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All Journal Althea Medical Journal Care : Jurnal Ilmiah Ilmu Kesehatan Jurnal Respirasi (JR) Majalah Biomorfologi (Biomorphology Journal) INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL Bioculture Journal Folia Medica Indonesiana
I’tishom, Reny
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : Althea Medical Journal

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Penile Length of Prepubertal Children in Surabaya Susiana, Okta Margarita; Yuliawati, Tri Hartini; Purwanto, Bambang; Rezano, Andri; I’tishom, Reny
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n3.3094

Abstract

Background: Early recognition of phallic size abnormalities is essential to identify underlying endocrine and genetic disorders. Parents are concerned regarding their son’s penis length, especially obese and short-stature boys. This study aimed to investigate the factors of penile length in prepubertal boys aged 9-11 in Surabaya.Methods: A cross-sectional analytic observational study was conducted between October and November 2021 during the community services program of the Andrology Study Program, Universitas Airlangga. One hundred forty-eight healthy boys aged 9-11 years were enrolled in this study. Penile parameters and anthropometric measures were recorded. Data were analyzed with Spearman Rho’s formula to correlate the variables studied.Results: The average penile lengths and penile circumference of the penis were 6.3±1.4 and 5.2±1.0 cm, respectively. This study found two boys with micropenis (1.35%) with normal and overweight body mass index (BMI). The penile length was positively correlated with height but not with BMI.Conclusion: Androgen and growth hormones significantly influence penile length. Children with abnormal BMI tend to have smaller penile sizes, associated with increasing androgen aromatization.
Effects of Tamarillo (Solanum betaceum) Extract on Glutathione Peroxidase Expression and Inflammatory Reactions in Lead Acetate-Induced Lung Tissue of Mice Harjono, Shella; I’tishom, Reny; Rahniayu, Alphania; Fatimah, Nurmawati
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4460

Abstract

Background: Lead acetate exposure through oral route has a significant impact on lung tissue as lead can induces the formation of reactive oxygen species (ROS), resulting in decreased glutathione peroxidase (GPx) and triggering inflammatory responses. The induction of exogenous antioxidants may prevent this mechanism. This study aimed to evaluate the protective effect of Tamarillo ethanol extract on GPx expression and inflammatory reactions in the lung tissue of mice induced with lead acetate.Methods: This true experimental laboratory study utilized stored formalin-fixed-paraffin-embedded (FFPE) lung tissue  from 30 male mice (Mus musculus). The samples were divided into five intervention groups, each consisting of six mice. Immunohistochemistry and histopathology assessments were performed at 100x and 400x magnification to evaluate the GPx expression using the H-score and to assess inflammatory reactions based on five scoring parameters, which were summed to obtain the total lung injury score.Results: Lead exposure significantly increased inflammatory reactions, particularly in the hemorrhage parameters (p=0.041). A significant increase in GPx expression was observed following lead acetate administration (p=0.027). Administration of Tamarillo ethanol extract at a dose of 400 mg/kgBW increased GPx expression compared with the positive control group (p=0.027).Conclusion: Tamarillo ethanol extract, especially at a dose of 400 mg/kgBW, significantly increases GPx expression in lead acetate-induced lung tissue of mice. This finding highlights the potential role of Tamarillo extract as an antioxidant source to reduce lead-induced lung injury, supporting broader efforts to promote healthy lifestyle practices that protect against environmental toxin exposure.
Co-Authors A'yuni, Mila Qurotul Alphania Rahniayu Andri Rezano Angeline, Jennifer Anny Setijo Rahaju, Anny Setijo Atmaja, Muhammad Hidayat Surya Bambang Purwanto Fatimah, Nurmawati Fatkhurrohmah Leo Amalia Fauzana, Anindita Azkia Harjono, Shella Herley Windo Setiawan Iswandi, Cantika Marcellin Princess Jayanti, Ratna Dwi Maheswari, Efada Aini Ayu Margiana, Ria Marpaung, Zahra Thamizya Mohammad Ayodhia Soebadi Nur Arfian, Nur Qorib, Mohammad Fathul Rifatus Solicha Samara, Anggita Putri Santoso, Azizah Bonitha Zahrah Supardi Supardi Susiana, Okta Margarita Sutikno, Budi Wibowo, Kristophorus Jonathan Yuliawati, Tri Hartini