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All Journal Majalah Obat Tradisional Jurnal Pengabdian Masyarakat Bangsa
Wahyuni, Dinar Sari C.
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The Effect of Cultivation Site Altitudes on the Quality Parameters of Meniran (Phylanthus niruri L.) Wahyuni, Dinar Sari C.; Pangestika, Maya Widia; Andriyani, Della; Rinanto, Yudi; Fatimah, Siti
Majalah Obat Tradisional Vol 28, No 3 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.72163

Abstract

Meniran (Phyllanthus niruri L.) is known as a medicinal plant for immunomodulatory, hypoglycemic, diuretic treatment, and kidney disorders. It has phenolic and flavonoid as the active compounds. Several commercial products utilize meniran as the main ingredient for immunomodulators. However, the standard raw material for production has not been well reported. The study aimed to standardize the quality of meniran’s raw materials from different locations and altitudes. The phenolic compounds as the active component and their antioxidant activity were further studied. The raw materials were collected from Sukoharjo, Jember, and Karanganyar which are located from 104 masl, 243 masl, and 722 masl. The specific and non-specific standardization based on Indonesian Herbal Pharmacopoeia were investigated. The antioxidant activity was investigated. It resulted in the specific and non-specific parameters that were according to standard except for the acid soluble ash test from the Jember sample which was much higher (6.333% ± 0.969) than the standard (<1.2%). In addition, the flavonoid (1.529 ± 0.167%w/w) and phenolic (1.65 ± 0.006 %w/w) content showed that the sample collected from Jember was significantly higher than other locations. However, the strongest antioxidant activity was in the sample collected from Sukoharjo (IC50 101.84μg/mL). On the other hand, there was no correlation between the total flavonoid and the total phenolic to antioxidant activity in this plant. It suggested that the antioxidant activity in these plants did not depend on the flavonoid and phenolic compounds. In conclusion, the raw material of meniran (Phyllanthus niruri L.) collected from 3 different altitudes showed the quality of herbal medicine of mainly non-specific parameters and met the requirements of Indonesian Herbal Pharmacopoeia. The total phenolic and flavonoid as the active substances varied through all 3 different altitudes. It was in line with the antioxidant activity which varied to all 3 different altitudes due to the phytochemical profile variety.
Standarisasi Proses Manufaktur Granul Jamu Instan Berbasis Kadar Fenolik Total, Aktivitas Antioksidan, dan Evaluasi Sifat Fisik Ainurofiq, Ahmad; Choiri, Syaiful; Hadi, Saptono; Wahyuni, Dinar Sari C.; Rakhmawati, Rita; Nugraheni, Estu Retnaningtyas; Pratama, Tiara Dewi S.; Azizah, Salma Nur
Jurnal Pengabdian Masyarakat Bangsa Vol. 2 No. 9 (2024): November
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v2i9.1551

Abstract

Jamu merupakan warisan budaya Indonesia yang telah digunakan secara turun menurun oleh nenek moyang. Penggunaan jamu dalam pengobatan hanya didasarkan pada data empiris yang diturunakan terus menerus antar generasi. Pembuktian khasiat dan kemanan jamu secara ilmiah telah diatur dalam Peraturan Menteri Kesehatan Republik Indonesia Nomor : 003/MENKES/PER/I/2010 dalam bentuk saintifikasi jamu. Saintifikasi produk jamu industri perlu dilakukan untuk mempertahankan eksistensi produk jamu di masyarakat. Tujuan pengabdian ini yaitu untuk meningkatkan penyediaan jamu berkhasiat melalui pembuktian khasiat jamu secara ilmiah. Standarisasi proses manufaktur granul jamu instan dilakukan sebagai bentuk saintifikasi jamu di industri. Standarisasi proses dilakukan berdasarkan penetapan kadar fenolik total dan nilai aktivitas antioksidan. Kadar fenolik total dianalisis dengan teknik Folin-Ciocalteu menggunakan asam galat sebagai senyawa pembanding. Aktivitas antioksidan dianalisis berdasarkan reaksi transfer electron senyawa antioksidan dengan •ABTS. Hasil penetapan menunjukkan adanya penurunan kadar fenolik total dari rimpang (0.1% GAE/g), hasil penyarian (0.065% GAE/g), dan hasil ruahan (0.057% GAE/g). Hasil penetapan aktivitas antioksidan menunjukkan adanya penurunan aktivitas antioksidan dari rimpang (29.79 IC50 mg/mL) ke hasil penyarian (34.62 IC50 mg/mL) serta terdapat peningkatan pada hasil ruahan (17.18 IC50 mg/mL) karena adanya bahan tambahan.
Co-Authors Ahmad Ainurofiq, Ahmad Andriyani, Della Azizah, Salma Nur ESTU RETNANINGTYAS N Pangestika, Maya Widia Pratama, Tiara Dewi S. Rita Rakhmawati, Rita Saptono Hadi, Saptono Siti Fatimah Syaiful Choiri Yudi Rinanto