Nadirah Rasyid Ridha, Nadirah Rasyid
Departemen Ilmu Kesehatan Anak Subdivisi Hematologi-Onkologi Fakultas Kedokteran Universitas Hasanuddin/RSUP Dr. Wahidin Sudirohusodo, Makassar, Indonesia

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Juvenile-type Chronic Myeloid Leukemia pada Bayi Usia 3 Bulan Sanda, Arfandhy; Abdullah, Agus Alim; Arif, Mansyur; Ridha, Nadirah Rasyid
Cermin Dunia Kedokteran Vol 46, No 2 (2019): Penyakit Dalam
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (666.657 KB) | DOI: 10.55175/cdk.v46i2.523

Abstract

Leukemia Mieloid Kronik (LMK) pada anak mencakup 2-5% kasus mieloproliferatif pada anak. LMK pada anak dibagi dalam 2 tipe yaitu tipe dewasa dan tipe remaja berdasarkan ada tidaknya kromosom Philadelphia beserta fusi gen BCR-ABL dalam kromosom tersebut. Kasus Seorang bayi laki-laki usia 3 bulan dengan keluhan utama perut membesar. Diagnosis berdasarkan gejala klinis and pemeriksaan laboratorium : leukosit 41.700/µl, hemoglobin 8,6 g/dl, trombosit 46.000/µl. Pada apusan darah tepi ditemukan semua tahapan maturasi sel seri mieloid dan mieloblast 5%. Aspirasi sumsum tulang mendapatkan peningkatan leukopoietik dengan semua tahapan maturasi mieloid. Malaria mikroskopik negatif. Hasil pemeriksaan molekular tidak ditemukan fusi gen BCR-ABL.Chronic myeloid leukemia (CML ) consist of 2-5% of myeloproliferative cases in children. CML in children are divided into two types: adult and juvenile type based on presence of Philadelphia chromosome with fusion gene BCR-ABL in chromosome. Case A baby boy aged 3 months with chief complaint of enlarged abdomen. Diagnosis was based on clinical symptoms and laboratory tests : leukocytes 41.700/µl, hemoglobin 8.6 gr/dl, platelets 46,000/µl. Peripheral blood smear shows all stages of cell myeloid series maturation and 5% myeloblast. Bone marrow aspiration shows increased leukopoietic activity and all stages of myeloid cell series. Malaria microscopy was negative. Molecular test results found no BCR- ABL fusion gene.
HUBUNGAN JENIS KELAMIN DAN RELAPS PADA LEUKEMIA Rahma, Rahma; Rasyid Ridha, Nadirah; Daud, Dasril
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 3 No. 2 (2017)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (691.71 KB) | DOI: 10.22487/htj.v3i2.47

Abstract

Meskipun pengobatan Leukemia Limfoblasik Akut (LLA) pada anak telah mengalami perbaikan, sekitar 20 % anak masih mengalami relaps. Penelitian ini bertujuan mengetahui pengaruh jenis kelamin terhadap kejadian relaps pada penderita LLA-L1 anak. Penelitian ini dilaksanakan di RSUP Dr. Wahidin Sudirohusodo, Makassar sejak tahun 2006-2015. Penelitian ini menggunakan metode kohort retrospektif berdasarkan data rekam medis pasien yang dirawat. Sampel sebanyak 91 pasien, yakni penderita anak yang memenuhi kriteria inklusi dan eksklusi. Sampel dibagi atas kelompok relaps dan tidak relaps. Data dianalisis menggunakan metode analisis bivariat. Hasil penelitian menunjukkan bahwa terdapat 23 (25,3%) sampel mengalami relaps dan 68 (74,7%) sampel tidak relaps. Berdasarkan analisis bivariat terdapat sampel berjenis kelamin laki-laki mengalami relaps 11 (20%) dan sampel tidak relaps 44 (80%). Terdapat sampel berjenis kelamin perempuan mengalami relaps 12 (33,3%) dan sampel yang tidak relaps 24 (66,7%) dengan nilai p=0,152 (p>0,05). Interval waktu saat diagnosa awal sampai terjadinya relaps pada kelompok berjenis kelamin laki-laki memiliki mean 20,09 bulan, sedangkan pada kelompok berjenis kelamin perempuan memiliki nilai mean 21,75 bulan dengan nilai p=0,739 (p>0,05). Mean interval waktu saat remisi komplit sampai terjadinya relaps pada kelompok berjenis kelamin laki-laki adalah 17,72 bulan, sedangkan mean interval pada kelompok berjenis kelamin perempuan adalah 19,66 bulan dengan nilai p=0,700 (p>0,05).
Do the acute lymphoblastic leukemia and non-hodgkin lymphoma patients have a worse prognosis of COVID-19 infection in children?: a case report Nadirah Rasyid Ridha; Bahrul Fikri; Rahmawaty Rahimi; Amiruddin Laompo; Conny Tanjung; Dasril Daud; Nasrum Massi
Health Science Journal of Indonesia Vol 12 No 1 (2021)
Publisher : Sekretariat Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/hsji.v12i1.4467

Abstract

Background: Coronavirus Disease 2019 (COVID-19) is a contagious disease caused by a new type of Coronavirus namely Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Children with tumors or autoimmune diseases are more susceptible, because of suppression of their immune system, chemotherapy, radiotherapy, or surgery on tumors. Case presentation: We present the clinical features 3 Acute Lymphoblastic leukemia and 1 Non-Hodgkin lymphoma patients who were infected with COVID-19 since July to August 2020 in our hospital. These were the first four cases identified as COVID-19 positive in Dr Wahidin Sudirohusodo Hospital. Case 1, 2, and 4 were diagnosed as moderate and common type of COVID-19, while case 3 was classified as severe type. They may be transmitted COVID-19 infection during hospitalization. All cases were recovered from COVID-19 after a combination therapy against virus, bacteria, and also respiratory support. Conclusion: Our case series of four pediatric cancer patients showed a good outcome after prompt treatment, suggesting that malignancy in children may not be a contributor factor for COVID-19 recovery. Keywords: COVID-19; acute lymphoblastic leukemia; non-hodgkin lymphoma; children Abstrak Latar belakang: Covid-19 (Coronavirus disease 2019) adalah penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Anak yang menderita kanker atau penyakit autoimun lebih rentan tertular karena penurunan system kekebalan tubuh, dampak kemoterapi, radioterapi, atau operasi tumor. Penyajian kasus: Kami melaporkan 3 pasien leukemia limfoblastik akut dan 1 pasien limfoma non-Hodgkin yang terinfeksi Covid-19 sejak Juli-Agustus 2020. Kasus tersebut adalah 4 kasus pertama yang teridentifikasi Covid-19 di Rumah Sakit Dr. Wahidin Sudirohusodo. Kasus 1,2, dan 4 terdiagnosis positif Covid -19 derajat sedang, sedangkan kasus 3 tergolong berat. Mereka kemungkinan terinfeksi Covid-19 saat perawatan. Semua kasus dinyatakan sembuh dari Covid-19 setelah pemberian obat anti virus, antibiotik, dan alat bantu pernapasan. Kesimpulan: Serial kasus dari 4 pasien kanker anak dengan outcome yang baik setelah pengobatan yang cepat mengindikasikan bahwa penyakit keganasan pada anak kemungkinan bukan faktor yang berkontribusi dalam kesembuhan Covid-19. Kata kunci: COVID-19; leukemia limfoblastik akut; limfoma non-hodgkin; anak
Hubungan Kadar Hepcidin dengan Status Besi pada Inflamasi Akibat Obesitas Nadirah Rasyid Ridha; Dasril Daud
Sari Pediatri Vol 16, No 3 (2014)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp16.3.2014.161-6

Abstract

Latar belakang. Angka kejadian obesitas yang tinggi cenderung mengalami komplikasi jangka panjang, yaitu penyakit kardiovaskular, diabetes mellitus, dan gangguan homeostasis besi.Tujuan. Menilai hubungan kadar hepcidin dengan status besi akibat inflamasi pada anak obesitas.Metode. Telah dilakukan penelitian dengan desain potong lintang mengenai hubungan kadar hepcidin dengan status besi (feritin, sTfR) pada anak obesitas (IL-6, Hs-CRP). Subjek berasal dari siswa SMP Z di Makassar yang memenuhi kriteria inklusi. Penelitian berlangsung dari September sampai November 2012. Analisis statistik menggunakan uji student t dan Mann Whitney U dengan nilai kemaknaan p=0,05.Hasil. Jumlah subjek yang memenuhi kriteria inklusi 20 anak obes, 20 superobes, dan 35 berat badan normal. Hasil analisis statistik menunjukkan tidak terdapat perbedaan bermakna rerata kadar hepcidin pada obes dengan berat badan normal (p=0,850), tetapi terdapat perbedaan bermakna rerata kadar hepcidin pada superobes dengan berat normal (p=0,012), rerata IL-6 antara obes dengan berat normal (p=0,01), superobes dengan berat normal (p=0,000), rerata hs-CRP antara obes dengan berat normal (p=0,004), superobes dengan berat normal (p=0,011). Tidak terdapat perbedaan bermakna rerata feritin dan sTfR antara superobes dan obes dengan berat normal (p=0,05).Kesimpulan. Pada anak superobes, terjadi peningkatan kadar hepcidin akibat inflamasi tetapi belum menyebabkan gangguan status besi. Sementara itu, pada obes terjadi inflamasi, tetapi belum menyebabkan peningkatan kadar hepcidin
TESTICULAR YOLK SAC TUMOR IN AN ONE- YEAR AND SEVENT- MONTHS OLD Nadirah Rasyid Ridha; Farid Huzein; Emir Amal
Jambura Journal of Health Sciences and Research Vol 4, No 1 (2022): JANUARI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i1.11666

Abstract

Background: Yolk sac tumor (YST), which most frequently arises in the gonads as a type of germ cell tumor, is rare in children but is highly malignant. He most common testicular tumor in young children under the age of 3 is yolk sac tumor, and it is also known as infantile embryonal carcinoma. Case Presentation: We present the clinical future YST in an one- year and sevent-months old. In this report, we described testicular of YST in terms of the clinical manifestation, imaging, and histopathology findings, diagnosis and treatment. It has been suggested that alpha-fetoprotein (AFP) can be applied as a feasible tumor marker because its level was elevated in 90% of YST. The treatment generally involves debulking surgery of tumors followed by systemic chemotherapy. Conclusion: Our case report has a good prognosis because good responds with chemotherapy. Although YST is rare in children, pediatric physicians should be aware of this and prompt treatment should be addressed.Keywords: yolk sac tumor, chemotherapy, pediatric
COMPARISON OF BONE MARROW ASPIRATION INTERPRETATION WITH IMMUNOPHENOTYPING IN CHILDREN'S LEUKEMIA DIAGNOSIS Nadirah Rasyid Ridha; Dasril Daud
Jambura Journal of Health Sciences and Research Vol 4, No 2 (2022): Jambura Journal of Health Sciences and Research
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i2.13587

Abstract

Prevalensi kanker pada anak semakin meningkat. Terdapat 90 pasien leukemia yang dirawat di RS Wahidin Sudirohusodo selama tahun 2013-2017. Diagnosis morfologi leukemia akut dibagi menjadi ALL dan AML dan kadang-kadang tidak sesuai dengan diagnosis flow cytometry, yang menunjukkan karakteristik sel ganas. Penelitian ini bertujuan untuk membandingkan hasil interpretasi aspirasi sumsum tulang dengan imunofenotip dalam mendiagnosis leukemia pada anak. Metode Data dari rekam medis digunakan dalam studi kohort retrospektif pada anak dengan leukemia (usia 1–18 tahun) yang dirawat di RS. Wahidin Sudirohusodo Makassar dari tahun 2013 hingga 2017. Semua pasien dengan diagnosis kerja leukemia diperiksa aspirasi sumsum tulangnya, diikuti oleh immunophenotyping, dan masing-masing kelompok dianalisis. Hasil Dari total 90 subjek penelitian, diagnosis akhir berdasarkan imunofenotipe adalah 60 pasien ALL dan 30 pasien AML dengan usia rata-rata 8 tahun 3 bulan. Rasio laki-laki dan perempuan adalah 1,7:1 (p = 0,353). Usia rata-rata kelompok ALL adalah 7 tahun 10 bulan, dan AML, 9 tahun (p = 0,409). Kesesuaian morfologi dan flow cytometry terhadap ALL dan AML berturut-turut adalah 92,3% dan 50%. Sebagian besar penanda berada pada kelompok ALL CD 10 dan CD 20 dengan sensitivitas masing-masing 100%, dan AML CD 117 dengan sensitivitas 92%.  Kesimpulan Diagnosis morfologi dan imunofenotipe 92,3% pada kasus ALL dan 50% pada kasus AML. Hal ini penting dalam penilaian garis keturunan dan diagnosis definitif leukemia serta deteksi dini leukemia.Kata kunci: leukemia; anak; Immunophenotyping. ABSTRACT The prevalence of cancer in children is increasing. There were 90 leukemia patients treated at Wahidin Sudirohusodo hospital during the years 2013–2017. The morphological diagnosis of acute leukemia is divided into ALL and AML and is sometimes incompatible with the diagnosis of flow cytometry, which shows the characteristics of malignant cells. This study aims to compare the results of the interpretation of bone marrow aspiration with immunophenotyping in diagnosing childhood leukemia. Methods  Data from medical records was used in a retrospective cohort study of children with leukemia (ages 1–18 years) admitted to Dr. Wahidin Sudirohusodo Makassar from 2013 to 2017. All patients with a working diagnosis of leukemia were examined for bone marrow aspiration, followed by immunophenotyping, and each group was analyzed. Results Of a total of 90 study subjects, the final diagnosis based on immunophenotyping was 60 ALL and 30 AML patients with a mean age of 8 years and 3 months. The male to female ratio was 1.7:1 (p = 0.353). The mean age of the ALL group was 7 years and 10 months, and AML, 9 years (p = 0.409). The suitability of morphology and flow cytometry to ALL and AML was 92.3% and 50%, respectively. Most markers were in the ALL CD 10 and CD 20 groups with a sensitivity of 100% each, and AML CD 117 with a sensitivity of 92%. Conclusion Morphological diagnosis and immunophenotyping of 92.3% in ALL cases and 50% in AML cases. This is important in lineage assessment and definitive diagnosis of leukemia as well as early detection of leukemia.
Identification of risk factors for recurrent febrile convulsion Nadirah Rasyid Ridha; P. Nara; Hadia Angriani; Dasril Daud
Paediatrica Indonesiana Vol 49 No 2 (2009): March 2009
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (98.415 KB) | DOI: 10.14238/pi49.2.2009.87-9

Abstract

Background Febrile convulsion (FC) occurs in about 2 to 4percent of all children, approximately one third of whom willthen develop recurrent febrile convulsion (RFC). Risk factorsfor RFC are family history of convulsions, an age of less than 18months, a relatively lower temperature and shorter duration offever preceeding the first FC.Objective The aim of the study was to determine the risk factorsfor RFC.Methods One hundred children aged 6 months to 5 years withFC or RFC were included in this case-controlled study, which wascarried out from July 2006 to June 2007. Data on the children'sfirst FC were collected from medical records and the family historywas taken directly from the parents.Results Fifty children with RFC and 50 children withoutrecurrence were included in this study. An age of less than 18months (P< 0.0001, COR= 71.37), a family history of FC(P< 0.0001, COR= 6.00), and a fever duration ofless than 12hours preceding the first FC (P< 0.0001, COR = 4.96) wereassociated with a risk of recurrence. A relatively lower degree oftemperature at first febrile convulsion did not increase the riskfor RFC (P = 1.21). Multivariate logistic regression showed thatyounger age and shorter duration of fever preceding the first FCwere associated with RFC.Conclusion Younger age and shorter duration of fever precedingthe first FC are associated with an increased risk ofRFC.
Vascular endothelial growth factor (VEGF) expression in induction phase chemotherapy of acute lymphoblastic leukemia Dasril Daud; Merlyn Meta Astari; Nadirah Rasyid Ridha
Paediatrica Indonesiana Vol 59 No 4 (2019): July 2019
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (217.682 KB) | DOI: 10.14238/pi59.4.2019.217-21

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Background Leukemia is a hematolymphoid malignancy originating from bone marrow. The progression of hematolymphoid malignancies depends on new formation of vasculature, called angiogenesis. Angiogenesis is regulated by vascular endothelial growth factor (VEGF), which is secreted by paracrine and autocrine signaling mechanisms. Objective To evaluate VEGF expression in induction phase chemotherapy of acute lymphoblastic leukemia (ALL) patients. Methods This prospective, cohort study was conducted in ALL patients admitted to Dr. Wahidin Sudirohusodo Hospital, Makassar, South Sulawesi, from October 2016 to October 2017. Subjects’ VEGF levels were measured at diagnosis and at the end of induction chemotherapy. Results VEGF levels were analyzed in 59 patients, 29 of whom were diagnosed with standard risk ALL and 30 patients with high risk ALL. VEGF levels were significantly decreased after induction phase chemotherapy in standard risk ALL and in high risk ALL subjects. There was no significant difference in VEGF levels before induction phase chemotherapy between the standard and high risk groups (P=0.405). There was also no significant difference in VEGF levels after induction phase chemotherapy between the two risk groups (P=0.094). Conclusion The VEGF level is significantly lower after ALL induction phase chemotherapy in both the standard risk and high risk ALL groups. However, there are no significant differences in VEGF levels between the standard and high risk groups before as well as after induction phase chemotherapy.
THALASSEMIA β MAJOR WITH EXTRAHEPATIC CHOLESTASIS AND CHOLELITHIASIS IN GIRL 11 YEARS 9 MONTHS Nadirah Rasyid Ridha; Yusriwanti Kasri; Setia Budi Salekede; Farid Huzein; Sri Hardiyanti Putri
Journal Health & Science : Gorontalo Journal Health and Science Community Vol 6, No 1 (2022): APRIL: JOURNAL HEALTH AND SCIENCE : GORONTALO JOURNAL HEALTH AND SCIENCE COMMUNI
Publisher : Gorontalo State University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/gojhes.v5i3.13586

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Kolestasis dapat disebabkan oleh gangguan fungsional hepatosit dalam sekresi empedu dan/atau karena obstruksi pada setiap tingkat jalur ekskresi empedu. Pada pasien thalassemia terjadi hemolisis kronis yang berakibat bilirubin tak terkonjugasi akan mengkristal dan akhirnya membentuk batu. Selanjutnya dapat terjadi penumpukan bilirubin disaluran empedu sehingga kemudian menyumbat dan terjadi gangguan pengeluaran bilirubin direk sehingga terjadi kolestasis. Kebaruan penelitian ini adalah meneliti kejadian kasus Thalassemia Mayor Dengan Kolestasis Ekstrhepatis Dan Kolelitiasis Pada Anak Perempuan 11 Tahun 9 Bulan. Tujuan penelitian ini untuk menggambarkan kejadian kolesatasis dan kolelitiasis yang terjadi akibat proses hemolisis pada thalassemia β mayor dengan keluhan utama nyeri perut dan ikterus pada seluruh tubuh. Pasien didiagnosis berdasarkan temuan laboratorium yakni peningkatan enzim transaminase, bilirubin direk dan pemeriksaan multislice computerized tomography abdomen dengan kontras. Tatalaksana pasien ini dilakukan endoscopy retrograde cholangiopancreatography dan asam ursodeoksilat disertai terapi thalassemia. Kesimpulan penelitian ini memiliki prognosis yang baik karena respon yang baik. Meskipun kolestasis jarang terjadi pada pasien thalassemia pada anak-anak, dokter anak harus menyadari hal ini dan pengobatan segera harus ditangani.Kata kunci: Thalassemia; Kolestasis ; Kolelitiasis. AbstractCholestasis can be caused by functional impairment of hepatocytes in bile secretion and/or by obstruction at any level of the bile excretory pathway. In patients with thalassemia, chronic hemolysis occurs, which results in unconjugated bilirubin crystallizing and eventually forming stones. Furthermore, there can be a buildup of bilirubin in the bile duct so that it clogs and interferes with the release of direct bilirubin, resulting in cholestasis. The novelty of this study is to examine the incidence of cases of Thalassemia Major with Cholestasis Extrhepatis and Cholelithiasis in 11 Years 9 Months Girls. The purpose of this study is to describe the incidence of cholestasis and cholelithiasis that occur due to the hemolysis process in thalassemia β major with the main complaints of abdominal pain and jaundice throughout the body. The patient was diagnosed based on laboratory findings, namely elevated transaminase enzymes, direct bilirubin, and multislice computerized tomography of the abdomen with contrast examination. The management of this patient was endoscopic retrograde cholangiopancreatography and ursodeoxylic acid, accompanied by thalassemia therapy. Conclusion of this research has a good prognosis because of the good response. Although cholestasis is rare in thalassemia in children, pediatricians should be aware of this and seek immediate treatment.
Juvenile-type Chronic Myeloid Leukemia pada Bayi Usia 3 Bulan Arfandhy Sanda; Agus Alim Abdullah; Mansyur Arif; Nadirah Rasyid Ridha
Cermin Dunia Kedokteran Vol 46, No 2 (2019): Penyakit Dalam
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i2.523

Abstract

Leukemia Mieloid Kronik (LMK) pada anak mencakup 2-5% kasus mieloproliferatif pada anak. LMK pada anak dibagi dalam 2 tipe yaitu tipe dewasa dan tipe remaja berdasarkan ada tidaknya kromosom Philadelphia beserta fusi gen BCR-ABL dalam kromosom tersebut. Kasus Seorang bayi laki-laki usia 3 bulan dengan keluhan utama perut membesar. Diagnosis berdasarkan gejala klinis and pemeriksaan laboratorium : leukosit 41.700/µl, hemoglobin 8,6 g/dl, trombosit 46.000/µl. Pada apusan darah tepi ditemukan semua tahapan maturasi sel seri mieloid dan mieloblast 5%. Aspirasi sumsum tulang mendapatkan peningkatan leukopoietik dengan semua tahapan maturasi mieloid. Malaria mikroskopik negatif. Hasil pemeriksaan molekular tidak ditemukan fusi gen BCR-ABL.Chronic myeloid leukemia (CML ) consist of 2-5% of myeloproliferative cases in children. CML in children are divided into two types: adult and juvenile type based on presence of Philadelphia chromosome with fusion gene BCR-ABL in chromosome. Case A baby boy aged 3 months with chief complaint of enlarged abdomen. Diagnosis was based on clinical symptoms and laboratory tests : leukocytes 41.700/µl, hemoglobin 8.6 gr/dl, platelets 46,000/µl. Peripheral blood smear shows all stages of cell myeloid series maturation and 5% myeloblast. Bone marrow aspiration shows increased leukopoietic activity and all stages of myeloid cell series. Malaria microscopy was negative. Molecular test results found no BCR- ABL fusion gene.