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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Pengabdian Ilmu Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Ardhi: Jurnal Pengabdian dalam Negri Journal of Clinical Pharmacy and Pharmaceutical Science Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Arie Vonikartika
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Uji Efek Stimulan Sistem Saraf Pusat Dari Ekstrak Etanol Biji Pala (Myristica fragrans H.) Pada Mencit Putih Jantan Delladari Mayefis; Shinta Sari Dewi; Nurlia Oktaviyanti; Arie Vonikartika
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 1 No. 2 (2021): JULI : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v1i2.2943

Abstract

Research on the effects of central nervous system stimulants from nutmeg (Myristica Fragrans H.) ethanol extract on male white mice has been carried out using the methods of: sleep onset test, hanging test, swimming test, and evacuation test. In this study, the test animals were divided into five groups in which each group consisted of three animals for three experiments, the first group was given a 0.5% NaC CMC suspention, the next three groups were given extracts of nutmeg seed ethanol (Myristica Fragrans H. ) with three variations of doses, namely 150, 300, and 600 mg / Kg BW, the next group as a comparison was given a caffeine solution of 13 mg / kg BW. Each preparation was given orally and then carried out a observation of several test methods. The results showed that the ethanol extract of nutmeg (Pala H.) can provide a good stimulant effect at a dose of 300 mg / kg BW (p <0.05) which was clearly seen in the swimming test and the hanging test method.
Co-Authors Delladari Mayefis Diani Mega Sari Eka Febriyanti Ghalib Syukrillah Syahputra Habibie Deswilyaz Habibie Deswilyaz Ghiffari Henny Rachdianti T S Henny Rachdianti Tjahjono Suyarto Hesti Marliza Ibnu Rusyd Komang Natalia Fitriani Lupina Lupina Meddo Lorenza Garnida Mega Sari, Diani Nurlia Oktavianty Nurlia Oktaviyanti Reny Haryani Rury Trisa Utami Shinta Sari Dewi Suci Fitriani Sammulia Suhaera Suhaera Yunisa Friscia Yusri Yustika Sandey Margaretha Zahara Zahara