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All Journal Jurnal Farmasi Klinik Indonesia INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia Syntax Literate: Jurnal Ilmiah Indonesia JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Ilmu Kefarmasian Indonesia Journal of Pharmaceutical and Sciences.
Zazuli, Zulfan
Department Of Pharmacology, Clinical Pharmacy, School Of Pharmacy Institut Teknologi Bandung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Future Prospects for Pharmacogenomics of Immune Checkpoint Inhibitors Cardiotoxicity Aryantha, Hasna Firdaus; Wisasani, Amiiratu Muthiia; Anggadiredja, Kusnandar; Zazuli, Zulfan
Indonesian Journal of Clinical Pharmacy Vol 13, No 1 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2024.13.1.34

Abstract

Immune checkpoint inhibitors (ICIs), including PD-1, PD-L1, and CTLA-4 inhibitors, have revolutionized cancer therapy but are associated with immune-related adverse events (IRAEs). Among these, ICI-associated cardiotoxicity is an uncommon yet serious complication, often resistant to glucocorticoid therapy, which effectively manages most IRAEs. A pharmacogenomic approach might be useful in prescribing ICIs and screening for relevant clinically measurable phenotypes such as the history of autoimmune diseases and cardiovascular disorders. This review explores the impact of genetic variations on ICI-associated cardiotoxicity, the mechanistic basis behind it, potential clinical applications, and directions of the future on how pharmacogenomics can assist oncologists in reducing the risk of cardiotoxicity. Evidence-based hypotheses on how ICI-associated cardiotoxicity occurs suggest that genetic differences might play a role in ICI response, especially regarding cardiotoxic IRAEs. Pharmacogenomic studies and multi-omics profiling might provide valuable insight regarding ICI-induced cardiotoxicity. They could be implemented to make fine-tuned clinical decisions for individual patients in the future.
Perceptions, Expectations, Reality, and Public Confidence Regarding the Role of Pharmacists in Pharmacy Services in Bandung Zazuli, Zulfan; Anjasmara, Aulia Putri; Amalia, Lia
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 14, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.87938

Abstract

Background: The shifting from the old paradigm to the new paradigm with the philosophy of pharmaceutical care demands pharmacists to enhance the quality of pharmaceutical services. However, this role has not been optimally fulfilled, especially in the community setting.Objectives: This study aimed to identify the perceptions and expectations, the gap between expectations and reality, and public confidence as well as to analyze the relationship between sociodemographic factors and the perceptions, expectations, and public confidence in Bandung City regarding the role of pharmacists in pharmaceutical services.Methods: A cross-sectional study was conducted using a validated survey instrument with 440 respondents in Bandung, West Java, from March to April 2023. The survey data were analyzed descriptively and through inferential statistics.Results: The analysis showed that 58.41% of the community had a positive perception, 56.82% had high expectations, the average gap between expectations and reality was 14.04%, and more than 51.36% had a high level of public confidence in pharmacists. Sociodemographic factors influencing perceptions were age and the highest level of education (p = 0.005; p = 0.003), factors influencing public confidence were age, the highest level of education, residence address according to ID card (KTP), and occupation (p < 0.001; p = 0.034; p = 0.001; p = 0.001), and the factor influencing expectations was the residence address according to ID card (KTP) (p = 0.043). A correlation was found between the dimensions of perceptions, expectations, and public confidence.Conclusion: Most participants held a positive perception, had high expectations, and shown high confidence in the pharmacist's position, despite the existence of a disparity between expectations and the actual provision of pharmacy services. The elements of perception, expectations, and confidence are interrelated.
Dampak Intervensi Edukasi dan Aplikasi Pengingat Minum Obat terhadap Pengetahuan dan Kepatuhan Pasien Tuberkulosis Paru di Puskesmas di Kota Bandung Reyaan, Irianti Bahana Maulida; Faustincia, Ivena; Zazuli, Zulfan
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 13, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.88408

Abstract

Tuberculosis (TB) patient compliance with ongoing therapy and knowledge regarding TB has an impact on the cure rate. Despite implementing various strategies, the prevalence of TB in Indonesia remains high, and the success rate of its treatment is still below the global average, potentially leading to continued transmission of TB within the community. This study aims to determine the improvement of knowledge and compliance among pulmonary TB patients following an intervention involving education and the use of a medication reminder application in two community health centers in the city of Bandung. The research design was experimental, where 29 subjects recruited were randomized into two groups: one group receiving additional education and introduction to the mobile application (Jadwal Minum Obat), and the other group receiving only counseling at the health centers. Primary data that was collected include baseline test scores and final test scores of subjects based on the KATUB-Q questionnaire. Patient compliance was assessed using the self-assessment method with the MARS-5 questionnaire and the pill count method. The subjects' experiences in the intervention group while using the mobile application were also documented. A total of 16 subjects completed the study. The education method and medication reminder application used in this study have not significantly improved the knowledge and compliance of pulmonary TB patients in taking their medication (p > 0.05). However, percentage of consumed medication compared to the prescribed medication in the intervention group higher than the control group (87.4 ± 4.8% vs 78.8 ± 8.3%). Subjects found the application useful, though there were still some shortcomings. Further research with a larger sample size using an improved medication reminder application is needed.
Analisis Kepatuhan Pengobatan Antiretroviral Tenovir-Lamivudin -Dolutegravir (TLD) di Salah Satu Puskemas di Kota Bandung Basuki, Basuki; Amalia, Lia; Zazuli, Zulfan; Rukmawati, Iis; Akromy, Muhammad Zidan Fikri
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i12.17132

Abstract

Kepatuhan (adherence) adalah minum obat sesuai dosis, tidak pernah lupa, tepat waktu, dan tidak pernah putus. Kepatuhan dalam meminum Antiretroviral merupakan faktor terpenting dalam menekan jumlah virus HIV dalam tubuh manusia.Kepatuhan minum obat ARV <80% merupakan suatu prediktor bagi kegagalan pengobatan HIV. WHO merekomendasikan dolutegravir sebagai terapi yang lebih dianjurkan sebagai terapi lini pertama ataupun terapi lini kedua pada pasien HIV yang sebelumnya gagal dengan pengobatan regimen tanpa dolutegravir. Penelitian ini bertujuan untuk menganalisis dan evaluasi kepatuhan pasien pengguna terapi Kombinasi Dosis Tetap (KDT) TLD di salah satu puskesmas di Kota Bandung serta faktor-faktor yang mempengaruhi kepatuhan pengobatan. Hal ini untuk meningkatkan keberhasilan terapi KDT TLD bagi pasien HIV positif di puskesmas. Jenis Penelitian ini observasional analitik dengan pendekatan menggunakan desain cross sectional. Pengumpulan data dilakukan secara retrospektif menggunakan data sekunder berupa catatan rekam medis, data Sistem Informasi HIV AIDS (SIHA) Kemenkes serta laporan pill count penggunaan obat. Dari 161 orang populasi yang memenuhi kriteria inklusi, sebanyak 143 orang (88,82%) pasien yang menggunakan terapi KDT TLD patuh dan 18 orang (11,18%) tidak patuh terhadap pengobatan ARV KDT TLD yang sedang dijalaninya. Analisis Faktor-Faktor yang mempengaruhi kepatuhan pengobatan KLD TLD dengan uji chi square dan stepwise menunjukan bahwa jenis kelamin dengan p-value = 0,000 mempunyai pengaruh yang signifikan terhadap kepatuhan pengobatan pasien, begitupun dengan usia p-value= 0,000. Hal ini menunjukan bahwa variabel jenis kelamin dan usia pasien mempengaruhi secara signifikan terhadap kepatuhan pengobatan pasien penerima terapi KDT TLD.
Pengetahuan, Sikap, dan Perilaku Pengguna Metode Kontrasepsi Jangka Panjang dan Pendek di Daerah Terpencil Indonesia Hani Sri Fitriani; Pratiwi Wikaningtyas; Zulfan Zazuli
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1507

Abstract

The use of long-acting contraceptive methods (LACMs) in Indonesia remains relatively low despite government efforts to increase their adoption to reduce maternal and child mortality. This study aims to examine differences in knowledge, attitudes, and practices (KAP) between LACM users and non-LACM users, as well as to identify factors influencing contraceptive method selection among women of reproductive age in a rural area of Indonesia. A cross-sectional design was employed involving 394 respondents selected through Cluster Random Sampling, all of whom completed validated and reliable questionnaires. Data were analyzed descriptively. The Mann–Whitney test was used to compare KAP between LACM and non-LACM users. Chi-square tests and logistic regression analysis were conducted to identify factors associated with contraceptive method selection. The results showed significant differences between the two groups. LACM users demonstrated higher levels of knowledge, more positive attitudes, and better contraceptive practices compared with non-LACM users. Factors associated with LACM use included high knowledge (OR = 2.415; p = 0.001), education above primary school level (OR = 7.03; p = 0.003), exposure to print media (OR = 28.331; p = 0.000), and obtaining contraceptives from community health centers (OR = 6.6; p = 0.009). In conclusion, short-acting contraceptive users exhibited lower knowledge, attitudes, and practices than LACM users. Therefore, individuals with low KAP levels should be prioritized in reproductive health education and promotion programs.
Co-Authors Akromy, Muhammad Zidan Fikri Anjasmara, Aulia Putri Aryantha, Hasna Firdaus Basuki , Bhekti Pratiwi Cahyono, Nur Sidik Cherry Rahayu Elin Y. Sukandar Fadhila, Genialita Faustincia, Ivena Furqani, Winda Haniva Hani Sri Fitriani Hendrayana, Tomi I Ketut Adnyana I Ketut Adnyana Ida Lisni Keri Lestari Kogilavani Ramasamy Kusnandar Anggadiredja LIA AMALIA Nabilah Nadhif Nugrahani, Retta Pratiwi Wikaningtyas Pratiwi, Bhekti Putri, Suci Utami Ayungga Rahayu, Cherry Rahmawati, Siti Farah Ramasamy, Kogilavani Retta Nugrahani Reyaan, Irianti Bahana Maulida Rizky Abdulah Rukmawati, Iis Shalvierra Polyta Fitriah Siti Saidah Suwendar Suwendar Tomi Hendrayana Winda H. Furqani Wisasani, Amiiratu Muthiia