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All Journal JURNAL JAMU KUSUMA JURNAL KESEHATAN YAMASI MAKASSAR Journal Pharmacy and Application of Computer Sciences
Duppa, Muhammad Taufiq
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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FORMULATION AND ACTIVITY TESTS OF EUPHATORIUM LEAF (Euphatorium oradatum L.) ETHANOL EXTRACT GEL ON BURNS HEALING OF RABBITS Firmansyah, Firmansyah; Taufiq; Hafid, Muliana; Sari, Alfiani; Duppa, Muhammad Taufiq
Jurnal Jamu Kusuma Vol. 4 No. 1 (2024): JURNAL JAMU KUSUMA
Publisher : Poltekkes Kemenkes Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37341/jurnaljamukusuma.v4i1.96

Abstract

A gel is a semisolid system consisting of small inorganic particles or large organic molecules suspended in a liquid. This study aims to determine if Euphatorium leaf extract can be formulated into a gel preparation that meets the physical quality requirements and to determine the activity of Euphatorium leaf extract gel on rabbit burn wound healing. This type of research was a laboratory experiment with gel preparation formulations and activity tests on rabbit burn wound healing. Preparation of Euphatorium leaf extract by maceration with 96% ethanol solvent. In this study, FI gel preparations (negative control), FII (2.5% extract), FIII (5% extract), FIV (10% extract), FV (Bioplacenton positive control). Furthermore, a physical stability test was carried out on the Euphatorium leaf extract gel which included; organoleptic test, homogeneity test, pH test, spreadability test, adhesion test, viscosity test and accelerated stability test. Then tested the activity of Euphatorium leaf extract gel on the healing of rabbit burns. In this test, 5 rabbits were used. Each rabbit was made a wound with an area of ​​2 cm on the back area which was divided into 3 wound areas. Each wound area is given the same concentration. Observations were made every 3 days of treatment. The results showed that Euphatorium leaf extract could be formulated into a gel preparation and met the physical stability requirements of the gel, and the activity test on the healing of rabbit burns obtained an average percentage of burn wound healing, namely FI (11.83%), FII (24.50) , FIII (31.33%), FIV (54.17%) and FV (66.17%). Based on the results of statistical analysis tests with one way ANOVA, it was shown that there were significant differences in the healing activity of rabbit burns between all treatment groups where the value of p <0.05.
UJI EFEKTIFITAS EKSTRAK ETANOL DAUN BIDARA (Ziziphus spina-christi L.) TERHADAP PERTUMBUHAN Staphylococcus aureus DAN Escherichia coli Rukman, Wira Yustika; Masri, Anshari; Syafruddin, Syafruddin; Duppa, Muhammad Taufiq
Journal Pharmacy and Application of Computer Sciences Vol. 2 No. 2: Agustus: 2024: JOPACS
Publisher : Arlisaka Madani Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59823/jopacs.v2i2.62

Abstract

Infeksi merupakan penyakit yang dapat ditularkan dari satu manusia ke manusia lain atau dari hewan ke manusia. Infeksi dapat disebabkan oleh berbagai mikroorganisme seperti virus, bakteri, jamur. Penelitian ini bertujuan untuk mengetahu efektivitas ekstrak etanol daun Bidara (Ziziphus spina-christi L.) terhadap pertumbuhan Staphylococcus aureus dan Escherichia coli Desain penelitian yang digunakan adalah eksperimental yang dilaksanakan di Laboratorium Mikrobiologi Prodi Farmasi Fakultas FKIK Universitas Muhammadiyah Makassar. Penelitian ini menggunakan ekstrak daun bidara dibagi menjadi 5 kelompok yang terdiri atas kelompok I yang diberikan Na CMC 1% b/v sebagai kelompok kontrol negatif, kelompok II ( ekstrak 5 %), kelompok III (ekstrak 10%), kelompok IV (ekstrak 15%) dan kelompok V kontrol positif (Tetrasiklin). Hasil penelitian menunjukkan bahwa ekstrak daun bidara pada kelompok II ( ekstrak 5 %), kelompok III (ekstrak 10%), kelompok IV (ekstrak 15%) memiliki efektivitas terhadap pertumbuhan Staphylococcus aureus dan Escherichia coli. Ekstrak daun Bidara kelompok IV (ekstrak 15%) memiliki efek yang tinggi yaitu 15,67 mm. Namun pemberian tetrasiklin sebagai kontrol positif memiliki efek penuruanan lebih besar yaitu 32,33 mm dibandingkan dengan ekstrak Bidara. Hasil uji statitistik dengan One Way Anova menunjukkan bahwa terdapat perbedaan yang signifikan rata-rata antar kelompok perlakuan dengan nilai sig. < 0,05.
UJI EFEKTIVITAS EKSTRAK ETANOL BUAH BINTARO (Cerbera odollam Gaerthn) TERHADAP PENURUNAN GLUKOSA DARAH PADA TIKUS PUTIH (Rattus norvegicus) Masri, Anshari; duppa, muhammad taufiq; Rukman, Wira Yustika; Syafruddin; Sitti Nurjannah; Delvi Sara JIhan; Ermawati; dupppa, muhammad taufiq
Jurnal Kesehatan Yamasi Makassar Vol 9 No 2 (2025): Jurnal Kesehatan
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/jurkes.v9i2.386

Abstract

This study aims to determine the efectivity of Bintaro Fruit (Cerbera odollam gaerthn) Ethanol Extract Against Blood Glucose Decrease in White Rats (Rattus Norvegicus. The research design used was an experimental laboratory carried out in the pharmacology laboratory of the Department of Pharmacy, Pancasakti University. This study used 15 rats. male white rats were divided into 5 groups consisting of group I as a negative control by giving 1% w/v Na.CMC suspension, groups II, III, IV as a treatment group given Bintaro Fruit extract 1% w/v, 3% w/v, 5% w/v And group V was given Glibenclamide suspension as a positive control.The results showed that the percentage reduction in blood glucose for negative control, treatment and positive groups was 11.37%, 32.03%, 65, respectively. 46%, 86.15%, 95.5% The most effective concentration was 5% w/v concentration with an average value of 86.15% reduction, but it has not been able to match the effectiveness of Glibenclamide. in statistical testing using the Graphad Prims program for an alpha rate of 0.05, P value of 0.0001 is significant, the F value is 608.3.
Co-Authors Delvi Sara JIhan dupppa, muhammad taufiq Ermawati Firmansyah Firmansyah Hafid, Muliana Masri, Anshari Nurjanna, Sitti Rukman, Wira Yustika Sari, Alfiani Syafruddin Syafruddin Syafruddin Taufiq