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All Journal Jurnal Pendidikan Biologi Undiksha Biotropika Jurnal Sumberdaya Hayati Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Pembelajaran dan Biologi Nukleus Jurnal Ilmiah Kesehatan Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Abdimas Berdaya : Jurnal Pembelajaran, Pemberdayaan dan Pengabdian Masyarakat Jurnal Biosense Quagga: Jurnal Pendidikan dan Biologi Bagimu Negeri : Jurnal Pengabdian Kepada Masyarakat Maximus: Journal of Biological and Life Sciences Indonesian Journal of Jamu
Iffa Afiqa Khairani
Institut Teknologi Sumatera
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MALFORMASI BAGIAN – BAGIAN TUBUH FETUS MENCIT (Mus musculus L.) SETELAH PEMBERIAN EKSTRAK BUAH PARE (Momordica charantia L.) Silvia Andriani; Nuning Nurcahyani; Hendri Busman; Evi Kurniawaty; Iffa Afiqa Khairani
Jurnal Ilmiah Kesehatan Vol 12, No 1 (2023): Jurnal Ilmiah Kesehatan
Publisher : Universitas Muhammadiyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52657/jik.v12i1.2136

Abstract

Pare memiliki khasiat sebagai tanaman obat tradisional. Pada buah pare terdapat beberapa senyawa yang bersifat toksik yaitu senyawa momordikosida K dan L, yang diduga mempunyai sifat sitotoksik. Penelitian ini bertujuan untuk mengetahui panjang kranium, dan panjang sternum fetus mencit (Mus musculus L.) setelah pemberian ekstrak buah pare (Momordica charantia L.) terhadap mencit yang sedang hamil. Ekstrak pare diperoleh dengan cara maserasi menggunakan etanol 95%. Pemberian ekstrak buah pare (M. charantia L.) sebagai uji teratogenik pada kelainan fetus mencit. Rancangan penelitian adalah rancangan acak lengkap dengan analisis varian, yaitu menggunakan 20 ekor mencit jantan dan 20 ekor mencit betina yang dibagi dalam 4 kelompok. Setiap kelompok terdiri dari 5 ekor mencit betina yang telah hamil di beri ekstrak buah pare secara oral dimulai hari ke - 6 sampai hari 17 masa kehamilan sehari sekali pada pagi hari dengan dosis Perlakuan, aquabidest sebagai kontrol [A], [B] 22,5 mg/30 grBB , [C] 30 mg/30 grBB, dan [D] 37,5 mg/30 grBB . Selanjutnya induk mencit dibedah diambil fetusnya untuk dilakukan pengukuran terhadap panjang kranium dan panjnag sternum. Dari hasil analisis data menunjukkan bahwa secara umum pemberian perlakuan ekstrak buah pare menyebabkan penurunan rata-rata panjang kranium,dan sternum. Hasil analisis lanjut dengan BNT pada taraf 5 % menunjukkan bahwa pemberian dosis [B], [C], [D] memberikan pengaruh yang nyata terhadap penurunan panjang kranium, dan sternum. Pemberian ekstrak buah pare pada mencit hamil dosis yang paling efektif untuk menurunkan panjang kranium dan panjang sternum yaitu dosis 37,5 mg/30 grBB.
PEMERIKSAAN GOLONGAN DARAH DAN RHESUS PADA MASYARAKAT DESA SENDANG MULYO KECAMATAN SENDANG AGUNG KABUPATEN LAMPUNG TENGAH Andriani, Silvia; Puspa, Egita Windrianatama; Sahroni, Mizan; Arif, Muhammad; Sandro, Mario; Putra, Yogi Catur; Kurniawaty, Evi; Khairani, Iffa Afiqa
Bagimu Negeri Vol 7, No 2 (2023)
Publisher : Universitas Muhammadiyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52657/bagimunegeri.v7i2.2181

Abstract

Darah merupakan salah satu komponen paling penting yang ada dalam tubuh, mengingat fungsinya sebagai alat transportasi. Pemeriksaan golongan darah adalah salah satu aspek dalam upaya pencegahan penyakit. Identifikasi golongan darah dengan melihat penggumpalan darah yang telah diberi reagen banyak dilakukan secara manual berdasarkan pengamatan visual secara langsung. Pemeriksaan golongan darah dapat menjadi informasi penting dalam konteks perawatan kesehatan, terutama dalam situasi darurat atau ketika transfusi darah diperlukan. Indonesia masih mengalami kekurangan jumlah penyediaan darah secara nasional sebanyak 500 ribu kantong. Kekurangan ketersediaan darah tersebut meliputi golongan darah langka seperti golongan darah AB dan rhesus negatif. Pengabdian masyarakat adalah suatu kegiatan yang bertujuan untuk membantu masyarakat dalam meningkatkan pengetahuan dan derajat kesehatan. Kegiatan pengabdian masyarakat menjadi salah satu bagian dari Catur Dharma Perguruan Tinggi. Tujuan kegiatan pengabdian masyarakat ini adalah untuk mengetahui hasil pemeriksaan golongan darah dan rhesus pada masyarakat di desa Sendang Mulyo Kecamatan Sendang Agung. Desain kegiatan ini menggunakan desain deskriptif observational yaitu menggambarkan hasil pemeriksaan golongan darah berdasarkan hasil observasi dilapangan. Pemeriksaan Golongan darah sistem ABO yang dilakukan di Desa Sendang Mulyo diperoleh hasil golongan darah A sebanyak 9 orang, golongan darah B sebanyak 18  orang, golongan darah O sebanyak 24 orang, sedangkan untuk golongan darah AB sebanyak 4 orang
Deteksi Konsentrasi Fe, Cu, Zn dan Pb Air Sungai dan Ikan yang Tercemar Air Lindi di Bandar Lampung Dengan Menggunakan SSA: Detections of Fe, Cu, Zn and Pb Concentration in River Water and Fish Polluted by Leachate in Bandar Lampung Using AAS Andriyana, Ahmad Dodi; Mulyana, Jeane Siswitasari; Khairani, Iffa Afiqa; Riana, Elisa Nurma
Jurnal Sumberdaya Hayati Vol. 10 No. 2 (2024): 2024
Publisher : Departemen Biologi, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jsdh.10.2.97-101

Abstract

Leachate is a pollutant produced by landfills which can pollute the aquatic environment. This will have an impact on fish that live in waters contaminated with leachate and if consumed by the public it will harm health. The toxic effects of leachate are caused by the content of toxic chemicals, one of which is heavy metals. The aim of this research was to determine the concentrations of Fe, Cu, Zn and Pb in Bakung landfill leachate, Sukamaju river water and fish meat. Bakung landfill leachate samples were taken from two outlet points. The fish sampling location was carried out in the Sukamaju River. The physical factors of water measured are temperature, pH, salinity, turbidity, DO, COD and BOD. Fe, Cu, Zn and Pb concentrations were measured using the Atomic Absorption Spectrophotometry (AAS) method. The results show that the physicochemical parameters in leachate and river water exceed the threshold. The contents of Zn, Cu, Fe and Pb in the leachate at both outlet points exceeded the threshold value with values of 2.48 mg/L and 2.80 mg/L; 16.55 mg/L and 17 mg/L; 0.078 mg/L and 0.113 mg/L; 3.26 mg/L and 3.01 mg/L. The concentration of heavy metals Pb and Fe in river water is 0.083-0.162 mg/L and 2.68-2.97 mg/L which are above the quality standard value, while the heavy metal Fe content in fish meat exceeds the specified threshold value, namely 0.557 mg/100 g and 0.564 mg/100 g.
Effect Of Compost Tea and JADAM Microorganism Solution On Growth Of Chili Pepper In PT. Cinquer Agro Nusantara Khairani, Iffa Afiqa; Novriadi, Novriadi; Wandasari, Septi Putri; Nanda, M. Zulhiyadi; Anshori, Andi
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 9, No 1: Jurnal Pembelajaran Dan Biologi Nukleus March 2023
Publisher : Fakultas Keguruan dan Ilmu Pendidikan Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v9i1.3807

Abstract

Chili pepper (Capsicum frustescens) is herbaceous plant from the family Solanaceae which is massively cultivated in Indonesia. It also can be used as raw material for food product and pharmacy industries. Organic fertilizer usage has been both a solution to increase productivity and a replacement to chemical fertilizer usage. The aim of this study is to examine the effect of compost tea organic fertilizer and JADAM Microorganism Solution (JMS) on the growth of chili pepper in PT. Cinquer Agro Nusantara, Bangka Belitung. This research used a completely randomized design with 15 unit treatments which were divided into control group, compost tea group, and JMS group. The result showed that the plant group with JMS performed the highest height expansion, increasing the number of leaves significantly compared to control and compost tea group. This study concludes that application of compost tea and JADAM Microorganism Solution (JMS) as organic fertilizer on C. frustescens can increase the plant’s growth.Keywords : chili pepper, compost tea, JADAM microorganism solution
Sosialisasi Potensi Etnobotani dan Etnozoologi Desa Pahawang Maretta, Gres; Nurhayu, Winati; Novriadi, Novriadi; Yanti Ariyanti, Yanti Ariyanti; Wahyuni, Kurnia; Riana, Elisa Nurma; Khairani, Iffa Afiqa; Darmawan, Andy; Leksikowati, Sovia Santi; Kesuma, Andri Jaya
Abdimas Galuh Vol 7, No 1 (2025): Maret 2025
Publisher : Universitas Galuh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25157/ag.v7i1.17818

Abstract

Etnobiologi adalah evaluasi ilmiah terhadap pengetahuan penduduk tentang biologi, meliputi pengetahuan tentang tumbuhan (etnobotani), hewan (etnozoologi) dan lingkungannya (etnoekologi). Kajian etnobiologi dapat menghubungkan biologi dan etnis yang ada pada suatu tradisi adat. Melalui kegiatan Pengabdian Kepada Masyarakat, mendorong masyarakat untuk peduli terhadap pelestarian sumber daya alam yang ada di Desa Pahawang. Hasil akhir dari pelaksanaan kegiatan adalah pengetahuan masyarakat tentang pemanfaatan etnobotani dan etnozoologi yang ada di desa Pahawang. Kami melakukan penilaian terhadap pengetahuan dan ketertarikan masyarakat mengenai pemanfaatan etnobotani dan etnozoologi yang ada dan diterapkan di desa Pahawang. Pengetahuan masyarakat mengenai potensi dan pemanfaatan etnobotani dan etnozoologi di desa Pahawang meningkat setelah pelatihan jika dibandingkan dengan sebelum pelatihan. Hal ini dapat dilihat dari ketercapaian tujuan dari kegiatan dari hasil pengolahan data kuesioner. Rerata ketercapaian tujuan dapat dikatakan baik (75,6%) berdasarkan dari hasil pre-test dan post-test, dimana terdapat peningkatan pengetahuan dari ibu-ibu peserta kegiatan sebesar dari awal hingga akhir kegiatan. Kemampuan melakukan budidaya tanaman pangan, dan pengetahuan tentang pengobatan alami merupakan potensi besar untuk dikembangkan demi meningkatkan ketahanan pangan dan kesehatan yang lebih baik bagi masyarakat Desa Pahawang ke depan.
Pelatihan Pemanfaatan Limbah Minyak Jelantah menjadi Produk Lilin Aromaterapi di Desa Pahawang, Pesawaran Khairani, Iffa Afiqa; Anbar Istiadi, Khaerunissa; Chusniasih, Dewi; Suryanti, Erma; Arliani Nur Anisa, Hida; Natalia Pardede, Desta
Jurnal Abdimas Berdaya : Jurnal Pembelajaran, Pemberdayaan dan Pengabdian Masyarakat Vol 8, No 1 (2025): Jurnal Abdimas Berdaya
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/jab.v8i1.1040

Abstract

Caffeine Molecular Target Identification and Protein Interaction Analysis in Alzheimer's Disease Fatriani, Rizka; Haryandi, Yopi; Khairani, Iffa Afiqa; Anisa, Hida Arliani Nur
MAXIMUS: Journal of Biological and Life Sciences Vol. 3 No. 1 (2025)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/maximus.v3i1.2143

Abstract

Caffeine is known to have various biological effects, including its potential to modulate the central nervous system. This study aims to identify the molecular targets of caffeine and explore their relationship with Alzheimer's disease using a bioinformatics approach. The methods used include target prediction using SwissTargetPrediction and SuperPred, target relationship analysis with disease through the DAVID database, protein interaction exploration and enrichment analysis using STRING-DB, and network analysis using Cytoscape. The results showed that from the total targets obtained, there were 20 overlapping targets related to Alzheimer's. Protein interaction analysis revealed 17 nodes with 32 significant interactions, which provide insight into the molecular pathways that caffeine can manipulate in the context of neuroprotection. These findings are in line with various studies showing that caffeine consumption is associated with a reduced risk of Alzheimer's through modulation of the nervous system and inflammation.
Molecular Insights into the Therapeutic Potential of Curcuma amada Rhizome: A Network Pharmacology and Docking Approach Fatriani, Rizka; Istiadi, Khaerunissa Anbar; Khairani, Iffa Afiqa
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.397

Abstract

The rhizome of Curcuma amada (ginger mango) has traditionally been used for various medicinal purposes. However, its molecular targets and mechanisms of action are still poorly understood. This study aimed to predict the potential bioactive compounds and target proteins of C. amada using network pharmacology and molecular docking approaches. A total of 110 compounds were identified, and their predicted targets were analyzed through a protein-protein interaction (PPI) network, enrichment, and disease analysis. Key targets include phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) and tyrosine-protein kinase JAK2 (JAK2), both of which are closely related to cancer-related pathways. Four compounds, β-eudesmol, (E,Z)-farnesol, spathulenol, and τ-muurolol, were selected for molecular docking studies. Validation of the docking protocol through re-docking showed low RMSD values ​​(0.667 Å for PIK3CA and 0.474 Å for JAK2), confirming the reliability of the method. The docking results demonstrated that the native ligands and selected compounds formed multiple hydrogen bonds and extensive hydrophobic interactions with key residues in the active site. Notably, most of the interactions were hydrophobic, which is consistent with the volatile nature of the ligands. The binding affinity was below –5 kcal/mol for all tested compounds. These findings suggest that C. amada rhizomes contain bioactive compounds capable of modulating cancer-related targets, thus providing a molecular basis for their potential therapeutic effects. 
IMMUNOSTIMULATORY EFFECT OF VITAMIN C ON MICE INDUCED BY STAPHYLOCOCCUS AUREUS Khairani, Iffa Afiqa; Riana, Elisa Nurma; Maretta, Gres; Azizah, Najla Nur; Putri, Isnaini Anggraini; Maruli, Berkat Afni; Mulyadi, Salsa Pratiwi; Antonius, Antonius
MAXIMUS: Journal of Biological and Life Sciences Vol. 1 No. 2 (2023)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/maximus.v1i2.1636

Abstract

Several compounds that can boost immune activity (immunostimulatory) include vitamin E, curcumin, flavonoids, and vitamin C. In this study, ascorbic acid or vitamin C, was used as one method to enhance the immune system. This study aims to determine the immunostimulatory effect of vitamin C on the phagocytosis activity of macrophages in mice induced by Staphylococcus aureus. The mice were divided into two groups: the control group, which received 0.3 ml of distilled water orally, and the treatment group, which received 0.036 mg/g BW of vitamin C orally for 14 days. On the 15th day, each mouse was intraperitoneally induced with 0.5 mL of Staphylococcus aureus bacterial suspension and left for two hours. The phagocytic activity value represents the percentage of active macrophage cells among all macrophages observed. The result showed that the value of % phagocytic activity in the control group was 21.43% ± 7.92, whereas the % phagocytic activity in the treatment group was 48.31% ± 22.27. The group of mice given vitamin C 0.036 mg/g BW orally showed increased phagocytic activity compared to the control group mice. This shows that vitamin C has potential as an immunostimulator.
Quantitative Analysis of Phytochemical Compounds and Antihyperglycemic Potential of Robusta Coffee from West Lampung Khairani, Iffa Afiqa; Mulyana, Jeane Siswitasari; Olivia, Rahel Noviantika; Riana, Elisa Nurma; Anisa, Hida Arliani Nur
Jurnal Sumberdaya Hayati Vol. 10 No. 1 (2024): 2024
Publisher : Departemen Biologi, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jsdh.10.1.1-6

Abstract

West Lampung Regency in Lampung Province produces high quality robusta coffee with a distinct, strong bitter flavour. Bitter flavour indicates the amount of bioactive substances produced by plants called phytochemicals. The aim of this study is to analyse the phytochemical compounds and antihyperglycemic potential of robusta coffee beans from West Lampung, Indonesia. Quantitative phytochemical analysis was carried out using the thin layer chromatography method and spectrophotometry. Animal experimental design using robusta coffee on hyperglycemia conditions in mice which was induced by alloxan 170 mg/kgBW subcutaneously and given by 1 ml of brewed robusta coffee for 10 days. The robusta coffee from West Lampung contained total caffeine 4,014.87 µg/g, total flavonoid content (TFC) 93.6 mg quercetin equivalent per gram of sample, with total alkaloid content (TAC) 0.848 mg of quinine equivalent per gram of sample, total tannin content (TTC) 182.3 mg of tannic acid equivalent per gram of sample, and total saponin content (TSC) 24.2 mg of quillaja bark equivalent per gram of sample. The administration of 1 ml/mice/day of robusta coffee brewed for 10 days did not show a decrease in blood sugar level in hyperglycemic mice, due to the short duration of the study, so the role of coffee in decreasing hyperglycemia conditions has not been optimally observed.
Co-Authors Anbar Istiadi, Khaerunissa Andri Jaya Kesuma Andriani, Silvia Andriyana, Ahmad Dodi Andy Darmawan ANDY DARMAWAN Anisa, Hida Arliani Nur Anshori, Andi Antonius Antonius Arliani Nur Anisa, Hida Azizah, Najla Nur Dewi Chusniasih Evi Kurniawaty Fatriani, Rizka Gres Maretta, Gres Haryandi, Yopi Hendri Busman Hida Arliani Nur Anisa Hida Arliani Nur Anisa Jeane Siswitasari Mulyana Khaerunissa Anbar Istiadi Khaerunissa Anbar Istiadi Kurnia Wahyuni Kurniawaty, Evi Leksikowati, Sovia Santi Maruli, Berkat Afni Mulyadi, Salsa Pratiwi Mulyana, Jeane Siswitasari Nanda, M. Zulhiyadi Natalia Pardede, Desta Nawang Restiawati Novriadi, Novriadi Nuning Nurcahyani Nurhayu, Winati Olivia, Rahel Noviantika Puspa, Egita Windrianatama Putri, Isnaini Anggraini Rara Mulia Sari Riana, Elisa Nurma Rizka Fatriani Sahroni, Mizan Sandro, Mario Silvia Andriani Silvia Andriani Siswahyudianto Suryanti, Erma Wahyuni Dian Lestari Wandasari, Septi Putri Winati Nurhayu Yanti Ariyanti, Yanti Ariyanti Yogi Catur Putra