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Peningkatan Kelarutan dan Kecepatan Disolusi Obat dengan Metode Dispersi Padat untuk Meningkatkan Bioavailabilitas Obat: Review Artikel Irwanto, Mohammad Firman
Jurnal Riset Sains dan Kesehatan Indonesia Vol. 2 No. 1 (2025): Jan-Feb
Publisher : CV. Science Tech Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69930/jrski.v2i1.275

Abstract

Kelarutan obat dalam air adalah salah satu faktor utama yang menentukan kecepatan disolusi dan memengaruhi bioavailabilitas obat. Obat dengan sifat lipofilik atau sulit larut dalam air sering kali memiliki kecepatan disolusi yang rendah dalam cairan gastrointestinal, sehingga menghasilkan bioavailabilitas yang rendah. Tantangan ini mendorong pengembangan berbagai strategi untuk meningkatkan kelarutan obat, salah satunya adalah metode dispersi padat. Dispersi padat merupakan sistem dispersi di mana satu atau lebih zat aktif didistribusikan ke dalam pembawa inert atau matriks dalam bentuk padat melalui teknik peleburan (fusi), pelarutan, atau kombinasi keduanya. Metode ini memungkinkan pengurangan ukuran partikel, pembentukan partikel amorf, serta peningkatan keterbasahan partikel. Artikel ini menggunakan metode literatur review untuk menganalisis dan menyajikan informasi terkini mengenai teknik dispersi padat serta potensinya dalam meningkatkan bioavailabilitas obat. Dengan penerapan metode ini, bioavailabilitas obat dapat ditingkatkan secara signifikan, menjadikannya pendekatan yang menjanjikan dalam formulasi farmasi.
Ekstraksi dan Uji Stabilitas Limbah Kulit Umbi Bit Merah (Beta Vulgaris L.) sebagai Alternatif Pewarna Alami pada Lipstick: Extraction and Stability Test of Red Bit (Beta Vulgaris L.) Umb Culk Waste as An Alternative Natural Color in Lipstick Nurwahidah, Andi Tenri; Moh. Firman Irwanto; Anisa Fitriyani; Ashar Prima; Fauziah H Wada; Amzal Mortin Andas
Indonesian Journal of Pharmacy and Natural Product Vol. 8 No. 01 (2025): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ijpnp.v8i01.3513

Abstract

Lipstick is a cosmetic that can be used to color the lips so that it adds to the beauty of the makeup on the lips. Red beetroot skin has a natural pigment content that can be used as a natural dye. The purpose of this study was to formulate and evaluate solid lipstick preparations from red beetroot skin extract (Beta vulgaris L.) as a natural dye. The research stages were sample collection, extraction, lipstick formulation and evaluation of the physical properties of the lipstick including organoleptic tests, homogeneity tests, spreadability tests, pH tests, melting point tests, irritation tests, and stability tests. The red beetroot skin lipstick formula consists of 4 formulas with variations in concentration, namely F0 (0%), F1 (5%), F2 (10%), F3 (15%). The resulting red beetroot skin extract is a thick extract that is dark brown in color and has a distinctive extract aroma with a yield of 46.69%. The resulting lipstick preparation is a homogeneous preparation with the colors of the F0, F1, F2, F3 formulas, namely bone white, brown, light brown, and dark brown. The evaluation results of lipstick formula F0, F1, F2, F3 obtained pH values ​​of 6.36-6.10; melting point 51°C-58°C and had good spreadability. The results of the stability test of lipstick preparations of all formulas at a temperature of 28°C were stable for 4 weeks of storage. The results of the irritation test using the patch test method on all lipstick formulas did not cause irritation. Based on the overall evaluation results, the red beetroot skin extract formulated in lipstick successfully met the standards for lipstick preparations, the red beetroot skin extract lipstick formulation provided good color at concentrations of 10% and 15%.   ABSTRAK Lipstick merupakan kosmetik yang dapat digunakan untuk mewarnai bibir sehingga menambah keindahan riasan pada bibir. Kulit umbi bit merah memiliki kandungan pigmen alami untuk dimanfaatkan sebagai pewarna alami. Tujuan penelitian ini adalah melakukan formulasi dan evaluasi sediaan lipstick padat dari ekstrak kulit umbi bit merah (Beta vulgaris L.) sebagai pewarna alami. Tahap penelitian adalah pengumpulan sampel, ekstraksi, formulasi lipstick dan evaluasi sifat fisik lipstick meliputi uji organoleptik, uji homogenitas, uji daya oles, uji pH, uji titik leleh, uji iritasi, dan uji stabilitas. Formula lipstick kulit umbi bit merah terdiri dari 4 formula dengan variasi konsentrasi yaitu F0 (0%), F1 (5%), F2 (10%), F3 (15%). Ekstrak kulit umbi bit merah yang dihasilkan merupakan ekstrak kental berwarna coklat pekat dan memilik aroma khas ekstrak dengan rendemen sebesar 46,69%. Sediaan lipstick yang dihasilkan merupakan sediaan homogen dengan warna formula F0, F1,F2, F3 yaitu putih tulang, coklat, coklat muda, dan coklat tua. Hasil evaluasi sediaan lipstick formula F0, F1, F2, F3 diperoleh nilai pH 6,36-6,10; titik leleh 51°C-58°C dan mempunyai daya oles yang baik. Hasil uji stabilitas sediaan lipstick semua formula pada suhu ruang 28°C stabil selama 4 minggu penyimpanan. Hasil uji iritasi dengan metode patchtest pada semua formula sediaan lipstick tidak menyebabkan iritasi. Berdasarkan hasil evaluasi keseluruhan, ekstrak kulit umbi bit merah yang diformulasikan dalam lipstick berhasil memenuhi standar untuk sediaan lipstick, formulasi lipstick ekstrak kulit umbi bit merah memberikan warna yang baik pada konsentrasi 10% dan 15%.
The Relationship Therapeutic Communication With Level Anxiety Of The Patient's Family In The Intensive Care Unit. Hasiolan, Mara Imbang Satriawan; Irwanto, Moh Firman
Nursing Genius Journal Vol. 1 No. 3 (2024): Nursing Genius Journal Vol. 1 No. 3 July 2024
Publisher : PT. Nursing Genius Care

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65874/ngj/v1.i3.2024.54

Abstract

Type here, write the abstract in Indonesian, maximum 250 words and structured including: Background, Objectives, Methods, Results and Conclusions.   Background: The intensive care unit is a special room equipped with special medical equipment, and provided by the hospital to treat patients with conditions that require close supervision. Nurses' skills in communicating can help patients and their families communicate thoughts and feelings more effectively. Purpose: This study aims to explore the relationship between therapeutic communication and the anxiety level of families of patients treated in the Intensive Care Unit. Methods:   This is quantitative research with a correlational design. The sampling used was purposive sampling, with inclusion and exclusion criteria totaling 71 people. The instrument used is a questionnaire. Results: The results showed that the majority of respondents were adults 83.1% (n=59), high school education 73.3% (n=52), and male 76.1% (n=54). Family experience of being treated in the ICU was never 98.5% (n=68). The therapeutic communication is good 73.2% (n=52), level of anxiety is moderate 69.0% (n=49).  p-value 0.036 < (α=0.05), there is a significant relationship between therapeutic communication and the patient's family's anxiety level in the intensive care unit. Conclusion: Implementing effective communication strategies can provide a better understanding of the patient's condition, and involve the family in the care process. Therefore, developing therapeutic communication skills among medical personnel should be a priority to improve the quality of care in the ICU.
The Relationship Between Pregnant Women's Knowledge About Antenatal Care and Their Antenatal Visit Behavior in the Working Area Public Health Center Bekasi Sari, Leni Permata; Sunirah, Sunirah; Puspitasari, Indah; Shoaliha, Maratun; Irwanto, Moh. Firman
Nursing Genius Journal Vol. 2 No. 1 (2025): Nursing Genius Journal Vol. 2 No. 1 Januari 2025
Publisher : PT. Nursing Genius Care

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65874/ngj/v2.i1.2025.79

Abstract

Low levels of knowledge about Antenatal Care (ANC) among pregnant women contribute to reduced participation in antenatal visits. Adequate knowledge is expected to strongly motivate pregnant women to take care of themselves and their pregnancies by adhering to the advice provided by antenatal care providers. Objective: This study aims to examine the relationship between pregnant women's knowledge about ANC and their antenatal visit behavior.Methods: This research employed a descriptive quantitative design with a cross-sectional approach. The study population consisted of 104 respondents, selected through accidental sampling. The variables analyzed included pregnant women's knowledge about ANC, their antenatal visit behavior, and family support.Results: The highest proportion of respondents demonstrated good knowledge about ANC (95.2%). A majority also exhibited good antenatal visit behavior (78.8%), and most received moderate family support (83.7%). Conclusion: The study findings indicate a positive relationship between pregnant women's knowledge of ANC and their antenatal visit behavior at the Karang Kitri Public Health Center in Bekasi City, with a generally favorable outcome.
SEHATI: SEHAT BERSAMA IBU HAMIL DAN WARGA MELALUI PEMERIKSAAN TERPADU DI DESA PANTAI HARAPAN JAYA, MUARA GEMBONG Puspitasari, Indah; Irwanto, Mohamad Firman; Astuti, Puji; Sulijaya, Benso; Lelyati, Sri
PEDAMAS (PENGABDIAN KEPADA MASYARAKAT) Vol. 3 No. 05 (2025): SEPTEMBER 2025
Publisher : MEDIA INOVASI PENDIDIKAN DAN PUBLIKASI

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Melalui Pemeriksaan Terpadu merupakan hasil kerja sama antara Universitas Bani Saleh dan Fakultas Kedokteran Gigi Universitas Indonesia yang dilaksanakan di Desa Pantai Harapan Jaya, Kecamatan Muara Gembong. Kegiatan ini bertujuan meningkatkan derajat kesehatan ibu hamil dan masyarakat umum melalui pemeriksaan dan edukasi terpadu. Layanan yang diberikan meliputi pemeriksaan hemoglobin (Hb) pada ibu hamil untuk deteksi dini risiko anemia, pemeriksaan kesehatan gigi ibu hamil sebagai bagian dari perawatan antenatal yang komprehensif, serta pemeriksaan kesehatan umum bagi ibu hamil dan seluruh warga. Metode pelaksanaan meliputi skrining kesehatan, pemeriksaan fisik, edukasi, dan rujukan bagi peserta yang memerlukan perawatan lanjutan. Hasil kegiatan menunjukkan ditemukannya terdapat kasus anemia pada ibu hamil, masalah kesehatan gigi dan mulut, serta keluhan kesehatan umum pada masyarakat, yang kemudian ditangani dengan intervensi awal dan penyuluhan kesehatan. Kolaborasi lintas institusi ini memperkuat sinergi perguruan tinggi dalam mendukung upaya promotif dan preventif di wilayah pesisir yang memiliki keterbatasan akses layanan kesehatan.
Loneliness in the Elderly: A Community-Based Assessment of Prevalence and Demographic Correlates in Bekasi, Indonesia Prima, Ashar; Rahayu, Istiana; Andas, Amzal Mortin; Firman Irwanto, Moh; Lanahdiana, Lu’lu; Shoaliha, Maratun; Romantika, I Wayan
Nursing Genius Journal Vol. 1 No. 1 (2026): Nursing Genius Journal Vol. 1 No. 1 January 2026
Publisher : PT. Nursing Genius Care

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65874/ngj/v1.i1.2026.180

Abstract

Background: Loneliness among the elderly is a critical public health concern associated with adverse mental and physical health outcomes. In Indonesia, rapid urbanization and shifting family structures may exacerbate this issue, yet data on its prevalence at the primary healthcare level remain limited. Objective: This study aimed to assess the prevalence of loneliness and identify key demographic correlates among community-dwelling elderly in the working area. Methods: A community-based cross-sectional study was conducted from March to June 2024. Using consecutive sampling, 109 elderly participants aged ≥60 years were enrolled. Data were collected using the validated Indonesian version of the UCLA Loneliness Scale (Version 3) and a structured demographic questionnaire. Descriptive statistics and frequency distributions were used for data analysis. Results: The study revealed that 74.3% of participants experienced mild loneliness, while 16.5% reported no loneliness, 8.3% had moderate loneliness, and 0.9% experienced severe loneliness. Significant demographic correlates included female gender (72.5%), age 60-69 years (78.9%), elementary education level (47.7%), unemployment status (69.7%), widowhood (51.4%), and low income (<IDR 1,500,000; 87.2%).Conclusion: Mild loneliness is prevalent among the elderly in this community, with distinct demographic correlates. These findings emphasize the need for targeted, community-based psychosocial interventions integrated into primary healthcare services to address loneliness among vulnerable elderly populations.