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All Journal Heca Journal of Applied Sciences Malacca Pharmaceutics Journal of Educational Management and Learning
Abas, Abdul Hawil
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Other

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Journal : heca journal of applied sciences

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A Review on Mitochondrial Genome of Ants (Hymenoptera: Formicidae) Kolondam, Beivy Jonathan; Tallei, Trina Ekawati; Koneri, Roni; Abas, Abdul Hawil; Mamahit, Juliet Merry Eva
Heca Journal of Applied Sciences Vol. 1 No. 2 (2023): October 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v1i2.74

Abstract

Ants, which are members of the Formicidae family, have been the subject of considerable scientific scrutiny due to their remarkable diversity and ecological importance. Extensive research endeavors have been directed towards understanding the complex behaviors and ecological responsibilities exhibited by these organisms. The advent of cutting-edge sequencing technology in recent times has sparked a significant breakthrough in the deciphering of mitochondrial genomes in many animals, including ants. The objective of this review paper is to provide an informative summary of the mitochondrial DNA of ants. Exploring the intricate structural aspects, we investigate the genetic diversity that exists in the mitochondrial genomes of ants. The investigation of evolutionary processes provides insight into the complex alterations that have shaped genomes throughout time. The broader ramifications of these genetic differences for the fields of ant biology and conservation are thoroughly considered. An examination is conducted on the structural characteristics, genetic variations, and evolutionary features of ant mitochondrial genomes, along with an investigation into their physiological impacts. As the molecular complexities of ant mitochondrial genomes are revealed, there is an opportunity to further explore their realm, leading to a more comprehensive comprehension of these extraordinary organisms.
Integrative Network Pharmacology Study of Cordyceps militaris Compounds for Prostate Cancer Treatment Laihad, Sarah Cecilia Astrid; Tallei , Trina Ekawati; Tendean , Lydia Estelina Naomi; Turalaki, Grace Lendawati Amelia; Marunduh, Sylvia Ritta; Purwanto , Diana Shintawati; Kepel, Billy Johnson; Abas, Abdul Hawil
Heca Journal of Applied Sciences Vol. 4 No. 1 (2026): March 2026
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v4i1.382

Abstract

Prostate cancer remains one of the leading causes of cancer-related mortality in men, while adverse effects and the development of drug resistance often limit current therapeutic strategies. Natural products have gained increasing attention as potential sources of novel anticancer agents due to their multitarget properties and relatively low toxicity. Cordyceps militaris, a medicinal fungus rich in bioactive compounds, has been reported to exhibit anticancer activity; however, its compound-target interactions in prostate cancer have not been comprehensively elucidated. This study aimed to explore the interactions between C. militaris bioactive compounds and prostate cancer-associated targets using a pharmacology network-based in silico approach. A total of 50 bioactive compounds were collected from metabolite profiling studies, of which 19 compounds were selected based on high predicted TP53 expression enhancer activity (Pa ≥ 0.7) using WAY2DRUG PASS analysis. Protein targets were predicted using SwissTargetPrediction and the Similarity Ensemble Approach, and then intersected with prostate cancer-associated proteins retrieved from GEPIA2, GeneCards, and OMIM, yielding 499 overlapping targets. Protein interaction network analysis was performed using STRING and visualized in Cytoscape, enabling the identification of key hub proteins based on the applied parameters, highlighting ten key proteins, including SRC, ESR1, MAPK1, AKT1, HSP90AA1, MAPK3, HSP90AB1, EGFR, GRB2, and PRKACA, within the interaction network. Pathway enrichment analysis indicated that these targets were predominantly involved in cancer-associated signaling pathways, such as the EGFR tyrosine kinase inhibitor resistance pathway. Furthermore, the results revealed that the selected compounds interact with these key prostate cancer-associated proteins. Pharmacokinetic and toxicity evaluation predicted favorable drug-likeness and acceptable safety profiles for selected compounds. Overall, this study highlights the potential of C. militaris bioactive compounds as promising alternative for prostate cancer through multitarget modulation of clinically relevant signaling pathways. Further experimental validation is still required to confirm these findings.
Co-Authors Bachtiar, Boy Muhclis BEIVY JONATHAN KOLONDAM Celik, Ismail Diana Setya Ningsih, Diana Setya Fatimawali . Ghazi Mauer Idroes Irvanizam, Irvanizam Kemala, Pati Kepel, Billy Johnson Laihad, Sarah Cecilia Astrid Lala, Andi Mamahit, Juliet Merry Eva Marunduh, Sylvia Ritta Maulana, Aga Maulydia, Nur Balqis Purwanto , Diana Shintawati Rinaldi Idroes Roni Koneri Tallei , Trina Ekawati Tendean , Lydia Estelina Naomi Teuku Rizky Noviandy TRINA EKAWATI TALLEI Turalaki, Grace Lendawati Amelia Zulkarnain Jalil