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All Journal Majalah Obat Tradisional BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks Bioedukasi: Jurnal Pendidikan Biologi JPSCR : Journal of Pharmaceutical Science and Clinical Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Pengabdian Masyarakat Bangsa
ESTU RETNANINGTYAS N
Program Studi S1 Farmasi, FMIPA, Universitas Sebelas Maret
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Implementasi Teknik Granulasi Serbuk Jamu untuk Optimalisasi Proses Produksi Pabrik Jamu Suti Sejati Ahmad Ainurofiq; Syaiful Choiri; Dinar Sari Cahyaningrum Wahyuni; Saptono Hadi; Rita Rakhmawati; Nestri Handayani; Estu Retnaningtyas Nugraheni; Muhammad Adam Firdausi
Berdikari: Jurnal Inovasi dan Penerapan Ipteks Vol 10, No 2 (2022): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/berdikari.v10i2.13262

Abstract

The process of making herbal powder needs to be optimized because it is not efficient, and the filling process is still manually into teabags. The purpose of empowerment is to increase the effectiveness and efficiency of the herbal medicine-making process through a pharmaceutical approach with granulation techniques. This service is based on data obtained quantitatively in the laboratory, including the characteristics of the size distribution of Simplicia powder and granules and the flowability of herbal medicine powders. The data obtained were analyzed statistically with a 95% confidence level (p=0.05). The results showed that the granulation technique increased the flowability of the herbal powder with a flowability of 0 to 11.94±0.54 g/second. The granulation technique is able to improve the process of extracting herbs during brewing. The success of this activity is measured through the technique of increasing the flowability of herbal powders and the use of automatic teabag fillers. The results of the program showed that the granulation technique was able to increase the efficiency of the herbal powder manufacturing process at the Suti Sehati Herbal Medicine Factory, Sukoharjo.
Penggunaan Pewarna Alami dan Pengisi Jamu Instan Bagi UKM Obat Tradisional Syaiful Choiri; Estu Retnaningtyas Nugraheni; Rita Rakhmawati; Ahmad Ainurofiq; Saptono Hadi; Dinar Sari Cahyaningrum Wahyuni
Berdikari: Jurnal Inovasi dan Penerapan Ipteks Vol 11, No 1 (2023): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/berdikari.v11i1.12975

Abstract

The demand for traditional medicine increased during the pandemic, including instant herbal medicine for children. Children who consume herbal medicine are more interested in colorful products according to the advertised taste, while adult consumers are more interested in herbal compositions that are slightly sweeter (less sugar). This service aims to provide alternative natural dyes and non-sugar fillers for instant herbal products. Accordingly, the service was carried out in two stages. The service program was carried out using the tutorial method and focus group discussions (FGD). Tutorials were carried out online with natural materials as a source of alternative natural dyes and innovations in the use of non-sugar fillers. Group discussions focused on innovations in using non-sugar fillers with low production costs. The results showed that Rosella flowers (Hibiscus sabdariffa L.) are recommended as natural dyes for instant herbal medicine for children for red, yellow, and purple colors, while Suji leaves (Dracaena Angustifolia) for green colors. Additionally, Maltodextrin Fluidized Bed Dryer (FBD) ) is recommended as a non-sugar filler.
In vivo Wound Healing Activity of Tamanu Oil (Calophyllum inophyllum l.) Extracted by Cold-Pressed and Hot-Pressed Methods and Their Fatty Acids Composition Rakhmawati, Rita; Wahyuni, Dinar Sari Cahyaningrum; Ainurofiq, Ahmad; Hadi, Saptono; Choiri, Syaiful; Retnaningtyas, Estu; Pratama, Tiara Dewi Salindri
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.97146

Abstract

Tamanu oil is a promising natural wound healer due to its chemical compounds, particularly fatty acids. Cold-pressed or hot-pressed methods are commonly used to obtain this oil from Calophyllum seed. However, there needs to be research documenting the impact of these two extraction methods on the fatty acid profile and wound healing activity. Therefore, the study aims to characterize the fatty acid profiles of cold-pressed and hot-pressed tamanu oils using Gas Chromatography and evaluate their wound healing activity in vivo. The fatty acid profiles were analyzed using GC, and the wound healing tests were conducted on animal subjects divided into four groups: negative control, positive control (Bioplacenton®), cold-pressed tamanu oil, and hot-pressed tamanu oil. Cold-pressed tamanu oil showed superior fatty acid characteristics with an acid value of 38,71 Mg KOH/g fat and a peroxide value of 3,0095 mEq O2/kg, indicating that oil is stable against oxidation.  The length of the wound was observed daily for up to 8 days to assess its effect. The parameters observed were the percentage of wound healing and the total AUC based on the average length of the wound. Cold-pressed tamanu oil demonstrated the highest wound healing efficacy compared to both the positive control and hot-pressed tamanu oils. Both cold (11,67± 0,78) and hot-pressed tamanu oil (11,87 ± 0,61) exhibited significant differences in AUC value compared to the negative control group (13,07 ± 0,38), highlighting the potential of tamanu oil as a wound healing agent.
Pemanfaatan Sumber Daya Alam Lokal dalam Peningkatan Produktivitas Industri Rumah Tangga di Ingasrejo, Gondangrejo, Kabupaten Karanganyar Ainurofiq, Ahmad; Hadi, Saptono; Rakhmawati, Rita; Choiri, Syaiful; Wahyuni, Dinar Sari C; Nugraheni, Estu Retnaningtyas; Pratama, Tiara Dewi Salindri
Jurnal Pengabdian Masyarakat Bangsa Vol. 2 No. 8 (2024): Oktober
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v2i8.1497

Abstract

Indonesia memiliki keanekaragaman hayati yang melimpah. Banyak tanaman di negara ini memiliki potensi besar untuk dimanfaatkan sebagai bahan baku produk bernilai ekonomi tinggi. Salah satunya adalah tanaman lerak (Sapindus rarak). Namun, tidak semua masyarakat mampu mengoptimalkan potensi tersebut karena kurangnya pengetahuan dan keterampilan mengenai pengolahan dan pemanfaatan bahan alam. Oleh karena itu, pengabdian ini ditujukan untuk memanfaatkan sumber daya alam lokal dalam meningkatkan produktivitas industri rumah tangga. Pengabdian ini dilakukan dengan metode sosialisasi, pendampingan, dan pelatihan untuk masyarakat Dusun Ingasrejo dalam mengoptimalkan buah lerak sebagai sabun cuci antiiritasi dan ramah lingkungan serta memilki nilai komersial. Dari hasil pengabdian didapatkan masyarakat memiliki pengetahuan lebih dan mendalam mengenai bahan alam khususnya buah lerak. Hal tersebut dibuktikan dengan adanya peningkatan pemahaman warga setelah dilakukan evaluasi, serta mengasah keterampilan baru yaitu pembuatan produk sabun cuci buah lerak. Selain itu juga memberikan manfaat ekonomi serta pelestarian lingkungan.
Standarisasi Proses Manufaktur Granul Jamu Instan Berbasis Kadar Fenolik Total, Aktivitas Antioksidan, dan Evaluasi Sifat Fisik Ainurofiq, Ahmad; Choiri, Syaiful; Hadi, Saptono; Wahyuni, Dinar Sari C.; Rakhmawati, Rita; Nugraheni, Estu Retnaningtyas; Pratama, Tiara Dewi S.; Azizah, Salma Nur
Jurnal Pengabdian Masyarakat Bangsa Vol. 2 No. 9 (2024): November
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v2i9.1551

Abstract

Jamu merupakan warisan budaya Indonesia yang telah digunakan secara turun menurun oleh nenek moyang. Penggunaan jamu dalam pengobatan hanya didasarkan pada data empiris yang diturunakan terus menerus antar generasi. Pembuktian khasiat dan kemanan jamu secara ilmiah telah diatur dalam Peraturan Menteri Kesehatan Republik Indonesia Nomor : 003/MENKES/PER/I/2010 dalam bentuk saintifikasi jamu. Saintifikasi produk jamu industri perlu dilakukan untuk mempertahankan eksistensi produk jamu di masyarakat. Tujuan pengabdian ini yaitu untuk meningkatkan penyediaan jamu berkhasiat melalui pembuktian khasiat jamu secara ilmiah. Standarisasi proses manufaktur granul jamu instan dilakukan sebagai bentuk saintifikasi jamu di industri. Standarisasi proses dilakukan berdasarkan penetapan kadar fenolik total dan nilai aktivitas antioksidan. Kadar fenolik total dianalisis dengan teknik Folin-Ciocalteu menggunakan asam galat sebagai senyawa pembanding. Aktivitas antioksidan dianalisis berdasarkan reaksi transfer electron senyawa antioksidan dengan •ABTS. Hasil penetapan menunjukkan adanya penurunan kadar fenolik total dari rimpang (0.1% GAE/g), hasil penyarian (0.065% GAE/g), dan hasil ruahan (0.057% GAE/g). Hasil penetapan aktivitas antioksidan menunjukkan adanya penurunan aktivitas antioksidan dari rimpang (29.79 IC50 mg/mL) ke hasil penyarian (34.62 IC50 mg/mL) serta terdapat peningkatan pada hasil ruahan (17.18 IC50 mg/mL) karena adanya bahan tambahan.
Upaya Peningkatan Kesejahteraan Masyarakat melalui Pemanfaatan Bahan Alam di Randusari, Mojosongo, Surakarta: Improving Community Welfare through the Utilization of Natural Resources in Randusari, Mojosongo, Surakarta Wahyuni, Dinar Sari Cahyaningrum; Handayani, Nestri; Rakhmawati, Rita; Nugraheni, Estu Retnaningtyas; Pribadi, Fitrawan Hernuza
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 11 No. Suppl-1 (2026): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v11iSuppl-1.10434

Abstract

Randusari Hamlet, located in Mojosongo Village, Jebres District, Surakarta City, faces environmental and health problems due to its location close to the Putri Cempo Final Disposal Site (TPA). To address social and health issues, the Natural Product Pharmacy Research Group, Pharmacy Department, Faculty of Mathematics and Natural Sciences, Universitas Sebelas Maret, conducted educational activities on the utilization of natural materials, namely citronella (Cymbopogon nardus L.). The activity was carried out on May 4, 2025, and involved 75 participants from PKK RW 30 in Randusari Hamlet. It included preparation, presentation, leaflet distribution, demonstration of simple extraction of essential oils from citronella, and evaluation through pre- and post-tests. It led to various understandings of the applications of herbal medicine. The average increase in the pre-test and post-test study was 8.4%. It showed that the activity has successfully increased public knowledge and understanding regarding the use of herbal medicines. This activity is expected to increase the knowledge of the benefits, methods, and processing of medicinal plants into valuable products.
IDENTIFIKASI JENIS, KERAPATAN DAN DIVERSITAS PLANKTON BENTOS SEBAGAI BIOINDIKATOR PERAIRAN SUNGAI PEPE SURAKARTA (IDENTIFICATION, DENSITY AND DIVERSITY OF PLANKTON AND BENTOS AS BIOINDICATOR AT PEPE RIVER SURAKARTA) INDROWATI, METI; PURWOKO, TJAHJADI; RETNANINGTYAS, ESTU; YULIANTI, RARAS IKA; NURJANAH, SITI; PURNOMO, DWITO; WIBOWO, PANDU HARYO
Bioedukasi: Jurnal Pendidikan Biologi Vol 5, No 2 (2012): Bioedukasi: Jurnal Pendidikan Biologi
Publisher : Department of Biology Education Faculty of Teacher Training and Education Sebelas Maret Un

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/bioedukasi-uns.v5i2.3938

Abstract

Plankton and benthos are two communities of organisms that can be used as bioindicator of aquatic environment. The purpose of this research were to determine kinds, density and diversity of plankton and benthos in Pepe river Surakarta as bioindicator.Study site was devided into 3 station as sampling location. Data sampling of identifying the type, density and calculating the value of diversity index (ID) according to Shannon Wiener for-mula. Investigations carried out measurements of environmental parameters, namely tempera-ture, pH and Dissolved OxygenThe result showed that 1) identified 20 kinds of plankton in Pepe river Surakarta namely Spirogy- ra, Eustbidentat, Pleurosigma, Oscilatoria, Euglena, Aungilospora, Gonatozygon, Dendrospora, Amoeba, Blepharisma sp, Hapalosiphon, Skeletonema, Synura, Stentor, Worochinia, Leptomitus, Peridinium, Paramecium, Volvox, Rhizosolenia, and Lyngbia with the composition and density vary between each sampling site, 2) Identified 3 kinds of benthos in Pepe river Surakarta namely Melanoides sp, Lymnaea sp and Fimbria fimbriata with the composition and density vary between each sampling site and 3 ) the Shannon Wiener Diversity Index (ID) of plankton and benthos in Pepe river Surakarta ranged from 0.98 to 1.98, showing the condition of polluted waters from mild to severe, varied between sampling sites.
Systematic Review: Skrining Aktivitas Anti Quorum sensing Tumbuhan Terhadap Pseudomonas aeruginosa Nugraheni, Estu Retnaningtyas; W, Anindita Aulianisa; Pangastuti, Artini
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 1 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i1.64578

Abstract

Multi Drug Resistance (MDR) yang ditunjukkan Pseudomonas aeruginosa salah satunya dilatar belakangi oleh faktor virulensi seperti Las A, Las B dan formasi biofilm. Proses produksi ini dikontrol oleh sistem komunikasi quorum sensing (QS), sehingga penghambatan QS berpotensi mencegah resistansi lebih lanjut. Fitokomponen telah dilaporkan memiliki aktivitas anti QS, tetapi belum terdapat review yang merangkum laporan tersebut secara sistematis dan komprehensif. Penelitian ini bertujuan mengidentifikasi dan menyediakan rujukan berkualitas tentang aktivitas anti QS tumbuhan terhadap P. aeruginosa yang memenuhi parameter tertentu dalam bentuk Systematic Review. Systematic Review ini mengikuti permodelan PRISMA, analisis data menggunakan meta-sintesis-meta-agregasi, dan pencarian paper di 3 database (Pubmed, Sciencedirect, Scopus) menggunakan kata kunci Pseudomonas aeruginosa AND Quorum sensing AND Plants. Paper berjumlah 26 paper lolos saring yang memuat informasi terkait 18 famili (25 genus dan 28 spesies), 11 jenis organ tumbuhan, 3 jenis metode purifikasi, 4 jenis aktivitas anti QS dan 21 jenis fitokomponen yang dilaporkan menunjukkan aktivitas anti QS terhadap bakteri C. violaceum dan P. aeruginosa. Data yang tersedia dari 26 paper menunjukkan 9 laporan menyajikan data aktivitas anti QS relatif tinggi. Laporan tersebut terbagi menjadi 3 tingkat metode purifikasi yaitu isolat petroleum eter-etil asetat yang menghasilkan fitokomponen golongan phytosterol, fraksi etil asetat yang menghasilkan fitokomponen golongan flavonoid, dan ekstrak dengan pelarut metanol yang menghasilkan fitokomponen golongan terpenoid dan turunannya.
Uji Aktivitas Afrodisiaka Ekstrak Sambiloto (Andrographis Paniculata) pada Tikus Jantan Galur Wistar Pratama, Tiara Dewi Salindri; Wahyuni, Dinar Sari Cahyaningrum; Ainurofiq, Ahmad; Hadi, Saptono; Choiri, Syaiful; Rakhmawati, Rita; Nugraheni, Estu Retnaningtyas
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 11, No 1 (2026)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v11i1.94957

Abstract

Salah satu obat tradisional yang sudah digunakan sejak zaman dahulu secara turun menurun di Indonesia adalah sambiloto.  Permasalahan disfungsi seksual, terutama pada pria, dapat berdampak signifikan terhadap kualitas hidup dan kesehatan mental. Pemilihan sambiloto sebagai bahan baku karena tanaman sambiloto memiliki aktifitas sebagai afrodisiak melalui pengaturan kadar hormon atau efek langsung pada jaringan seksual. Penelitian ini memiliki tujuan untuk mengkaji aktivitas seksual hewan uji tikus jantan galur Wistar pada efek pemberian ekstrak etanol sambiloto. Selama tujuh hari, hewan uji akan diberikan ekstrak setiap hari, dan perilaku seksualnya akan diamati 30 menit setelah pemberian terakhir. Kelompok perlakuan pada penelitian ini dibagi menjadi 5 yaitu perlakuan kontrol negatif yang diberikan aquades, perlakuan kontrol positif yang menerima ekstrak pasak bumi dengan dosis sebanyak 7,5 mg/kgBB, serta kelompok perlakuan dengan ekstrak sambiloto, kelompok perlakuan dosis pertama (26,5 mg/kgBB), dosis kedua (50,5 mg/kgBB), dan dosis ketiga (100,5 mg/kgBB). Setiap kelompok terdiri dari tujuh tikus jantan. Dilakukan pengamatan setelah 30 menit pemberian ekstrak dengan memasukkan tikus jantan ke dalam chamber tikus betina dan diamati selama 30 menit. Parameter yang diamati meliputi Frekuensi pemasangan (Mounting Frequency), frekuensi intromisi (Intromission Frequency), latensi pemasangan (Mounting Latency), dan latensi intromisi (Intromission Latency). Hasil dari penelitian menunjukkan jika pemberian ekstrak etanol sambiloto pada dosis 26,5 mg/kgBB, 50,5 mg/kgBB, dan 100,5 mg/kgBB memengaruhi aktivitas seksual hewan uji yang dilihat dari parameter frekuensi pemasangan (Mounting Frequency), frekuensi intromisi (Intromission Frequency), latensi pemasangan (Mounting Latency), dan latensi intromisi (Intromission Latency).
Tamanu Oil (Calophyllum inophyllum L.) Promotes Wound-Healing Activity in Alloxan-Induced Diabetic Rats, and Its Fatty Acids Profile Rakhmawati, Rita; Hadi, Saptono; Ainurofiq, Ahmad; Nugraheni, Estu Retnaningtyas; Choiri, Syaiful; Pratama, Tiara Dewi Salindri
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 2 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i2.80107

Abstract

Diabetes Mellitus (DM) is a metabolic disease and is a severe threat because it causes diabetic wounds. Treating injuries in patients with DM is dominated by synthetic chemicals such as anti-inflammatory, corticosteroids, and antibacterial. It has side effects, so further exploration of natural ingredients is needed. One plant that has the potential to heal wounds is tamanu oil or nyamplung oil. This study aimed to investigate the effect of tamanu oil on the healing of diabetic wounds and the fatty acid composition profile. Male rats of the Wistar strain (Ratus novergius) were given incision wounds along a 2 cm depth of 2 mm, randomly divided into three groups, by applying topically twice a day. We are profiling fatty acids using gas chromatography-mass spectrometry (GC-MS). As far as we know, this is the first study showing that tamanu oil can speed up the healing of diabetic wounds in rats. The Tamanu oil containing oleic acid (42.65%), linoleic acid (25.69%), stearic acid (16.50%), and palmitic acid (12,93) had better effectiveness than other groups, demonstrated by wound closure exceeding 50% on day six and wound closure by 100% on day nine.
Co-Authors Ahmad Ainurofiq Ahmad Ainurofiq Ahmad Ainurofiq, Ahmad Ari Eka Suryaningsih ARTINI PANGASTUTI Azizah, Salma Nur Dinar Sari Cahyaningrum Wahyuni Dwito Purnomo Eka Puspita Rini Eni Purwani Hendri Hermawan Adinugraha Meti Indrowati Muhammad Adam Firdausi Nestri Handayani Nestri Handayani, Nestri Pandu Haryo Wibowo Pratama, Tiara Dewi S. Pratama, Tiara Dewi Salindri Pribadi, Fitrawan Hernuza RARAS IKA YULIANTI Rita Rakhmawati Rita Rakhmawati, Rita Saptono Hadi Saptono Hadi, Saptono Siti Nurjanah Sofiatun Sofiatun Sri Mulyani Syaiful Choiri Syamsul Arifin TJAHJADI PURWOKO W, Anindita Aulianisa Wahyuni, Dinar Sari C Wahyuni, Dinar Sari C. YULIANTI, RARAS IKA