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All Journal Judika (Jurnal Nusantara Medika) JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Gema Kesehatan JENGGALA: Jurnal Riset Pengembangan dan Pelayanan Kesehatan
Frieti Vega Nela
Institut Ilmu Kesehatan Bhakti Wiyata Kediri
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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Journal : Gema Kesehatan

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UJI SENSITIVITAS ANTIBIOTIK CIPROFLOXACIN DENGAN CEFIXIME PADA Escherichia coli : STUDI KASUS INFEKSI SALURAN KEMIH : ANTIBIOTIC SENSITIVITY TEST OF CIPROFLOXACIN AND CEFIXIME AGAINST Escherichia coli: A CASE STUDY OF URINARY TRACT INFECTION Imasari, Triffit; Ermawati, Nita; Nela, Frieti Vega; Senjani, Salwa Fitri
GEMA KESEHATAN Vol. 17 No. 1 (2025): Juni 2025
Publisher : POLTEKKES KEMENKES JAYAPURA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47539/gk.v17i1.486

Abstract

Keberadaan mikroorganisme dalam urin menjadi indikator utama infeksi saluran kemih (ISK). ISK disebabkan oleh berbagai macam bakteri seperti Eschericia coli, Klebsiella sp, Proteus sp, Providensia, Citrobacter, Pseudomonas aeruginosa, Acinetobacter, Enterococcus faecali, dan Staphylococcus saprophyticus. Lonjakan kasus resistensi antibiotik dan kemunculan patogen multidrug-resistant (MDR) pada ISK berkorelasi erat dengan tingginya insiden pemberian terapi antibiotik empiris yang kurang tepat. Praktik peresepan antibiotik tanpa diawali uji mengakibatkan  inefektivitas penanganan ISK. Penelitian ini bertujuan mengidentifikasi bakteri E. coli sebagai penyebab ISK pada urin pasien penderita ISK serta membandingkan tingkat sensitivitas E. coli terhadap dua jenis antibiotik, yaitu Ciprofloxacin dan Cefixime.Metode yang digunakan adalah metode kultur dengan media Eosin Methilen Blue dan disk cakram. Sampel diperoleh sebanyak 13 sampel ISK dengan teknik accidental sampling. Hasil penelitian menunjukkan ada 9 sampel positif E. coli dan dengan tingkat sensitivitas pada antibiotik Ciprofloxacin sebanyak lima sampel (58%) sensitif, Intermediet satu sampel (11%), Resisten tiga sampel (33%) dan uji sensitivitas antibiotik Cefixime resisten sembilan sampel (100%). Penelitian ini disimpulkan pada penderita ISK ditemukan bakteri E. coli dan terdapatnya  perbandingan antara hasil uji sensitivitas antibiotik Ciprofloxacin dan antibiotik Cefixim terhadap bakteri E. coli. Kata kunci: Eschericia coli, Cefixime, Ciprofloxacin, Infeksi Saluran Kemih   The presence of microorganisms in urine is a primary indicator of a Urinary Tract Infection (UTI). UTIs are caused by various bacteria such as Escherichia coli, Klebsiella sp., Proteus sp., Providencia, Citrobacter, Pseudomonas aeruginosa, Acinetobacter, Enterococcus faecalis, and Staphylococcus saprophyticus. The surge in antibiotic resistance cases and the emergence of multidrug-resistant (MDR) pathogens in UTIs are closely correlated with the high incidence of inappropriate empirical antibiotic therapy. The practice of prescribing antibiotics without prior testing leads to the ineffectiveness of UTI management. This research aimed to identify E. coli bacteria as a cause of UTIs in the urine of patients suffering from UTIs and to compare the sensitivity levels of E. coli to two types of antibiotics: Ciprofloxacin and Cefixime. The method was culture with Eosin Methylene Blue media and disk diffusion. A total of 13 UTI samples were obtained using an accidental sampling technique. The research results showed that nine samples were positive for E. coli. For Ciprofloxacin, five samples (58%) were sensitive, 1 sample (11%) was intermediate, and three samples (33%) were resistant. For Cefixime, all nine samples (100%) were resistant. This research concluded that E. coli bacteria were found in UTI patients, and there was a comparison between the sensitivity test results of Ciprofloxacin and Cefixime antibiotics against E. coli bacteria. Keywords : Eschericia coli, Cefixime, Ciprofloxacin, Urinary Tract Infection
KORELASI HIGH SENSITIVITY C-REACTIVE PROTEIN (hs-CRP) DENGAN MONOSIT PADA PASIEN TUBERKULOSIS SETELAH PENGOBATAN: CORRELATION BETWEEN HIGH-SENSITIVITY C-REACTIVE PROTEIN (hs-CRP) AND MONOCYTES IN TUBERCULOSIS PATIENTS AFTER TREATMENT Vega Nela, Frieti; Erawati; Imasari, Triffit; Ningrum, Erlina Setia
GEMA KESEHATAN Vol. 17 No. 1 (2025): Juni 2025
Publisher : POLTEKKES KEMENKES JAYAPURA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47539/gk.v17i1.488

Abstract

Tuberkulosis (TBC) merupakan penyakit infeksius yang berlangsung lama dan utamanya mempengaruhi organ paru. Kondisi ini disebabkan oleh bakteri Mycobacterium tuberculosis, yang biasanya menyerang sistem pernapasan manusia. Pemeriksaan High Sensitivity C-Reactive Protein (hs-CRP) dan monosit dapat digunakan sebagai pemeriksaan untuk mengetahui terjadinya inflamasi pasien tuberkulosis. Tujuan penelitian ini untuk mengetahui hubungan hs-CRP dengan monosit pada pasien tuberkulosis setelah pengobatan. Desain penelitian yang digunakan adalah cross sectional dengan teknik pengambilan sampel menggunakan metode accidental sampling dengan jumlah sampel sebanyak 15 sampel. Hasil pemeriksaan hs-CRP didapatkan nilai rata-rata 3,22 mg/L dan rata-rata monosit pada pasien tuberkulosis setelah pengobatan yaitu 540,80 mm3. Analisa data dilakukan dengan menggunakan uji normalitas Shapiro-wilk dan uji korelasi menggunakan uji pearson product moment. Berdasarkan uji pearson product moment didapatkan nilai signifikasi 0,037 dengan nilai koefisien korelasi yang diperoleh yaitu 0,542. Kesimpulan dari penelitian ini menunjukkan adanya korelasi antara hs-CRP dengan monosit pada pasien tuberkulosis setelah pengobatan, dengan korelasi positif yang menandakan korelasi kuat antara hasil hs-CRP dengan monosit pada pasien tuberkulosis setelah pengobatan. Kata kunci: hs-CRP, Monosit, Tuberkulosis   Tuberculosis (TB) is a chronic infectious disease that primarily affects the lungs and is caused by Mycobacterium tuberculosis. This pathogen typically targets the human respiratory system. High-sensitivity C-reactive protein (hs-CRP) and monocyte levels can serve as diagnostic indicators to assess inflammation in TB patients. This study examines the relationship between hs-CRP and monocyte levels in tuberculosis patients following treatment. A cross-sectional study design with accidental sampling was employed, involving 15 participants. The mean hs-CRP level was 3.22 mg/L, while the mean monocyte count was 540.80 cells/mm³. Data were analyzed using the Shapiro-Wilk normality test and Pearson product-moment correlation test. The Pearson test yielded a significance value of 0.037 and a correlation coefficient (r) of 0.542. The results indicate a statistically significant positive correlation between hs-CRP and monocyte levels in tuberculosis patients after treatment. This suggests a moderate to strong association between inflammatory response and monocyte activity post-therapy. Keywords : hs-CRP, Monocytes, Tuberculosis
Co-Authors Ayu Prihandarini, Diaz Binti Mu'arofah Erawati Erawati, Erawati Ermawati, Nita Fery Eko Pujiono, Fery Eko Fery Pujiono Kurniasari, Mia Ashari Mu`arofah, Binti Ningrum, Erlina Setia Oktavia, Fryscilla Restuaji, Ibnu Muhariawan Sabilla Hanum Oktavianing Putri Senjani, Salwa Fitri Siska Kusuma Wardani, Siska Kusuma Tri Ana Mulyati, Tri Ana Triffit Imasari Wardhani, Siska Yuwana Putri, Zulfaa