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All Journal Maximus: Journal of Biological and Life Sciences Khazanah Sosial
Putri, Isnaini Anggraini
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Economics, Econometrics & Finance Immunology & microbiology Law, Crime, Criminology & Criminal Justice Social Sciences

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IMMUNOSTIMULATORY EFFECT OF VITAMIN C ON MICE INDUCED BY STAPHYLOCOCCUS AUREUS Khairani, Iffa Afiqa; Riana, Elisa Nurma; Maretta, Gres; Azizah, Najla Nur; Putri, Isnaini Anggraini; Maruli, Berkat Afni; Mulyadi, Salsa Pratiwi; Antonius, Antonius
MAXIMUS: Journal of Biological and Life Sciences Vol. 1 No. 2 (2023)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/maximus.v1i2.1636

Abstract

Several compounds that can boost immune activity (immunostimulatory) include vitamin E, curcumin, flavonoids, and vitamin C. In this study, ascorbic acid or vitamin C, was used as one method to enhance the immune system. This study aims to determine the immunostimulatory effect of vitamin C on the phagocytosis activity of macrophages in mice induced by Staphylococcus aureus. The mice were divided into two groups: the control group, which received 0.3 ml of distilled water orally, and the treatment group, which received 0.036 mg/g BW of vitamin C orally for 14 days. On the 15th day, each mouse was intraperitoneally induced with 0.5 mL of Staphylococcus aureus bacterial suspension and left for two hours. The phagocytic activity value represents the percentage of active macrophage cells among all macrophages observed. The result showed that the value of % phagocytic activity in the control group was 21.43% ± 7.92, whereas the % phagocytic activity in the treatment group was 48.31% ± 22.27. The group of mice given vitamin C 0.036 mg/g BW orally showed increased phagocytic activity compared to the control group mice. This shows that vitamin C has potential as an immunostimulator.
Determinants of Aggression in Non-Urban Sumatra: Age, Handedness, and Regional Context Putri, Isnaini Anggraini; Badriah, Nur; Muktiono, Permesyawari; Mulyana, Jeane Siswitasari; Maretta, Gres; Nurhayu, Winati; Darmawan, Andy
Khazanah Sosial Vol. 8 No. 2 (2026): Khazanah Sosial
Publisher : UIN Sunan Gunung Djati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ks.v8i2.49227

Abstract

This study aims to analyze regional variation in aggressiveness in non-urban areas of Sumatra and to examine the simultaneous influence of demographic, biological, and regional factors on individual aggression levels. This study is important because comparative quantitative research across regions in Indonesia, particularly outside urban contexts, remains limited, even though aggression directly relates to social dynamics and regional violence risks. The study employs a quantitative approach with a cross-sectional design. The researchers collected data from 610 respondents aged 14–87 years in Simalungun Regency (North Sumatra), as well as South Lampung, Way Kanan, and Central Lampung, using convenience sampling. The researchers measured aggressiveness using the Buss–Perry Aggression Questionnaire (BPAQ) and analyzed the data through Kendall’s correlation and multiple linear regression. The findings show a mean aggressiveness score of 2.815 (on a 1–5 scale), with the verbal subscale recording the highest score. The regression model explains 7.6 % of the variance in aggression and identifies four significant predictors: Simalungun region, age (negatively correlated), left-handedness, and Lampung ethnicity. Sex, income, and birth order do not demonstrate significant effects. These findings indicate that aggression is shaped more strongly by developmental factors, biological proxies, and sociocultural and regional dynamics than by economic factors alone. This study implies the importance of regionally and culturally based interventions to strengthen emotional regulation, particularly among young populations in areas with higher aggression scores. In terms of originality, this study represents the first comparative quantitative research that integrates regional, ethnic, and handedness variables within a single regression model in a non-urban Sumatran context, thereby providing empirical and methodological contributions to locally grounded social policy development.
Co-Authors ANDY DARMAWAN Antonius Antonius Azizah, Najla Nur Badriah, Nur Gres Maretta, Gres Iffa Afiqa Khairani Maruli, Berkat Afni Muktiono, Permesyawari Mulyadi, Salsa Pratiwi Mulyana, Jeane Siswitasari Nurhayu, Winati Riana, Elisa Nurma