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All Journal Bioscience Jurnal Kartika Kimia
Siti Nurbayti
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Immunology & microbiology

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Antioxidant Activity, Total Phenolic and Flavonoid Content of Honey Bee Narti Fitriana; Risya Raisyah; Siti Nurbayti; Festy Auliaur Rahmah
Bioscience Vol 7, No 2 (2023): Biology
Publisher : UNIVERSITAS NEGERI PADANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/bsc.v7i2.125200

Abstract

Honey is a natural product that has many benefits,for living organism. The composition of honey is very diverse and depends on the type of honey and the region of origin. Bioactive compounds in honey including phenolics and flavonoids cause honey to having antioxidant activity. This study aims to identify honey bees, determine the chemical properties of honey based on the parameters of water content, acidity, and reducing sugar, and analyze the antioxidant activity and phenolic and flavonoid content of honey from Bukit Tiga Puluh National Park Riau and Prabumulih South Sumatra. The research using descriptive method were morphological identification of bees, testing parameters of honey bee chemical properties, DPPH antioxidant test to obtain IC50 (Inhibition consenteration) values, total phenolic and flavonoid levels. The identified bees are Apis mellifera (from Riau) and A. dorsata (from Prabumulih). This essay showed that the determination of water content, acidity, reducing sugar, both honeys fulfill SNI 8664:2018 except the reducing sugar of A. dorsata honey bee. A. dorsata honey bee has antioxidant activity higher IC50 value (590 mg/L) than A. mellifera honey (678 mg/L). Total phenolic (TPC) and flavonoid (TFC) of A. mellifera honey were 7.51 mg GAE/g and 0.06 mg QE/g, respectively higher than A. dorsata honey bee (3.35 mg GAE/g and 0.42 mg QE/g).
Aktivitas Penghambatan α-Glukosidase secara in vitro dan in silico serta Penurunan Glukosa Darah pada Mencit dari Ekstrak Etanol Biji Gandaria (Bouea macrophylla) Tarso Rudiana; Eneng Elda Ernawati; Ayu Sunayah; Nuzulia Romadlotun Nikmah; Hasanah Hasanah; Siti Sawalia; Lia Permatasari; Arini Khaerunnisa; Dimas Danang Indriatmoko; Swastika Oktavia; Siti Nurbayti; Muhammad Ihda Hamlu Liwatu Zein
Jurnal Kartika Kimia Vol 9 No 1 (2026): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v9i1.1054

Abstract

Gandaria (Bouea macrophylla) merupakan tumbuhan topis mengandung senyawa golongan fenolik dan flavonoid yang dapat dimanfaatkan sebagai antidiabetes. Penelitian ini bertujuan untuk mengidentifikasi senyawa metabolit sekunder pada ekstrak etanol biji B. macrophylla, menentukan potensi antidiabetes melalui inhibisi enzim α-glukosidase secara in vitro dan in silico serta menentukan penurunan kadar gula darah secara in vivo. Ekstrak etanol biji B. macrophylla memiliki % rendemen sebesar 31,74% dengan kandungan metabolit sekunder seperti flavonoid, fenolik, alkaloid, saponin dan triterpenoid. Hasil analisis UPLCMS/MS ekstrak etanol biji B. macrophylla mengandung senyawa asam 3,4-dihidroksimandelat, larisitrin dan L-(-)-fenilalanin serta dapat menginhibisi enzim α-glukosidase dengan nilai IC50 sebesar 22,5627 µg/mL. Secara in silico senyawa L-(-)-fenilalanin dan larisitrin memiliki nilai energi bebas dan Konstanta inhibisi terbaik pada inhibisi enzim α-glukosidase (PDB ID: 3L4Y). Studi in vivo ekstrak etanol biji B. macrophylla dapat menurunkan kadar gula darah pada mencit Mus muscullus yang diinduksi aloksan sebesar 63,0 % pada dosis 500 mg/kg BB. Senyawa golongan fenolik dan flavonoid diduga berperan dalam menginhibisi enzim α-glukosidase secara in vitro dan in silico serta dalam menurunkan kadar gula darah mecit.
Co-Authors Arini Khaerunnisa Ayu Sunayah Dimas Danang Indriatmoko Eneng Elda Ernawati Festy Auliaur Rahmah hasanah hasanah Lia Permatasari Muhammad Ihda Hamlu Liwatu Zein Narti Fitriana Nuzulia Romadlotun Nikmah Risya Raisyah Siti Sawalia Swastika Oktavia Tarso Rudiana, Tarso