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All Journal Biomedical Journal of Indonesia Chimica et Natura Acta Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan SRIWIJAYA JOURNAL OF MEDICINE INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS IJOEP : International Journal of Ecophysiology Indonesia Berdaya Jurnal Kedokteran Raflesia Public Health and Safety International Journal (PHASIJ) (Medical Scientific Journal) MESINA
Siti Rohani
Universitas Muhammadiyah Palembang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Identification of Chemical Constituents in Ethanolic Extract of Hibiscus sabdariffa L. Calyces (Roselle) by FTIR and GC-MS: Preliminary Phytochemical Screening Rohani, Siti; Martha, Fadhil Rizki; Astri, Yesi; Putria, Sinta Julia Liona
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.360

Abstract

Indonesia is widely recognized for its rich biodiversity, which has long served as a valuable resource for traditional herbal medicine. In recent years, interest in plant-based therapies has grown significantly. One such plant, Hibiscus sabdariffa L., commonly known as Rosella, is valued for its therapeutic properties. These benefits arise from the combined effects of its bioactive compounds, allowing it to address a range of health issues. Research has shown that Rosella contains notable levels of flavonoids, saponins, tannins, and alkaloids—all of which contribute to its antibacterial activity. Techniques such as Fourier-transform infrared (FTIR) spectroscopy and gas chromatography–mass spectrometry (GC-MS) are employed to identify these chemical constituents. FTIR analysis has detected functional groups like amines, fatty acids, aldehydes, carboxylic acids, and aromatic rings. Additionally, GC-MS results have indicated the presence of major compounds belonging to the methyl ester group. Noteworthy identified substances include Hexadecanoic Acid Methyl Ester, Hexadecanoic Acid Ethyl Ester, and Benzenepropanoic Acid, 3,5-Bis(1,1-Dimethylethyl)-4-Hydroxy-, Methyl Ester. A review of existing prior research suggests that these compound groups exhibit significant pharmacological potential, including the usage for antioxidant, anticancer, antibacterial, antidiabetic, and anti-inflammatory effects.
Hubungan Lokasi Ovitrap Atraktan Fermentasi Air Cucian Beras terhadap Keberadaan Telur Aedes Rio, Muhammad; Ramayanti, Indri; Rohani, Siti; Prameswarie, Thia; Saraswati, Nia Ayu
MESINA (Medical Scientific Journal) Vol 6, No 1 (2025): Medical Scientific Journal (MESINA)
Publisher : Universitas Muhammadiyah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/msj.v6i1.9334

Abstract

Aedes merupakan vektor utama penyebab Demam Berdarah Dengue (DBD) yang masih menjadi masalah kesehatan di Indonesia, salah satu upaya pengendaliannya dapat dilakukan dengan menggunakan ovitrap dengan penambahan atraktan yaitu fermentasi air cucian beras yang terbukti menghasilkan senyawa ammonia, karbon dioksida dan asam sitrat. Penelitian ini bertujuan untuk mengetahui hubungan penempatan ovitrap dengan keberadaan telur nyamuk Aedes. Desain penelitian ini dengan quasy experiment posttest only. Pengambilan sampel dilakukan dengan teknik purposive sampling, yang didaparkan 6 rumah warga di RT 46, Kelurahan Sukajaya, Kecamatan Sukarami yang merupakan wilayah endemis DBD di Kota Palembang dengan kriteria inklusi yaitu rumah dengan halaman yang cukup luas serta banyak perpohonan. Ovitrap dengan atraktan fermentasi air cucian beras pada penelitian ini diletakkan di luar dan di dalam rumah warga konsentrasi 10%, 30% dan 60% dengan tiga kali ulangan. Analisis data yang digunakan dengan dan Chi-square. Hasil penelitian didapatkan tidak terdapat hubungan antara letak ovitrap dengan keberadaan telur nyamuk Aedes. 
Analysis of Risk Factors Influencing the Incidence of Breast Cancer at Muhammadiyah Palembang Hospital Lulu Salsabila; Fadillah Sayuti; Siti Rohani
JURNAL KEDOKTERAN RAFLESIA Vol 12 No 1 (2026): Juni
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v12i1.47984

Abstract

Breast cancer is a malignant disease that originates in the glandular ducts and supporting tissues of the breast and spreads to other regions of the body through a process known as metastasis. Age, hereditary factors, and dietary patterns contribute to an increased risk of developing breast cancer. This study aimed to evaluate the relationship between age, genetic variables, dietary patterns, and the incidence of breast cancer at the surgical outpatient clinic of Muhammadiyah Palembang Hospital. This study employed an observational analytic approach with a cross-sectional design. The population consisted of patients presenting with breast lumps, with a total of 45 respondents selected through purposive sampling. The findings indicated that 68.9% of the respondents were diagnosed with breast cancer, whereas 31.1% were not. Regarding age, 62.2% of the respondents were aged >40 years and had breast cancer, while 37.8% were aged ≤40 years and did not. Furthermore, 51.1% of the respondents had a family history of breast cancer and were affected by the disease, whereas 48.9% were not. In terms of dietary patterns, 37.8% of the respondents were categorized as having a high-risk diet, and 62.2% were classified as non-high risk. Statistical analysis demonstrated a significant association between age and breast cancer incidence (p < 0.001), as well as between hereditary factors and breast cancer incidence (p = 0.019). Conversely, dietary patterns were not significantly associated with the incidence of breast cancer (p = 0.235). In conclusion, age and hereditary factors are significantly associated with the occurrence of breast cancer, whereas dietary patterns show no significant association.
Shared Mattresses, Combs, and Residential Sanitation Associated with Pediculosis Capitis in Orphanages Qoonitah Salsabiil Putri Istanta; Siti Rohani; Chairil Anwar
Biomedical Journal of Indonesia Vol. 12 No. 2 (2026): Vol 12, No 2, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i2.325

Abstract

Introduction. Head lice infestation (pediculosis capitis) continues to be a widespread health issue among children, especially in orphanages. Pediculosis capitis often occurs due to sharing personal items and poor residential sanitation conditions. Methods. This study applied an observational analytic design using a cross-sectional approach, conducted across nine orphanages in South Sumatra Province. Independent variables included sharing personal items and residential sanitation factors such as occupancy density, ventilation, lighting, temperature, and humidity, while the dependent variable was pediculosis capitis occurrence. Results. Pediculosis capitis prevalence reached 37.7%. Sharing mattresses (p = 0.038) and combs (p = 0.016) showed a significant association with pediculosis capitis, while sharing bed sheets, blankets, pillows, towels, headscarves, prayer garments, and caps was not significantly associated. In terms of residential sanitation, occupancy density (p = 0.002), ventilation (p < 0.001), and lighting (p < 0.001) were significantly related to the occurrence of pediculosis capitis. Meanwhile, temperature (p = 0.678) and humidity (p = 0.585) did not show a significant relationship. Conclusion. Pediculosis capitis occurrence is linked to sharing certain personal items and various residential sanitation factors.
Spectroscopic characterization of rosella flower extract (Hibiscus sabdariffa L.) and its antibacterial activity against Enterobacter aerogenes in suspected typhoid cases Siti Rohani; Fadhil Rizki Martha; Trisnawati Mundijo; Yesi Astri; Malika Zilda; Agnes Melianti
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 7 No 1 (2025): Advances in Biomarkers, Therapeutics, and Probiotics: Recent Updates in Medical L
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v7i1.5577

Abstract

Typhoid, a serious bacterial disease, has spurred research into natural products like rosella (Hibiscus sabdariffa L.) for potential treatments. This study investigates the chemical components found in Rosella extract using spectroscopy approximation, assisted by Fourier transform infrared spectroscopy (FTIR) and Gas chromatography–mass spectrometry (GC–MS). The antibacterial activity of rosella extract on bacteria from stool cultures of suspected typhoid cases continues to be evaluated. The antibacterial experimental employed a post-test-only control group design, using 30 μg Chloramphenicol as a positive control, sterile distilled water as the negative control, rosella extract at concentrations of 25%, 50%, 75%, and 100% as the observed variable. Stool samples from typhoid patients were identified, and Enterobacter aerogenes were detected using VITEK®2 testing. Cultivated bacteria from the samples were tested to determine the antibacterial activity of the rosella extract. Phytochemical studies confirmed the presence of tannins, alkaloids, flavonoids, and saponins in the rosella extract. Additionally, the spectroscopic evaluation from FTIR and GC-MS showed the presence of chemical groups, including esters, aldehydes, and aromatics. Further clinical tests demonstrated antibacterial activity at the minimum inhibitory concentration. The results showed an increasing inhibition zone of bacterial growth, correlating with the increase in rosella extract concentration. Although the antibacterial activity of rosella extract was lower compared to commercial Chloramphenicol, this natural product has demonstrated antibacterial activity and shows potential as a candidate for future herbal medicine development.
Co-Authors Agnes Melianti Al Farizi, Ahmad Bayu Budi Utama Chairil Anwar Dwiryanti, Rizki Fadhil Rizki Martha Fadillah Fadillah, Yudhi Humaidi, Irfan Ahmad Indri Ramayanti Laila M.K, Putri Zalika Laila Rahmawati Liza Chairani Lulu Salsabila Lutfiah Hafidzah Malika Zilda Martha, Fadhil Rizki Melianti, Agnes Mitayani Purwoko, Mitayani Muhammad Umar Mundijo, Trisnawati Prameswarie, Thia Putria, Sinta Julia Liona Qoonitah Salsabiil Putri Istanta Raisha, Zafira Ananda Rio, Muhammad Saraswati, Nia Ayu Suarni, Ertati Trisnawati Vina Pramayastri Yanti Rosita Yesi Astri Zilda, Malika