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All Journal Acta Pharmaciae Indonesia : Acta Pharm Indo Mandala of Health : A Scientific Journal Medical and Health Journal
Yudhawan, Indra
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Dentistry Health Professions Medicine & Pharmacology Public Health

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Anti-inflammatory activity of combination of ethanol extracts of ginger (Zingiber officinale) and bangle (Zingiber cassumunar) in carrageenan-induced rats Hasyim, Bellia; Yudhawan, Indra; Ekowati, Heny; Rachmani, Eka Prasasti Nur
Acta Pharmaciae Indonesia Vol 11 No 2 (2023): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.2.11548

Abstract

Background: Inflammation is an essential innate immune response aimed at antigen elimination and preventing their spread. Ginger (Zingiber officinale) and bangle (Zingiber cassumunar) rhizomes have been empirically utilized as medicinal components due to their anti-inflammatory potential. However, the combined efficacy of these rhizomes has not been previously explored. Objective: This study aimed to assess the anti-inflammatory activity of a combination of ginger and bangle rhizome extracts. Method: Ginger and bangle rhizomes were individually subjected to extraction through maceration with 96% ethanol, followed by purification with n-hexane. The anti-inflammatory activity was evaluated via motility tests on subjects administered orally with 1% CMC-Na (control), diclofenac sodium (4.5 mg/kg body weight), ginger ethanol extract (200 mg/kg body weight), bangle ethanol extract (400 mg/kg body weight), and a combination of both extracts (100:200 mg/kg body weight). Observations were made over 6 hours, with motility scores subsequently analyzed using ANOVA and the LSD test for statistical significance. Results: Treatments involving ginger extract, bangle extract, and their combination significantly improved motility scores compared to the negative control. Furthermore, these treatments displayed no significant difference in effectiveness compared to the diclofenac sodium group (p > 0.05). Conclusion: The combined ethanol extracts of ginger and bangle rhizomes demonstrate anti-inflammatory activity comparable to diclofenac sodium, as evidenced by motility score evaluations. This suggests their potential as alternative anti-inflammatory agents.
BEETROOT (Beta vulgaris L.) AND ITS POTENTIAL AS AN ANEMIA TREATMENT IN PREGNANCY Fadlilah, Synta Haqqul; Suhartomo, Dalri Muhammad; Yusan, Rizak Tiara; Yudhawan, Indra
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.9070

Abstract

Anemia is one of the most common nutritional problems in pregnant women. It is defined as a condition in which the hemoglobin (Hb) level is lower than normal. The main cause of anemia in obstetrics is iron deficiency. To prevent this condition, the Government of Indonesia through the Ministry of Health made a rule by giving iron tablets to pregnant women at least 90 tablets during pregnancy (Kemenkes RI, 2022). However, some people are often bored with this pharmacological therapy due to the nausea and vomiting effect of the iron smell. Therefore, the development of alternative anemia therapy has been done to minimize those problems. One of the herbal ingredients that are being studied for its potential as anti-anemia in pregnancy is beetroot (Beta vulgaris L.). This research is included in the type of literature review. The selected literature is research articles published in the last 10 years (2013 to 2023). There are 10 articles that match the topic of study. A total of 7 publications demonstrated the effect of beetroot on anemia in pregnant women during the pregnancy period, and 2 articles in the post-partum period. A study performed in vivo experiments on pregnant female rats. Almost all of the studies did intervention by giving subjects beetroot juice. Only one study used beets as an intervention as ice cream. The results show that beetroot has the potential to prevent and treat anemia in pregnancy by increasing hemoglobin levels and the amounts of hematocrit. It contains a high level of folic acid which is important for normal cell and tissue growth. The iron content of beetroot also plays an essential role in the human body transporting oxygen to red blood cells, so it helps to cure anemia.
Formulation and physical quality evaluation of aromatherapy oil combining patchouli (Pogostemon cablin Benth.) and peppermint (Mentha piperita L.) essential oils Wahyudi, Hendra; Hamzah, Hasyrul; Yudhawan, Indra
Acta Pharmaciae Indonesia Vol 12 No 1 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.1.11608

Abstract

Background: Indonesia is a major producer of essential oils, with patchouli and peppermint oils being widely used in aromatherapy. Aromatherapy products, such as wind oil, provide therapeutic benefits but are often underused by younger consumers. Developing formulations that appeal to a broader audience may increase their use. Objective: This study aimed to formulate an aromatherapy oil using patchouli and peppermint essential oils, evaluate its physical properties, and test consumer preferences. Method: Four formulations (F1–F4) were prepared with varying concentrations of patchouli and peppermint oils. Physical tests, including organoleptic, homogeneity, clarity, pH, and spreadability, were conducted over four weeks. A hedonic test with 20 respondents assessed sensory preferences. Results: Formulations remained stable in terms of homogeneity and clarity throughout the study. pH values were within the acceptable range for skin application, though they increased slightly during storage. Spreadability improved over time, with F2, F3, and F4 meeting the ideal range by the fourth week. F4, containing 6% patchouli and 15% peppermint oils, was the most preferred in the hedonic test, particularly for color, smell, and clarity. Conclusion: Patchouli and peppermint essential oils can be effectively combined to create a stable, consumer-preferred aromatherapy oil. F4 showed the best physical and sensory qualities, making it a promising formulation for future development.
PEMANFAATAN DAN INOVASI DAUN KATUK (Sauropus androgynus) SEBAGAI SUPLEMENTASI ASI DI INDONESIA: MINI REVIEW Yudhawan, Indra; Cahyaningrum, Putri Khaerani; Suhartomo, Dalri Muhammad; Fadlillah, Synta Haqqul; Haresmita, Perdana Priya; Hamzah, Hasyrul; Sari, Mely Anita; Wicaksari, Sifa Aulia
Mandala Of Health Vol 17 No 1 (2024): Mandala of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.1.12017

Abstract

Zat gizi paling penting dalam masa emas pertumbuhan dan perkembangan bayi dalam 6 bulan pertama kehidupan adalah Air Susu Ibu (ASI). ASI mengandung zat gizi lengkap dan memiliki komponen imunitas yang penting bagi untuk pertumbuhan, perkembangan, dan sistem imun bayi. Akan tetapi, tidak semua ibu dapat menghasilkan ASI secara optimal dikarenakan berbagai faktor. Sehingga, sebagian ibu menyusui membutuhkan tambahan asupan berupa suplemen pelancar ASI. Salah satu tanaman yang banyak digunakan adalah daun katuk (Sauropus androgynus). Penelitian ini merupakan studi literatur terkait pemanfaatan daun katuk di Indonesia, sebagian besar pencarian adalah penelitian 5 tahun terakhir untuk mengetahui pemanfaatan dan pengembangan daun katuk di Indonesia. Hasil penelusuran menunjukkan bahwa terdapat efektivitas daun katuk dalam meningkatkan produksi ASI. Inovasi daun katuk sebagai suplementasi ASI banyak dilakukan, baik dalam bentuk makanan, cemilan, maupun minuman instan. Edukasi dan sosialisasi terkait pemanfaatan daun katuk juga telah banyak dilakukan oleh tenaga kesehatan. Namun, penelitian lebih dalam terkait mekanisme aksi daun katuk, serta pengembangannya dalam bentuk sediaan farmasi masih belum banyak dilakukan. Mengingat potensi yang besar dari daun katuk, perlu dilakukan penelitian lanjutan untuk mengeksplorasi mekanisme aksi dan mengembangkan produk daun katuk secara saintifik dalam bentuk nutrasetikal, obat herbal terstandar maupun fitofarmaka.
TORBANGUN (Coleus amboinicus) LEAF AS POTENTIAL NEWCOMER IN GALACTOGOGUE OR BREASTMILK BOOSTER: A NARRATIVE REVIEW Yudhawan, Indra; Daniel, Vino; Cahyaningrum, Putri Khaerani; Fadlilah, Synta Haqqul; Suhartomo, Dalri Muhammad; Wahyudi, Ari; Putra, Akwila Albert Dakusha; Pratiwi, Intan Diah; Hawwin, Nur; Kurniawan, Dhadhang Wahyu
Mandala Of Health Vol 18 No 1 (2025): Mandala of Health: A scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.1.16222

Abstract

The postpartum period is a critical phase for infant development, and one of the challenges during this time is inadequate or absent lactation, which leads to insufficient breast milk (ASI) production. Baby’s growth and development require an adequate amount of nutrition, especially during 6 months of life. Breast Milk is the most fundamental food for babies, and offers complete nutrition for growth and development. However, some mothers are unable to produce enough breast milk for the baby and need to take supplements to stimulate their milk production. Torbangun or Bangun-bangun (Coleus amboinicus) leaf is empirically used to increase milk production in some areas of Indonesia. Although, the use of torbangun is not widely used and known. This research offers an investigation and review of many references to find out the current research on torbangun, especially in association with breast milk production. The result shows that there are quite a lot of research has been done related to torbangun in increasing breast milk. Torbangun has proven to have significant potential as a supplement for increasing breast milk production. The research is still in a preliminary study and there is still a few research that could elucidate the mechanism of action of torbangun as galactogogue, the accuracy of dosage, phytochemical compound, and its safety. Therefore, further research is strongly suggested to elucidate this aspect, especially in dosage, standardization, mechanism of action, scientific formulation, phytochemical compound along with its activity and its safety.
Co-Authors ARI WAHYUDI Cahyaningrum, Putri Khaerani Daniel, Vino Dhadhang Wahyu Kurniawan Eka Prasasti Nur Rachmani Fadlilah, Synta Haqqul Fadlillah, Synta Haqqul Hamzah, Hasyrul Hasyim, Bellia Hawwin, Nur Hendra Wahyudi Heny Ekowati Perdana Priya Haresmita, Perdana Priya Pratiwi, Intan Diah Putra, Akwila Albert Dakusha Rizak Tiara Yusan Sari, Mely Anita Suhartomo, Dalri Muhammad Synta Haqqul Fadlilah Wicaksari, Sifa Aulia