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All Journal Jurnal Ilmu Pertanian Indonesia Jurnal Pendidikan Biologi Undiksha Jurnal Sumberdaya Hayati Jurnal Pembelajaran dan Biologi Nukleus Jurnal Ilmiah Kesehatan Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Abdimas Berdaya : Jurnal Pembelajaran, Pemberdayaan dan Pengabdian Masyarakat Bagimu Negeri : Jurnal Pengabdian Kepada Masyarakat Maximus: Journal of Biological and Life Sciences Indonesian Journal of Jamu
Iffa Afiqa Khairani
Institut Teknologi Sumatera
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MALFORMASI BAGIAN – BAGIAN TUBUH FETUS MENCIT (Mus musculus L.) SETELAH PEMBERIAN EKSTRAK BUAH PARE (Momordica charantia L.) Silvia Andriani; Nuning Nurcahyani; Hendri Busman; Evi Kurniawaty; Iffa Afiqa Khairani
Jurnal Ilmiah Kesehatan Vol 12, No 1 (2023): Jurnal Ilmiah Kesehatan
Publisher : Universitas Muhammadiyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52657/jik.v12i1.2136

Abstract

Pare memiliki khasiat sebagai tanaman obat tradisional. Pada buah pare terdapat beberapa senyawa yang bersifat toksik yaitu senyawa momordikosida K dan L, yang diduga mempunyai sifat sitotoksik. Penelitian ini bertujuan untuk mengetahui panjang kranium, dan panjang sternum fetus mencit (Mus musculus L.) setelah pemberian ekstrak buah pare (Momordica charantia L.) terhadap mencit yang sedang hamil. Ekstrak pare diperoleh dengan cara maserasi menggunakan etanol 95%. Pemberian ekstrak buah pare (M. charantia L.) sebagai uji teratogenik pada kelainan fetus mencit. Rancangan penelitian adalah rancangan acak lengkap dengan analisis varian, yaitu menggunakan 20 ekor mencit jantan dan 20 ekor mencit betina yang dibagi dalam 4 kelompok. Setiap kelompok terdiri dari 5 ekor mencit betina yang telah hamil di beri ekstrak buah pare secara oral dimulai hari ke - 6 sampai hari 17 masa kehamilan sehari sekali pada pagi hari dengan dosis Perlakuan, aquabidest sebagai kontrol [A], [B] 22,5 mg/30 grBB , [C] 30 mg/30 grBB, dan [D] 37,5 mg/30 grBB . Selanjutnya induk mencit dibedah diambil fetusnya untuk dilakukan pengukuran terhadap panjang kranium dan panjnag sternum. Dari hasil analisis data menunjukkan bahwa secara umum pemberian perlakuan ekstrak buah pare menyebabkan penurunan rata-rata panjang kranium,dan sternum. Hasil analisis lanjut dengan BNT pada taraf 5 % menunjukkan bahwa pemberian dosis [B], [C], [D] memberikan pengaruh yang nyata terhadap penurunan panjang kranium, dan sternum. Pemberian ekstrak buah pare pada mencit hamil dosis yang paling efektif untuk menurunkan panjang kranium dan panjang sternum yaitu dosis 37,5 mg/30 grBB.
PEMERIKSAAN GOLONGAN DARAH DAN RHESUS PADA MASYARAKAT DESA SENDANG MULYO KECAMATAN SENDANG AGUNG KABUPATEN LAMPUNG TENGAH Andriani, Silvia; Puspa, Egita Windrianatama; Sahroni, Mizan; Arif, Muhammad; Sandro, Mario; Putra, Yogi Catur; Kurniawaty, Evi; Khairani, Iffa Afiqa
Bagimu Negeri Vol 7, No 2 (2023)
Publisher : Universitas Muhammadiyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52657/bagimunegeri.v7i2.2181

Abstract

Darah merupakan salah satu komponen paling penting yang ada dalam tubuh, mengingat fungsinya sebagai alat transportasi. Pemeriksaan golongan darah adalah salah satu aspek dalam upaya pencegahan penyakit. Identifikasi golongan darah dengan melihat penggumpalan darah yang telah diberi reagen banyak dilakukan secara manual berdasarkan pengamatan visual secara langsung. Pemeriksaan golongan darah dapat menjadi informasi penting dalam konteks perawatan kesehatan, terutama dalam situasi darurat atau ketika transfusi darah diperlukan. Indonesia masih mengalami kekurangan jumlah penyediaan darah secara nasional sebanyak 500 ribu kantong. Kekurangan ketersediaan darah tersebut meliputi golongan darah langka seperti golongan darah AB dan rhesus negatif. Pengabdian masyarakat adalah suatu kegiatan yang bertujuan untuk membantu masyarakat dalam meningkatkan pengetahuan dan derajat kesehatan. Kegiatan pengabdian masyarakat menjadi salah satu bagian dari Catur Dharma Perguruan Tinggi. Tujuan kegiatan pengabdian masyarakat ini adalah untuk mengetahui hasil pemeriksaan golongan darah dan rhesus pada masyarakat di desa Sendang Mulyo Kecamatan Sendang Agung. Desain kegiatan ini menggunakan desain deskriptif observational yaitu menggambarkan hasil pemeriksaan golongan darah berdasarkan hasil observasi dilapangan. Pemeriksaan Golongan darah sistem ABO yang dilakukan di Desa Sendang Mulyo diperoleh hasil golongan darah A sebanyak 9 orang, golongan darah B sebanyak 18  orang, golongan darah O sebanyak 24 orang, sedangkan untuk golongan darah AB sebanyak 4 orang
Perbedaan Profil Protein Plasma Darah Mencit Menggunakan SDS-PAGE Tanpa Penambahan dan dengan Penambahan 2-Mercaptoethanol Istiadi, Khaerunissa Anbar; Khairani, Iffa Afiqa; Andriani, Silvia
Jurnal Pendidikan Biologi Undiksha Vol. 11 No. 2 (2024)
Publisher : Undiksha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/jjpb.v11i2.82139

Abstract

SDS-PAGE is a method used to analyze proteins based on differences in molecular weight. Sample preparation in SDS-PAGE with 2-mercaptoethanol will reduce disulfide bonds in proteins. The sulfide bond reduction process will cause differences in protein conformation and profile. The purpose of this study was to compare the pattern of blood plasma protein profiles of mice analyzed using SDS-PAGE, with the addition of 2-mercaptoethanol and without the addition of 2-mercaptoethanol in a mixture of sample buffer solutions. The results of SDS-PAGE showed that the blood plasma protein profile of mice without the addition and with the addition of 2-mercaptoethanol showed differences in the number of protein bands, the molecular weight of several proteins and the thickness of the protein bands. There were nine protein bands with a molecular weight above 52 kDa in the profile without the addition of 2-mercaptoethanol, while there were only five protein bands with a molecular weight above 52 kDa in the profile with the addition of 2-mercaptoethanol. The difference in protein profile patterns shows that mouse blood plasma contains proteins containing disulfide bonds that can be reduced by 2-mercaptoethanol.
Deteksi Konsentrasi Fe, Cu, Zn dan Pb Air Sungai dan Ikan yang Tercemar Air Lindi di Bandar Lampung Dengan Menggunakan SSA: Detections of Fe, Cu, Zn and Pb Concentration in River Water and Fish Polluted by Leachate in Bandar Lampung Using AAS Andriyana, Ahmad Dodi; Mulyana, Jeane Siswitasari; Khairani, Iffa Afiqa; Riana, Elisa Nurma
Jurnal Sumberdaya Hayati Vol. 10 No. 2 (2024): 2024
Publisher : Departemen Biologi, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jsdh.10.2.97-101

Abstract

Leachate is a pollutant produced by landfills which can pollute the aquatic environment. This will have an impact on fish that live in waters contaminated with leachate and if consumed by the public it will harm health. The toxic effects of leachate are caused by the content of toxic chemicals, one of which is heavy metals. The aim of this research was to determine the concentrations of Fe, Cu, Zn and Pb in Bakung landfill leachate, Sukamaju river water and fish meat. Bakung landfill leachate samples were taken from two outlet points. The fish sampling location was carried out in the Sukamaju River. The physical factors of water measured are temperature, pH, salinity, turbidity, DO, COD and BOD. Fe, Cu, Zn and Pb concentrations were measured using the Atomic Absorption Spectrophotometry (AAS) method. The results show that the physicochemical parameters in leachate and river water exceed the threshold. The contents of Zn, Cu, Fe and Pb in the leachate at both outlet points exceeded the threshold value with values of 2.48 mg/L and 2.80 mg/L; 16.55 mg/L and 17 mg/L; 0.078 mg/L and 0.113 mg/L; 3.26 mg/L and 3.01 mg/L. The concentration of heavy metals Pb and Fe in river water is 0.083-0.162 mg/L and 2.68-2.97 mg/L which are above the quality standard value, while the heavy metal Fe content in fish meat exceeds the specified threshold value, namely 0.557 mg/100 g and 0.564 mg/100 g.
Effect Of Compost Tea and JADAM Microorganism Solution On Growth Of Chili Pepper In PT. Cinquer Agro Nusantara Khairani, Iffa Afiqa; Novriadi, Novriadi; Wandasari, Septi Putri; Nanda, M. Zulhiyadi; Anshori, Andi
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 9, No 1: Jurnal Pembelajaran Dan Biologi Nukleus March 2023
Publisher : Fakultas Keguruan dan Ilmu Pendidikan Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v9i1.3807

Abstract

Chili pepper (Capsicum frustescens) is herbaceous plant from the family Solanaceae which is massively cultivated in Indonesia. It also can be used as raw material for food product and pharmacy industries. Organic fertilizer usage has been both a solution to increase productivity and a replacement to chemical fertilizer usage. The aim of this study is to examine the effect of compost tea organic fertilizer and JADAM Microorganism Solution (JMS) on the growth of chili pepper in PT. Cinquer Agro Nusantara, Bangka Belitung. This research used a completely randomized design with 15 unit treatments which were divided into control group, compost tea group, and JMS group. The result showed that the plant group with JMS performed the highest height expansion, increasing the number of leaves significantly compared to control and compost tea group. This study concludes that application of compost tea and JADAM Microorganism Solution (JMS) as organic fertilizer on C. frustescens can increase the plant’s growth.Keywords : chili pepper, compost tea, JADAM microorganism solution
Antioxidant Activity and Phenolics of Kabau (Archidendron bubalinum) Pod Peel Extract from East Lampung on Blood Cell Male Mice Induced by Cadmium Riana, Elisa Nurma; Prastya, Muhammad Eka; Primahana, Gian; Anisa, Hida Arliani Nur; Khairani, Iffa Afiqa; Imaniar, Lisana Husna
Jurnal Ilmu Pertanian Indonesia Vol. 30 No. 2 (2025): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18343/jipi.30.2.353

Abstract

Cadmium (Cd) increases oxidative stress, which increases the likelihood of health problems. To protect the body from oxidative stress, natural antioxidants obtained from plants are required. The kabau plant (Archidendron bubalinum) is thought to have antioxidant phytochemicals. The purpose of this study was to assess the antioxidant activity and total phenolic component content of kabau pod peels, as well as their effect on the quantity of erythrocytes and leukocytes in male mice exposed to cadmium. This study used a completely randomized design, with 24 mice divided into six groups: three control groups and three treatment groups. The findings of assessing the antioxidant activity of peel extract revealed that the IC50 was 93.6 ppm, which is considered strong. The phenolic content of peel extract was 72.26 mg GAE/g. Giving pod peel extract to mice increased the number of erythrocytes and leukocytes, however the impact was not significant (p = 0.028 and P = 0.239). Mice with 380 mg/kg BW produced better outcomes. Keywords: antioxidant, Archidendron, blood cell, kabau, phenolics
Phytochemical Compound, Antioxidant and Antibacterial Properties of Sargassum sp. Extracts from Pahawang Island, Lampung Province Khairani, Iffa Afiqa; Istiadi, Khaerunissa Anbar; Restiawati, Nawang
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 1: Jurnal Pembelajaran Dan Biologi Nukleus March 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i1.6558

Abstract

Pahawang Island, located in Lampung Bay, has a variety of potential natural resources, one of which is macroalgae. One of the abundant brown macroalgae is Sargassum sp., with phytochemical components (flavonoids, steroids, tannins, and glycosides) that have potential as antioxidants, antibacterial, antitumor, anticancer, antifouling, and others. Sargassum sp. from Lampung waters, especially Pahawang Island still lacks scientific studies on its bioactive content and properties. This study aims to examine the phytochemical compounds (qualitatively and quantitatively), antioxidant activity (DPPH method) and antibacterial potential of Sargassum sp. extract (MIC/MBC method) against Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The results of phytochemical assay  showed that Sargassum sp. extract contained phenolic compounds, flavonoids, tannins, and saponins. Quantification results on total phenolic content were 0.56 mgGAE/g extract, total tannins were 4.27 mgTAE/g extract, total flavonoids were 14.19 mgQE/g extract, and total saponins were 5.54 %. Sargassum sp. extract classified as a very weak antioxidant with IC50 value of 964.10 ppm, and moderate antibacterial activity at a concentration of MIC/MBC 250/250 ppm against B. subtilis, E. coli, P. aeruginosa, and S. aureus
Sosialisasi Potensi Etnobotani dan Etnozoologi Desa Pahawang Maretta, Gres; Nurhayu, Winati; Novriadi, Novriadi; Yanti Ariyanti, Yanti Ariyanti; Wahyuni, Kurnia; Riana, Elisa Nurma; Khairani, Iffa Afiqa; Darmawan, Andy; Leksikowati, Sovia Santi; Kesuma, Andri Jaya
Abdimas Galuh Vol 7, No 1 (2025): Maret 2025
Publisher : Universitas Galuh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25157/ag.v7i1.17818

Abstract

Etnobiologi adalah evaluasi ilmiah terhadap pengetahuan penduduk tentang biologi, meliputi pengetahuan tentang tumbuhan (etnobotani), hewan (etnozoologi) dan lingkungannya (etnoekologi). Kajian etnobiologi dapat menghubungkan biologi dan etnis yang ada pada suatu tradisi adat. Melalui kegiatan Pengabdian Kepada Masyarakat, mendorong masyarakat untuk peduli terhadap pelestarian sumber daya alam yang ada di Desa Pahawang. Hasil akhir dari pelaksanaan kegiatan adalah pengetahuan masyarakat tentang pemanfaatan etnobotani dan etnozoologi yang ada di desa Pahawang. Kami melakukan penilaian terhadap pengetahuan dan ketertarikan masyarakat mengenai pemanfaatan etnobotani dan etnozoologi yang ada dan diterapkan di desa Pahawang. Pengetahuan masyarakat mengenai potensi dan pemanfaatan etnobotani dan etnozoologi di desa Pahawang meningkat setelah pelatihan jika dibandingkan dengan sebelum pelatihan. Hal ini dapat dilihat dari ketercapaian tujuan dari kegiatan dari hasil pengolahan data kuesioner. Rerata ketercapaian tujuan dapat dikatakan baik (75,6%) berdasarkan dari hasil pre-test dan post-test, dimana terdapat peningkatan pengetahuan dari ibu-ibu peserta kegiatan sebesar dari awal hingga akhir kegiatan. Kemampuan melakukan budidaya tanaman pangan, dan pengetahuan tentang pengobatan alami merupakan potensi besar untuk dikembangkan demi meningkatkan ketahanan pangan dan kesehatan yang lebih baik bagi masyarakat Desa Pahawang ke depan.
Pelatihan Pemanfaatan Limbah Minyak Jelantah menjadi Produk Lilin Aromaterapi di Desa Pahawang, Pesawaran Khairani, Iffa Afiqa; Anbar Istiadi, Khaerunissa; Chusniasih, Dewi; Suryanti, Erma; Arliani Nur Anisa, Hida; Natalia Pardede, Desta
Jurnal Abdimas Berdaya : Jurnal Pembelajaran, Pemberdayaan dan Pengabdian Masyarakat Vol 8, No 1 (2025): Jurnal Abdimas Berdaya
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/jab.v8i1.1040

Abstract

Caffeine Molecular Target Identification and Protein Interaction Analysis in Alzheimer's Disease Fatriani, Rizka; Haryandi, Yopi; Khairani, Iffa Afiqa; Anisa, Hida Arliani Nur
MAXIMUS: Journal of Biological and Life Sciences Vol. 3 No. 1 (2025)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/maximus.v3i1.2143

Abstract

Caffeine is known to have various biological effects, including its potential to modulate the central nervous system. This study aims to identify the molecular targets of caffeine and explore their relationship with Alzheimer's disease using a bioinformatics approach. The methods used include target prediction using SwissTargetPrediction and SuperPred, target relationship analysis with disease through the DAVID database, protein interaction exploration and enrichment analysis using STRING-DB, and network analysis using Cytoscape. The results showed that from the total targets obtained, there were 20 overlapping targets related to Alzheimer's. Protein interaction analysis revealed 17 nodes with 32 significant interactions, which provide insight into the molecular pathways that caffeine can manipulate in the context of neuroprotection. These findings are in line with various studies showing that caffeine consumption is associated with a reduced risk of Alzheimer's through modulation of the nervous system and inflammation.
Co-Authors Anbar Istiadi, Khaerunissa Andri Jaya Kesuma Andriani, Silvia Andriyana, Ahmad Dodi ANDY DARMAWAN Anisa, Hida Arliani Nur Anshori, Andi Antonius Antonius Arliani Nur Anisa, Hida Azizah, Najla Nur Dewi Chusniasih Evi Kurniawaty Fatriani, Rizka Gres Maretta, Gres Haryandi, Yopi Hendri Busman Imaniar, Lisana Husna Khaerunissa Anbar Istiadi Kurnia Wahyuni Kurniawaty, Evi Leksikowati, Sovia Santi Maruli, Berkat Afni Muhammad Arif Mulyadi, Salsa Pratiwi Mulyana, Jeane Siswitasari Nanda, M. Zulhiyadi Natalia Pardede, Desta Novriadi, Novriadi Nuning Nurcahyani Nurhayu, Winati Olivia, Rahel Noviantika Prastya, Muhammad Eka Primahana, Gian Puspa, Egita Windrianatama Putri, Isnaini Anggraini Restiawati, Nawang Riana, Elisa Nurma Sahroni, Mizan Sandro, Mario Silvia Andriani Suryanti, Erma Wandasari, Septi Putri Yanti Ariyanti, Yanti Ariyanti Yogi Catur Putra