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All Journal Indonesian Journal of Chemistry SPIN: Jurnal Kimia & Pendidikan Kimia
Chasani, Moch
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Chemical Engineering, Chemistry & Bioengineering Chemistry Education

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FORMULATION AND NANOEMULSION OF NUTMEG ESSENTIAL OIL (Myristica fragrans Houtt.) AND SUNSCREEN ACTIVITY TEST USING UV-VIS SPECTROPHOTOMETRY Sheiliyani, Cindy; Hidayat, Arif Nur; Rastuti, Undri; Chasani, Moch; Diastuti, Hartiwi
SPIN JURNAL KIMIA & PENDIDIKAN KIMIA Vol. 5 No. 2 (2023): Juli - Desember 2023
Publisher : UIN Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/spin.v5i2.7871

Abstract

Nutmeg essential oil (Myristica fragrans Houtt) is a natural ingredient that has potential as a sunscreen. This research aims to formulate and characterize nutmeg essential oil nanoemulsion and test the sunscreen activity of nutmeg essential oil and its nanoemulsion. The essential oil and nanoemulsion formulas were made with 5 variations of essential oil concentrations namely F0 (0%), F1 (1%), F2 (2%), F3 (4%) and F4 (6%). The nanoemulsion characterization includes organoleptic test, pH measurement, nanoemulsion type examination, viscosity measurement, percent transmittance test, particle size distribution measurement, centrifugation test, freez-thaw cycle test. Testing the potential of sunscreen was carried out using a UV-Vis spectrophotometer at a wavelength range of 290-400 nm with ethanol as a blank. The results of the nanoemulsion organoleptic characterization showed a clear and stable appearance. Measurements of pH, type of nanoemulsion, viscosity, percent transmittance, and particle size of nanoemulsion preparations showed good results and were in accordance with the parameters. The nutmeg essential oil nanoemulsion had better SPF, %Te and %Tp values than the essential oil. Nanoemulsion preparations that had the best sunscreen activity in this study were F4 (6%) with an SPF value of 1.538; %Te value of 37.375%; and %Tp value of 80.732%.
Toxicity Test of Nanoemulsions of Nutmeg Fruits and Leaves Essential Oil against Artemia salina Leach and Its Cytotoxicity Test against Breast Cancer Cells T47D Rastuti, Undri; Diastuti, Hartiwi; Widyaningsih, Senny; Chasani, Moch; Sheiliyani, Cindi; Rahmasari, Anisa; Fajriyah, Bunga Sita Roihanul; Mesayu, Puspa Rahma; Habibie, Ranti Kamila
Indonesian Journal of Chemistry Vol 24, No 5 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.91077

Abstract

Nutmeg (Myristica fragrans Houtt) is a widely known spice plant, which has been reported to offer several benefits. Therefore, this study aims to develop and analyze nanoemulsions of nutmeg leaves and fruit essential oil, as well as determine their toxicity and cytotoxicity. Nanoemulsions were formulated with varying concentrations of essential oil, including 0, 1, 2, 4, and 6%. Characterization included organoleptic assessment, pH measurement, type examination, viscosity testing, transmittance analysis, particle size distribution measurement, centrifugation, and freeze-thaw cycle test. Toxicity testing results using the brine shrimp lethality test (BSLT) showed that nanoemulsions were toxic except NF F4 with high toxicity. Cytotoxicity testing on T47D breast cancer cells showed moderate activity for NF F4 nanoemulsions (IC50: 34.363 ppm), while NL nanoemulsions were deemed inactive (IC50: 33576.430 ppm). In addition, the organoleptic characteristics of all nanoemulsions were stable, and most parameters met the desired standards. Based on the results, further studies exploring nanoemulsions with natural products must be carried out to determine their advantages, specifically in the development of sciences.
Co-Authors Arif Nur Hidayat, Arif Nur Fajriyah, Bunga Sita Roihanul Habibie, Ranti Kamila Hartiwi Diastuti Mesayu, Puspa Rahma Rahmasari, Anisa Senny Widyaningsih Sheiliyani, Cindi Sheiliyani, Cindy Undri Rastuti