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Antidiabetic activity of of green tea ethanol extract on white mouse Rohdiana, Dadan; Firmansyah, Adang; Setiawati, Anik; Yunita, Nuni
Jurnal Penelitian Teh dan Kina Vol 15, No 1 (2012)
Publisher : Research Institute for Tea and Cinchona

In China, India, United State, and some small other countries, tea has been consumed to prevent various disease, such as diabetes mellitus. A number of recent research revealed that consumption of green tea has an impact on the ability of insulin sensitivity in reducing glucose content in human body. Research to know antidiabetic activity of ethanol extract of green tea on experimental rats has been conducted using glucose tolerance method on rats. Results showed that application of 720 mg/kg BW of ethanol extract of green tea at 120, 180, and 240 minutes after application could reduce glucose content in the body. While applications of 180 mg/kg BW and 360 mg/kg BW of ethanol extract of green tea reduced glucose content of the body at 180 and 240 minutes after application respectively.

Dyes Removal from Wastewater by Coral Reef Waste as a Low-Cost Adsorbent Umi Baroroh; Adang Firmansyah; Deni Deni; Lina Maudyawati; Ahmad Zainuddin
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 8, No. 1, May 2022
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v8i1.20673

Despite the positive impact of the rapid industrial growth in Indonesia, it has caused several problems. The non-biodegradable pollutant, such as reactive dyes that result from the textile industry, is harmful to the environment and human health. This contaminating agent should be removed from the waste before being disposed to the surrounding ecosystem. Adsorption is one of the simple and low-cost techniques to eliminate dye from the effluent. Waste from coral reefs is interesting to be explored as a dye-removing adsorbent because it is abundant in nature, cheap, and reusable. Therefore, this study aims to determine the adsorption performance of coral reef waste in removing several dyes, i.e., methylene blue (MB), remazol brilliant blue (RBB), disperse orange (DO), and vinyl sulfone (VS) from wastewater. The adsorption capacity was determined to evaluate the effectiveness of coral reef waste in removing the dyes at the isotherm model. Adsorption capacity and isotherm model were used to evaluate the effectiveness of this natural adsorbent. Based on the percentage removal and coefficient distribution value, the removal selectivity of RBB was the best, followed by DO, VS, and MB, respectively. In conclusion, coral reef waste is promising to be developed as a low-cost adsorbent for removing dyes from wastewater.

Antidiabetic activity of of green tea ethanol extract on white mouse Dadan Rohdiana; Adang Firmansyah; Anik Setiawati; Nuni Yunita
Jurnal Penelitian Teh dan Kina Vol 15 No 1 (2012)
Publisher : Research Institute for Tea and Cinchona

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22302/pptk.jur.jptk.v15i1.19

In China, India, United State, and some small other countries, tea has been consumed to prevent various disease, such as diabetes mellitus. A number of recent research revealed that consumption of green tea has an impact on the ability of insulin sensitivity in reducing glucose content in human body. Research to know antidiabetic activity of ethanol extract of green tea on experimental rats has been conducted using glucose tolerance method on rats. Results showed that application of 720 mg/kg BW of ethanol extract of green tea at 120, 180, and 240 minutes after application could reduce glucose content in the body. While applications of 180 mg/kg BW and 360 mg/kg BW of ethanol extract of green tea reduced glucose content of the body at 180 and 240 minutes after application respectively.

RP-HPLC Method Validation for Purity Assay of α-Mangostin Isolate Ratih, Ratih; Budipramana, Krisyanti; Firmansyah, Adang
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 2 (2023): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i2.6108

The quality of natural products regarding the purity of their active compounds, such as α-mangostin isolate from mangosteen pericarp, may vary depending on cultivation, harvest season, and isolation process. Thus, extensive isolation procedures are involved in obtaining a certain level of purity of the active compounds. Studies on the yield of α-mangostin isolate and its effectiveness as an active compound in health care have been reported. The quality parameter of the isolate as the intended active compound can be indicated by its purity level. Measuring the purity of the active compound is proposed to define the grade α-mangostin isolate as a starting material or even reference standard. The higher the purity level of α-mangostin isolate, the greater its potential as a reference standard candidate. Therefore, a selective analytical method is required to measure the purity level accurately. For this reason, a rapid analytical method to ensure α-mangostin isolate was developed and validated to confirm its purity. Separation condition semployed an X-Terra® C18 column 5 μm, 4.6 x 150 mm under an isocratic system with a mobile phase composition of MeCN:water (85:15) at a flowrate of 0.5 mL/ min and a detector wavelength of 243 nm were selected. Acceptable validation parameters of linearity in the range of 2.6 –52 μg/mL with r2 = 0,9994, Vx0 = 2.64%; accuracy 96.38 – 100.99%; precision 1.36%; and LOD/LOQ = 4.6 μg/mL/ 13.7μg/mL were achieved. The validated method was successfully applied to the purity assay α-mangostinisolate with a run time of less than 9 minutes.

AKTIVITAS IMUNOMODULATOR REGIMEN ISOLAT MANGOSTIN, KURKUMINOID, PIPERIN, METIL SINAMAT DAN VITAMIN C DENGAN METODE CARBON CLEREANCE Fauzi, Novi Irwan; Sari, Nia Kurnia; Fathurrahman, Muhammad Hilmi; Firmansyah, Adang; Ferdiansyah, Rival; Ismayadi, Pupung; Herawati, Irma Erika
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/7sr0rm77

The regimen of test materials consisting of mangostin isolate, curcuminoid, piperine, methyl cinnamate, and vitamin C is combined to help increase body immunity (immunostimulant). Immunostimulant activity testing was carried out using the carbon clearance method. 30 male Wistar rats were randomly divided into 5 groups, namely the normal control group, the comparison drug control, and dose groups I, II and III where the regimen of the test material was given at consecutive doses of 7.2; 72; 720 mg /kg respectively. The treatment was given for 6 days, then a carbon suspension dose of 0.5 mL / BW was given intravenously. Blood samples from the tail vein at 5, 10, and 15 minutes were measured for absorbance using a UV-Vis spectrophotometer at a wavelength of 650 nm. Phagocytosis constant and Phagocytosis Index (IF) were determined to assess immunostimulant activity. The phagocytosis constant in the regimentation of the test material showed a faster pattern in eliminating carbon compared to the normal control group and the reference drug. The regimentation of the test material also had an IF value > 1.5 which is a strong immunostimulant category.

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