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All Journal Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Molekul: Jurnal Ilmiah Kimia Jurnal Pengabdian Masyarakat Bangsa
Ahmad Ainurofiq, Ahmad
Faculty of Mathematic and Natural Science, Sebelas Maret University, Jl. Ir. Sutami 36A, Surakarta 57126
Agriculture, Biological Sciences & Forestry Arts Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Health Professions Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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SPECTROPHOTOMETRIC ANALYSIS OF DESLORATADINE MULTICOMPONENT CRYSTAL FORMULATION: COMPARISON OF CONVENTIONAL METHODS AND CHEMOMETRIC ANALYSIS Ainurofiq, Ahmad; Choiri, Syaiful
Molekul Vol 15, No 1 (2020)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (236.942 KB) | DOI: 10.20884/1.jm.2020.15.1.560

Abstract

Multicomponent crystal (MCC) formulation consists of drug and co-former that spectrophotometrically has an interference each other. The aim of this research was to evaluate and develop the analytical method to obtain a fast, cheap, efficient, and adequate method to estimate desloratadine (DES) in MCC formulation using three different methods. Single wavelength calibration model was constructed at 290 nm, multiple component equations was obtained from 273 nm and 283 nm, and multivariate analysis consists of PLS and PCA, a chemo-metric based, assisted the model selection and model calibration. Single wavelength method and multivariate analysis model had been fully validated i.e. range, specificity, accuracy, precision, limit of detection, and limit of quantification. A multivariate analysis had more adequate ability to estimate the DES and co-former in the MCC formulation.Keywords: Desloratadine, multicomponent crystal, multivariate, PLS
APPLICATION OF MONTMORILLONITE, ZEOLITE AND HYDROTALCITE NANOCOMPOSITE CLAYS-DRUG AS DRUG CARRIER OF SUSTAINED RELEASE TABLET DOSAGE FORM Ainurofiq, Ahmad
Indonesian Journal of Pharmacy Vol 25 No 3, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (763.663 KB) | DOI: 10.14499/indonesianjpharm25iss3pp125

Abstract

Captopril is an angiotensin converting enzyme (ACE) inhibitor as  antihypertensive treatment with half-life about 2h. Development of sustained-release dosage form can maintenance the drug concentration at therapeutic window in long period of time with constant release. Montmorillonite, zeolite and hydrotalcite nano-composites were used as drug carrier as sustained release dosage form. This study aimed to determine the drug release from nanocomposite of montmorillonite-drug, zeolite-drug and hydro-talcite-drug. Nanocomposite drug and carriers were made with the model drug was dispersed in carrier with matrix system. Matrices used montmorillonite, zeolite and hydrotalcite with concentrations of 20%, 30% and 40%. Characterization of matrices were done by testing the physical properties of the granules and drug release. Dissolution test using apparatus II USP model with speed rotation of 50rpm of, 900mL of HCl 0.1N as medium. The results were compared statistically with one way ANOVA 95% of interval confidence. The results showed that the difference of matrices and concentrations gave the difference effect in flow time, compact-tibility, DE360, initial burst release and maintenance release (p<0.05). Nanocomposites between drug and nanoclays occurred after 60min were shown with decreasing the drug release rate. Nanocomposite was formed with the drug molecules adsorb on nanoporous of carrier material. Increasing of clays concentration improved the fluidity and compactibility, reduced the drug release.
In vivo Wound Healing Activity of Tamanu Oil (Calophyllum inophyllum l.) Extracted by Cold-Pressed and Hot-Pressed Methods and Their Fatty Acids Composition Rakhmawati, Rita; Wahyuni, Dinar Sari Cahyaningrum; Ainurofiq, Ahmad; Hadi, Saptono; Choiri, Syaiful; Retnaningtyas, Estu; Pratama, Tiara Dewi Salindri
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.97146

Abstract

Tamanu oil is a promising natural wound healer due to its chemical compounds, particularly fatty acids. Cold-pressed or hot-pressed methods are commonly used to obtain this oil from Calophyllum seed. However, there needs to be research documenting the impact of these two extraction methods on the fatty acid profile and wound healing activity. Therefore, the study aims to characterize the fatty acid profiles of cold-pressed and hot-pressed tamanu oils using Gas Chromatography and evaluate their wound healing activity in vivo. The fatty acid profiles were analyzed using GC, and the wound healing tests were conducted on animal subjects divided into four groups: negative control, positive control (Bioplacenton®), cold-pressed tamanu oil, and hot-pressed tamanu oil. Cold-pressed tamanu oil showed superior fatty acid characteristics with an acid value of 38,71 Mg KOH/g fat and a peroxide value of 3,0095 mEq O2/kg, indicating that oil is stable against oxidation.  The length of the wound was observed daily for up to 8 days to assess its effect. The parameters observed were the percentage of wound healing and the total AUC based on the average length of the wound. Cold-pressed tamanu oil demonstrated the highest wound healing efficacy compared to both the positive control and hot-pressed tamanu oils. Both cold (11,67± 0,78) and hot-pressed tamanu oil (11,87 ± 0,61) exhibited significant differences in AUC value compared to the negative control group (13,07 ± 0,38), highlighting the potential of tamanu oil as a wound healing agent.
Pemanfaatan Sumber Daya Alam Lokal dalam Peningkatan Produktivitas Industri Rumah Tangga di Ingasrejo, Gondangrejo, Kabupaten Karanganyar Ainurofiq, Ahmad; Hadi, Saptono; Rakhmawati, Rita; Choiri, Syaiful; Wahyuni, Dinar Sari C; Nugraheni, Estu Retnaningtyas; Pratama, Tiara Dewi Salindri
Jurnal Pengabdian Masyarakat Bangsa Vol. 2 No. 8 (2024): Oktober
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v2i8.1497

Abstract

Indonesia memiliki keanekaragaman hayati yang melimpah. Banyak tanaman di negara ini memiliki potensi besar untuk dimanfaatkan sebagai bahan baku produk bernilai ekonomi tinggi. Salah satunya adalah tanaman lerak (Sapindus rarak). Namun, tidak semua masyarakat mampu mengoptimalkan potensi tersebut karena kurangnya pengetahuan dan keterampilan mengenai pengolahan dan pemanfaatan bahan alam. Oleh karena itu, pengabdian ini ditujukan untuk memanfaatkan sumber daya alam lokal dalam meningkatkan produktivitas industri rumah tangga. Pengabdian ini dilakukan dengan metode sosialisasi, pendampingan, dan pelatihan untuk masyarakat Dusun Ingasrejo dalam mengoptimalkan buah lerak sebagai sabun cuci antiiritasi dan ramah lingkungan serta memilki nilai komersial. Dari hasil pengabdian didapatkan masyarakat memiliki pengetahuan lebih dan mendalam mengenai bahan alam khususnya buah lerak. Hal tersebut dibuktikan dengan adanya peningkatan pemahaman warga setelah dilakukan evaluasi, serta mengasah keterampilan baru yaitu pembuatan produk sabun cuci buah lerak. Selain itu juga memberikan manfaat ekonomi serta pelestarian lingkungan.
Standarisasi Proses Manufaktur Granul Jamu Instan Berbasis Kadar Fenolik Total, Aktivitas Antioksidan, dan Evaluasi Sifat Fisik Ainurofiq, Ahmad; Choiri, Syaiful; Hadi, Saptono; Wahyuni, Dinar Sari C.; Rakhmawati, Rita; Nugraheni, Estu Retnaningtyas; Pratama, Tiara Dewi S.; Azizah, Salma Nur
Jurnal Pengabdian Masyarakat Bangsa Vol. 2 No. 9 (2024): November
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v2i9.1551

Abstract

Jamu merupakan warisan budaya Indonesia yang telah digunakan secara turun menurun oleh nenek moyang. Penggunaan jamu dalam pengobatan hanya didasarkan pada data empiris yang diturunakan terus menerus antar generasi. Pembuktian khasiat dan kemanan jamu secara ilmiah telah diatur dalam Peraturan Menteri Kesehatan Republik Indonesia Nomor : 003/MENKES/PER/I/2010 dalam bentuk saintifikasi jamu. Saintifikasi produk jamu industri perlu dilakukan untuk mempertahankan eksistensi produk jamu di masyarakat. Tujuan pengabdian ini yaitu untuk meningkatkan penyediaan jamu berkhasiat melalui pembuktian khasiat jamu secara ilmiah. Standarisasi proses manufaktur granul jamu instan dilakukan sebagai bentuk saintifikasi jamu di industri. Standarisasi proses dilakukan berdasarkan penetapan kadar fenolik total dan nilai aktivitas antioksidan. Kadar fenolik total dianalisis dengan teknik Folin-Ciocalteu menggunakan asam galat sebagai senyawa pembanding. Aktivitas antioksidan dianalisis berdasarkan reaksi transfer electron senyawa antioksidan dengan •ABTS. Hasil penetapan menunjukkan adanya penurunan kadar fenolik total dari rimpang (0.1% GAE/g), hasil penyarian (0.065% GAE/g), dan hasil ruahan (0.057% GAE/g). Hasil penetapan aktivitas antioksidan menunjukkan adanya penurunan aktivitas antioksidan dari rimpang (29.79 IC50 mg/mL) ke hasil penyarian (34.62 IC50 mg/mL) serta terdapat peningkatan pada hasil ruahan (17.18 IC50 mg/mL) karena adanya bahan tambahan.
Co-Authors Azizah, Salma Nur Dinar Sari Cahyaningrum Wahyuni ESTU RETNANINGTYAS N Pratama, Tiara Dewi S. Pratama, Tiara Dewi Salindri Rita Rakhmawati, Rita Saptono Hadi, Saptono Syaiful Choiri Wahyuni, Dinar Sari C Wahyuni, Dinar Sari C.