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Journal : Hang Tuah Medical Journal

Peran Brain Stimulation TMS Pada Prajurit Penderita Depresi Yang Penugasan di Kapal Perang I KETUT TIRKA NANDAKA
HANG TUAH MEDICAL JOURNAL Vol 19 No 1 (2021): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v19i1.80

Abstract

Abstract Military personnel have a high risk of suffering from depression due to the nature of their work and training, separation from family, carrying out military missions, changing tasks, assignments in narrow places (warships) and being exposed to dangerous events and equipment. In a study by Al-Amri et al., in Saudi Arabia by taking 357 random samples, it was found that the prevalence of depression was 17.1% in an area of ​​military operations in the Middle East. PDSKJI (2017) reports that 3.7% of the population in Indonesia suffers from depressive disorders. This study is a case report pre and post test design as many as 4 patients of naval soldiers who have been diagnosed with major depressive disorder who will receive standard therapy in the form of antidepressants and psychotherapy. First, an assessment of the level of depression was carried out using the BDI (Beck Depression Inventory) and HDRS (Hamilton Depression Rating Scale). Standard therapy for depression was given to both groups and one group plus TMS augmentation therapy, power adjusted to RMT (resting motor threshold), TMS therapy protocol with amplitude 100% high frequency 18 Hz, 2 sec with inter-train intervals of 20 sec, 55 and 59 train for 20 minutes 5 times a week. From the results of this study, clinically all patients who received TMS augmentation showed better clinical results starting from the first week of therapy with a decrease in BDI scores of 15 points and HDRS scores of 14 points. Scores decreased by a difference of 6-8 points on the BDI scale and a difference of 5-7 on the HDRS scale in patients receiving standard therapy compared to those receiving standard therapy and TMS augmentation. Keywords : Depression – BDI / HDRS - Soldier - TMS
Metaplasia Myelofibrosis WIJAYANINGRUM, LENA; I DEWA MADE WIDI HERSANA; I KETUT TIRKA NANDAKA
Hang Tuah Medical Journal Vol 23 No 1 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v23i1.662

Abstract

Background: Myelofibrosis with myeloid metaplasia is a rare myeloproliferative disorder. Epidemiological data on the incidence of Myelofibrosis with myeloid metaplasia are still lacking. In Goteborg, Sweden, from 1983 to 1992, the incidence of the disease was retrospectively calculated at 0.4 per 100,000 population. In population- based leukemia data in the UK, the incidence of Myelofibrosis with myeloid metaplasia is estimated to be 0.73 per 100,000 person-years in men and 0.40 per 100,000 person-years in women. It is estimated that there are 230 new cases each year in England and Wales, 330 in Italy, and 1,600 in the United States. No medical therapies have been shown to be effective against the overall survival of patients. The prognosis of myelofibrosis with myeloid metaplasia varies widely. For this reason, it is necessary to report cases of Myelofibrosis Myeloid Metaplasia Methode: Descriptive research, in the form of case reports of patients with myelofibrosis metaplasia, with data obtained from primary data anamnesa and direct physical examination of patients and secondary data from medical records, the results of examinations of doctors at RSPAL Dr Ramelan Surabaya 2022-2024. Results: Since 13 December 2022 until this date 3 May 2024 (17 months).Patient with a diagnosis of Primary Myelofibrosis and high Uric Acid after undergoing therapy with jakavi 15 mg 1x1. Allopurinol 300mg 1x1 and Nabic 3x1. Experienced improvement in complaints of increased appetite. Resting at night there are no complaints. Activity such as walking is not easily tired, mass in the abdomen that does not cause pain. On physical examination, there was an increase in body weight from 50 kg to 55 kg and still found S IV splenomegaly, from the haematological examination there was a decrease in platelets 136.00 (10^3µL) which was previously 203.00 (10^3µL). Uric acid improved from 10.8 mg/dl to 7.7 mg/dl. Conclusion: Jakavi is a drug containing ruxolitinib that can treat splenomegaly or disease-related symptoms in adult patients with myelofibrosis. Keywords: Myelofibrosis Metaplasia.Splenomegaly.Jakavi