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All Journal Jurnal Kedokteran Brawijaya Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Obstetri dan Ginekologi Universa Medicina Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Indonesian Journal of Medicine Journal of Maternal and Child Health Jurnal Pengabdian Masyarakat: Darma Bakti Teuku Umar Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Jurnal Abdidas GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Plexus Medical Journal Indonesian Basic and Experimental Health Sciences
Eriana Melinawati
Departemen Ilmu Obstetri Dan Ginekologi, Fakultas Kedokteran, Universitas Sebelas Maret/RSUD Dr. Moewardi, Surakarta, Indonesia
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Mucin-1 expression in endometrium is higher in polycystic ovary syndrome than in normal women Budihastuti, Uki Retno; Sulistyowati, Sri; Melinawati, Eriana; Marbun, Yohan Pamuji
Universa Medicina Vol 39, No 2 (2020)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (589.805 KB) | DOI: 10.18051/UnivMed.2020.v39.74-80

Abstract

BackgroundThe polycystic ovary syndrome (PCOS) is caused by endocrine system dysfunction in women. MUCIN-1 (MUC-1) expression is found in endometrial tissues, which leads to implantation process dysfunction because of imbalance of trophoblast adhesion process. This study was conducted to compare endometrial MUC-1 expression between PCOS and normal women considering all existing external variables.MethodsThis cross-sectional study was conducted in General Hospital Dr. Moewardi Surakarta. Endometrial samples were obtained from 30 infertile PCOS women based on Rotterdam criteria, and 30 normal women. Life style and reproductive data such as age, menstrual problems, menstrual cycle, age at menarche, and BMI were collected. Subjects underwent endometrial biopsy in luteinizing hormone (LH) secretion phase LH + 5 days to LH + 10 days for immunohistochemistry (IHC) of MUC-1 expression. An independent-t and multiple linear regression test were used to analyze the data at significance level of p<0.05. ResultsMean MUC-1 expression in the PCOS endometrium (49.66 ± 47.79) was significantly higher than in normal women (7.66 ± 14.55) (p=0.03). Multivariate linear regression model of life style and reproductive variables with MUC-1 showed that PCOS (b=29.54; 95% CI 9.57-49.49; p=0.004) and BMI (b= 29.99; 95% CI 5.91-54.07; p=0.001) significantly increase MUC-1 expression. PCOS (Beta=0.37) was more important than BMI (Beta=0.30) in increasing the MUC-1 expression. ConclusionExpression of MUC-1 levels in the PCOS endometrium was higher than in normal women. This suggests that MUC-1 contributes to the unexplained reproductive failure in PCOS.
The Differences of Folliculogenesis between Treated with Letrozole and Letrozole-Electroacupuncture in Women with Polycystic Ovary Syndrome Yulyanti, Yulyanti; Budihastuti, Uki Retno; Melinawati, Eriana; Sulistyowati, Sri; Nurwati, Ida
Indonesian Journal of Medicine Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.835 KB) | DOI: 10.26911/theijmed.2020.5.3.295

Abstract

Background: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder that most often causes infertility. It occurs due to the failure of folliculogenesis, thus causing non-ovulation. Letrozole is a 3rd generation drug of non-ste­roidal aromatase inhibitors, which can increase ovulation rates. Electroacupuncture is the insert­ion and manipu­lation of needles into acupunc­ture points (acu­points) that are selected speci­fically based on the meridian system and con­nected to the electrode stimulator. This study aimed to determine the differences of the effects of letrozole and letrozoleelectroacupuncture (letrozole-EA) on the improve­ment of folliculo­genesis in women with PCOS.Subjects and Method: This was an analytic observational study with a case-control design. This study was conducted at the Gynecology Polyclinic and Sekar Clinic, Dr. Moewardi Hos­pital, Surakarta. A sample of 30 infertile women aged 20-45 years was selected by fixed disease sampling. The criteria of the PCOS were deter­mined based on Rotterdam criteria. The depen­dent variable was the diameter of the follicle. The independent vari­ables were the administration of letrozole and letrozole-EA. Transvaginal ultra­sound of Voluson P6 was used to measure the folliculo­genesis. The data were analyzed by independent t-test.Results: On the second day after treatment, the diameter of the follicles in the letrozole-EA group (mean= 6.92; SD= 1.60) was bigger than the letrozole group (mean=5.66; SD=1.11), and it was statistically significant (p=0.004).Conclusion: Combination of letrozole and letrozole-EA therapy is more effective in increasing follicular diameter development than letrozole therapy only.Keywords: polycystic ovary syndrome, folli­culogenesis, Letrozole, electro-acupunctureCorrespondence: Yulyanti. Department of Obstetrics and Gyneco­logy, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta, Cen­tral Java, Indonesia. Email: dr.yulyanti­@gmail­.­com. Seluler: +6285264806570.Indonesian Journal of Medicine (2020), 05(03): 214-223https://doi.org/10.26911/theijmed.2020.05.03.06
The Difference of Endometrial Vascular Endothelial Growth Factor (VEGF) Expression between Polycystic Ovarian Syndrome (PCOS) and Normal Women Saputra, Ricky Bernadi; Budihastuti, Uki Retno; Sulistyowati, Sri; Melinawati, Eriana; Respati, Supriyadi Hari
Indonesian Journal of Medicine Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (32.015 KB) | DOI: 10.26911/theijmed.2020.5.3.296

Abstract

Background: Polycystic Ovarian Syndrome (PCOS) is an endocrine disorder in women cha­rac­terized by increased levels of androgens, ovu­la­tory dysfunction, and Polycystic Ovarian Mor­p­ho­logy (PCOM), as well as a combination of clas­sic clinical features. Women with PCOS expe­ri­ence changes in the endometrium and endo­met­rial receptivity markers such as VEGF (Vascular En­dothelial Growth Factor). VEGF increases the per­meability and dilation of endometrial blood vessels which play an important role in imp­lan­ta­tion. This study aimed to analyze the difference of VEGF expression between women with PCOS and nor­mal women.Subjects and Method: This study was a case-con­trol study design conducted at the polyclinic of the Department of Obstetrics and Gynecology, Dr. Moewardi Hospital, Surakarta, Central Java, in July 2020. There were 30 infertile women with PCOS (diagnosis based on Rotterdam criteria, con­sensus 2003) and 30 women without PCOS as the sample of this study. The dependent variable was VEGF expression. The independent variables were age, BMI, family history with PCOS, menar­che, occu­pa­tion, and education. VEGF expression was ob­tained from an endometrial biopsy on days 19-24 of periods. The differences in VEGF exp­res­sion (in %) were analyzed by the Mann-Whitney test. VEGF determinants were analyzed by a mul­ti­ple linear regression.Results: The mean of VEGF expression in wo­men with PCOS (Mean=64.33; SD=44.43) was high­er than in women without PCOS (Mean­= 7.90; SD=8.73) and the result was statistically sig­ni­ficant (p<0.001). PCOS (b=42.09; 95%­CI­=­64.­2­6 to -19.93; p<0.001) and obese (b=38.63; 95%­CI=-63.44 to -13.82; p=0.003) increased VEGF expression.Conclusion: VEGF expression in the endo­met­rium of women with PCOS is higher than normal wo­men.Keywords: VEGF, endometrium, Polycystic Ova­rian SyndromeCorrespondence: Ricky Bernadi Saputra. Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sebe­las Maret/ Dr. Moewardi Hospital, Sura­karta, Indo­nesia. Telp: 081221161933 Email: ricky­sa­put­radr@gmail.comIndonesian Journal of Medicine (2020), 05(03): 230-239https://doi.org/10.26911/theijmed.2020.05.03.08
The Effectiveness of Letrozole Adjuvant Therapy - Electro Acupuncture in Reducing the Number of Follicles and Body Weight and Increasing Endometrial Thickness in Women with Polycystic Ovary Syndrome Wesliaprilius, Todung Antony; Budihastuti, Uki Retno; Melinawati, Eriana; Sulistyowati, Sri; Nurwati, Ida; Hadi, Cahyono
Journal of Maternal and Child Health Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (36.052 KB)

Abstract

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Acupuncture can improve menstrual cycle recovery and decrease body mass index (BMI) in women with PCOS. The effect of acupuncture can be enhanced by giving letrozol. Researchers are interested in knowing the comparison between letrozol therapy with letrozol + electroacupuncture on body weight, follicle count, and endometrial thickness in women with polycystic ovary syn
The Effectiveness of Letrozole-Electroacupuncture Adjuvant Therapy in Reducing Resistance and Pulsatility Indices in Women with Polycystic Ovarian Syndrome Octavia, Dhamayanti Eka; Budihastuti, Uki Retno; Melinawati, Eriana; Anggraini, Nutria Widya Purna; Yuliantara, Eric Edwin; Nurwati, Ida; Hadi, Cahyono
Journal of Maternal and Child Health Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (35.881 KB)

Abstract

Background: Polycystic Ovarian Syndrome (PC
Improved Understanding of IUD and Implant Family Planning Acceptors in Family Planning Services at Solo Peduli Clinic Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru; Darto, Darto; Ratnasari, Affi Angelia; Anggraeni, Asih; Prisasanti, Dympna Prameilita
Journal of Maternal and Child Health Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (36.944 KB)

Abstract

Background: Family planning acceptor's understanding of intra uterine device (IUD) and implant contracep
Effect of ovarian autotransplantation on FSH levels in Wistar rats late menopause model Abdurahman Laqif; Dewi Kartika DJ Anwar; Eriana Melinawati
Majalah Obstetri dan Ginekologi Vol. 26 No. 1 (2018): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (185.064 KB) | DOI: 10.20473/mog.V26I12018.42-47

Abstract

Objectives: To determine the effect of ovarian autotransplan-tation on decreasing FSH level in Wistarrats late menopause model.Materials and Methods: Experimental analytic research on 27 Wistar rats (Rattus novergicus) was divided into 3 groups. Group 1 (K1) or control. Group 2 (K2) performed bilateral oophorec-tomy without autotransplantation. Group 3 (K3) performed bilateral oophorectomy with autotransplantation. Measurements of FSH levels were performed on the first day, day 28 (four weeks after bilateral oophorectomy, during late menopause) and 56 day (four weeks after autotransplant). Measurement of FSH levels using ELISA. Data analysis used ANOVA and Post Hoc test.Results: The mean FSH level measured on day 56 at K1 = 63.400 ng/mL, at K2 = 78.416 ng/mL and K3 = 31.991 ng/mL. There were significant differences between K1 and K2 (p = 0,000), K1 and K3 (p = 0,000), and between K2 and K3 (p = 0,000).Conclusion: Ovarian autotransplantation decrease FSH levels in Wistar rats late menopause model.
Changes in LIF expression on PCOS as biomarker implantation Uki Retno Budihastuti; Eriana Melinawati; Sri Sulistyowati; Tanti Arianti
Majalah Obstetri dan Ginekologi Vol. 29 No. 1 (2021): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V29I12021.23-27

Abstract

Objectives: This study aimed to compare the endometrial expression of LIF PCOS compared to normal and determine the effect of PCOS and external variables that affect LIF expression.Materials and Methods: This retrospective case control study with a correlational approach was conducted at Sekar Clinic, General Hospital Dr. Moewardi Surakarta. Subject were taken by consecutive sampling starting from September 2018 –. Februari 2019. External variable: age, occupation, family history PCOS, menarche, and BMI were recorded. The research samples were 60 subjects consisting of 30 PCOS patients based on Rotterdam criteria and 30 fertile women. In the luteinizing hormone (LH) secretion phase at LH + 5 days - LH + 10 days, an endometrial biopsy is performed with pipelle curettage, then it is examined by immunohistochemistry. Statistical analysis was performed using the Mann-Whitney, linier regression test.Results: Mean of LIF expression was found significantly lower in PCOS group (1.53±3.65) compared to control group (35.33±21.04, with p=<0.001). Multivariate analysis linear regression in the effect of PCOS and external variables to endometrial LIF expression models showed PCOS (b=-1.14; 95% CI=-1.56 – -0.72; p=<0.001) and occupation (b = 0.32; 95% CI=0.14 – 0.52; p=0.001) significantly decreases LIF expression. PCOS (B=-1.14) is more important than Occupation (B=0.33) in decreasing LIF expression.Conclusion:LIF expression decreased in the endometrium of PCOS patients and occupations compared to normal group, with considering all existing variables. 
PERBEDAAN KECEMASAN DAN KUALITAS HIDUP WANITA MENOPAUSE DI WILAYAH RURAL DAN URBAN Alfi Marita Tristiarti; Uki Retno Budihastuti; Eriana Melinawati; Abdurahman Laqif
JURNAL KEDOKTERAN DAN KESEHATAN Vol 9, No 3 (2022)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V9I3.18902

Abstract

Menopause merupakan proses alamiah pada wanita terkait dengan penuaan. Proses tersebut berdampak terhadap turunnya kualitas hidup atau Quality of Life (QoL) para wanita menopause akibat beragam gejala baik fisik maupun kejiwaan khususnya peningkatan kecemasan. Kecemasan saat menopause dipengaruhi oleh banyak hal seperti ada tidaknya sindrom menopause, tingkat pengetahuan dan wilayah demografi. Penilitian ini bertujuan untuk mengetahui perbedaan derajat kualitas hidup dan tingkat kecemasan pada wanita menopause di wilayah rural dan urban.  Penelitian ini menggunakan desain penelitian observasional analitik dengan pendekatan cross-sectional yang dilakukan di wilayah rural (pedesaan) dan urban (perkotaan). Besar sampel adalah 100 wanita menopause yang tinggal di wilayah rural dan 100 wanita menopause bertempat tinggal di wilayah urban yang dipilih melalui fix disease sampling. Pengambilan data pada penelitian ini menggunakan alat bantu kuesioner yang telah diuji validitas dan reliabilitasnya.  Penelitian menunjukkan bahwa tidak terdapat perbedaan antara tingkat kecemasan antara wanita menopause di wilayah rural dengan urban dengan nilai signifikansi  . Penelitian menunjukkan tidak terdapat perbedaan derajat kualitas hidup antara wanita menopause rural dengan wanita menopause urban, baik pada domain Occupational QoL, Health QoL  Sexual QoL dan  Emotional QoL. Hasil penelitian menunjukkan bahwa tidak terdapat perbedaan tingkat kecemasan dan kualitas hidup pada wanita menopause yang bertempat tinggal di rural dengan wanita menopause yang bertempat tinggal di urban.
Biopsychosocial Analysis of Factors on COVID-19 Screening Awareness of Infertile Couples in Assisted Reproductive Technology Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru Priyanto; Darto, Darto; Rantasari, Affi Angelia; Wasyanto, Trisulo; Anggraeni, Asih; Wijayanti, Agung Sari
Journal of Maternal and Child Health Vol. 6 No. 5 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (36.67 KB) | DOI: 10.26911/thejmch.2021.06.05.04

Abstract

Background: The development of screening methods for infertility patients during the Coronavirus-2019 (COVID-19) pandemic provides new challenges in the adaptation of children's want programs in the era of the COVID-19pandemic. Several screening methods have been developed but various factors affect the awareness of couples to want to do COVID-19 screening. This study aimed to analyze biopsychosocial factors associated with awareness of COVID-19 screening in infertile couples. Subjects and Method: A cross-sectional study conducted at The Sekar Polyclinic of Dr. Moewardi Regional General Hospital during the COVID-19 pandemic. A number of 60 infertile couple of reproductive age who underwent the ART program was selected by random sampling. The dependent variable was awareness for COVID-19 screening. The independent variables were anxiety, knowledge, age, and length of infertility. The data were obtained from medical record and questionnaire and analyzed by a multiple logistic regression. Results: Anxiety (OR= 26; 95% CI; p<0.001) and above-average knowledge levels (OR=16; 95% CI; p<0.001) affected awareness for COVID-19 screening. While the age and length of infertility do not affect awareness for COVID-19 screening (p >0.05). Conclusion: Anxiety and above-average knowledge levels affect awareness for COVID-19 screening.
Co-Authors ., Darto Abd. Rasyid Syamsuri Abdurahman Laqif Abdurahman Laqif Abida Zuhra Jatiningtyas Alfi Marita Tristiarti Alfi Marita Tristiarti Alfi Marita Tristiarti Alifa, Rosita Amira Masiah Syahvira Andreas Peter Sitorus Andreas Peter Sitorus Angelia Ratnasari, Affi Anggraeni, Asih Annang Giri Moelyo Asih Anggraeni Besar, Dwi Sakti Berlian Cahyono Hadi Darto Darto Darto - Darto - Darto Darto Dewi Kartika DJ Anwar Dwi Septiadi Badri Dyah Ratna Budiani Ediningtyas, Atifa Nadira Elita Rahmi Eric Edwin Yuliantara Fahsan, Fatmiyanti Farras Wahdan, Arib Hadi, Cahyono Hafiizha, Attahira Amalia Hanifah Karim Hapsari Nur Primastuti Hapsari Nur Primastuti Hermawan Udiyanto Heru Priyanto Heru Priyanto Ida Nurwati Jatiningtyas, Abida Zuhra Kartika Pertiwi Ksatriya, Yudhistya Ngudi Insan Laqif, Abdurahman Laqif, Abdurrahman Lukman Aryoseto Lukman Aryoseto Lunardhi Susanto Marbun, Yohan Pamuji Mashuri, Yusuf Ari Metanolia Sukmawati Mufidah, Amatullah Mulyoto Pangestu Ngudi Insan Ksyatria, Yudhistira Nutria Widya Purna Anggraini Nuur, Aliffudin Octavia, Dhamayanti Eka Prastyoningsih, Aris Prisasanti, Dympna Prameilita Raden Rara Pandhan Budi Larasati Rakano Kautsar Dwiyana Rantasari, Affi Angelia Ratnasari, Affi Angelia Regita, Immanuela Maria Saputra, Ricky Bernadi Sari, Arum Dessy Rahma Septiana, Yesika Cahya Sri Sulistyowati Sri Sulistyowati Supriyadi Hari Respati Supriyadi Hari Respati Tanti Arianti Teguh Prakosa, Teguh Tri Nugraha Susilawati Uki Retno Budihastuti Vicky Eko N.H Vicky Eko N.H Wasyanto, Trisulo Wesliaprilius, Todung Antony Wijayanti, Agung Sari WISNU PRABOWO Yulyanti, Yulyanti Zacky Arda, Mohammad