasi konsentrasi minyak atsiri tidak memberikan pengaruh pada sifat organoleptis, pH dan kestabilan lotion. Diketahui pula bahwa semakin tinggi konsentrasi minyak atsiri pada sediaan lotion maka semakin tinggi daya sebar dan diameter zona hambatnya terhadap pertumbuhan Staphylococcus aureusdan Pseudomonas aeruginosa. Minyak atsiri buah adas memiliki aktifitas antibakteri setelah dibuat dalam sediaan lotion meskipun lemah. Formula yang menunjukkan aktivitas antibakteri yang paling tinggi adalah formula III dengan konsentrasi 10% minyak atsiri.

Antiproliferative Effect of Chloroform Extract of Cangkring Leaves (Erythrina fusca Lour.) and Its Isolates against HeLa Cells Endah Puspitasari; Endah Dwi Setyowati; Binar Asrining Dhiani; Sugeng Riyanto
Indonesian Journal of Cancer Chemoprevention Vol 3, No 1 (2012)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev3iss1pp358-363

Cervical cancer is a type of cancer possessing the 3rd highest incidence among women worldwide. Today’s therapies against cancer are still ineffective, thus people are seeking for alternative method. Erythrina fusca Lour. has been used traditionally as anticancer. This experiment is conducted to study the ability of chloroform extract of E. fusca Lour. leaves and its isolates on HeLa cervical cancer cells. The cytotoxicity assay and doubling time assay were done using direct counting method, while the DNA staining assay was done using acrydine orange. The chloroform extract and isolate # 30 showed cytotoxic activity with IC50 of 16 and 5 µg/ml, respectively, while isolate # 2 and isolate # 8 didn’t. The effluent # 30 could not affect HeLa cells growth at the given concentration, but it might promote DNA fragmentation indicating apoptosis induction. The molecular mechanisms underlying these effects still need to be further explored.Keywords: Erythrina fusca Lour., isolate and effluent of chloroform extract, antiproliferative, cervical cancer

Peningkatan pengetahuan guru dan orang tua siswa taman kanak-kanak tentang penggunaan suplemen vitamin yang tepat Binar Asrining Dhiani; Siti Nurjanah; Narendra Istia Putri; Ihza Ihtimamul Umam
Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Vol 4, No 2 (2021): Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS)
Publisher : University of Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jipemas.v4i2.9138

COVID-19 global pandemic increases the usage of vitamin supplement products. However, easy access to purchase and consume the product increases the risk for its misuse. Lack of information and or misinformation available for vitamin supplement product usage leads to its abuse. Teachers' and parents' role in deciding the choice and use of vitamin supplement products for the pupil and children is crucial. Thus, a program was held to provide information about the correct usage of vitamin supplement products for teachers and parents. The program was performed for the teachers and pupil parents of TK Aisyiyah Ledug via online. The attractive audio-visual program materials were delivered via animation video, artistic leaflet, and presentation. The teachers and parents responded positively toward the program. All attendants actively participated, and 100% of attendants agreed that the program was interesting and increased their knowledge on the appropriate usage of vitamin supplement products.

FORMULASI GRANUL INSTAN JUS KELOPAK BUNGA ROSELA (Hibiscus sabdariffa L) DENGAN VARIASI KONSENTRASI POVIDON SEBAGAI BAHAN PENGIKAT SERTA KONTROL KUALITASNYA M. Dafit Mulyadi; Ika Yuni Astuti; Binar Asrining Dhiani
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 08 No. 03 Desember 2011
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v8i03.1128

ABSTRAK Rosela (Hibiscus sabdariffa L) merupakan tanaman yang serba guna. Sebagai obat tradisional, kelopak rosela berkhasiat sebagai antioksidan, antiseptik, diuretik, antikolesterol. Penelitian ini bertujuan untuk mengetahui konsentrasi povidon terhadap persyaratan mutu granul yang baik, tanggapan rasa dan deteksi kandungan flavonoid dalam granul instan ekstrak rosela. Kelopak segar rosela dihaluskan dengan bantuan berupa blender kemudian sari yang diperoleh diuapkan untuk menghilangkan kandungan air sampai terbentuk ekstrak kental. Granul instan jus rosela dibuat dengan metode granulasi basah dalam 3 formula yang berdasarkan konsentrasi povidon yang berbeda yaitu F I 1%, F II 3%, FIII 5%. Uji yang dilakukan terhadap granul instant ekstrak rosela adalah uji fisik granul dan uji tanggapan rasa. Hasil uji fisik granul instan menunjukaan bahwa formula I memenuhi persyaratan sifat fisik granul yang baik. Untuk uji waktu alir granul (8,29 0,38 detik), uji sudut diam (39,11 0,790), uji susut pengeringan %MC (2,99 0,046), uji distribusi ukuran partikel (692,1797 µm). Hasil uji tanggapan rasa menunjukan bahwa granul instan ekstrak rosela dapat diterima oleh responden. Kata kunci: kelopak bunga rosela, povidon, granul instan. ABSTRACT Roselle is a very useful plant. Widely used as traditional medicine, its calyx functions as antioxidant, antiseptic, diuretic, and anticholesterol. This research is aimed at knowing the concentrate of povidone toward the condition of a good quality of granule, taste reaction, and the detection of content of flavonoid in the instant granule of the roselle extract. The fresh calyx roselle was pounded with mixer and then the obtained essence was steamed to lose the water content, until thick extract was derived. The instant granule of rosella juice was formulated with wet granulation method in 3 formulas which is based on differrent concentrate of povidone, they are F I (1%), F II (3%), F III (5%). The test were done to the instant granule from the extract Hibiscus sabdariffa for its granule physical test and taste reaction test. The result of the test of physical instant granule showed that F I meet the requirement of good granule. For flow rate test (8,29 0,38 second), point of quit test (39,11 0,790), moisture content test with %MC (2,99 0,046), and for test distribution of the size of particle with microscopis method (692,1797 µm). The result of the test of taste reaction showed that the extract of instant granule can be accept by the respodent. Keyword ׃ fresh calyx roselle, Povidone, granule instant

Protein-protein Docking Studies of Estrogen Receptor Alpha and TRIM56 Interaction for Breast Cancer Drug Screening Binar Asrining Dhiani; Nunuk Aries Nurulita; Fitriyani Fitriyani
Indonesian Journal of Cancer Chemoprevention Vol 13, No 1 (2022)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev13iss1pp46-54

Breast cancer is the highest mortality cause in women with cancer. Protein-protein docking for target-based screening is an effective approach in breast cancer drug discovery via estrogen receptor (ER) signaling. TRIM56, an E3 ubiquitin protein ligase, can bind to and stabilize ER alpha. Thus, drug screening that can inhibit or weaken the interaction between ER alpha and TRIM56 is promising to obtain novel yet specific breast cancer drugs. In this study, we performed protein-protein docking studies for ER alpha and TRIM56 interaction and virtual screening for FDA-approved drugs from the ZINC database against ER alpha and TRIM56 complex protein model structure. We utilized Cluspro 2.0, PyRx 0.8, and Pymol 2.4.1 to conduct protein-protein docking, virtual screening, and model structure visualization. PIP and PLIP software were also applied to analyze the amino acid residue between proteins or protein-ligands. Based on the protein-protein docking, ER alpha and TRIM56 established interaction. Utilizing this complex protein as a macromolecule in the virtual screen of 1071 molecules of FDA-approved drugs, we obtain the top five lowest binding energy molecules i.e., dutasteride, dihydroergotamine, nilotinib, ergotamine, and bromocriptine. In addition, the energy binding affinity between ER alpha-dutasteride complex with TRIM56 was weakened in the presence of dutasteride. In conclusion, protein-protein docking between ER alpha-TRIM56 was able to select FDA-approved drugs that could bind to the complex, and dutasteride binding to ER alpha-TRIM56 complex weakened the interaction.Keywords: protein-protein docking, estrogen receptor alpha, TRIM56, breast cancer, ubiquitin.

The Potential Roles of Jamu for COVID-19: A Learn from the Traditional Chinese Medicine Hartanti, Dwi; Dhiani, Binar Asrining; Charisma, Shintia Lintang; Wahyuningrum, Retno
Pharmaceutical Sciences and Research Vol. 7, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

As the pandemic of the coronavirus disease 2019 (COVID-19) continues while there is no drug and vaccine available, every effort to discover one should be considered. This review aimed to discuss the potential use of jamu, the Indonesian traditional herbal medicine, to deal with COVID-19 by following those of more-established traditional Chinese medicine (TCM). The online literature search using the PubMed database, as well as the circulars from the Indonesian Ministry of Health, were carried out to collect data up to June 07, 2020. The use of TCM for the treatment and prevention of COVID-19 has been officiated in the Chinese National Clinical Guideline on COVID-19 Associated Pneumonia, with shen-fu-tang + su-he-xiang pill and xiang-sha-liu-junzi- tang as the most frequently suggested formulae to treat severe and recovery stages of COVID-19, respectively. In Indonesia, the highly promoted product for the prevention of this disease is likely the adaptation of a TCM formula, while the use of some other formulae, which mainly containing Zingiberaceae, is suggested by the Government for the said purpose. The rationalization of the use of medicinal plants and suggested polyherbal formulae, based on their available pharmacological activity and the bioactive compounds, is also discussed in this review. The use of jamu for COVID-19, however, needs to be carefully considered for the limited scientific data available to support it.

Virtual Screening on Molecules Targeting the Interaction Between Estrogen Receptor Beta and Murine Double Minute 2 Novyananda Salmasfattah; Nunuk Aries Nurulita; Binar Asrining Dhiani
Indonesian Journal of Cancer Chemoprevention Vol 13, No 3 (2022)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev13iss3pp184-194

Estrogen receptor beta (ERβ) is an isoform of estrogen receptor that plays a role in breast cancer. An E3 ubiquitin ligase, murine double minute 2 (MDM2), can bind to ERβ and degrade it. Virtual screening and protein-protein docking studies are one of the approaches that can be performed to discover FDA-approved drugs targeting the interaction of the ERβ-MDM2 complex. This study aimed to conduct virtual screening of 1615 compounds targeting the interaction between ERβ-MDM2 as an initial study to discover potential breast cancer drugs. Biovia Discovery Studio 2021, ClusPro 2.0, PyRx 8.0, and PyMOL software were utilized in this study. ERβ (PDB ID: 3OLS) and MDM2 (PDB ID: 1T4E) receptors were docked to obtain the ERβ-MDM2 protein complex. The ligands used in the virtual screening were FDA-approved drugs downloaded from the ZINC database. PIC and PLIP web tools were also utilized to analyze the amino acid residues involved in the interaction. The virtual screening results showed that ergotamine was the drug with the lowest energy score (-12.0 kcal/mol) among 1057 drugs and was able to establish the strongest interaction between ERβ-MDM2. In conclusion, based on this computational study, ergotamine strengthens the interaction between ERβ-MDM2 and thus could be used as a candidate for breast cancer drug. Thorough validation of in vitro, biochemical, and in vivo studies are needed to confirm this finding.Keywords: Estrogen receptor beta, breast cancer, protein-protein interaction, MDM2.

Co-Authors Adi Garnadi Rahman, Adi Garnadi Anisah Arif Dwi Utomo Astri Puspitasari Caesar, Rahma Yuanita Charisma, Shintia Lintang Dewi Andriyani Didik Setiawan Dwi Hartanti Elis Yuliya Sandi, Elis Yuliya Endah Dwi Setyowati Endah Dwi Setyowati Endah Puspitasari Faisal Akhmal Muslikh Fitriyani Fitriyani Galih Satrio Putra Ihza Ihtimamul Umam Ika Yuni Astuti Indri Hapsari Indri Hapsari M. Dafit Mulyadi Mardhiyyah, Cut Ainul Nabilla, Ishma Yasmin Narendra Istia Putri Nimas Mahataranti Novyananda Salmasfattah Nunuk Aries Nurulita Nunuk Aries Nurulita Pri Iswati Utami Putri, Irsalina Nurul Rahma Yuanita Caesar Rahma Yuanita Caesar Retno Wahyuningrum Salmasfattah, Novyananda Sarmoko Sarmoko Siti Nurjanah Sudarso Sudarso Sugeng Riyanto Sugeng Riyanto Sundhani, Elza Susanti Susanti Tri Setyo Bayuaji, Tri Setyo Wahyuningrum4, Retno Wiranti Sri Rahayu Yulia Ratnasari Yulianto, Akbar

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