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All Journal Jurnal Medika Malahayati Bioscientist : Jurnal Ilmiah Biologi The Avicenna Medical Journal
Larasari, Andira
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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STUDI LITERATUR: NYERI KEPALA PADA EPILEPSI Aswar, Andini; Hairunisa, Nany; Primandari, Rima Anindita; Larasari, Andira
Jurnal Medika Malahayati Vol 8, No 1 (2024): Volume 8 Nomor 1
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v8i1.12231

Abstract

Abstrak: Studi Literatur: Nyeri Kepala Pada Epilepsi. Epilepsi merupakan salah satu gangguan neurologi dengan rata-rata prevalensi 8% di seluruh dunia. Kelainan ini dapat disertai dengan berbagai komorbid salah satunya adalah nyeri kepala. Nyeri kepala dapat ditemukan pada 8-15% populasi epilepsi, dimana kelainan ini bisa terjadi sebelum, saat, atau setelah suatu episode bangkitan, dan bisa juga tidak berkaitan dengan bangkitan. Nyeri kepala pada epilepsi merupakan gejala yang sering sekali tidak terdiagnosis dan tidak diobati karena baik dokter dan pasien akan lebih fokus pada penyakit epilepsi sendiri dibanding nyeri kepalanya. Epilepsi adalah kelainan otak yang ditandai oleh kecenderungan terjadinya bangkitan epileptik dengan konsekuensi neurobiologi, kognitif, psikologi dan sosial. Nyeri kepala preiktal adalah nyeri kepala yang terjadi < 24 jam sebelum terjadinya bangkitan dan berlangsung sampai terjadinya bangkitan. Nyeri kepala iktal adalah nyeri kepala yang terjadi disertai dengan gambaran abnormal pada perekaman EEG. Nyeri kepala pasca iktal adalah nyeri kepala yang terjadi dalam waktu 3 jam setelah terjadinya bangkitan dan hilang spontan 72 jam setelah onset bangkitan. Nyeri kepala interiktal yaitu nyeri kepala yang tidak berkaitan dengan terjadinya bangkitan biasanya terjadi > 24 jam sebelum  dan > 72 jam setelah bangkitan epilepsi. Migrain merupakan nyeri kepala yang banyak ditemukan pada pasien epilepsi. Baik migrain dan epilepsi memiliki patofisiologi yang hampir sama sehingga apabila kelainan ini ditemukan pada epilepsi maka perlu dipertimbangkan pemberian OAE yang juga efektif untuk migrain.
Hubungan Profil Lipid dan Kejadian Migren pada Karyawan di Jakarta Satyasari, Daniella; Larasari, Andira; Faradilla, Meutia Atika; Anastasya, Karina Shasri
Bioscientist : Jurnal Ilmiah Biologi Vol. 13 No. 1 (2025): March
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v13i1.14885

Abstract

One of the risk factor for migraines is an elevated lipid profile. The most significant of the primary lipoproteins that causes atherosclerosis and readily binds to blood vessel walls is LDL. Because lipoprotein A (Lp(a)) levels have an atherogenic ApoA structure, increasing oxidative stress and fat oxidation can lead to endogenous vascular injury. Cross-sectional design was used to perform this study from October 2023 to June 2024 in Universitas Trisakti, Faculty of Medicine. The purpose of this study is to evaluate the association between the lipid level and the incidence of migraines among employees in Jakarta. The target population consists of Jakarta's private employees. With a total sample size of 66 employees that meet the inclusion and exclusion criteria, the study sample will be drawn using the sequential sampling method. The study's findings highlighted that high LDL (p=0.002) and total cholesterol (p=0.0001) had a significant relationship with migraines, whereas HDL, triglycerides, and Lp(a) had an insignificant link with the incidence of migraine (p>0.05). The study concluded that LDL is a powerful predictor of migraine occurrence and has a significant association with migraine.
The Relationship Between Nutritional Status with Malondialdehyde (MDA) and Vitamin D Level Anastasya, Karina Shasri; Faradilla, Meutia Atika; Satyasari, Daniella; Larasari, Andira
The Avicenna Medical Journal Vol. 6 No. 2 (2025): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v6i2.47151

Abstract

Background: Nutritional status has been found to be correlated with malondialdehyde (MDA) profiles in the blood. MDA is a marker of oxidative stress in the body and is the final product of lipid peroxidation chain reactions. The long-term undernutrition and excess status will be closely related to metabolic disorders and degenerative diseases. Street cleaning staff are often exposed to free radicals that will improve lipid peroxidation, which will also break down into MDA. Vitamin D serum levels have an inverse correlation with adipose tissue mass, where the higher the BMI and body fat mass of a person, the lower the levels of vitamin D serum. The purpose of this study was to determine the relationship of nutritional status with MDA and vitamin D levels in the blood. Methods: This research will be conducted from July 2024 to February 2025, using a cross-sectional design at the Faculty of Medicine, Trisakti University, with the target population being the street cleaning staff in Jakarta. The samples were taken by consecutive sampling for all street cleaning staff who met the inclusion and exclusion criteria, with a total of 76 samples. Results: The results showed that there was no significant relationship between nutritional status with MDA and vitamin D, but there was a significant relationship between vitamin D and MDA (r=0.190; p=0.047). Conclusion: Higher BMI is associated with a relative reduction in muscle mass percentage and a substantial increase in visceral adiposity, irrespective of sex. These findings suggest that BMI alone may not adequately represent body composition or metabolic risk and support the routine use of body composition assessment as a complementary tool in clinical obesity evaluation. Keywords: Nutritional status, MDA, vitamin D
Co-Authors Anastasya, Karina Shasri Aswar, Andini Faradilla, Meutia Atika Hairunisa, Nany Primandari, Rima Anindita Satyasari, Daniella