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All Journal Alchemy : Journal of Chemistry Jurnal Fitofarmaka Indonesia Jurnal Kartika Kimia Jurnal Farmasi Indonesia Pharmaceutical And Biomedical Sciences Journal (PBSJ) International Journal Mathla'ul Anwar of Halal Issues International Journal of Medicine and Health Jurnal Pengabdian Pada Masyarakat Pharmacon: Jurnal Farmasi Indonesia Journal of Pharmascience
Arini Khaerunnisa
Universitas Mathla'ul Anwar
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Aktivitas Fraksi Air Kulit Batang Mahoni (Swietenia macrophylla King.) dan Studi In Silico Senyawa Kimia Penghambat Enzim α-Glukosidase Khaerunnisa, Arini; Djamil, Ratna; Sulastri, Lilik; Simanjuntak, Partomuan
Jurnal Fitofarmaka Indonesia Vol 9, No 1 (2022): JURNAL FITOFARMAKA INDONESIA
Publisher : Jurnal Fitofarmaka Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i1.800

Abstract

 Inhibition of the α-glucosidase can be used as antidiabetic therapy because it can reduce postprandial blood sugar levels. The stem bark of mahogany (Swietenia macrophylla King.) have properties as inhibitors of enzyme α-glucosidase. The purpose of this study was to determine the active compound of mahogany stem bark against α-glucosidase enzyme in vitro and in silico. 96% ethanol extract of mahogany stem bark was partitioned with n-hexane, ethyl acetate and water. Testing of inhibition of α-glucosidase enzyme work done with substrate p-nitrophenyl-α-D-glucopyranoside. The water fraction was separated on silica gel column chromatography (SiO2 : dichloromethane-methanol = 10 : 1 ~ 1 : 1 and methanol). Molecular docking using AutoDock 4.2.6 was performed to predict the binding modes of α-glucosidase enzyme with chemical compound from water subfraction of stem bark mahogany. The results showed that water fraction of stem bark mahogany have antidiabetic activity with IC50 value of 1.51 µg/mL. Fraction Fr-1 gave an inhibition of 83.61 ± 1.11 %. Fr-1 contains chemical compound catechin, evodionol, swietenitin E, 11-deoxyswienialide D, swietenitin J and H. In silico study showed that catechin and evodionol free energy value (ΔG) -6.98 and -6.25 Kcal/mol and inhibition constanta (Ki) 7.61 and 26.18 µM.
Aktivitas Fraksi Air Kulit Batang Mahoni (Swietenia macrophylla King.) Dan Studi In Silico Senyawa Kimia Penghambat Enzim α-Glukosidase Arini Khaerunnisa; Ratna Djamil; Lilik Sulastri; Partomuan Simanjuntak
Jurnal Fitofarmaka Indonesia Vol 9, No 1 (2022): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i1.807

Abstract

Inhibition of the α-glucosidase can be used as antidiabetic therapy because it can reduce postprandial blood sugar levels. The stem bark of mahogany (Swietenia macrophylla King.) have properties as inhibitors of enzyme α-glucosidase. The purpose of this study was to determine the active compound of mahogany stem bark againstα-glucosidase enzyme in vitro and in silico. 96% ethanol extract of mahogany stem bark was partitioned with n-hexane, ethyl acetate and water. Testing of inhibition of α-glucosidase enzyme work done with substrate p-nitrophenyl-α-D-glucopyranoside. The water fraction was separated on silica gel column chromatography (SiO2 : dichloromethane-methanol = 10 : 1 ~ 1 : 1 and methanol).Molecular docking using AutoDock 4.2.6 was performed to predict the binding modes of α-glucosidase enzyme with chemical compound from water subfraction of stem bark mahogany. The results showed that water fraction of stem bark mahogany have antidiabetic activity with IC50 value of 1.51 µg/mL. Fraction Fr-1 gave an inhibition of 83.61 ± 1.11 %. Fr-1 contains chemical compound catechin, evodionol and swietenitin K. In silico study showed that catechin and evodionol free energy value (ΔG) -6.98 and -6.25 Kcal/mol and inhibition constanta (Ki) 7.61 and 26.18 µM.
ILMU KEFARMASIAN DALAM DUNIA ISLAM Arini Khaerunnisa; Dimas Danang Indriatmoko
International Journal Mathla’ul Anwar of Halal Issues Vol. 3 No. 1 (2023)
Publisher : Universitas Mathla’ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ilmu farmasi saat ini telah berkembang dengan pesat, dan telah terjadi perubahan orientasi dalam perkembangan tersebut, yang dahulu berorientasi pada produk sekarang berorientasi pada pasien. Perkembangan ilmu farmasi ini tidak bisa dilepaskan dari dunia Islam. Turunnya Al-Qur’an serta ajaran Islam yang disampaikan Rasulullah SAW mengajarkan prinsip-prinsip pengobatan yang mengandung nilai-nilai yang tinggi dan mulia. Prinsip ini sama sekali menolak cara-cara pengobatan jahiliah yang berdasarkan pada nilai perdukunan serta cara lainnya yang tidak sesuai dengan syariat seperti yang telah dilakukan oleh orang terdahulu. Banyak tokoh-tokoh Islam yang menghidupkan ilmu farmasi serta ilmu-ilmu lain yang berkaitan dengannya sehingga ilmu farmasi dapat lebih berkembang dengan pesat. Tokoh-tokoh tersebut juga membentuk pondasi dalam perkembangan ilmu farmasi saat ini.
Penyuluhan DAGUSIBU Obat Sebagai Upaya Peningkatan Pengetahuan Masyarakat di Desa Kutakarang – Cibitung, Kabupaten Pandeglang Eka Yulli Kartika; Arini Khaerunnisa; Dhyneu Dwi Jayanti; Eneng Elda Ernawati; Candra Junaedi; Dimas Danang Indriatmoko; Tarso Rudiana; Cory Novi; Agus Setiawan; Dwi Marwati Juli Siswanti; Gina Siti Nurhayati; Hadi Susilo; Swastika Oktavia
Jurnal Pengabdian Pada Masyarakat Vol 8 No 4 (2023): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/jppm.v8i4.662

Abstract

Swamedikasi (pengobatan sendiri) meningkat dikalangan masyarakat, tidak terkecuali masyarakat di Desa Kutakarang, Cibitung Kabupaten Pandeglang. Hal ini perlu diimbangi dengan pengetahuan cara mengelola obat dengan baik dan benar agarr obat dapat memberikan efek terapeutik yang diharapkan dan menghindari kesalahan dalam penggunaan dan pengelolaan obat. DAGUSIBU adalah dapat, guna, simpan dan buang obat dengan benar merupakan salah satu upaya peningkatan penggunaan obat bagi masyarakat yang diselenggarakan melalui kegiatan pelayanan kesehatan oleh tenaga kefarmasian. Pelayanan kesehatan yang dapat diberikan tenaga kefarmasian kepada masyarakat yakni kegiatan pemberian informasi tentang penggunaan dan penyimpanan sediaan farmasi dan alat kesehatan. Tujuan pengabdian ini adalah peningkatan pengetahuan masyarakat dalam memahami cara mendapatkan, menggunakan, menyimpan dan membuang obat, serta memahami cara mengkonsumsi obat dengan baik dan benar. Metode yang digunakan adalah presentasi dan penyulihan. Peserta kegiatan sosialisasi tentang DAGUSIBU berjumlah 54 peserta. Para peserta yang hadir sangat antusias dalam mendengarkan penjelasan dan aktif bertanya terkait penggunaan obat dan penanganannya. Harapan setelah Pengabdian kepada Masyarakat ini, yaitu peserta dapat lebih memahami dalam mengkonsumsi dan mengelola obat dengan baik dan benar. Self-medication is increasing among the community, including the people in Kutakarang Village, Cibitung, Pandeglang Regency. This needs to be balanced with knowledge of how to administer drugs properly and correctly so that drugs can provide the expected therapeutic effect and avoid errors in drug use and management. DAGUSIBU is getting, using, storing and disposing of drugs properly is one of the efforts to increase the use of drugs for the community which is organized through health service activities by pharmacists. Health services that can be provided by pharmacists to the community are the activities of providing information about the use and storage of pharmaceutical preparations and medical devices. The purpose of this service was to increase public knowledge in understanding how to obtain, use, store and dispose of drugs, and understand how to take drugs properly and correctly. The method used is presentation and lecture. Socialization activities about DAGUSIBU went well. There were 54 participants in this activity. The participants who attended were very enthusiastic in listening to explanations and actively asked questions regarding the use of drugs and their treatment. The hope after this Community Service is that participants can have a better understanding of consuming and managing drugs properly and correctly.
Sediaan Gel dari Kombinasi Ekstrak Buah Gandaria (Bouea macrophylla Griff.) dan Ekstrak Belimbing Wuluh (Averhoa bilimbi L) dan Bioaktivitasnya Jayantie, Dhyneu Dwi; Khaerunnisa, Arini; Renaldy, Renaldy; Suryani, Nani; Rudiana, Tarso
ALCHEMY:Journal of Chemistry Vol 12, No 1 (2024): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v12i1.23451

Abstract

Melanin is the main pigment thfunctions to protect the skin from exposure to ultraviolet light, excessive melanin synthesis can cause skin hyperpigmentation. A. bilimbi and B. macrophylla fruits have bioactive compounds such as phenolics, flavonoids that function as antioxidants and tyrosinase inhibitors. This study aims to formulate a gel preparation of a combination of fruit extracts of A. bilimbi and B. macrophylla, test antioxidant activity using the DPPH method, and test tyrosinase inhibition enzymes. Three formulas were made, namely F0 (Basis), FI (50x extract), and FII (100x extract). Physical evaluation includes organoleptic, homogeneity, pH, adhesion, spreadability, viscosity, viscosity and irritation. Test of antioxidant activity and tyrosinase enzyme inhibition. Then the data were analyzed descriptively and statistically. The results of the evaluation of homogeneous preparations, dispersion, pH, viscosity, mandatory, meet the standards. Adhesion below standard, irritation test (mild irritation). The results of IC50 antioxidants were F0 (2,352 ppm), FI (1,448 ppm), FII (419,74 ppm) and gel brand x (77,429 ppm). The results of the tyrosinase inhibition test were the highest concentration of 10% F0 (7.828%), a concentration of 10% FI (18.245%), a concentration of 10% FII (25.814) kojic acid gel (brand x) as a comparison with a concentration of 10% (51.211%). The higher the concentration used, the greater the inhibition of the tyrosinase enzyme produced
Penambatan Molekul Senyawa Swietemacrophyllanin dari Kulit Batang Mahoni (Swietenia macrophylla King,) sebagai Inhibitor Enzim Alfa Glukosidase Arini Khaerunnisa; Ratna Djamil; Lilik Sulastri; Tarso Rudiana; Partomuan Simanjuntak
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 2 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.32926

Abstract

Mahogany (Swietenia macrophylla King.) is one of the plants used as an antidiabetic agent. 96% ethanol extract of S. macrophylla stem bark can inhibit the α-glucosidase enzyme. Methanol and aqueous extracts of S. macrophylla stem bark can reduce rat blood glucose levels induced by streptozotocin. Molecular docking is one of the most widely used structural-based drug design strategies due to its wide application in the analysis of binding energy and molecular interactions between drug compounds and receptors. This study aims to identify the compounds in the stem bark of S. macrophylla and analyze the molecular anchoring of the compounds produced by the aid. The research was carried out by means of the water fraction of the stem bark of S. macrophylla and was purified by column chromatography. Fraction 2 was identified by LCMS-MS. Molecular docking using AutoDock 4.2.6. The results of Fraction 2 showed the presence of catechins, evodionol, swietemacrophyllanin, swietenitin K and β-sitosterol. The results of an in-silico study showed that swietemacrophyllanin provided a better affinity than acarbose with a binding energy value of -8.57 kcal/mol and an inhibition constant of 0.52 µM. Forms hydrogen bonds with catalytic residues (Glu277 and Asp352) from the active site of the α-glucosidase enzyme. Swietemacrophyllanin has potential as an antidiabetic agent
Standardisasi Ekstrak Khaya (Khaya anthotheca) Sebagai Antikanker Payudara MCF-7 (Michigan Cancer Foundation-7) Parwaz Setaviani; Nani Suryani; Zahra Khaerul Kamila; Siti Amaliya; Eneng Elda Ernawati; Tarso Rudiana; Arini Khaerunnisa
Jurnal Farmasi Indonesia Vol 21 No 2 (2024): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v21i2.2475

Abstract

Cancer is the second non-communicable disease that causes the largest number of deaths after cardiovascular disease. The chemical compounds contained in the Khaya anthotheca plant and which have anticancer activity include methyl angolensate, 7-deacetylhivorin, grandifolione, gedunin, , obacunone and Cathecin. This research aims to determine the standardization of extracts and determine anticancer activity against MCF-7 breast cancer cells. The method used in this research is standardization of specific and non-specific parameters, and cytotoxic testing using Prestoblue. The results of extract standardization of specific parameters have values ​​for soluble essence in water and ethanol of 4.68% and 5.80% (meeting the requirements). Non-specific parameters drying loss 0.739%, ash content 8.02%, microbial contamination 0 colonies, lead (Pb) 0.2976 mg/kg, cadmium (Cd) ≤0.001 mg/kg (qualified) and IC₅₀ value of anticancer activity breast MCF-7 from Khaya anthoteca extract was 194.20 µg/mL in the medium/moderate category
Perbandingan Aktivitas Antioksidan dan Antikolesterol serta Kandungan Fenolik dan Flavonoid dari Ekstrak Khaya (Khaya anthotheca) Suryani, Nani; Komalasari, Komalasari; Sulistriyani, Sulistriyani; Rudiana, Tarso; Ernawati, Eneng Elda; Indriatmoko, Dimas Danang; Jayantie, Dhyneu Dwi; Khaerunnisa, Arini
Jurnal Kartika Kimia Vol 8 No 1 (2025): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v8i1.906

Abstract

Hypercholesterolemia is closely related to cardiovascular disease, which can increase the risk of atherosclerosis. Oxidative stress is related to the development of atherosclerosis because it is related to cellular responses triggered by an imbalance between oxidants and reductants in various layers of blood vessel tissue. K. anthotheca has pharmacological benefits as an antileishmaniasis and antimalarial. The purpose of this study was to determine the antioxidant and anticholesterol activity of K. anthotheca bark based on the type of solvent and to determine the phenolic and flavonoid content of the most active extract. The results indicated that ethyl acetate extract had the best antioxidant activity compared to n-hexane and ethanol extracts, with an IC50 value of 47.82 ppm, followed by ethanol extract at 48.46 ppm and n-hexane extract at 101.89. The value of antioxidant activity is directly proportional to the anticholesterol activity, where the ethyl acetate extract has an EC50 value of 20.42 ppm, the ethanol extract 445.58 ppm, and the n-hexane extract 1,073 ppm. The ethyl acetate extract has a phenolic content of 229.765 mgGAE/g extract and a flavonoid content of 7.63 mgQE/g.
Peningkatan Pengetahuan Siswa dan Siswi SMA Presiden 2 Tanjung Lesung melalui Pelatihan Pembuatan Sabun Cair Ekstrak Daun Sisik Naga Kartika, Eka Yulli; Oktavia, Swastika; Junaedi, Candra; Indriatmoko, Dimas Danang; Jayantie, Dhyneu Dwi; Ernawati, Eneng Elda; Khaerunnisa, Arini; Suryani, Nani; Nurhayati, Ghina Siti; Siswanti, Dwi Marwati Juli; Novi, Cory; Setiawan, Agus
Jurnal Pengabdian Pada Masyarakat Vol 10 No 2 (2025): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/jppm.v10i2.1033

Abstract

Sabun terbentuk melalui reaksi antara asam lemak dan basa kuat, dan umumnya digunakan sebagai pembersih untuk menghilangkan kotoran pada kulit. Salah satu jenis sabun yang diminati pada saat ini oleh masyarakat yaitu sabun cair. Hal ini dikarenakan penggunaannya yang lebih praktis dan efisien. SMA Presiden 2 Tanjung Lesung merupakan sekolah umum semi militer yang memiliki 2 bidang ilmu yaitu IPA dan IPS. Kegiatan ini bertujuan untuk memberikan pengetahuan dan keterampilan kepada siswa/i SMA Presiden 2 Tanjung Lesung tentang pengaplikasian ilmu dan tekonologi dalam menghasilkan sabun mandi. Metode kegiatan yang dilakukan berupa pemaparan materi dan pelatihan pembuatan sabun cair dengan campuran ekstrak daun sisik naga (bahan alam) serta memberikan kuisioner berupa pretest dan postest untuk mengetahui pengaruhnya kepada siswa/i. Hasilnya didapatkan bahwa terdapat peningkatan pengetahuan dari kegiatan pengabdian kepada masyarakat (PKM) dari nilai rata-rata prestest 70,23 menjadi 86,28 untuk nilai posttest. Soap is formed through a reaction between fatty acids and a strong base and is commonly used as a cleanser to remove dirt from the skin. One type of soap that is currently popular among the public is liquid soap due to its practical and efficient use. SMA Presiden 2 Tanjung Lesung is a semi-military public school that offers two fields of study: Science and Social Studies. This activity aims to provide knowledge and skills to the students of SMA Presiden 2 Tanjung Lesung on the application of science and technology in producing bath soap. The methods used in this activity include material presentation, hands-on training in making liquid soap with dragon scale leaf extract (a natural ingredient), and pretest and post-test to measure the impact. The results showed an increase in knowledge from this community service activity, with the average pretest score rising from 70.23 to an average post-test score of 86.28.
Penambatan Molekul Senyawa Swietemacrophyllanin dari Kulit Batang Mahoni (Swietenia macrophylla King,) sebagai Inhibitor Enzim Alfa Glukosidase Khaerunnisa, Arini; Djamil, Ratna; Sulastri, Lilik; Rudiana, Tarso; Simanjuntak, Partomuan
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.32926

Abstract

Mahogany (Swietenia macrophylla King.) is one of the plants used as an antidiabetic agent. 96% ethanol extract of S. macrophylla stem bark can inhibit the α-glucosidase enzyme. Methanol and aqueous extracts of S. macrophylla stem bark can reduce rat blood glucose levels induced by streptozotocin. Molecular docking is one of the most widely used structural-based drug design strategies due to its wide application in the analysis of binding energy and molecular interactions between drug compounds and receptors. This study aims to identify the compounds in the stem bark of S. macrophylla and analyze the molecular anchoring of the compounds produced by the aid. The research was carried out by means of the water fraction of the stem bark of S. macrophylla and was purified by column chromatography. Fraction 2 was identified by LCMS-MS. Molecular docking using AutoDock 4.2.6. The results of Fraction 2 showed the presence of catechins, evodionol, swietemacrophyllanin, swietenitin K and β-sitosterol. The results of an in-silico study showed that swietemacrophyllanin provided a better affinity than acarbose with a binding energy value of -8.57 kcal/mol and an inhibition constant of 0.52 µM. Forms hydrogen bonds with catalytic residues (Glu277 and Asp352) from the active site of the α-glucosidase enzyme. Swietemacrophyllanin has potential as an antidiabetic agent
Co-Authors Agus Setiawan Ayu Febi Lestari Ayu Sunayah Candra Junaedi Cory Novi Dhyneu Dwi Jayantie Dhyneu Dwi Jayantie Dhyneu Dwi Jayantie Dimas Danang Indriatmoko Dimas Danang Indriatmoko Dimas Danang Indriatmoko Djamil, Ratna Dwi Marwati Juli Siswanti Eka Yulli Kartika Eneng Elda Ernawati Eneng Elda Ernawati Eva Vauziah Fatimah Zahra Gina Siti Nurhayati Hadi Susilo hasanah hasanah Indriatmoko, Dimas Danang Irfan Iryana Iryana, Irfan Jayantie, Dhyneu Dwi Kartika, Eka Yulli Komalasari Komalasari Lia Permatasari Lilik Sulastri Muhammad Ihda Hamlu Liwatu Zein Nani Suryani Nani Suryani Nani Suryani Nurhayati, Ghina Siti Nurul Hida Nuzulia Romadlotun Nikmah Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Parwaz Setaviani Ratna Djamil Ratna Djamil Renaldy, Renaldy Siswanti, Dwi Marwati Juli Siti Amaliya Siti Nurbayti Siti Sawalia Sulistriyani, Sulistriyani Sutihat Sutihat Swastika Oktavia Swastika Oktavia Tarso Rudiana Tarso Rudiana, Tarso Vauziah, Eva Zahra Khaerul Kamila