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All Journal Jurnal Biologi Tropis UMI Medical Journal
Wiriansyah, Edward Pandu
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology

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Karakteristik serta Profil Koagulasi Pasien Covid-19 Anggita, Dwi; Djaharuddin, Irawaty; Iskandar, Harun; Tabri, Nur Ahmad; Madolangan, Jamaluddin; Putrawan, Harry Akza; Wiriansyah, Edward Pandu
UMI Medical Journal Vol 8 No 2 (2023): UMI Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/umj.v8i2.234

Abstract

Latar belakang: Derajat keparahan Covid-19 dikaitkan dengan koagulasi dan kerusakan endotel yang dipicu oleh reaksi inflamasi akibat dari pelepasan sitokin proinflamasi yang berlebihan oleh karena infeksi SARS CoV-2. Metode: Penelitian deskriptif analitik yang dilakukan dengan pendekatan kohor retrospektif dilakukan di Rumah Sakit Umum Pemerintah Wahidin Sudirohusodo Makassar dengan mengumpulkan data rekam medis pasien Covid-19 pada bulan Juni 2020 – Juni 2021 dengan menggunakan total sampling yang memenuhi kriteria inklusi dan eksklusi. Hasil: Pada penelitian ini didapatkan rerata trombosit lebih rendah (265.442) pada kasus berat, sedangkan rerata fibrinogen (405,54) dan D-dimer (9,84) lebih tinggi pada derajat keparahan lebih berat, serta Prothrombin time (PT) lebih panjang (10,92) pada derajat keparahan lebih berat. Kesimpulan: Profil koagulasi penderita Covid-19 didatakan rerata rombosit lebih rendah pada derajat keparahan lebih berat, sedangkan fibrinogen dan D-dimer lebih tinggi serta Prothrombin time (PT) lebih panjang pada derajat keparahan lebih berat.
Prevalence of COVID-19 Incidence Rates in Hypertension Patients at Ibnu Sina Hospital Makassar in 2020 Saputra, Pryantama; Wiriansyah, Edward Pandu; Ardiansar, Abdul Mubdi; Tulak, Sandy; Rahman, Rusman
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7624

Abstract

The COVID-19 virus, which is caused by SARS-CoV-2, is a global health problem that affects many nations. Similar to the H7N9, SARS, and MERS viruses, COVID-19 can be more severe in hypertensive individuals. With a prevalence of 50.1% among COVID-19 patients, hypertension is a significant comorbidity that increases the risk of death by 1.37 times due to the increased number of ACE2 receptors that facilitate the virus's spread. This study uses a descriptive cross-sectional design with secondary data from medical records of COVID-19 patients with hypertension at Rumah Sakit Ibnu Sina Makassar. Data were collected through total sampling after obtaining permission from the hospital and then processed and analyzed descriptively. The study shows that the majority of COVID-19 patients with hypertension are aged 65 and over (33.4%). Male patients are slightly more prevalent (53%) compared to females (47%), possibly due to genetic factors affecting the immune system. Seventy-three percent of patients adhered to hypertension treatment, while 27% did not. The function of the ACE-2 enzyme, which is also affected by antihypertensive treatment, may have an impact on the relationship between COVID-19 and hypertension. These findings emphasize the significance of treating the elderly and remaining on treatment in order to reduce the likelihood of contracting COVID-19. The survey derives that the vast majority of Covid patients with hypertension are developed 65 and over (33.4%), with an insignificantly higher inescapability of folks (53.3%) diverged from females. Adherence to hypertension treatment is high, with 73.3% of patients following their prescribed regimen.
Co-Authors Anggita, Dwi Ardiansar, Abdul Mubdi Djaharuddin, Irawaty Iskandar, Harun Madolangan, Jamaluddin Putrawan, Harry Akza Rahman, Rusman Saputra, Pryantama Tabri, Nur Ahmad Tulak, Sandy