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All Journal Jurnal Kedokteran Brawijaya Narra J
Laqif, Abdurrahman
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Impacts of Phyllanthus niruri extract on biomarker levels, macrophage count, and lesion area in an endometriotic rat model Wulandari, Eka T.; Soetrisno, Soetrisno; Purwanto, Bambang; Reviono, Reviono; Wasita, Brian; Laqif, Abdurrahman
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1002

Abstract

Endometriosis is a gynecological disorder characterized by chronic inflammation, anatomical changes, prolonged pain, and infertility. On the other hand, Phyllanthus niruri is recognized for its pharmacological effects, which might be beneficial in managing endometriosis. The aim of the study was to investigate the pharmacological effects of P. niruri as a potential therapy for endometriosis by using an animal model. An experimental laboratory study with randomized, controlled trial, pre-test, and post-test design using 40 female Wistar rats (Rattus norvegicus) was conducted at the Integrated Research and Testing Laboratory (LPPT) of Universitas Gadjah Mada, Yogyakarta, Indonesia, from February to June 2023. Endometriosis was induced in female Wistar rats by suturing a 0.5 cm2 flap from the uterine horn to the peritoneal cavity. Changes in serum interleukin 1β (IL-1β), malondialdehyde (MDA), and matrix metalloproteinase 9 (MMP-9), before and after the treatment, were analyzed using enzyme-linked immunosorbent assay. Hematoxylin and eosin (HE) staining were used to evaluate lesion size and macrophage quantity. The results suggested that the P. niruri extract with a dose of 196 mg/200 g body weight (BW) could significantly attenuate serum IL-1β (p=0.004), MMP-9 (p=0.021), and MDA (p=0.021). Rats receiving the P. niruri extract (196 mg/200 g BW) had significantly higher macrophage counts (p=0.003), but similar lesion area (p=0.093) as compared with the negative control. In conclusion, P. niruri demonstrated promising therapeutical effects on endometriosis by modulating IL-1β, MDA, and MMP-9 levels, although the effect was not pronounced on macrophage counts and lesion area.
Sexual Function Disorders after Hormonal Therapy or Surgery for Endometriosis in Moewardi General Hospital, Surakarta Anggraeni, Asih; Budihastuti, Uki Retno; Darto, Darto; Laqif, Abdurrahman; Melinawati, Eriana; Ksatriya, Yudhistya Ngudi Insan; Wijayanti, Agung Sari; Nuur, Aliffudin
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.01.1

Abstract

Endometriosis significantly affects women’s sexual health, manifesting as pain and dyspareunia, which reduces quality of life. In Indonesia, hormonal and surgical interventions are both used to manage endometriosis. However, the study of their effect on sexual function among Indonesia’s population is still unclear. This quasi-experimental study included 60 women, divided into two groups based on the type of therapy. This study was conducted from June to September 2024 at the Department of Obstetrics and Gynecology, Dr. Moewardi General Hospital. Outcomes were assessed with the Female Sexual Function Index (FSFI) questionnaire, before and after treatment. The analysis showed the mean rank of the surgical intervention (44.97) is higher than the hormonal intervention (16.03). The Mann-Whitney U test revealed a significant difference between the two groups of intervention (p=0.000). These findings indicate that surgical intervention is superior to hormonal therapy in improving the FSFI score that reflects sexual function among women.  
Relationship between Urinary Disorders and Body Mass Index in Women with Polycystic Ovary Syndrome Anggraeni, Asih; Budihastuti, Uki Retno; Darto, Darto; Laqif, Abdurrahman; Melinawati, Eriana; Insan Ksyatria, Yudhista Ngudi; Wijayanti, Agung Sari; Putrinadia, Aninditya Verinda
Jurnal Kedokteran Brawijaya Vol. 34 No. 2 (2026): Article in Press 2026
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Early detection and management of obesity in women with polycystic ovary syndrome (PCOS) have been shown to reduce the risk of urinary problems and enhance their overall quality of life. The present study investigates the correlation between urinary disorders and body mass index (BMI) in women diagnosed with PCOS at Dr. Moewardi Regional General Hospital, Surakarta. A retrospective cohort approach was used over a 12-month time frame in both the outpatient clinic and the inpatient ward. The diagnosis of PCOS was made in accordance with the Rotterdam criteria (2003), whereby it is imperative that a woman fulfils two out of the three criteria, established after ruling out other hormonal disorders. Patients were stratified according to their BMI levels and the presence of urinary symptoms. Information on urinary issues, including urgency, frequency, nocturia, stress incontinence, and symptoms during and after urination, was extracted from the medical records. Statistical analysis was conducted to examine the correlation between urinary dysfunction and body mass index. In 54% of patients diagnosed with PCOS, urinary issues were identified. Of these, 63% were classified as obese. The study established that women diagnosed with PCOS who were obese were found to have more than twice the probability of developing urinary dysfunction in comparison to those with a normal weight. The most commonly reported symptoms included urgency and frequency, nocturia, stress incontinence, and post-voiding complaints. The present study demonstrates a significant correlation between urinary dysfunction and obesity in women diagnosed with PCOS.
Co-Authors Anggraeni, Asih Bambang Purwanto Brian Wasita Darto Darto Eriana Melinawati Insan Ksyatria, Yudhista Ngudi Ksatriya, Yudhistya Ngudi Insan Nuur, Aliffudin Putrinadia, Aninditya Verinda Reviono Reviono Soetrisno Soetrisno Uki Retno Budihastuti Wijayanti, Agung Sari Wulandari, Eka T.