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Physicochemical Characterization and Fatty Acid Profiles of Catfish Oil (Clarias gariepinus) Ningrum, Karina Primatyas; Rohman, Abdul; Martien, Ronny
Journal of Food and Pharmaceutical Sciences Vol 11, No 2 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.7418

Indonesian aquaculture cultivation production of catfish has been growing faster than other fish. It is a potential source of fish oil and contains polyunsaturated fatty acids that have health benefits. The objective of this study was to perform physicochemical characterization and fatty acid profile of catfish oil. This study used fish oil extracted from the head and the flesh of catfish using dry rendering with a mechanic press. The result showed that catfish flesh oil (CFO) and catfish head oil (CHO) were significantly different parameters (p<0.05) in terms of physicochemical characteristics including acid value, peroxide value, iodine value, and saponification value. The best characteristics are catfish flesh oil than catfish head oil for acid value, peroxide value, iodine value, and saponification value following the number is 2.17 mg KOH/g, 5.15 meqO2/kg, 76.13 I2/100 g, 175.86 mg KOH/g. The predominant fatty acids were oleic, palmitic, and linoleic acids. These catfish oils are found suitable for consumption for beneficial health effects.

Analisis Kadar Flavonoid Total Ekstrak dan Fraksi-Fraksi Tanaman Sawi Langit (Vernonia cinerea L) dengan Metode Spektrofotometri Uv-Vis Mulyani, Elly; Herlina; Ningrum, Karina Primatyas; Roki Pernandes
PUCUK : Jurnal Ilmu Tanaman Vol 4 No 2 (2024): Desember
Publisher : Fakultas Pertanian Universitas Ratu Samban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58222/pucuk.v4i2.391

Indonesia merupakan sebuah negara yang kaya akan keanekaragaman hayati, yang dapat dimanfaatkan sebagai sumber tanaman obat. Salah satu tanaman gulma yang bermanfaat adalah sawi langit (Vernonia cinerea L). Tanaman ini dikenal memiliki berbagai khasiat untuk kesehatan, berkat kandungan senyawa flavonoid di dalamnya. Namun, tingkat kandungan flavonoid ini bisa dipengaruhi oleh pemilihan pelarut yang digunakan. Penelitian ini bertujuan untuk menganalisis kandungan total flavonoid dalam ekstrak dan fraksi sawi langit. Metode yang digunakan dalam penelitian ini meliputi uji kualitatif dan kuantitatif. Uji kualitatif dilakukan dengan menggunakan pereaksi Wilstater dan Bate-Smite-Metcalfe, yang menunjukkan hasil positif bagi keberadaan flavonoid. Sementara itu, uji kuantitatif dilakukan menggunakan spektrofotometri UV-Vis dengan quersetin sebagai standar. Hasil penelitian menunjukkan bahwa kandungan flavonoid total dalam ekstrak etanol 96% sawi langit adalah 82,96±1,03 mgQE/g, fraksi etil asetat memperoleh 54,09±0,35 mgQE/g, dan ekstrak n-heksana menghasilkan 42,45±0,35 mgQE/g

Application of Clustering Analysis with Unsupervised Technique on Fish Oil Samples Miftahul Jannah, Nadia; Primatyas Ningrum, Karina; Anggriani Syafrie, Firhani
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21517

Fish oil contains many fatty acids (FAs) important for human health. Each fish oil tends to have a different fatty acid content. This study aims to group the fish oil content profile in several samples, such as keting fish oil (KFO), catfish oil (CFO), and pomfret fish oil (PFO), based on GC-MS analysis data with unsupervised techniques. GC-MS is a method that can be used to identify the fatty acid content in fish oil. Fish oil is extracted using the dry rendering method combined with a hydraulic press to obtain the oil, then derivatised before being analysed on the GC-MS instrument. Due to the multivariate data from GC-MS, multivariate statistical techniques are required to effectively group the fish oil samples based on their Fatty Acid profiles. Principal Component Analysis (PCA) and Cluster Analysis (CA) chemometrics are unsupervised techniques that can group multivariate data by displaying plot scores and dendrograms of sample analysis results. The fatty acid content of keting fish, catfish, and pomfret fish oil has three dominant compounds in sequence, namely oleic acid, palmitic acid, and stearic acid, with different percentages. Thegrouping profile of fish oil was successfully determined by PCA, total variance explained by the first four components (PC4) of 99.4%, and CA, which produced three groups based on the fatty acid content of fish oil.

Application of Clustering Analysis with Unsupervised Technique on Fish Oil Samples Miftahul Jannah, Nadia; Primatyas Ningrum, Karina; Anggriani Syafrie, Firhani
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21517

Fish oil contains many fatty acids (FAs) important for human health. Each fish oil tends to have a different fatty acid content. This study aims to group the fish oil content profile in several samples, such as keting fish oil (KFO), catfish oil (CFO), and pomfret fish oil (PFO), based on GC-MS analysis data with unsupervised techniques. GC-MS is a method that can be used to identify the fatty acid content in fish oil. Fish oil is extracted using the dry rendering method combined with a hydraulic press to obtain the oil, then derivatised before being analysed on the GC-MS instrument. Due to the multivariate data from GC-MS, multivariate statistical techniques are required to effectively group the fish oil samples based on their Fatty Acid profiles. Principal Component Analysis (PCA) and Cluster Analysis (CA) chemometrics are unsupervised techniques that can group multivariate data by displaying plot scores and dendrograms of sample analysis results. The fatty acid content of keting fish, catfish, and pomfret fish oil has three dominant compounds in sequence, namely oleic acid, palmitic acid, and stearic acid, with different percentages. Thegrouping profile of fish oil was successfully determined by PCA, total variance explained by the first four components (PC4) of 99.4%, and CA, which produced three groups based on the fatty acid content of fish oil.

EVALUASI WAKTU HANCUR TABLET ASAM MEFENAMAT DENGAN VARIASI KONSENTRASI SODIUM STARCH GLYCOLATE SEBAGAI SUPERDISINTEGRAN MELALUI METODE GRANULASI BASAH Anjeliani, Cindy Choirina; Sari, Delia Komala; Sutanto, Teja Dwi; Dominica, Dwi; Ningrum, Karina Primatyas
BENCOOLEN JOURNAL OF PHARMACY Vol. 5 No. 2 (2025): Oktober
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v5i2.43233

Latarbelakang: Keberhasilan formulasi tablet sangat dipengaruhi oleh parameter mutu fisik, salah satunya adalah waktu hancur. Waktu hancur dapat memengaruhi bioavailabilitas obat, terutama pada zat aktif yang memiliki kelarutan rendah seperti asam mefenamat, sehingga pemilihan bahan penghancur seperti sodium starch glycolate (SSG) dan metode pembuatan yang tepat seperti granulasi basah sangat penting untuk memperbaiki kelarutan zat aktif. Metode: Penelitian ini merupakan studi eksperimental berupa formulasi tablet dengan granulasi basah menggunakan SSG 1–5%, lalu diuji waktu hancurnya. Hasil dan Pembahasan: Waktu hancur masing-masing formula, F1 (1%), F2 (2%), F3 (3%), F4 (4%), F5 (5%) berturut-turut adalah 3,52 menit, 2,72 menit, 2,56 menit, 1,52 menit, dan 1,31 menit, kelima formula memenuhi syarat uji waktu hancur yang baik. Kesimpulan: Semakin meningkat konsentrasi SSG, maka waktu hancur tablet menjadi semakin cepat, dan sebaliknya. Uji statistik one way ANOVA menunjukkan variasi konsentrasi SSG berpengaruh signifikan terhadap waktu disintegrasi tablet asam mefenamat.

Physicochemical Characterization and Fatty Acid Profiles of Catfish Oil (Clarias gariepinus) Ningrum, Karina Primatyas; Rohman, Abdul; Martien, Ronny
Journal of Food and Pharmaceutical Sciences Vol 11, No 2 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.7418

Indonesian aquaculture cultivation production of catfish has been growing faster than other fish. It is a potential source of fish oil and contains polyunsaturated fatty acids that have health benefits. The objective of this study was to perform physicochemical characterization and fatty acid profile of catfish oil. This study used fish oil extracted from the head and the flesh of catfish using dry rendering with a mechanic press. The result showed that catfish flesh oil (CFO) and catfish head oil (CHO) were significantly different parameters (p<0.05) in terms of physicochemical characteristics including acid value, peroxide value, iodine value, and saponification value. The best characteristics are catfish flesh oil than catfish head oil for acid value, peroxide value, iodine value, and saponification value following the number is 2.17 mg KOH/g, 5.15 meqO2/kg, 76.13 I2/100 g, 175.86 mg KOH/g. The predominant fatty acids were oleic, palmitic, and linoleic acids. These catfish oils are found suitable for consumption for beneficial health effects.

Studi perbandingan profil asam lemak minyak ikan lele dan minyak ikan keting melalui pemurnian dengan bentonit Jannah, Nadia Miftahul; Ningrum, Karina Primatyas
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.378

In general, fish have high omega-3 and omega-9 fatty acid content and are beneficial for health. This makes fish oil develop into a food supplement. Increasing the amount of free fatty acids in oil can potentially reduce the quality and damage of fish oil. Adsorbents have bleaching properties that can affect color changes in fish oil and fish oil content. This study aims to determine the effect of bentonite adsorbent treatment on the fatty acid profile of catfish oil and keting fish oil analyzed using the Gas Chromatography Mass Spectrometry (GC-MS) method. Catfish oil (CFO) and Keting fish oil (KFO) samples were extracted without using organic solvents and then treated with bentonite as an adsorbent. The extracted oil was derivatized and then injected into the GC-MS instrument system. There were 29 types of fatty acids detected in each sample, namely 12 types of saturated fatty acids (SFA), 8 types of monounsaturated fatty acids (MUFA), and 9 types of double unsaturated fatty acids (PUFA). The effect of purification with bentonite was analyzed using One-way ANOVA from Minitab19 software showing that there were differences in the content of fatty acid profiles of CFO and KFO that were purified and not purified with bentonite, shown in each category of fatty acids SFA, MUFA and PUFA which had a p value <0.05.

Biji Kurma sebagai Sumber Fitokimia dan Antioksidan untuk Minuman Fungsional Bebas Kafein Ningrum, Karina Primatyas; Zulfaidah, Nanda Tsalasani; Jannah, Nadia Miftahul
Jurnal Riset Farmasi Volume 5, No. 2, Desember 2025, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrf.v5i2.8567

Abstract. Date seeds (Phoenix dactylifera L.) are abundant agro-industrial by-products that remain underutilized. Numerous studies have reported that date seeds contain phenolic and flavonoid compounds with notable antioxidant activity and are naturally caffeine-free, indicating their potential as functional beverage ingredients and coffee alternatives. However, systematic evidence summarizing the variability of bioactive composition, antioxidant capacity, and the influence of variety and processing methods remains limited and scattered across the literature. This study aimed to comprehensively evaluate the bioactive profile, antioxidant activity, and potential utilization of date seeds as a caffeine-free functional beverage through a systematic literature review. Literature searches were conducted following the PRISMA 2020 guidelines using PubMed, ScienceDirect, DOAJ, and Google Scholar, focusing on articles published between 2020 and 2025. The reviewed studies reported total phenolic contents ranging from 135 to 448 mg GAE and total flavonoid contents of 6.8–7.5 mg CE/g, with antioxidant activity classified as moderate to strong based on DPPH assays (IC₅₀: 28–49 µg/mL). Overall, the findings indicate that date seeds have potential for development as caffeine-free functional beverage ingredients; however, further standardized studies are required to support optimal product development. Abstrak. Biji kurma (Phoenix dactylifera L.) merupakan limbah agroindustri yang melimpah dan hingga kini belum dimanfaatkan secara optimal. Berbagai studi melaporkan bahwa biji kurma mengandung senyawa fenolik dan flavonoid dengan aktivitas antioksidan yang signifikan serta bersifat bebas kafein secara alami, sehingga berpotensi dikembangkan sebagai bahan minuman fungsional alternatif kopi. Namun, kajian ilmiah yang merangkum secara sistematis variasi kandungan bioaktif, aktivitas antioksidan, serta pengaruh varietas dan metode pengolahan biji kurma masih terbatas dan tersebar dalam berbagai publikasi.Penelitian ini bertujuan untuk mengkaji secara komprehensif profil senyawa bioaktif, aktivitas antioksidan, dan potensi pemanfaatan biji kurma sebagai minuman fungsional bebas kafein melalui pendekatan systematic literature review. Penelusuran literatur dilakukan mengikuti pedoman PRISMA 2020 pada basis data PubMed, ScienceDirect, DOAJ, dan Google Scholar untuk artikel terbitan tahun 2020–2025. Hasil kajian menunjukkan bahwa biji kurma memiliki kandungan total fenolik pada kisaran 135–448 mg GAE dan total flavonoid 6,8–7,5 mg CE/g, dengan aktivitas antioksidan kategori sedang hingga kuat berdasarkan uji DPPH (IC₅₀ 28–49 µg/mL). Secara keseluruhan, biji kurma berpotensi dikembangkan sebagai bahan baku minuman fungsional bebas kafein, meskipun penelitian lanjutan yang terstandarisasi masih diperlukan untuk mendukung pengembangan produk secara optimal.

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