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All Journal Jurnal SOLMA Muhammadiyah Medical Journal
Mawanti, Wening Tri
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Anti-Inflammatory Cytokine (IL-10) Profiles and Ratio of IL-6/IL-10 in Covid-19 Patients Sari, Shinta Dewi Permata; Listiyaningsih, Erlin; Mawanti, Wening Tri; Martalena, Dewi
Muhammadiyah Medical Journal Vol 5, No 1 (2024): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.5.1.1-8

Abstract

Background: The number of COVID-19 cases in Indonesia has continually increased since the first cases appeared in March 2020. This disease is due to SARS-CoV-2 virus infection in the respiratory system that induces an immune response. The innate and adaptive immune response triggered the secretion of an excessive pro-inflammatory cytokine-caused cytokine storm that became one of the mechanisms of acute respiratory distress (ARDS). The anti-inflammatory cytokines (IL-10, IL-13, and IL-4) were secreted as the immune response in the ARDS condition. Purposes: This study aims to determine the ratio of the IL-6/IL-10 profile as basic information for the therapeutic approach to prevent ARDS. Methods: This cross-sectional study used stored biological material in plasma form from COVID-19 patients in Jakarta Islamic Hospital – Pondok Kopi and Dr. M. Goenawan Partowidigdo Hospital, Cisarua. The plasmas were from severe (n=20) patients and mild to moderate severity (n=25). The negative control sample was collected from 13 healthy subjects. Assessment of IL-10 levels in plasma using ELISA technique. Results: Our analysis showed that IL-10 has no statistical difference between negative control, mild to moderate, and severe categories (p=0.629). Meanwhile, the ratio IL-6/IL-10 presented statistical differences between mild to moderate and severe categories (p=0.011). The average ratio of IL-6/IL-10 in severe categories is two-fold higher than in mild-moderate categories. Conclusion: We conclude that there is a cytokine storm condition in severe COVID-19 patients with an imbalance ratio of pro-and anti-inflammatory cytokines and could be used as basic information for drug development in cytokine storm conditions to prevent ARDS.
Edukasi Pengenalan Dan Pengendalian Bahaya Potensial Pekerjaan Pada Guru SD Muhammadiyah 16 Dan 15 Bukit Duri Mawanti, Wening Tri; Harahap, Roito Elmina Gogo; Yati, Kori; Setiawan, Abdul Aziz; Khoirunisa, Irbah; Intan, Annisa; Abdulloh, Abdulloh
Jurnal SOLMA Vol. 14 No. 2 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v14i2.15248

Abstract

Background: Upaya penerapan Keselamatan dan Kesehatan Kerja di sekolah melalui edukasi pengenalan dan pengendalian bahaya potensial terutama bagi para guru penting dilakukan agar proses belajar-mengajar tidak terhambat yang diakibatkan oleh guru yang cidera atau sakit. Meningkatkan pengetahuan setiap guru tentang berbagai bahaya potensial pekerjaannya dan mampu melakukan langkah pengendalian terhadap bahaya potensial yang ditemukan. Metode: Metode yang digunakan adalah penyuluhan atau edukasi ceramah dengan penyajian materi selama 30 menit, diikuti diskusi tanya jawab. Peserta yang terlibat adalah guru SD Muhammadiyah 16 dan 52 Bukit Duri. Peningkatan pengetahuan diukur dengan melakukan pre-tes sebelum ceramah dan dilakukan post-test setelah ceramah. Hasil pre-test dan post-test dilakukan analisis menggunakan program IBM SPSS Statistic 24 metode uji paired T-test. Hasil: Nilai Korelasi antara 2 variabel pretest dan posttest responden penyuluhan “Edukasi Potensi Bahaya Keselamatan dan Kesehatan Kerja Guru di SDN Muhammadiyah 16 dan 52 Bukit Duri” sebesar 0,632, artinya terdapat hubungan yang hubungan kuat dan positif. Nilai probabilitas/p value uji T Paired sebesar 0,027, artinya terdapat perbedaan antara sebelum dan sesudah perlakuan, sebab nilai p value < 0,05 (95 % kepercayaan). Kesimpulan: Edukasi pengenalan dan pengendalian bahaya potensial pekerjaan efektif dalam meningkatkan pengetahuan Guru SD Muhammadiyah 16 dan 52 Bukit Duri.
Co-Authors Abdulloh Abdulloh Dewi Martalena ERLIN LISTIYANINGSIH Harahap, Roito Elmina Gogo Intan, Annisa khoirunisa, irbah Kori Yati Sari, Shinta Dewi Permata Setiawan, Abdul Aziz