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All Journal International Journal of Public Health Science (IJPHS) Indonesian Journal of Pharmaceutical Science and Technology Mutiara Medika: Jurnal Kedokteran dan Kesehatan Berkala Kedokteran Jurnal Farmasi Sains dan Komunitas BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JCPS (Journal of Current Pharmaceutical Sciences) Community Empowerment Journal of Fundamental and Applied Pharmaceutical Science Prosiding Seminar Nasional Program Pengabdian Masyarakat Jurnal Medika: Medika
Salmah Orbayinah
Universitas Muhammadiyah Yogyakarta
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

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Evaluation of Sidr Leaf Ethanol (Ziziphus mauritiana Lam.) Extract-Based Tablets as Antihypercholesterolemia Orbayinah, Salmah; Dewi, Yunita P.; Kurniawan, Fariez; Krisridwany, Annisa
Indonesian Journal of Pharmaceutical Science and Technology 2025: Vol. 12 Suppl. 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s1.57926

Abstract

Sidr leaf extract (Ziziphus mauritiana Lam.) is effective against hypercholesterolemia by blocking the HMG-CoA reductase. This study seeks to identify the characteristics of tablets formulated from the ethanol extract of Sidr leaf and their efficacy in lowering total blood cholesterol levels. The tablets were produced using the wet granulation method and processed into three formulations, F1, F2, and F3, with differing dosages of 100, 150, and 250 mg, along with placebo. The granules produced were evaluated for their physical characteristics. The tablets were evaluated for their physical characteristics and tested for effectiveness in lowering cholesterol levels. The efficacy of tablet-form sidr leaf ethanol extract was assessed by analyzing cholesterol levels in mouse serum samples compared to simvastatin. The data were statistically analyzed using one-way ANOVA and post-hoc Tukey HSD test. In the disintegration time test, F1 and F2 tablets satisfied the criteria. However, F3 exceeded the limit of 60 minutes. Among the three tablet doses, the F2 tablet (150 mg) demonstrated superior efficacy in lowering total cholesterol levels relative to the F1 and F3 tablets. Consequently, tablets containing Sidr leaf extract demonstrate potential for hypercholesterolemia management at an effective dosage of 150 mg, warranting further investigation through clinical trials.
Co-Authors - Restu Abidin, Ghaida Rahmani Putri Adhe Filiyahtri Mohdar Ardi Pramono Auliya, Rizqa Dewi, Yunita P. Dina Khoirin Wahidah Dini, Riyanti Raf’al Faizah Nurul Latifah Fathinah Hanun Fitra Korniawan Hari Widada Hari Widada Hari Widada Hari Widada, Hari Haryono, Dedy Hasna Nuansa Sasadara Indardi Indardi Indriastuti Cahyaningsih Ingenida Hadning Kartyanto, Adhita Krisridwany, Annisa Kurnia Eka Permana, Kurnia Eka Kurniawan, Fariez Laksmi Putri Utami Lilis Suryani Lilis Suryani Lukluk Purbaningrum, Lukluk Muhammad Thesa Ghozali Nanang Kurniawan Nosa Septiana Anindita Nurul Maziyyah Nurul Maziyyah Pinasti Utami Pinasti Utami R. Sapto Hendri Boedi Soesatyo Sabtanti Harimurti Supono Supono Surria Dwiwahyu Suryani, Lilis Tri Wulandari Kesetyaningsih Tsania Khusnul Khotimah Utami, Inta Resty Vella Lailli Damarwati Wiwik Kusumawati