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All Journal Jurnal MIPA Nusantara Medical Science Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Journal Syifa Sciences and Clinical Research (JSSCR) Indonesian Journal of Community Dedication Diagnosis: Jurnal Ilmiah Kesehatan Jurnal Riset Kefarmasian Indonesia Borneo Journal Of Pharmascientech Wal'afiat Hospital Journal WAL'AFIAT HOSPITAL JOURNAL Journal of Pharmaceutical Science and Herbal Technology
Usman, Yusnita
Sekolah Tinggi Ilmu Kesehatan Nani Hasanuddin
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Efektivitas Teh Celup Daun Bidara Laut Kombinasi Bubuk Kayu Manis sebagai Antidiare pada Mencit Bakkareng, Hasma Hasma; Muin, Rahmatullah; Panaungi, Andi Nurpati; Usman, Yusnita
Wal'afiat Hospital Journal Vol. 6 No. 2 (2025): Wal'afiat Hospital Journal
Publisher : Rumah Sakit Ibnu Sina, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/4288pz24

Abstract

Diarrhea is characterized by increased defecation frequency and altered stool consistency. Castor oil (Oleum ricini) induces diarrhea mainly through ricinoleic acid, which enhances intestinal secretion and motility. Sea bidara leaves (Ziziphus mauritiana) and cinnamon (Cinnamomum burmannii) contain tannins, flavonoids, and aromatic constituents (e.g., cinnamaldehyde) that may contribute to antidiarrheal activity. To evaluate the antidiarrheal effect of a combined sea bidara–cinnamon tea bag preparation in male Swiss Webster mice. An experimental study was conducted using 15 mice (n=3/group): negative control (castor oil + distilled water), positive control (loperamide), and three tea infusion groups—F1 (90%:10%), F2 (25%:75%), and F3 (50%:50%). Mice were fasted for 8 h, induced with castor oil (0.5 mL/20 g BW), and treated by oral gavage 30 min after induction. Observations were recorded at 30, 60, 90, and 120 min post-treatment. The primary Endpoint was total bowel movement (BM) frequency over 0–120 min. The secondary Endpoint was a standardized ordinal stool consistency score (0–3; 0=no BM, 1=formed, 2=soft, 3=watery/mucoid). Data were analyzed using Kruskal–Wallis with appropriate post-hoc testing (α=0.05) and effect size reporting. Significant between-group differences were observed in total BM frequency (H=10.24; p=0.0366; ε²=0.624) and stool consistency scores (H=11.74; p=0.0194; ε²=0.774). Descriptively, F3 showed the lowest total BM frequency, while F2 demonstrated faster cessation of BMs after 60 min. The combined sea bidara–cinnamon tea bag infusion exhibited antidiarrheal activity in the castor oil model; findings should be interpreted as preliminary due to the pilot sample size.
In Vitro Test of Fraction N-Hexan, Aquadest and Crude Ethanol Extract of Moringa Leaves (Moringa oleifera L.) by Cholesterol Lowering Using a UV-Vis Spectrophotometer Usman, Yusnita; B, Muthmainna
Jurnal Penelitian Pendidikan IPA Vol 12 No 1 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i1.13752

Abstract

This research is an experimental research study on in vitro test that uses sampling test from herbal medicine. The purpose of this study is to determine the anticholesterol activity and EC50 value of n-hexan farction, aquadest fraction and ethanol extract of moringa leaves. Moringa leaves (Moringa oleifera L.) contain secondary metabolite compounds that can lower blood cholesterol levels. The analysis method uses UV-Vis spectrophotometry at a wavelength of 665 nm with a series of test sample concentrations of 100 ppm; 300 ppm; and 500 ppm. Research data shows a decrease in cholesterol levels is directly proportional to the increase in concentration in the sample. The EC50 value of n-hexane partition was 142.57 ppm, aquadest partition was 737.88 ppm, and ethanol extract was 156,7 ppm. This indicates that the lower polarity of the solvent used in the extraction process, better than the anticholesterol activity of the extract. Conclusion, the best anticholesterol activity was found in the n-hexane fraction with an EC50 value of 142.57 ppm.
PEMANFAATAN POTENSI LIMBAH KULIT BAWANG MERAH (Allium Cepa. L) SEBAGAI SEDIAAN GEL HAND SANITIZER Usman, Yusnita
Jurnal Riset Kefarmasian Indonesia Vol. 2 No. 2 (2020): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v2i2.79

Abstract

The increased health problems caused by microorganisms at the hands, hand sanitizer gel as the way out to maintained health and hand hygiene because it is more practical and easy to carry. The purpose of this study was to make formulations of gel with physically stable and had inhibitory activity against the Staphylococcus aureus bacteria. In this study three formulations were made with a ratio of Hydroxy ethyl selilulose 0.5% (F1), 1% (F2) and 2% (F3) then physical stability testing included organoleptic, homogeneity, pH and dispersion before and after accelerated storage, then antimicrobial activity by sump method. Organoleptic test showed there is no color, smell and texture changes. The results of the homogenety test, formula with concentration of Hydroxy ethyl cellulose 1% and 2% is homogeneous. The pH test results showed that the gel preparation did not change pH. Dispersing test showed concentration hydroxyethyl cellulose 1% has the highest dispersion value. but statistical paired T test results showed that the dispersion before and after storage was accelerated significantly different 0.043 (p <0.05), but still in accordance with the range of dispersion specifications for a good semisolid preparation.The MIC test results showed Formulation F1, F2 and F3 ethanol extract red onion skin gel are strong inhibitory effect, ethanol extract of red onion skin gel F1 inhibitory zone is 16mm, F2 and F3 had the same inhibitory zone is 14.33. It can be concluded F2 has the best physical stability, but F1 is the most effective to inhibit Staphylococcus aureus.
Co-Authors Andi Nurpati Panaungi Ayu Andira B, Muthmainna Bakkareng, Hasma Hasma Hasma Hasma Bakkareng Hasma Hasma Hasma Hasma Muin, Rahmatullah Muthmainna B Muthmainnah B Mutmainnah Baharuddin Panaungi, Andi Nurpati Rachman, Afifah Rahmatullah Reosi, Karina