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All Journal E-Jurnal Medika Udayana Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) UMI Medical Journal Diversity: Disease Preventive of Research Integrity Advance Sustainable Science, Engineering and Technology (ASSET)
Iskandar, Harun
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Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Public Health

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RELATIONSHIP BETWEEN PULMONARY VASCULAR THICKENINGS WITH CT-SEVERITY SCORE IN COVID-19-CONFIRMED PATIENTS Danu, Alex; Asriyani, Sri; Latief, Nikmatia; Alfian, Andi; Iskandar, Harun; Rauf, Rafikah
E-Jurnal Medika Udayana Vol 13 No 8 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i08.P05

Abstract

Introduction: Previous studies have shown pulmonary vascular thickening found in COVID- 19 patients. In addition, the CT-Severity Score (CT-SS) scoring system have become a reference in assessing the severity of COVID-19. This study analyzes the relationship between pulmonary vascular thickening on CT-Scan thorax with CT-SS in patients with confirmed COVID-19.Materials and Methods: A retrospective cross-sectional study was conducted on 137 patients with confirmed COVID-19 at the Radiology Installation of Doctor Wahidin Sudirohusodo Hospital Makassar. Patients who were eligible and had undergone a chest CT-Scan were then measured for their pulmonary vascular thickness in the intralesional and extralesional areas of the secondary lung lobes. The CT-SS score was assessed to determine the degree of mild or severe disease based on the opacity of the involved lung segment. Independent T-test and Chi- square were used to determine the differences and relationships between the variables studied. Results: Based on CT-SS, most subjects were classified as mildly ill (CT-SS < 19.5, 78/137 people). The mean intralesional and extralesional vascular thickening was 2.65 ± 0.48 and 2.17 ± 0.36, respectively. There was a significant difference between vascular thickness between subjects with mild and severe CT-SS categories (intralesion: 2.4 ± 0.33 vs. 2.99 ± 0.47, p=0.001; extralesion: 2.04 ± 0.28 vs. 2.35 ± 0.39), Conclusion: Vascular thickening on CT-Scan chest images is related to the severity of COVID-19 as measured by CT-SS scoring. Keywords: COVID-19, Chest CT-Scan, CT-Severity Score, Pulmonary Vascular Thickening
Karakteristik serta Profil Koagulasi Pasien Covid-19 Anggita, Dwi; Djaharuddin, Irawaty; Iskandar, Harun; Tabri, Nur Ahmad; Madolangan, Jamaluddin; Putrawan, Harry Akza; Wiriansyah, Edward Pandu
UMI Medical Journal Vol 8 No 2 (2023): UMI Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/umj.v8i2.234

Abstract

Latar belakang: Derajat keparahan Covid-19 dikaitkan dengan koagulasi dan kerusakan endotel yang dipicu oleh reaksi inflamasi akibat dari pelepasan sitokin proinflamasi yang berlebihan oleh karena infeksi SARS CoV-2. Metode: Penelitian deskriptif analitik yang dilakukan dengan pendekatan kohor retrospektif dilakukan di Rumah Sakit Umum Pemerintah Wahidin Sudirohusodo Makassar dengan mengumpulkan data rekam medis pasien Covid-19 pada bulan Juni 2020 – Juni 2021 dengan menggunakan total sampling yang memenuhi kriteria inklusi dan eksklusi. Hasil: Pada penelitian ini didapatkan rerata trombosit lebih rendah (265.442) pada kasus berat, sedangkan rerata fibrinogen (405,54) dan D-dimer (9,84) lebih tinggi pada derajat keparahan lebih berat, serta Prothrombin time (PT) lebih panjang (10,92) pada derajat keparahan lebih berat. Kesimpulan: Profil koagulasi penderita Covid-19 didatakan rerata rombosit lebih rendah pada derajat keparahan lebih berat, sedangkan fibrinogen dan D-dimer lebih tinggi serta Prothrombin time (PT) lebih panjang pada derajat keparahan lebih berat.
Relationship between Serum Vitamin D Levels and Asthma Control in Adult Patients Sabaruddin, Haeriah; Djamaluddin, Fauzan; Ilyas, Muh.; Iskandar, Harun; Lihawa, Nurjannah; Nurisyah, Siti; Wiriansya , Edward Pandu
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 1 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i1.2376

Abstract

Asthma is a heterogeneous disease characterized by respiratory symptoms that vary both over time and in intensity, along with limited expiratory airflow. This heterogeneity is related to the patient's genetic and environmental phenotype. Vitamin D levels can affect the severity of asthma and the success of asthma treatment. Vitamin D can also influence the effectiveness of glucocorticoid therapy as an anti-inflammatory. This study aimed to determine the relationship between serum vitamin D levels and asthma control, severity, obstruction, and exacerbation levels. This research was a descriptive cross-sectional study on asthma patients at Wahidin Sudirohusodo Hospital and its network for the period October–December 2023. Each research subject had a venous blood sample taken and then checked vitamin D levels at the Hasanuddin University Teaching Hospital Research Laboratory. This research involved 72 research subjects. Most of the research subjects were female (61.1%), aged <45 years (52.8%), worked as housewives (29.2%), had overweight BMI (33.3%), and had a history of atopy (59.7%). The degree of airway obstruction in the study subjects was mostly mild (66.7%) and the degree of severity was intermittent, persistent, and the degree of exacerbation in the same sample (33.3%). The results of the study showed a relationship between vitamin D levels and nutritional status, history of atopy, degree of asthma control using the ACT questionnaire, degree of stable asthma, and exacerbations where p<0.05. Also, it is found that a weakly positive connection (R: 0.2–0.4) between vitamin D levels and ACT, FEV1, FEV/FVC. There is a relationship between vitamin D levels and nutritional status, history of atopy, degree of asthma control using the ACT questionnaire, degree of stable asthma, and exacerbations. There was a relationship between vitamin D levels and the degree of obstruction assessed by spirometry in this study.
Association Between PAI-1 4G/5G Genetic Polymorphism and Uncontrolled Allergic Asthma Iskandar, Harun; Ilyas, Muh; Muis, Eliana; Tabri, Nur Ahmad; Setiawati, Dewi
Advance Sustainable Science Engineering and Technology Vol. 7 No. 3 (2025): May - July
Publisher : Science and Technology Research Centre Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/asset.v7i3.1872

Abstract

Airway remodeling is a major challenge in the management of uncontrolled allergic asthma, despite standard therapy with a combination of inhaled corticosteroids (ICS) and long-acting bronchodilators (LABA). Increased levels of Plasminogen Activator Inhibitor-1 (PAI-1) are thought to play a role in this process, and the 4G/5G polymorphism in the PAI-1 gene is one of the genetic factors that affect it. This study aimed to analyze the association between the 4G/5G PAI-1 genetic polymorphism and uncontrolled allergic asthma. A case-control study was conducted at Wahidin Sudirohusodo General Hospital between January-March 2024 on 40 patients with allergic asthma and 40 non-asthmatic subjects. Diagnosis was made through prik test (+), bronchodilator test (+), and asthma control classification according to GINA criteria. All asthmatic patients received Budesonide-Formoterol therapy for 4 weeks. PAI-1 levels were measured and 4G/5G polymorphism was analyzed by RT-PCR. Results showed that PAI-1 levels were significantly higher in uncontrolled asthma patients and in individuals with the 4G/4G genotype compared to non-4G/4G (2.38 ± 0.770 vs 1.65 ± 0.714; p=0.001). The 4G/4G genotype was more common in uncontrolled asthma (OR: 5.8) and was associated with the risk of severe obstruction (OR: 11.6). Thus, it was concluded that the 4G/4G genotype in the PAI-1 gene is associated with increased PAI-1 levels, risk of uncontrolled allergic asthma, and more severe degree of airway obstruction. The implication of the results shows that genetic testing of PAI-1 has the potential to be a predictive biomarker in personalized asthma therapy strategies. This approach can help clinicians identify high-risk patients and tailor interventions early and effectively to prevent remodeling and reduce long-term morbidity.
Local Culture and The Risk of Pulmonary Tuberculosis: A Case Study in Teminabuan Community Health Center, Indonesia Iskandar, Ishaq; Naolin, Imelda; Adam, Arlin; Iskandar, Harun; Syakri, Syamsuri
Diversity: Disease Preventive of Research Integrity Volume 6, Issue 1, August 2025
Publisher : Program Studi Kesehatan Masyarakat UIN Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/diversity.v6i1.59052

Abstract

Pulmonary tuberculosis (TB) remains a persistent public health challenge globally, with Indonesia ranking among the highest burden countries. In regions such as Southwest Papua, the incidence of TB is strongly influenced by cultural practices and daily behavioral patterns, yet limited studies have explored this dimension. This study aimed to analyze behavioral factors related to pulmonary TB incidence in Teminabuan, Indonesia, focusing on ventilation practices, cough etiquette, sputum disposal, smoking, and betel nut chewing. A cross-sectional design was conducted from May to June 2024 involving 97 respondents, consisting of families and neighbors of TB patients, selected through purposive sampling. The majority of participants were indigenous Papuans (76.29%), with 44.33% consuming betel nut and 43.33% spitting indiscriminately. Bivariate analysis showed that poor ventilation, inadequate cough etiquette, and indiscriminate spitting were significantly associated with TB incidence (p < 0.05). Among these, indiscriminate spitting was the most influential factor (PR = 0.421; 95% CI: 0.194–0.648). Smoking showed no significant association, while betel nut chewing, often accompanied by spitting, was found to increase TB transmission risk. These findings underscore the urgent need for culturally sensitive interventions that address traditional practices, while promoting the principle of cleanliness as part of faith in Islam, thereby strengthening family health protection and TB control efforts.
Co-Authors Alfian, Andi Anggita, Dwi Arlin Adam, Arlin Asriyani, Sri Danu, Alex Dewi Setiawati Djaharuddin, Irawaty djamaluddin, fauzan Ilyas, Muh Ilyas, Muh. Iskandar, Ishaq Latief, Nikmatia Lihawa, Nurjannah Madolangan, Jamaluddin Muis, Eliana Naolin, Imelda Putrawan, Harry Akza Rauf, Rafikah Sabaruddin, Haeriah Siti Nurisyah Syamsuri Syakri Tabri, Nur Ahmad Wiriansya , Edward Pandu Wiriansyah, Edward Pandu