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All Journal Journal Pharmaceutical Science and Application (JPSA) Pharmascience Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Cahaya Mandalika JOURNAL SCIENTIFIC OF MANDALIKA (JSM) Jurnal Pengabdian kepada Masyarakat Wahana Usada Bali Medical and Wellness Journal
I Putu Riska Ardinata
Farmasi Klinis, Fakultas Ilmu-ilmu Kesehatan Universitas Bali Internasional
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Uji Aktivitas Peningkatan Fibrogenesis Salep Ekstrak Daun Binahong (Anredera Scandens (L.) Moq.) 10% Dalam Penyembuhan Luka Diabetes Pada Tikus Galur Sprague dawley I Putu Riska Ardinata; Bagus Komang Satriyasa; I Wayan Sumardika
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 4, No 1 (2023): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v4i1.11376

Abstract

Desain penelitian ini adalah eksperimen labrotatorik post test only. Penelitian menggunakan tikus jantan Galur Sprague dawley yang sudah diiduksi dengan STZ (Streptozotocin) dengan dosis 40mg/kgBB. Tikus dibagi ke dalam 4 kelompok yaitu normal yang tidak dberikan perlakuan apapun, negatif yang hanya diberikan perlukaan, positif diberikan salep gentamisin, dan kelompok uji ekstrak yang diberikan salep 10%. Dilakukan uji untuk melihat peningkatan aktivitas fibrogenesis berupa pembentukan jaringan ikat dengan melihat sel fibroblast dengan histopatologi.Hasil penelitian menunjukkan bahwa kelompok uji yang diberi salep ekstrak 10% daun Anredera scandens (L.) Moq. skoring histopatologi fibrogenesis pada kelompok esktrak 10% daun Anredera scandens (L.) Moq. Menunjukkan rata-rata nilai skor sebesar 3,5 yang signifikan (P=0,032) dibandingkan kelompok negatif dengan nilai rata-rata sebesar 2,75 pada hari ke-14. Namun jika dibandingkan dengan skoring kelompok positif sebesar 3,5 kelompok esktrak daun Anredera scandens (L.) Moq. menunjukkan nilai skor tidak signifikan (P=1,000) atau memiliki kemampuan yang setara dalam pembentukan jaringan ikat.Berdasarkan penelitian didapatkan hasil ekstrak daun Anredera scandens (L.) Moq. memiliki kemampuan dalam meningkatkan aktivitas fibrogenesis secara histopatologi mampu mempercepat pembentukan jaringan ikat pada hari ke-14 yang setara dengan kontrol positif.
OPTIMALISASI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL 70% DAUN BINAHONG TERHADAP BAKTERI Staphylococcus aureus I Putu Gede Adi Purwa Hita; I Putu Riska Ardinata; Zainal Firdaus Wardhana
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 12 No 1 (2023): MEDFARM: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v12i1.174

Abstract

Binahong leaf (Anredera cordifolia (Ten.) Steenis) contains flavonoids, alkaloids, tannins and saponins that function as antibacterial. Although antibacterial activity test of binahong leaves was done before, but not yet obtained optimum results using ethanol 70% as an extraction solvent. This study aims to determine the optimum antibacterial activity and the effect of increasing the concentration of 70% ethanolic extract of binahong leaves on Staphylococcus aureus bacteria. Binahong leaves were extracted by maceration method using ethanol 70% as solvent. The antibacterial activity was measured using the disc diffusion method and the inhibition zone obtained was also analyzed using statistical analysis. The results showed that the extract had good extract characteristics and contained a class of flavonoids, alkaloids, saponins, and tannins. The antibacterial activity of the binahong leaf extract showed a significant p-velue <0.05 from the Kruskal Wallis test with an inhibition zone in the moderate to strong group. Based on the results of this study it was concluded that the extract had good extract characteristics and contained several classes of phytochemical compounds. For antibacterial activity, the optimum concentration of antibacterial activity of 70% ethanolic extract of binahong leaves was obtained at an extract concentration of 80% with an inhibition zone was 12.85 mm and it also performed that the higher the concentration of the extract, the higher the antibacterial activity obtained. Keywords: Phytochemical Screening, Antibacterial Activity, Staphylococcus Aureus, Anredera cordifolia (Ten.) Steenis.
PENGARUH PENGETAHUAN ORANG TUA TERHADAP PERILAKU SWAMEDIKASI ANALGETIKA DI KOTA DENPASAR Ni Kadek Weni Diah Gayatri; Ni Putu Aryati Suryaningsih; I Ketut Tunas; I Putu Riska Ardinata
Jurnal Cahaya Mandalika ISSN 2721-4796 (online) Vol. 4 No. 3 (2023): Jurnal Cahaya Mandalika
Publisher : Institut Penelitian Dan Pengambangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/jcm.v4i3.1692

Abstract

Self-medication (self-medication) is an effort made by ordinary people to overcome the disease or symptoms of a disease that is experienced by themselves. Analgesics or painkillers are drugs that can reduce pain without reducing consciousness. Knowledge about the use of drugs is low due to the limited knowledge of the community about drugs. Self-medication can be very risky, especially in cases of irresponsible self-medication. This behavior using the Theory of Planned Behavior (TPB) is the result of a modification and development of the previous theory, namely the theory of reasoned action.The purpose of this study was to determine the effect of knowledge level and behavior level on analgesic self-medication.This research was conducted in an observational manner using a Cross Sectional design, in May-June 2023, using a validated questionnaire. A total of 96 respondents who participated, at the level of parental knowledge included in the Fairly Good category of 65.76%, at the level of parental behavior including the positive category of 54 (56.3%). There is a significant influence between the level of knowledge and the level of parental behavior, namely the calculated F value of 25.163 with a p value (0.000) from the Multiple Linear Regression Test Summary Model can explain the magnitude of the value (R) which is equal to 0.460 and obtained (R2) of 0.211 that the effect of the independent variable (Knowledge) on the dependent variable (Behavior) is 21.1%.There is a significant influence between knowledge and behavior in analgetic self-medication for parents of children in Denpasar City. There needs to be counseling and always providing information to the public about the importance of self-medication.
Formulasi dan Evaluasi Salep Hidrofilik 10%, 20% dan 30% dari Ekstrak Daun Binahong (Anredera scandens (L.) Moq.) I Putu Riska Ardinata; Ni Putu Wintariani; Dhiancinantyan Windydaca Brata Putri
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 4, No 2 (2023): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v4i2.11582

Abstract

Tanaman Binahong secara traditional sudah digunakan oleh masyarakat Indonesia sebagai obat untuk luka namun dalam pengaplikasiannya memerlukan media pembawa, salahsatunya adalah salep. Penelitian ini bertujuan untuk membuat formulasi dan evaluasi salep hidrofilik dari ekstrak daun binahong (Anredera scandens (L.) Moq.). yang dapat digunakan sebagai dasar pembuatan kosmetika atau obat topikal. Penelitian ini merupakan penelitain eksperimental laboratorik. Ekstrak daun binahong (Anredera scandens (L.) Moq.) akan dicampurkan kedalam basis salep hidrofilik yang akan dibuat menjadi 3 konsentrasi berbeda yaitu salep 10%, 20% dan 30%, selanjutnya akan dilakukan uji organoleptis, uji daya sebar, uji daya lekat, uji iritasi pada kulit, uji homogenitas dan uji pH. Hasil uji evaluasi dari ketiga salep ekstrak daun binahong (Anredera scandens (L.) Moq.) menunjukkan uji organoleptis yang serupa hanya berbeda dari warna. Uji daya sebar menunjukan diameter setelah ditekan sebesar 5,4cm, 5.3cm dan 5,1cm. Uji daya lekat menunjukkan hasil sebesar 12 detik, 14 detik dan 15 detik. Uji iritasi pada kulit menunjukkan tidak ada reaksi iritasi. Uji homogenitas menunjukkan salep yang dibuat sudah homogen dan uji pH sebesar 5,6; 5,6 dan 5,7. Hasil ini menunjukkan salep yang dihasilkan sudah baik dan sesuai standar.
Hubungan Tingkat Pengetahuan, Dukungan Keluarga, dan Peran Petugas Kesehatan Terhadap Kepatuhan Minum Obat pada Lansia Penderita Hipertensi di Puskesmas Kintamani V Ni Luh Sasih; I Gusti Ayu Agung Septiari; Ni Putu Wintariani; I Putu Riska Ardinata
JOURNAL SCIENTIFIC OF MANDALIKA (JSM) e-ISSN 2745-5955 | p-ISSN 2809-0543 Vol. 4 No. 9 (2023): September
Publisher : Institut Penelitian dan Pengembangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/10.36312/vol4iss9pp151-163

Abstract

Hypertension or better known as high blood pressure is often experienced by the elderly where blood pressure is above the normal limit of 120/80 mmHg. Adherence to taking medication in the elderly is very important because regular use of blood pressure medication can keep blood pressure under control and controlled. This study will be carried out at Kintamani V Health Center, because it is the highest hypertension sufferer after Bangli Health Center. This study aims to examine the relationship between the level of knowledge, family support, and the role of health workers on medication adherence in elderly people with hypertension at Kintamani V Health Center. The research method used is a type of quantitative research using a cross-sectional design. Data were collected using questionnaires. The results showed that the majority of respondents had a high level of knowledge (68.3%), as 51.7% of respondents received good family support, and the majority of respondents had the role of health workers as many as 73.3% of respondents. Statistical analysis showed that there was a significant relationship between the level of knowledge (p-value = 0.000), family support (p-value = 0.000) and the role of health workers (p-value = 0.000) with medication adherence in elderly people with hypertension. In conclusion, this study shows that there is a significant relationship between the level of knowledge, family support, and the role of health workers on medication adherence in elderly people with hypertension at Kintamani V Health Center.
Pemberdayaan, Pelatihan dan Sertifikasi Instruktur Senam Pencegahan Osteoporosis Widowati, I Gusti Ayu Rai; Manuaba, IA Ratih Wulansari; Sutema, IA Manik Partha; Putra, IGNA Windra Wartana; Suryaningsih, NP Aryati; Dewi, DAP Satrya; Ardinata, I Putu Riska; Maharianingsih, NM
Jurnal Pengabdian kepada Masyarakat Wahana Usada Vol. 5 No. 2 (2023): Desember: Jurnal Pengabdian kepada Masyarakat Wahana Usada
Publisher : Sekolah Tinggi Ilmu Kesehatan KESDAM IX/Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47859/wuj.v5i2.366

Abstract

Background: Osteoporosis is a common disease that needs to be treated by a health professional promptly. To address this issue, osteoporosis prevention exercise instructors were trained and certified as part of empowerment initiatives. Purpose: The aims of this program was to create competent, nationally certified instructors. Method: The Indonesian Healthy Bones Community Association (PERWATUSI), a non-profit organization whose objective is to ensure that Indonesians have healthy and strong bones, is responsible for carrying out this empowerment program. The event took place on July 19–20, 2023, in a hall at Bali International University. Results: A total of 59 instructors were selected from various sports communities and trained to provide the public on how to prevent early osteoporosis, conduct suitable exercise program, and emphasize safety training. Before the training started, candidates had to have the necessary educational background, professional qualifications, training in osteoporosis preventive activity, and a commitment to continuing learning. All of participants (100%) met the qualification. Conclusion: These instructors are crucial to the fight against osteoporosis. Those who have earned certification are anticipated to be committed to encouraging healthy lives and lowering the risk of bone fractures.
SYNERGISTIC EFFECT OF CURCUMA XANTHORRHIZA AND PHYSALIS ANGULATA EXTRACTS AS ANTIOXIDANTS AGAINST DPPH RADICALS Setiawan, Putu Yudhistira Budhi; Hita, I Putu Gede Adi Purwa; Ardinata, I Putu Riska; Suryaningsih, Ni Putu Aryati
Journal Pharmaceutical Science and Application Vol 5 No 2 (2023): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2023.v05.i02.p05

Abstract

Background: As a single extract, Curcuma xanthorrhiza and Physalis angulata are known to have antioxidant activity. However, the interaction effect of antioxidants in suppressing DPPH (2,2-difenil-1-pikrilhidrazil) radicals that arise in these two combinations of plant extracts is not yet known. In this study, the combination of these two plants was investigated for their antioxidant properties and synergistic effects. Objective: This study aims to determine the effect of the combination of Curcuma xanthorrhiza and Physalis angulata as antioxidants and the interactions they cause. Methods: The rhizomes of Curcuma xanthorrhiza and the herb Physalis angulata were extracted separately with ethanol. After evaporation, the crude xtract was tested individually to obtain the IC50 value. Based on the IC50 value of each extract, 9 combination variations were made and the combination index (CI) value was calculated to determine the resulting interaction effect. Result: The antioxidant activity of Curcuma xanthorrhiza IC50 extract is 51.015 ppm, higher than Physalis angulata IC50 extract which is 90.488 ppm. The CI value observed in the combination of extracts in all combinations had a CI value <1. Conclusion: This research shows that the combination of Curcuma xanthorrhiza rhizome extract and Physalis angulata herb has synergistic antioxidant properties. Keywords: Combination; Synergis; Antioxidant; Combination Index
Enhanced Fibrogenesis Activity in Diabetic Wound Using 20% Anredera scandens (L.) Moq. Leaves Extract Ointment in Sprague dawley Rats: Peningkatan Aktivitas Fibrogenesis pada Penyembuhan Luka Diabetik Menggunakan Salep Ekstrak Daun Anredera scandens (L.) Moq. 20% pada Tikus Sprague Dawley Ardinata, I Putu Riska; Setiawan, Putu Yudhistira Budi; Hita, Putu Gede Adi Purwa
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 1 (2024): (March 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i1.16865

Abstract

Background: In diabetic conditions, decreased glucose-6-phosphate dehydrogenase activity results in reduced nitric oxide synthesis. Reduced nitric oxide synthesis results in the production of ROS. This may impede the processes of angiogenesis and vasoconstriction and prolong inflammation. Objective: We were interested in investigating the mechanism by which 20% of Anredera scandens leaves extract ointment increases fibrogenesis activity because this condition can affect the development of damaged skin tissue. This study's design is a post-test-only laboratory experiment. Material and methods: The study employed male Sprague dawley strain rats that were induced with 40 mg/kgBW of STZ. The mice were divided into four groups: the negative group (which got diabetic wounds only), the positive group (which got Gentamicin ointment), and the test group (which got 20% extract ointment). Results: The skin tissue from each group was then examined histopathologically. After receiving 20% ointment of Anredera scandens leaves extract, the test group's mean fibrogenesis histopathology score on day 14 was significantly higher (P=0.022) at 3.75 than that of the negative group, which had a mean score of 2.75. Following that, the skin tissue of both the extract test group and the normal group was examined histopathologically. In comparison to the normal group mean score of 4.0 on day 14, the test group, which received 20% ointment of Anredera scandens leaves extract, had a non-significant (P=0.317) mean fibrogenesis histopathology score of 3.75. Subsequently, skin tissue was examined histopathologically for both the positive and normal groups. According to the results, on day 14, the positive group's average fibrogenesis histopathology score was 3.5, while the normal group's average score was 4.0. This difference was not statistically significant (P=0.127). Conclusions: Thus, it can be said that 20% Anredera scandens leaf extract ointment is comparable to gentamicin ointment in its capacity to promote fibrogenesis activity in diabetic wounds.
Efektifitas Edukasi Video Terhadap Tingkat Pengetahuan dan Kesadaran Penggunaan Antibiotik: Sebuah Studi Kuasi Eksperimental Adriani, Ni Putu Rina; Widowati, I Gusti Ayu Rai; Ardinata, I Putu Riska; Putri, Dhiancinantyan Windydaca Brata
Jurnal Pharmascience Vol 11, No 2 (2024): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i2.20454

Abstract

Penggunaan antibiotik yang tidak tepat dapat menyebabkan masalah kesehatan serius, termasuk meningkatnya resistensi antibiotik. Penelitian ini bertujuan untuk mengevaluasi pengaruh edukasi video terhadap pengetahuan dan kesadaran penggunaan antibiotik pada pasien di Puskesmas II Denpasar Utara. Pendekatan kuantitatif ini menggunakan  metode quasi-experimental The Static Group Comparison, dengan melibatkan 140 pasien yang dibagi menjadi dua kelompok yaitu kelompok uji terdiri dari 70 pasien yang diberikan edukasi video dan kelompok kontrol terdiri dari 70 pasien yang diberikan pelayanan sesuai standar puskesmas. Pengumpulan data menggunakan kuisioner tervalidasi. Data dianalisis dengan uji non parametrik Mann-Whitney. Hasil menunjukkan bahwa terdapat perbedaan yang signifikan antar kedua kelompok pada variabel pengetahuan (p<0.001) dan kesadaran (p=0.028). Edukasi video memiliki potensi besar dalam meningkatkan kesehatan masyarakat secara keseluruhan, terutama dalam penggunaan antibiotik yang lebih bijak dan rasional.
Exploring Pharmaceutical Personnel’s Insight and Attitudes Toward Complementary and Alternative Medicine: Preferences for Common Cold Remedies Maheni, Ni Putu Asri Dewi; Ardinata, I Putu Riska; Rudiartha, I Gusti Lanang Made; Widowati, I Gusti Ayu Rai
Bali Medical and Wellness Journal Vol. 2 No. 1 (2025): Bali Medical and Wellness Journal
Publisher : PT BMW Journal Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71341/bmwj.v1i3.27

Abstract

Background: Pharmaceutical personnel are responsible for providing accurate advice and therapeutic options to ensure safe and effective treatments. Insufficient knowledge of medications can lead to inappropriate drug selections, adversely affecting patient outcomes. Objectives: This study aims to assess the knowledge of pharmaceutical personnel regarding complementary and alternative medicine (CAM) and their preferences for remedies used to treat the common cold. Method: A cross-sectional design was utilized, involving 35 respondents from selected chain pharmacies. Data were collected using a validated questionnaire that included the Guttman scale for knowledge assessment and the Likert scale for evaluating attitudes and behaviors. Descriptive analysis was performed using SPSS. Results: Most respondents were aged 17-25 years (60.0%), predominantly female (94.3%), held a diploma degree (65.7%), had a monthly income between 2.5-5 million rupiah (74.3%), and had less than three years of work experience (68.6%). Notably, 60.0% had not received training in CAM. The findings indicated that 54.3% of respondents had adequate knowledge of CAM, and 68.6% displayed a positive attitude toward selecting common cold remedies. Additionally, 62.9% recommended supplements or herbal products to patients for preventing or treating the common cold and provided guidance on their proper use. Conclusion: To enhance their knowledge and ensure evidence-based recommendations, pharmaceutical personnel could benefit from additional training on CAM. Furthermore, ongoing education about safe and effective cold remedies may improve patient care and promote better decision-making.
Co-Authors Adriani, Ni Putu Rina Bagus Komang Satriyasa Dewi, DAP Satrya Dhiancinantyan Windydaca Brata Putri Hita, Putu Gede Adi Purwa I Gusti Ayu Agung Septiari I Ketut Tunas I Putu Gede Adi Purwa Hita I Wayan Sumardika Maharianingsih, NM Maheni, Ni Putu Asri Dewi Manuaba, IA Ratih Wulansari Ni Kadek Weni Diah Gayatri Ni Luh Sasih Ni Putu Aryati Suryaningsih Ni Putu Wintariani Ni Putu Wintariani Putra, IGNA Windra Wartana Putri, Dhiancinantyan Windydaca Brata Putu Yudhistira Budhi Setiawan Rudiartha, I Gusti Lanang Made Setiawan, Putu Yudhistira Budi Suryaningsih, NP Aryati Sutema, IA Manik Partha Widowati, I Gusti Ayu Rai - Zainal Firdaus Wardhana