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All Journal Indonesian Journal of Tropical and Infectious Disease Paediatrica Indonesiana Narra J
Hidayah, Najdah
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Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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A Prototype N95 Sterilizer: An Alternative Solution during Personal Protective Equipment Crisis Azhar, Muh. Aprizal; Natzir, Rosdiana; Sjahril, Rizalinda; Palantei, Elyas; Katu, Sudirman; Hidayah, Najdah; Massi, Muhammad Nasrum
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 3 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i3.37427

Abstract

The high demand for N95 masks, especially during the COVID (Coronavirus disease)-19 pandemic, has caused shortages worldwide. This study aimed to examine the sterilization ability of the portable sterilizer prototype for N95 masks and its effect on the filtration ability and changes in air resistance on the N95 mask in order to thrift personal protective equipment (PPE) use during a shortage. The sample used was an N95 mask type 1860. The mask was contaminated with 0.6-0.8 MFU Staphylococcus aureus and Escherichia coli. The sterilization methods used were Ultraviolet Germicidal Irradiation (UVGI), Heat at 75°C, and a combination of both from 1 to 120 minutes. Next, the masks were cultured in a nutrient agar medium. For aerosol penetration and air resistance tests, masks were tested before and after the sterilization process, lasting from 5 to 60 minutes. This prototype sterilizer with Heat effectively killed E. coli and S. aureus starting from 3 minutes. The filtration ability of the N95 mask was maintained at >95% even after the sterilization process with 75°C heat, UVC, or a combination of both for up to 60 minutes. There was also no significant difference in air resistance between new masks and masks that had been sterilized using a portable sterilizer. This prototype sterilizer with Heat at 75°C can effectively sterilize against both gram-positive and negative bacteria in the N95 mask without reducing the aerosol filtration ability and changing the air resistance of the N95 mask.
Cord blood iron status and vitamin D concentration in newborns of anemic and non-anemic mothers in Makassar, Indonesia Ridha, Nadirah Rasyid; Massi, Muhammad Nasrum; Fikri, Bahrul; Putri, Sri Hardiyanti; Hidayah, Najdah; Arsyad, Andi Fatimah
Paediatrica Indonesiana Vol 64 No 6 (2024): November 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.6.2024.483-9

Abstract

Background Iron deficiency (ID) is a common micronutrient problem, especially in pregnant women in developing countries such as Indonesia. Moreover, vitamin D deficiency is also a major concern in worldwide public health. A correlation between anemia, ID, and vitamin D deficiency in children has been identified, but investigations in pregnant women and their newborn babies are still limited. Objective To assess association between iron status and vitamin D levels in umbilical cord blood and maternal anemia. Methods This cross-sectional study involved 109 pregnant women and their newborns. They were divided into two groups, with and without maternal anemia. Collected cord blood (2 mL) was placed in tubes with ethylenediaminetetraacetic acid (EDTA). Plasma ferritin and vitamin D (25-hydroxyvitamin D, 25(OH)D) levels were measured by enzyme-linked immunosorbent assay (ELISA). Results Maternal anemia was found in 60 mothers (55% subjects). The mean cord blood hemoglobin levels for the anemic and non-anemic groups were 15.19 (SD 2.25) g/dL and 15.12 (SD 1.98) g/dL, respectively (P=0.87). Median cord blood ferritin levels were slightly lower in anemic [12.95 (range 0.42-17.69) µg/L] than in non-anemic mothers[13.45 (range 7.10-22.12) µg/L], but were not significantly different (P=0.555). Median cord blood 25(OH)D levels were lower in the anemic group [12.24 (range 8.53-32.99) ng/dL] than in the non-anemic group [14.26 (range 9.84-61.44) ng/dL], but the difference was not significant (P=0.964). Conclusion Maternal anemia was not significantly associated with cord blood hemoglobin, ferritin, or 25(OH)D levels.
Computational drug repurposing for tuberculosis by inhibiting Ag85 complex proteins Iskandar, Israini W.; Nurhasanah, Astutiati; Hatta, Mohammad; Hamid, Firdaus; Handayani, Irda; Chaera, Ummi; Yusriyyah, Andi A.; Jamaluddin, Balqis D.; Zaenab, St; Hidayah, Najdah; Karimah, Nihayatul; Permana, Andi D.; Massi, Muhammad N.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1130

Abstract

Tuberculosis (TB) remains a significant and deadly infection among pulmonary diseases caused by Mycobacterium tuberculosis, a highly adaptive bacterium. The ability of M. tuberculosis to evade certain drugs has been linked to its unique structure, particularly in the cell envelope, where the Ag85 complex proteins play an essential role in this part.  The aim of this study was to utilize a drug repurposing strategy targeting the Ag85 complex proteins. This study utilized a computational approach with 120 selected drugs experimentally identified to inhibit Tuberculosis. A virtual screening molecular docking with Autodock Vina was used to filter the compounds and identify the strong binders to the Ag85 Complex. Molecular dynamics simulations employed the Gromacs Packages to evaluate the stability of each complex, including root mean square deviation (RMSD), root mean square fluctuation (RMSF), and radius of gyration (RoG). Additionally, absorption, distribution, metabolism, excretion, and toxicity (ADMET) assessments were conducted to gather more information about the drug-likeness of each hit compound. Three compounds, selamectin, imatinib, and eltrombopag were selected as potential drugs repurposed to inhibit the activity of the Ag85 complex enzyme, with binding affinities ranging between -10.560 kcal/mol and -11.422 kcal/mol. The MD simulation within 100 ns (3 replicas) showed that the average RMSD of each Ag85A complex was 0.15 nm–0.16 nm, RMSF was 0.09 nm–0.10 nm, and RoG was 1.80 nm–1.81 nm. For Ag85B, the average RMSD was 1.79 nm–1.80 nm, RMSF was 0.08 nm–0.09 nm, and RoG was 1.79 nm – 1.80 nm. Then, for Ag85C, the mean RMSD was 0.16 nm–0.18 nm, RMSF was 0.09, and RoG was 1.77 nm. The study highlights that these promising results demonstrate the potential of some repurposed drugs in combating the Ag85 complex.
Co-Authors Arsyad, Andi Fatimah ASTUTIATI NURHASANAH Azhar, Muh. Aprizal Chaera, Ummi Fikri, Bahrul Hamid, Firdaus Handayani, Irda Hatta, Mohammad Iskandar, Israini W. Jamaluddin, Balqis D. Karimah, Nihayatul Massi, Muhammad N. Muh. Nasrum Massi Nadirah Rasyid Ridha, Nadirah Rasyid Palantei, Elyas Permana, Andi D. Putri, Sri Hardiyanti Riza Linda Rosdiana Natzir Sudirman Katu, Sudirman Yusriyyah, Andi A. Zaenab, St